• Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. (wikipedia.org)
  • Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. (bioactiva.com)
  • Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. (bioactiva.com)
  • Western blot analysis of mouse recombinant Ago2 full length protein (lanes 1-4). (ecmbio.com)
  • The antibody detects a 97 kDa* protein corresponding to the apparent molecular mass of phosphorylated Ago2 on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A and mouse recombinant Ago2 full length protein. (ecmbio.com)
  • The antibody detects a 215 kDa* protein corresponding to the apparent molecular mass of MYH13 on SDS-PAGE immunoblots of mouse extraocular muscle, and does not detect MYHs in mouse diaphragm, gastrocnemius, or brain. (ecmbio.com)
  • In vivo imaging of annexin V (A5) was performed at 12 hr, 24 hr, 48 hr, and 4 days after 90-min transient middle cerebral artery occlusion (tMCAO) in mice with a fluorescent protein Cy5.5. (elsevierpure.com)
  • Immunohistochemistry for heat shock protein 70 (HSP70), A5, and TUNEL were also performed with brain sections after the tMCAO. (elsevierpure.com)
  • To elucidate the role of this protein in vivo, we have generated LECT2-deficient (LECT2(-/-)) mice. (ox.ac.uk)
  • Annexin A5 is a protein which binds to cells undergoing apoptotic cell death. (abcdocz.com)
  • The protein annexin A1 (ANXA1) is key to the phagocytosis of apoptotic leukocytes during peripheral inflammatory resolution, but the pathophysiological significance of its expression in the CNS that is restricted almost exclusively to microglia is unclear. (westminster.ac.uk)
  • The study shows that a plasma protein Annexin A5 decreases inflammation and modulates immune reactions to modified LDL, which creates a protective effect. (ki.se)
  • Zonal ex vivo fluorescent signals were surrounding the ischemic core, and double-positive cells with Cy5.5/exogenous A5 antibody were found in this area. (elsevierpure.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Dipeptidyl Peptidase IV (DPP4) in serum, plasma, tissue homogenates and other biological fluids. (elisastrip.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Dipeptidyl Peptidase IV (DPP4) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisastrip.com)
  • Monovariate logistic regression evaluation demonstrated a optimistic dose-effect relationship for anti-annexin V IgM with VOC, with elevated VOC danger seen with elevated antibody titers. (ncbcs.org)
  • Induction of apoptosis by cross-linking antibodies certain to human B-lymphoma cells: expression of Annexin V binding websites on the antibody cap. (ncbcs.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 18 (IL18) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (agctsequencing.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 18 (IL18) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 18 (IL18). (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) in tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
  • Annexin A5(ANXA5), is a member of the structurally related family of?annexin?proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. (bioactiva.com)
  • Purpose: Annexin A5 (ANXA5) features a potential role in cellular signal transduction, inflammation, and pathology. (netkumar1.co.in)
  • Methods: A murine model of respiratory illness iatrogenic by fixings (OVA) and titania (TiO2) nanoparticles has been established mistreatment BALB/c mice, and that we examined the ANXA5 expression and respiratory organ pathology mistreatment this model. (netkumar1.co.in)
  • Description: A sandwich ELISA kit for detection of Dipeptidyl Peptidase IV from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisastrip.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 18 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)
  • q g Investigations and research Advances in cardiovascular molecular imaging: the case of Annexin A5 Apoptosis helps identify patients at risk of stroke or myocardial infarction. (abcdocz.com)
  • In this article we briefly discuss the opportunities for using Annexin A5 for the non-invasive detection of apoptosis in patients with cardiovascular disease. (abcdocz.com)
  • In this article we briefly describe the various aspects of molecular imaging using Annexin A5 in cardiovascular disease. (abcdocz.com)
  • Most basic scientific studies in the field are based mouse models with genetic changes as mice cannot develop arteriosclerosis or cardiovascular disease. (ki.se)
  • Annexins are a multigene family of Ca++-regulated phospholipid-binding proteins. (rndsystems.com)
  • The name annexin derives from the fact that initial studies suggested that acidic membrane phospholipids and Ca++ annexed, or recruited, special cytosolic proteins into a membrane-interacting ternary complex. (rndsystems.com)
  • The number of TUNEL-positive cells increased at 24 hr and retained the high level until 4 days, showing a dissociating temporal pattern with A5. (elsevierpure.com)
  • Double-positive cells for A5/TUNEL reached their peak at 48 hr. (elsevierpure.com)
  • Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. (ox.ac.uk)
  • We found that the proportion of NKT cells in the liver increased significantly in LECT2(-/-) mice, although those of conventional T cells, NK cells, and other cell types were comparable with those in wild-type mice. (ox.ac.uk)
  • Consistent with increased hepatic NKT cell number, the production of IL-4 and IFN-gamma was augmented in LECT2(-/-) mice upon stimulation with alpha-galactosylceramide, which specifically activates Valpha14 NKT cells. (ox.ac.uk)
  • In addition, NKT cell-mediated cytotoxic activity against syngeneic thymocytes increased in hepatic mononuclear cells obtained from LECT2(-/-) mice in vitro. (ox.ac.uk)
  • All four adenosine receptors are expressed on the surface of mouse invariant NKT (iNKT) cells. (guidetomalariapharmacology.org)
  • Annexin A5 has the unique property of targeting and binding to cells undergoing cell death through apoptosis [3]. (abcdocz.com)
  • 6. Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. (mutalig.eu)
  • Also, we propose two new targets of therapy (WG2-T1), which are TCL1 and Annexin A4, respectively involved in lymphoma development and drug resistance to paclitaxel in lung cancer cells. (mutalig.eu)
