Mice and human fetal and adult mouse tissues fetal proteins. Medical search. Frequent questions

Li et al, Development 2019) as well as the developing cardiac conduction system at embryonic day 16.5 of mouse development (Goodyer et al, Circulation Research 2019). (stanford.edu)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)

A protein known to be involved in a rare hereditary cancer syndrome may have a role in the regulation of liver stem cells and the development of liver cancer. (vetscite.org)
In the August 15 issue of Genes & Development, a Massachusetts General Hospital (MGH) research team describes finding that the protein called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. (vetscite.org)
We found that mutation of the NF2 tumor suppressor gene in the mouse liver led to a dramatic overproliferation of liver stem cells - the cells that contribute to the liver's remarkable ability to regenerate," says Andrea McClatchey, PhD, of the MGH Center for Cancer Research, who led the study. (vetscite.org)
These mice go on to develop the two forms of liver cancer that are most common in humans, suggesting that liver stem cells may be the cells of origin of these tumors. (vetscite.org)
These liver stem cells have been identified in rodents, and potential equivalents found but not confirmed in humans. (vetscite.org)
The researchers found that infant mice lacking functioning NF2 in their livers developed dramatic overgrowth of liver stem cells, to the point of crowding out hepatocytes. (vetscite.org)
Schwank et al used CRISPR/Cas9 to investigate the treatment of CF. Using adult intestinal stem cells obtained from two patients with CF, they successfully corrected the most common mutation causing CF in intestinal organoids. (bmj.com)
We also use human stem cells as a test-tube model to study the process of heart formation and to create new human heart tissues and organs from these stem cells. (stanford.edu)
1. Development of a ML/AI pipeline for the prediction of subtypes and differentiation stage of developing mouse cardiac cells from mesoderm to birth and from in vitro differentiation of human induced pluripotent stem cells (hiPSCs). (stanford.edu)
Multiplying in maternal chests, the fetal stem cells transform into blood vessel-like tubes and, more significant, cells that resemble full-fledged heart muscle cells, which cardiologists have struggled for decades to recreate in a lab. (smithsonianmag.com)

Thyroid hormones (THs) regulate muscle formation and fuel energy utilization by modulating carbohydrates and lipid and protein metabolism. (bvsalud.org)
Alterations in thyroid function test findings may reflect changes in production of thyroid hormone by effects on the thyroid itself, on the hypothalamic-pituitary-thyroid axis, on peripheral tissue metabolism of the hormones, or by a combination of these effects. (medscape.com)
Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)

We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders. (researchgate.net)
Tumour the fetus via the maternal circulation utero, but when the reactive metab multiplicity rises to a maximum in must have crossed the placenta, and olites formed in maternal tissues are offspring exposed at approximate consequently are generally referred too unstable to circulate in the mater ly 21 days of gestation, a few days to as transplacental carcinogens. (who.int)

The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)
In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)
Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)
In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
in this tissue they found upregulation of Wnt signaling-related genes compared to control tissues. (alzforum.org)
Among the dementia-linked genes with altered expression were glycogen synthase kinase 3β (GSK-3β) protein phosphatase 2 A (PP2A), and APC, which are scaffolds mediating presenilin-1/β-catenin interactions. (alzforum.org)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Salistick detects pregnancy by identifying a hormone called human chorionic gonadotropin (hCG), which is present in the body of a pregnant person. (medicaldaily.com)
During pregnancy the fetal mouse cells cross the placenta into the mother's body, joyriding through her blood vessels until cardiac damage happens, at which point they sense inflammation and make a beeline for her wounded heart. (smithsonianmag.com)

Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. (cdc.gov)
We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. (cdc.gov)
An active lifestyle and not smoking may have additive effects on reducing the genetic susceptibility to obesity in adults. (nature.com)
At least in experimental animals, genetical y modified strains, because on the differential effects of a wide greater susceptibility to chemical in these species the interval between variety of carcinogens in humans at carcinogens in utero and during birth and sexual maturity is only a different stages of life, including var early postnatal life is usual y man few weeks. (who.int)
This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
The susceptibility of but a few known transplacental car and reach the fetus, a carcinogenic the fetus relative to that of adult rats cinogens are organic compounds chemical may have no transplacen is measured as the incidence and that act principal y or entirely by a ge tal carcinogenic activity or may only multiplicity of tumours that develop notoxic mode of action. (who.int)

Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice. (researchgate.net)
In addition, FACL4 was highly expressed in both adult and newborn mouse brain especially in the granule cells of the dentate gyrus and the pyramidal cell layer of CA1 in hippocampus, and the granular cell layer and Purkinje cells of the cerebellum. (nih.gov)
Immune molecules in mothers who have children with autism target neurons in the frontal cortex, cerebellum and hippocampus of mouse brains. (spectrumnews.org)

This ties together the epidemiological finding that women who have autoimmune disease are more likely to have kids with autism, with the idea that there are actually antibodies against fetal brain in their serum," says Paul Patterson , professor of biology at the California Institute of Technology, who was not involved in the work. (spectrumnews.org)
A general conviction exists that patients with thyroid function test result abnormalities do not have hypothyroidism despite the low serum hormone levels in blood and low T3 in most of the tissues. (medscape.com)
Some authors propose that serum thyroid hormone abnormalities are due to inhibition of thyroid hormone binding to proteins, thus preventing tests from appropriately reflecting free hormone levels. (medscape.com)
This binding inhibitor can be present both in the serum and in body tissues and might inhibit uptake of thyroid hormones by cells or prevent binding to nuclear T3 receptors, thus inhibiting the action of the hormone. (medscape.com)

We examined the effect of BPA and DES on EZH2 expression and function in MCF-7 cells and in mammary glands of mice exposed in utero. (nih.gov)
Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma (cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion abrogated DMBA-TPA-induced skin tumorigenesis in mice. (bvsalud.org)
To assess the role of THs on the lipidic composition of SkM fibers, we performed lipidomic analyses of SkM cells and tissues, glucose tolerance experiments, and exercise performance tests. (bvsalud.org)
However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. (nature.com)
Mice that did not die from a lack of functioning liver cells soon developed the two major types of liver cancer, and the fact that stem cell overgrowth preceded tumor development strongly suggested that the undifferentiated progenitors were the source of the tumors. (vetscite.org)
We have cloned previously the human long-chain fatty acid-CoA ligase 4 (FACL4), which is a central enzyme in controlling the free arachidonic acid level in cells and thereby regulating eicosanoid production. (nih.gov)
DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
We subsequently became interested in developing a developing heart expression atlas in order to identify the cell type, developmental stage, and anatomical location of each single cardiac cells during mouse heart development using a random forest-based computational algorithm that we termed ATLAS-seq. (stanford.edu)
Recent Accomplishments - Starting in 2013, we incorporated Fluidigm-based multiplex single cell PCR equipment HD Biomark to analyze the differentiation of single cardiac progenitor cells in vitro and found that Nkx2.5 expression marks a subpopulation of committed endocardial precursor cells in the mouse heart (Li et al, Development 2015). (stanford.edu)
Vestibular hair cells serve as sensory receptors in the inner ear that function to assess and monitor head motion, a sense of balance, allowing humans and animals to orient themselves," Dr. Robert Glatter , an emergency physician at Lenox Hill Hospital in New York, told Healthline. (healthline.com)
According to Glatter, the takeaway is that this study found that vestibular hair cells and Schwann cells express proteins that are essential for SARS-CoV-2 to enter cells. (healthline.com)
These proteins include the ACE2 receptor, which is found on the surface of cells," he said, "and two enzymes called furin and transmembrane protease serine 2 (TMPRSS2) , which allow SARS-CoV-2 to attach to the host cell. (healthline.com)
Human esophageal squamous epithelial (HET-1A) cells were treated with bile acid and used in transfection experiments. (jcancer.org)
2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
Adult heart tissue doesn't rally easily, but new mothers may somehow be able to regrow heart cells the way salamanders sprout new tails. (smithsonianmag.com)
In tests involving lab mice, which were surgically operated on to simulate a heart attack, she and her research team discovered something astonishing: heart cells with DNA that doesn't match the mother's own. (smithsonianmag.com)
The mystery cells belong to unborn mice. (smithsonianmag.com)
The lab has even found that these cells, harvested from mouse placentas, will travel to the damaged hearts of male mice after being artificially implanted in their tails. (smithsonianmag.com)
On a nearby computer screen, Chaudhry pulls up highly magnified video footage of these fugitive fetal mouse cells in a petri dish. (smithsonianmag.com)
Why on earth, I ask, are the fetal cells bopping around like that? (smithsonianmag.com)
Scientists discover fetal cells in the darnedest places. (smithsonianmag.com)
Scientists find rogue fetal cells while autopsying the cadavers of old women, whose babies are now middle-aged. (smithsonianmag.com)
The phenomenon is called "fetal microchimerism"-"micro," because these are typically teeny numbers of cells, only a handful per millimeter of blood in pregnant women, and fewer in moms later in life. (smithsonianmag.com)
Purified GST fusion proteins of the N and C termini of Na v 1.3 pull down contactin from lysates of transfected HEK 293 cells. (jneurosci.org)
To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. (biomedcentral.com)
Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)
The availability of real-time imaging of mice anatomy allows performing aspiration procedures under ultrasound guidance as well as the microinjection of cells, viruses, or other agents into precise locations. (hindawi.com)
PCB methyl sulphones and related compounds: Identification of target cells and tissues in different species. (cdc.gov)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)

