AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AntibodiesBromelainsAntibody SpecificityAntibodies, MonoclonalAntibodies, ViralProtozoan InfectionsEpitopesAntibodies, Anti-IdiotypicImmunoglobulin IdiotypesMice, Inbred BALB CAntibodies, BacterialImmunoglobulin GProtozoan ProteinsAntibody FormationMolecular Sequence DataAntibodies, NeutralizingImmunoglobulin Heavy ChainsEnzyme-Linked Immunosorbent AssayAmino Acid SequenceEukaryotaDNA, ProtozoanRabbitsAntibody AffinityCiliophoraFluorescent Antibody TechniqueAntibodies, ProtozoanGenes, ProtozoanRNA, ProtozoanBinding Sites, AntibodyHIV AntibodiesAntibodies, NeoplasmAntibodies, AntinuclearProtozoan Infections, AnimalGenome, ProtozoanCross ReactionsEntamoeba histolyticaImmunoglobulin MAutoantibodiesAntigens, ProtozoanAntibodies, FungalNeutralization TestsTrypanosoma cruziGiardia lambliaToxoplasmaAntigen-Antibody ReactionsAntibodies, BispecificLeishmaniaSingle-Chain AntibodiesAntibodies, BlockingAntigen-Antibody ComplexImmunoglobulin Fab FragmentsAlveolataTetrahymena pyriformisTrypanosomaAntiprotozoal AgentsAntibodies, HeterophileApicomplexaAntibodies, CatalyticTrypanosoma brucei bruceiKinetoplastidaFluorescent Antibody Technique, IndirectIntestinal Diseases, ParasiticImmunoglobulin ABase SequenceImmune SeraAntibodies, Monoclonal, HumanizedTrypanosomatinaHybridomasRecombinant ProteinsTrichomonasCell LineImmunizationEpitope MappingProtozoan VaccinesCrithidiaAntibodies, AntiphospholipidParasitesAntigensCattleHartmannellaTrichomonas vaginalisLeishmania majorAntigens, SurfaceRumenEntamoebaImmunoenzyme TechniquesBlotting, WesternMolecular WeightElectrophoresis, Polyacrylamide GelCoccidiosisCells, CulturedAntigens, BacterialGiardiasisImmunization, PassiveImmunoblottingImmunohistochemistryLeishmania donovaniImmunoassayImmunoglobulin FragmentsAcanthamoeba
AntigensPlasmodiumParasiteEnzyme-LinkeSpecificityBALBProteinsTrypanosomaInhibitory antibodiesMonoclonal antibodiesToxoplasmaLeishmaniaEpitopesImmunityPathogensMalariaBacteriaInfectionIntracellularGondiiELISAResponsesMacrophagesCellsSerumVaccineImmunoassaysCharacterizationBovineVirusesRecombinantHumansExtracellularRatsVitroBloodChickenGoat
Antigens5
  • Vaccine antigens bio-encapsulated in plant cells upon oral delivery after priming, conferred both mucosal and systemic immunity and protection against bacterial, viral or protozoan pathogens or toxin challenge. (upenn.edu)
  • CD206 mediates phagocytic and endocytic uptake of fungal, bacterial, protozoan and viral antigens, and plays an important role in immune defense and immune regulation. (fishersci.com)
  • Antibodies against carbohydrate antigens on red blood cells and against measles were quantified. (itg.be)
  • Characterization of Tritrichomonas foetus antigens by use of monoclonal antibodies. (docksci.com)
  • Since these functions are in vitro correlates of protection, the antigens recognized by these monoclonal antibodies may induce protective immunity. (docksci.com)
Plasmodium9
Parasite9
  • T. cruzi is the protozoan parasite that causes Chagas disease (American trypanosomiasis), the leading cause of infectious heart disease worldwide and the highest-impact parasitic disease in the Western Hemisphere . (findaphd.com)
  • We also found that mice infected with the rodent malaria parasite P. yoelii 17XNL succumbed to otherwise non-lethal infection when mice were co-infected with an intestinal helminth Heligmosomoides polygyrus 10 . (nature.com)
  • Among these zoonotic pathogens, the protozoan parasite T. gondii is perhaps the most ubiquitous, having been identified in the tissues of a variety of animal hosts, including both mammalian and avian species. (usda.gov)
  • Intro Chagas disease can be endemic to Latin America [1] [2] and it is due to Mouse monoclonal to Metadherin the protozoan parasite is regarded as a significant vector in SOUTH USA being in charge of half of the condition transmission to human beings. (hiv-proteases.com)
  • the major helminth parasites found in wild, semi-wild and golden sovereign stock guinea fowl were heterakis gallinarum, ascaridia galli, capillaria caudinflata, raillietina tetragona and r. echinobothrida, while eimeria species was the most important gastro-intestinal protozoan parasite. (liverpool.ac.uk)
  • Toxoplasma gondii is a wide spread protozoan parasite belonging to the phylum Apicomplexa. (pdfmedarticles.com)
  • This signaling circuit is crucial in renal defenses against uropathogenic Escherichia coli [UPEC, ( 32 )] under regular diet conditions as well as in cutaneous macrophage-driven antimicrobial responses against the protozoan parasite Leishmania major under experimental HS diet ( 8 ). (frontiersin.org)