  • The in vivo Cy5.5 fluorescence representing A5 signal spatially surrounding the ischemic core temporally detects an early-stage apoptosis after cerebral ischemia. (elsevierpure.com)
  • A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the hinge region from mouse MYH13/extraocular myosin. (ecmbio.com)
  • Using an in vitro model comprising microglial and neuronal cell lines, as well as primary microglia from wild-type and ANXA1 null mice, we have identified two distinct roles for microglial ANXA1: 1) controlling the noninflammatory phagocytosis of apoptotic neurons and 2) promoting resolution of inflammatory microglial activation. (westminster.ac.uk)
  • Male C57Bl/6 mice were subjected to focal cerebral ischemia and periods of reperfusion (0, 8 and 24 h). (biomedcentral.com)
  • A research from TLR4-deficient mice confirmed the essential role of TLR4 in mediating neutrophil migratory phagocytic functions, attenuating inflammation, reducing reactive oxygen species generation, and enhancing bacterial clearance ( 13 ). (frontiersin.org)
  • We have shown that Annexin 5 is a possible new therapy for fighting inflammation and supports the immune defence system is a positive way. (ki.se)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Dipeptidyl Peptidase IV (DPP4) in samples from serum, plasma, tissue homogenates or other biological fluids. (elisastrip.com)
  • Scientific significance of serum anti- annexin V antibodies in Egyptian sufferers with scleroderma. (ncbcs.org)
  • In conclusion, measurement of serum anti-annexin V IgG antibodies in scleroderma sufferers could also be necessary for early prognosis of vascular and pulmonary issues. (ncbcs.org)
  • Description: Quantitative sandwich ELISA for measuring Mouse Prolactin (PRL) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (agctsequencing.com)
  • A new study in mice, conducted by researchers at Sweden's Karolinska Institutet together with colleagues in Singapore and the United States, shows that our natural gut-residing microbes can influence the integrity of the blood-brain barrier, which protects the brain from harmful substances in the blood. (metabolomics.se)
  • The investigators reached this conclusion by comparing the integrity and development of the blood-brain barrier between two groups of mice: the first group was raised in an environment where they were exposed to normal bacteria, and the second (called germ-free mice) was kept in a sterile environment without any bacteria. (metabolomics.se)
  • Maintained into adulthood The team also showed that the increased 'leakiness' of the blood-brain barrier, observed in germ-free mice from early life, was maintained into adulthood. (metabolomics.se)
  • q g One of the most promising developments in molecular imaging that has emerged in recent years, even in clinical studies, is the use of Annexin A5. (abcdocz.com)
  • Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. (cancerindex.org)
  • PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
  • Annexins possess a series of unique 70 amino acid annexin-repeat modules that form a curved disk and allow for the creation of an intercessory complex between plasma membrane and cytofilaments. (rndsystems.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
  • Interestingly, the hepatic injury was exacerbated in LECT2(-/-) mice upon treatment with Con A, possibly because of the significantly higher expression of IL-4 and Fas ligand. (ox.ac.uk)
  • Interestingly, this 'leakiness' could be abrogated if the mice were exposed to fecal transplantation of normal gut microbes. (metabolomics.se)
  • Here, we report that annexin A5, an important component of the matrix vesicle membrane, plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis. (bvsalud.org)
  • We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice. (bvsalud.org)
  • Finally, we proved its protective role in resisting bone loss by applying it to osteoporotic mice. (bvsalud.org)
  • Taken together, these data revealed the importance of annexin A5, originating from adherent MVs of osteoblasts, in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss. (bvsalud.org)
  • Live cell morphology and process activity were measured from movies acquired in acute brain slices from GFP-CX3CR1 transgenic mice after IS and 24-h reperfusion. (biomedcentral.com)
  • This gene encodes a member of the annexin family. (wikipedia.org)
  • Methods: Mice received either one high or multiple low doses of Stx to simulate the (clinically well-known) different disease courses. (bvsalud.org)
  • The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
  • Scientists have used a mice model to reverse a number of the foremost severe injury done to the brain by insanity - and that they did this with an astonishingly recent medication generally used for respiratory illness. (netkumar1.co.in)
  • The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.". Biochemistry. (wikipedia.org)
  • Annexin A4 " has 3 results in Products. (rndsystems.com)
  • Results: All Stx-challenged mice showed reduced cardiac output and depletion of intravascular volume indicated by a reduced end-diastolic volume and a higher hematocrit. (bvsalud.org)
  • By using blockers of PKA and CaMKII and a Caveolin-3-knockout mouse model, we conclude that the β2AR-LTCC regulation requires the presence of caveolin-3 and the activation of the CaMKII pathway. (imperial.ac.uk)
  • In view of their prothrombotic nature, we hypothesized that SCA-associated VOC could also be because of the presence of anti-annexin V antibodies. (ncbcs.org)
  • We investigated the prevalence of anti-annexin V IgG and IgM antibodies in sera of scleroderma sufferers and their relation to the presence of different antibodies and improvement of illness morbidity. (ncbcs.org)
  • Western blot analysis of MYH13 in mouse extraocular muscle. (ecmbio.com)
  • Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)
  • Moreover, treatment with baricitinib at 1h or 3h post-CLP protected mice from sepsis-induced cardiac injury and multiple-organ failure. (bvsalud.org)
  • Some mice exhibited myocardial injury (measured as increases in cTNI levels). (bvsalud.org)