The researchers found that plasma from 260 of the women, or 10.5 percent, reacts strongly with mouse brain tissue, a signal that the blood contains anti-brain antibodies. (spectrumnews.org)
Researchers analyzed inner ear tissue sourced from humans and mice to create in-vitro cellular models of the inner ear. (healthline.com)
Researchers noted that they observed SARS-Cov-2 infection of OPCs , a cell type present in the developing fetal inner ear. (healthline.com)

Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. (researchgate.net)
The monkeys' brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. (cdc.gov)

In contrast to previous findings in heart tissue, expression of the pathological gene program in heart failure was not accompanied by changes in the CM DNA methylome but by active histone marks. (nature.com)
Originally discovered through its involvement in the rare genetic disorder neurofibromatosis type 2, the NF2 gene codes for merlin, a protein known to suppress the activity of a number of cellular receptors. (vetscite.org)
We report here the expression of this gene in tissues, particularly in different parts of the brain. (nih.gov)
CRISPR/Cas9 is a gene-editing technology which involves two essential components: a guide RNA to match a desired target gene, and Cas9 (CRISPR-associated protein 9)-an endonuclease which causes a double-stranded DNA break, allowing modifications to the genome (see figure 1 ). (bmj.com)
Deletion of DAZ gene is the most common causes of infertility in humans. (ijbs.com)
The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
Translocations between MLL (a human trithorax -related gene) and AF4 or AF5q31 are involved in acute lymphoblastic leukemia (Wittwer, 2001, Tang, 2001 and Su, 2001). (sdbonline.org)
The dying neurons possess one good progranulin gene, but do not make enough of the protein. (alzforum.org)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

However, DES exposure in utero is also associated with an increased risk of breast cancer in adult women. (nih.gov)
Similarly, fetal exposure to BPA induces neoplastic changes in mammary tissue of mice. (nih.gov)
DES and BPA treatment approximated human exposure. (nih.gov)
Data on the efficacy of active and passive immunization after rabies exposure have come from both human and animal studies. (cdc.gov)
Thus, the likelihood of human exposure to rabies in domestic animals has decreased greatly, although bites by dogs and cats continue to be the principal reasons given for antirabies treatments. (cdc.gov)
In much of the world, including most of Asia and all of Africa and Latin America, the dog remains the major source of human exposure. (cdc.gov)
Several research groups have found these immune molecules, called antibodies, in mothers of children with autism , and have shown that prenatal exposure to the antibodies alters social behavior in mice and monkeys . (spectrumnews.org)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)
Human exposure may occur via inhalation due to the high vapor pressure of iodomethane. (cdc.gov)
A quantitative human health risk assessment was conducted for inhalation exposure. (cdc.gov)
The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. (cdc.gov)
A physiologically based pharmacokinetic (PBPK) model for iodomethane was developed to characterize poten- tial human health effects from iodomethane exposure. (cdc.gov)
Iodomethane is a new agricultural of approximately 24 hours due to the emission patterns of active ingredient, and there are no human exposure incident the compound and air dispersion patterns ( EPA OPP Health reports related to agricultural uses. (cdc.gov)