  • Tous les isolats ont été typés comme Leishmania donovani sur la base de l'amplification en chaîne par polymérase (PCR) de l'ADNk du parasite. (who.int)
  • Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
Enzyme-Linke2
Specificity3
BALB6
  • Immunogenicity of the other six proteins (SPELD, ETRAMP10.3, SIAP2, SPATR, HT, RPL3) was analyzed by immunization of inbred BALB/c and outbred CD-1 mice with viral-vectored (ChAd63 or ChAdOx1, MVA) vaccines, followed by challenge with chimeric sporozoites. (ox.ac.uk)
  • BALB/c mice immunized with the targeted vaccine induced higher PfRH5-specific IgG1 antibody responses than those vaccinated with a non-targeted vaccine or antigen alone. (ox.ac.uk)
  • By contrast, BALB/c mice are resistant to ECM and exhibit milder intestinal pathology and dysbiosis. (nature.com)
  • BALB/c mice were immunized intraperitoneally three times at 2- to 3-week intervals with 0.5 ml of freshly prepared, washed, live trichomonads (0.8 x 106 organisms). (docksci.com)
  • Production and Characterization of MAbs against WDV CP BALB/c mice were immunized with purified recombinant WDV CP. (thetechnoant.info)
  • Ascitic fluids with MAbs were produced by intraperitoneal inoculations of hybridoma cells to pristane-primed BALB/c mice. (thetechnoant.info)
Proteins3
  • For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P. berghei sporozoites were created that express the P. falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter. (ox.ac.uk)
  • Of the six proteins only SPELD immunized mice showed partial protection. (ox.ac.uk)
  • These data show that GPI-anchored proteins of L. mexicana are not essential for growth of promastigotes, invasion of macrophages by promastigotes, or infection of mice. (gla.ac.uk)
Trypanosoma5
  • In mice, experimental infection with Trypanosoma brucei causes decreased bone marrow B-cell development, abolished splenic B-cell maturation and loss of antibody mediated protection including vaccine induced memory responses. (itg.be)
  • Trypanosomatid parasitic protozoa such as Leishmania and Trypanosoma brucei make extensive use of this method of protein surface attachment. (gla.ac.uk)
  • The protozoan Trypanosoma cruzi presents a differentiated cytoskeleton, based on a sub-pellicular corset of microtubules. (fiocruz.br)
  • Trypanosoma cruzi trypomastigotes in a mouse blood smear (Giemsa, x625). (medscape.com)
  • Genetic control of resistance to Trypanosoma cruzi in inbred mice / by Ruth Anna Wrightsman. (who.int)
Inhibitory antibodies1
  • Oral delivery of blood clotting factors FVIII or FIX prevented inhibitory antibodies/complications after injection of blood clotting factors in hemophilia A/B mice or dogs by developing tolerance. (upenn.edu)
Monoclonal antibodies4
  • Monoclonal antibodies TF1.17 and TF1.15 recognized broad bands between 45 and 75 kilodaltons. (docksci.com)
  • The first two antibodies (TF3.8 and TF3.2) did not react with the surface of T. foetus, as determined by live-cell immunofluorescence, agglutination, and immobilization, whereas two other monoclonal antibodies (TF1.17 and TF1.15) did react with surface epitopes, as determined by these criteria. (docksci.com)
  • The latter two monoclonal antibodies also mediated complementdependent killing of T. foetus and prevented of adherence of organisms to bovine vaginal epithelial cells. (docksci.com)
  • Table?1 Properties of the acquired anti-WDV monoclonal antibodies. (thetechnoant.info)
Toxoplasma3
  • Toxoplasma gondii is one of the most prevalent zoonotic protozoan parasites worldwide and affects the vast majority of warm-blooded animal species, including humans. (chemnews-japan.com)
  • Seroprevalence of antibody to TgGRA7 antigen of Toxoplasma gondii in livestock animals from Western Java, Indonesia. (obihiro.ac.jp)
  • El Toxoplasma gondii es un parásito que se encuentra, aproximadamente, en el 30 % de la población humana. (bvsalud.org)
Leishmania1
Epitopes1
  • Recently, the crystal structure and key functional antibody epitopes for the truncated version of PfRH5 (PfRH5ΔNL) were characterized, suggesting PfRH5ΔNL to be a promising candidate for next-generation PfRH5 vaccine design. (ox.ac.uk)
Immunity4
  • The candidate will graduate with a clear understanding of mouse models of immunity and infection, cutting-edge molecular immunology technologies, as well as strong laboratory and transferrable skills. (findaphd.com)