FACL4 was expressed in early stages of development with a significant amount of FACL4 mRNA detected in an E7 mouse embryo. (nih.gov)
A human female embryo develops around 7 million proto-eggs, known as primordial oocytes. (discovermagazine.com)
This paper outlined the successful purification and identification of nerve growth factor (NGF) as a protein, the developmental effects of depriving an embryo of NGF, and the discovery that NGF is also required for the maintenance of the nervous system. (asu.edu)
A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo," by Rita Levi-Montalcini and Viktor Hamburger, appeared in 1953 in the Journal of Experimental Zoology. (asu.edu)
The consistent ultrasound image obtained with the UBM can be used to visualize and guide injection into target organs [ 9 , 10 ], including mouse embryo, to aid in targeted delivery of drugs and viral particles [ 7 , 11 ]. (hindawi.com)

The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)

As part of his vision of a dystopian future, Huxley took readers on a tour of a human hatchery where eggs matured in carefully maintained ovaries before being fertilized and developed in bottles. (discovermagazine.com)
In one set of experiments, begun in 1994, he removed ovaries from ewes, froze strips of the ovarian tissue, then later reimplanted the tissue in the same animals. (discovermagazine.com)

In vitro studies in resistive human lung epithelial cell monolayers grown at an air-liquid interface have supported these in vivo observations. (ersjournals.com)

CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
As outlined in one poster, Wexler and Rosen started with a study of Wnt1 signaling in fetal human neural progenitors (hNPs) that they differentiated into neurons. (alzforum.org)

This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
However, the detailed epigenetic processes involved in maturation from fetal to adult CMs and in cardiac disease leading to terminal heart failure have not been fully uncovered, yet. (nature.com)
Epigenetic mechanisms are highly cell-type-specific requiring cell separation techniques to determine epigenomic features in a specific cell type, especially when keeping in mind that the cellular composition of the human heart is highly dynamic. (nature.com)

Purification of CM nuclei by fluorescence-assisted sorting has led to the identification of cell-type-specific mCpG and histone modification signatures in CMs during mouse heart development and maturation 11 . (nature.com)
Based on this method 13 , 14 , we used a nuclear staining strategy to isolate CM nuclei from intact prenatal and postnatal human heart tissue and subjected these nuclei to comprehensive analysis of the epigenome during prenatal development, postnatal maturation, and in heart failure. (nature.com)
Here we describe the human CM epigenome during prenatal development and postnatal maturation of the heart from infant to adult age and in terminal failure. (nature.com)
The current study was designed to investigate the role of NF2 and merlin in the fetal and adult mouse liver, including possible involvement with tumor development. (vetscite.org)
Blocking the expression of NF2 in the livers of adult mice had minimal effect on the animals unless a portion of the liver was surgically removed, setting off the regeneration process and leading to the same stem cell overproliferation and tumor development. (vetscite.org)
We believe that by understanding the mechanisms regulating the formation of the heart during fetal development we can then apply these principles to understand the causes of adult heart diseases such as heart attack and heart failure. (stanford.edu)
Secreted a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS) proteases play crucial roles in tissue development and homeostasis. (encyclopedia.pub)
For some ADAMTS proteases, substrates have been identified and substrate cleavage has been implicated in tissue development and in disease. (encyclopedia.pub)
WMS can also be caused by mutations in fibrillin-1 (FBN1), which suggests that ADAMTS10 and ADAMTS17 cooperate with fibrillin-1 in a common biological pathway during tissue development and homeostasis. (encyclopedia.pub)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
Nerve growth factor (NGF) is a signaling protein and growth factor implicated in a wide range of development and maintenance functions. (asu.edu)
Since its discovery, NGF has been found to act in a variety of tissues throughout development and adulthood. (asu.edu)
Epidermal growth factor is a signaling molecule that stimulates the growth of epidermal tissues during development and throughout life. (asu.edu)
It can be also used to visualize the embryological development of mice in uterus or to examine their cardiovascular development. (hindawi.com)

In a therapeutic approach, i.e. treatment starting after papilloma appearance, the S6 group presented reduced papillomas (number and size), whereas MDL-800-treated mice displayed an opposite trend. (bvsalud.org)

Roger Gosden is the most outspoken champion of transplanting ovarian tissue and has provided much of the experimental support for it. (discovermagazine.com)
One version of the approach he envisions involves giving a woman back some of her ovarian tissue if she has been somehow sterilized. (discovermagazine.com)
No one knew whether human ovarian tissue could survive the process--after all, that kind of deep freeze normally kills mature eggs. (discovermagazine.com)
Gosden and his colleagues explored this idea by freezing strips of ovarian tissue donated by women undergoing medical treatments. (discovermagazine.com)

Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)

become manifest only during adult life than in adulthood. (who.int)

Knockout mice display a tendency to intestinal inflammation. (guidetopharmacology.org)
In an infection-induced colitis model, knockout mice were more prone to tissue damage and inflammatory cytokine expression. (guidetopharmacology.org)

expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound protein 2, and glycogen synthase kinase-3beta were assessed in cortical samples of newborn mice. (researchgate.net)
One of these is the epidermal growth factor receptor (EGFR), and oversignaling by that protein is known to lead to several types of cancer. (vetscite.org)
They discovered that both human and mouse inner ear tissue contained "molecular machinery to allow SARS-CoV-2 entry," like the ACE2 receptor . (healthline.com)
Anatomical profiling of G protein-coupled receptor expression. (guidetopharmacology.org)

1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)
Substantial progress has been made in testing species barriers for CWD by using transgenic mice expressing species-specific prion protein (PrP), by direct infection into new species, or by in vitro conversion assays. (cdc.gov)

HA371 trade name] is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children. (who.int)

Prenatal immune activation interacted with mhDISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses. (researchgate.net)

0.05) as well as increased EZH2 protein expression. (nih.gov)
New research presented at the annual Society for Neuroscience meeting, held 13-17 November 2010 in San Diego, California, suggests that the deficiency stems from a vicious feedback loop that keeps progranulin expression in neurons low, even as neighboring microglia produce plenty of the protein. (alzforum.org)

Epidemiologic evidence suggests that CWD continues to spread among cervid populations in North America ( 3 ), creating concern that CWD may cross species barriers to infect humans or domestic animals that may be eaten by humans. (cdc.gov)
In contrast, transgenic mice expressing human PrP were not susceptible to CWD by intracerebral infection ( 11 , 12 ), a finding that provided evidence for a human species barrier against CWD infection. (cdc.gov)
In some invertebrate species, BOULE protein play a pivotal role in germline specification and a conserved regulatory role in meiosis. (ijbs.com)

About one in ten women who have a child with autism have immune molecules in their bloodstream that react with proteins in the brain, according to a study published 20 August in Molecular Psychiatry 1 . (spectrumnews.org)

These epidermal and connective tissue layers protect against mechanical and chemical harm and repel pathogenic invaders [ 19 ]. (biomedcentral.com)

CWD has been successfully transmitted and adapted to laboratory rodents, including hamsters, transgenic mice expressing hamster PrP, and transgenic mice overexpressing mouse PrP ( 9 , 10 ). (cdc.gov)

1 It has already been demonstrated that it can be used to repair defective DNA in mice curing them of genetic disorders, 2 and it has been reported that human embryos can be similarly modified. (bmj.com)

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in older adults. (cdc.gov)

Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)
The maintenance of tissue homeostasis and proper wound healing is, therefore, a critical process that can be disturbed by a plethora of external and internal factors. (biomedcentral.com)

They confirmed, via Western blotting, that Wnt1 reduced PGRN protein levels in the hNP-derived neurons. (alzforum.org)

The Wu Laboratory seeks to identify mechanisms responsible for human heart diseases, the most common cause of death in the U.S. and the biggest contributor to morbidity and mortality worldwide. (stanford.edu)
EGF stimulates tissue growth by initiating a variety of cellular mechanisms. (asu.edu)
36 with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. (cdc.gov)

These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)

Now there is hope of leveling the reproductive playing field somewhat--several recent experiments promise to lead to a vast supply of human eggs. (discovermagazine.com)

In a perfused, fluid-filled, adult rat lung model, ASL glucose was estimated to be 0.5 mM when perfusate glucose was 10 mM [ 4 ]. (ersjournals.com)

Modulation of tissue trace metal concentrations in weanling rats fed different levels of zinc and exposed to oral lead and cadmium. (cdc.gov)

Additionally, this technique is useful to image the fetal mouse [ 4 - 6 ] and to obtain high-resolution images of mice tumors [ 7 , 8 ]. (hindawi.com)

Owing to technical restrictions, these studies were performed in heart tissue and therefore the affected cell type(s) could not be identified. (nature.com)

The increase in tissue turnover suggests an alteration in the regulation of the catecholamine biosynthesis and possibly suggests an alteration in the feedback inhibition of tyrosine hydroxylase, the key enzyme in the production of catecholamines. (medscape.com)

The mother's crippled organ likely uses this fresh tissue to heal. (smithsonianmag.com)
Skin is the largest and most versatile organ in the human body. (biomedcentral.com)

Abdominal CT scan demonstrating left suprarenal mass of soft tissue attenuation representing a paraganglioma. (medscape.com)

Afterward they transplanted the thawed strips into mice that, thanks to genetic engineering, lacked an immune system and so couldn't reject the foreign tissue. (discovermagazine.com)
Rabies Immune Globulin, Human (RIG): RIG (Cutter Laboratories' HYPERAB(R) and Merieux Institutes' IMOGAM(R)) is antirabies gamma globulin concentrated by cold ethanol fractionation from plasma of hyperimmunized human donors. (cdc.gov)
Antibodies help the body's immune system recognize and fight off disease-causing microorganisms such as bacteria and viruses, but sometimes the body mistakenly produces antibodies to its own proteins. (spectrumnews.org)

Join the New York Academy of Sciences and Johnson & Johnson for a series of engaging and insightful webinars with extraordinary scientists whose discoveries have made a profound impact on human health. (nyas.org)
For this research, scientists developed novel cellular models of the inner ear and used hard-to-obtain adult human inner ear tissue. (healthline.com)
Until pretty recently, few scientists, especially in cutting-edge fields like neuroscience, were curious about the inner happenings of the two billion or so human moms patrolling the planet today. (smithsonianmag.com)

However, she cautions that measuring reactivity to mouse brain tissue also has drawbacks, because of the action of chemicals used in preparing the brain tissue for analysis. (spectrumnews.org)
In this study, we show that contactin associates with Na v 1.3 in P0 brain tissue and interacts with both the N and C termini of Na v 1.3. (jneurosci.org)

We may soon be able to grow unlimited numbers of perfectly healthy, fertilizable human eggs in the laboratory. (discovermagazine.com)
We currently use laboratory mouse to help us understand the biology of heart formation. (stanford.edu)
Using data from the Respiratory Syncytial Virus-Associated Hospitalization Surveillance Network, a population-based hospitalization surveillance system operating in 12 states, this analysis examined characteristics (including age, underlying medical conditions, and clinical outcomes) of 3,218 adults aged ≥60 years who were hospitalized with laboratory-confirmed RSV infection during July 2022-June 2023. (cdc.gov)

Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)
We have more recently acquired the expertise to execute multi-omic technologies based on single cell microfluidic tools developed from 10x Genomics including single nuclear ATAC-seq with RNA-seq, single cell TCR sequencing with feature barcoding of surface protein (i.e. (stanford.edu)
Numerous studies have shown significant effects of bile salts and other components of gastroesophageal reflux on cellular physiology, including the activation of protein kinase C and nuclear transcription factors [ 7 ]. (jcancer.org)

Daz is found in fetal gonocytes, spermatogonia and spermatocytes of adult testes. (ijbs.com)

Our DISC1 mouse model is a valuable system to study GEI relevant to mental illnesses. (researchgate.net)
Next, the effects of SIRT6 pharmacological modulation were evaluated in a DMBA-TPA-induced skin cancer mouse model. (bvsalud.org)
Epithelial tissue from both the rat BE model and human BE patients strongly expressed KLF5, CDX2, MUC2, and villin. (jcancer.org)
The model enabled calculation of human equivalent con- centrations (HECs) to the animal no-observed-adverse-effect levels (NOAELs) using chemical-specific parameters to determine the internal dose instead of default assumptions. (cdc.gov)
Data demonstrated that humans are less sensitive to the effect that causes developmental toxicity in rabbits and the PBPK model incorporated this information, resulting in a higher HEC for the developmental endpoint than for the nasal endpoint. (cdc.gov)

Some examples include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, Creutzfeldt-Jakob disease (CJD) in humans, and chronic wasting disease (CWD) in cervids. (cdc.gov)

Progranulin mutations cause some forms of frontotemporal dementia, but exactly what the protein does and how it fails in disease are open questions. (alzforum.org)
In the recent years, a new ultrasound technology, called ultrasound biomicroscopy (UBM) was optimized to evaluate animal models of human disease. (hindawi.com)
In May 2023, two RSV vaccines were approved for prevention of RSV lower respiratory tract disease in adults aged ≥60 years. (cdc.gov)
Among a random sample of 1,634 older adult patients with RSV-associated hospitalization, 54.1% were aged ≥75 years, and the most common underlying medical conditions were obesity, chronic obstructive pulmonary disease, congestive heart failure, and diabetes. (cdc.gov)
These data highlight the importance of prioritizing those at highest risk for severe RSV disease and suggest that clinicians and patients consider age (particularly age ≥75 years), long-term care facility residence, and underlying medical conditions, including chronic obstructive pulmonary disease and congestive heart failure, in shared clinical decision-making when offering RSV vaccine to adults aged ≥60 years. (cdc.gov)
Adults aged ≥65 years remain at elevated risk for severe COVID-19 disease and have higher COVID-19-associated hospitalization rates compared with those in younger age groups. (cdc.gov)

Although rabies rarely affects humans in the United States, every year, approximately 25,000 persons receive rabies prophylaxis. (cdc.gov)

Similarly, mice exposed to BPA or DES in utero showed increased mammary histone H3 trimethylation. (nih.gov)

Anatomy59

Organisms17

Diseases4

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology1

Phenomena and Processes68

Disciplines and Occupations1

Information Science3

Health Care2

Embryonic5

Stem cells10

Metabolism3

Maternal2

Genes10

Pregnancy2

Susceptibility6

Hippocampus3

Serum4

Cells36

Researchers3

Brains2

Gene9

Exposure14

Embryo5

Regulate2

Ovaries2

Vivo1

Neural2

Epigenetic3

Development14

Therapeutic1

Ovarian tissue4

MRNA2

Adulthood1

Knockout mice2

Receptor4

Vitro2

Immunodeficiency virus1

Prenatal1

Expression2

Species3

Molecules1

Epidermal1

Transgenic1

Embryos1

Older adults1

Homeostasis2

Neurons1

Mechanisms3

Lipid1

Experiments1

Glucose1

Rats1

Tumors1

Heart tissue1

Inhibition1

Organ2

Attenuation1

Immune3

Scientists3

Brain tissue2

Laboratory3

Nuclear3

Found1

Model5

Sheep1

Disease6

Rarely1

Utero1