  • Although functionality of the B-cells was not verified, the results suggest that immunity was conserved in T.b. gambiense infected HAT patients and that B-cell dysfunction might not be that severe as in mouse models. (itg.be)
  • Unlike humoral immunity, cell-mediated immunity does not involve antibodies. (psychosocialsomatic.com)
  • The defense mechanisms of humoral immunity are the re- sponsibility of the antibodies circulating in the blood and on the surface of mucous membranes, as well as cytokine and complement systems. (psychosocialsomatic.com)
Pathogens1
  • Ticks (Acari: Ixodidae and Argasidae) transmit multiple and diverse pathogens (including bacteria, protozoa, and viruses), which cause a wide range of human and animal diseases, including rickettsial diseases, caused by bacteria in the order Rickettsiales. (cdc.gov)
Malaria3
  • The 24E9 mouse mAb was raised against PFD1235w DBLβ3_D4, a domain from the group A PfEMP1s associated with severe malaria. (ox.ac.uk)
  • In the present study, infection of C57BL/6 mice with P . berghei ANKA ( Pb A) caused intestinal pathological changes, such as detachment of epithelia in the small intestines and increased intestinal permeability, which correlated with development with experimental cerebral malaria (ECM). (nature.com)
  • A vaccine for malaria has existed for 35 years, but so far it only works in mice," says Kurtis. (lifespan.org)
Bacteria1
Infection3
  • The successful candidate will combine cutting-edge transcriptomics and proteomics with transgenic mouse models to further dissect the role of immune cells infiltrating the heart during T. cruzi infection. (findaphd.com)
  • for example, mice and yellow cattle are more sensitive than rats and water buffalo to infection with S. japonicum (Chinese strain)[ 3 ]. (biomedcentral.com)
  • 4 ). important to detect infection early in pregnancy to Serological testing to detect specific anti- T. gondii IgG prevent congenital fetal infection and minimize the risk and/or IgM antibodies is the first step in the diagnosis of of serious congenital conditions ( 8,9 ). (who.int)
Intracellular2
  • Applications Reported: This MR6F3 antibody has been reported for use in flow cytometric analysis, and intracellular staining followed by flow cytometric analysis. (fishersci.com)
  • Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. (fishersci.com)
Gondii7
  • In the present study, antibodies to T. gondii were found in 36 % of 914 deer across the USA and viable T. gondii was isolated from tissues of 36. (usda.gov)
  • Serum samples were initially screened for antibodies to T. gondii, and then the tissues of seropositive WTD were bioassayed in mice. (usda.gov)
  • In coinfected mice, elevated levels of T. gondii -specific IgG2a antibodies were detected. (ac.ir)
  • A cat becomes infected with T gondii by eating contaminated raw meat, wild birds, or mice. (medscape.com)
  • The blood samples were screened with VIDAS Toxo-IgG/IgM and SERIONE IgG/IgM and IgG avidity assays to detect T. gondii-specific antibodies. (who.int)
  • Overall seroprevalence of T. gondii IgG and IgM antibodies among pregnant women was 12.5% and 2.1%, respec- tively. (who.int)
  • A narrative bibliographic review article was done with the search of original and review articles in international scientific mentales en adultos journals, in English and Spanish listing the relationship between the seroprevalence of T. gondii and the development of mental disorders in the adult population. (bvsalud.org)
ELISA2
  • The antibody is suitable for ELISA and lateral flow applications. (thenativeantigencompany.com)
  • ACP-ELISA Detection of WDV The optimal operating dilutions of MAbs and the AP-conjugated goat anti-mouse IgG for the ACP-ELISA were determined by the phalanx checks. (thetechnoant.info)
Responses1
  • Vitamin A deficient mice have a selective defect in T H 2 responses to S. mansoni , but retained normal LCMV specific T H 1 responses. (prolekarniky.cz)
Macrophages2
  • They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells. (nih.gov)
  • Six parasites ont montré une résistance in vitro au stibogluconate de sodium en utilisant le test de détection des amastigotes dans les macrophages J774 murins. (who.int)
Cells10
  • Amyloid plaques were reduced in vivo by 70% in hippocampus and cortex brain regions when fed with myelin basic protein and reduced Aβ42 accumulation in retinae and prevented loss of retinal ganglion cells in 3xTg Alzheimer's disease mice. (upenn.edu)
  • The early mortality of infected IL-27R-/- mice was correlated with significantly elevated secretions of inflammatory cytokines, particularly IFN-, and enhanced service of CD4+ Th1 cells. (colinsbraincancer.com)
  • Either depletion of CD4+ Capital t cells, ensuing in a dramatically reduced secretion of IFN-, or neutralization of IFN-, prevented the early mortality of infected IL-27R-/- mice with a significantly reduced inflammatory response and a major amelioration of the liver pathology. (colinsbraincancer.com)
  • Therefore, our data determine IL-27 signaling as a book pathway to prevent the early mortality via inhibiting hyperactivation of CD4+ Th1 cells and their excessive secretions FH535 IC50 of IFN- during experimental illness with extracellular protozoan parasites African trypanosomes. (colinsbraincancer.com)
  • Recent studies shown that Kupffer cells efficiently engulf trypanosomes, which is definitely mediated by both IgM and IgG antibodies specific to the parasites [10C12]. (colinsbraincancer.com)
  • However, excessive secretions of these inflammatory cytokines by hyperactivated myeloid cells and Capital t cells lead to liver pathology and shorten the survival of infected mice [11,22,26C29]. (colinsbraincancer.com)
  • Using spatial transcriptomics, our team has identified a diverse immune cell infiltrate dominated by B cells in hearts from T. cruzi -infected mice. (findaphd.com)
  • Originally recognised as white blood cells that produce antibodies, B cells have been shown to play much broader roles, particularly orchestrating and modulating the immune response. (findaphd.com)
  • The effect of gambiense HAT on peripheral blood memory T- and B-cells and on innate and vaccine induced antibody levels was examined. (itg.be)
  • Splenocytes of immunized mice were fused with X-63 Ag8.653 myeloma cells (19). (docksci.com)
Serum3
  • A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. (fishersci.com)
  • Specimens tested for rabies antibodies include serum and CSF. (msdmanuals.com)
  • Thus, a sequence of 14 amino acids corresponding to a non-conserved region of actin 2 was used to immunize mice in order to obtain a polyclonal serum. (fiocruz.br)
Vaccine1
  • The CIHR team has developed a vaccine for schistosomiasis that works in mice and is showing promise in water buffalo, which are a major transmitter of the disease. (lifespan.org)
Immunoassays1
Characterization1
  • Its molecular characterization, subcellular localization and antibody recognition by infected sheep. (obihiro.ac.jp)
Bovine1
  • Effects of ethanol and water extracts from Phyllanthus emblica fruits on the growth of bovine Babesia and equine piroplasma parasites in vitro and Babesia microti in mice. (obihiro.ac.jp)
Viruses1
Recombinant3
  • Construction of a recombinant vaccinia virus expressing Babesia gibsoni thrombospondin-related anonymous protein and evaluation of its immunogenicity in mice. (obihiro.ac.jp)
  • These antibodies detected recombinant protein but failed to detect protein in L. mexicana cell lysates. (gla.ac.uk)
  • Antibodies raised against a peptide of GPI8 also recognised recombinant GPI8, but not GPI8 in L. mexicana lysates. (gla.ac.uk)
Humans1
  • Transmission of rabies to humans from small rodents (such as squirrels, chipmunks, rats, mice, hamsters, guinea pigs, gerbils) and lagomorphs (including rabbits and hares) has not been reported. (msdmanuals.com)
Extracellular2
  • These data are the 1st to show the important part of IL-27 signaling in controlling immune system reactions to extracellular protozoan infections. (colinsbraincancer.com)
  • Author Summary Illness with extracellular protozoan parasites, African trypanosomes, is definitely characterized by a continual inflammatory immune system response. (colinsbraincancer.com)
Rats1
  • the relationship between erythrocyte morphology and parasitization in chickens, rats, and mice. (liverpool.ac.uk)
Vitro1
  • Influence of organochlorine pesticides on development of mouse embryos in vitro . (cdc.gov)
Blood2
  • Centered on mouse models, although the parasites circulate in Mouse monoclonal to ATP2C1 the blood stream, the liver is definitely the major place for distance of the parasites [7C9]. (colinsbraincancer.com)
  • These salivary parts could be immunologically identified by their hosts and targeted with antibodies that may disrupt blood nourishing. (hiv-proteases.com)
Chicken1
Goat1
  • After three rinses with PBST, a diluted AP-conjugated goat anti-mouse IgG answer (100?L) was added into each well and the plates were incubated at 37?C for 1?h. (thetechnoant.info)