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  • protein
  • The results presented in this paper demonstrate that CD1.1 is expressed as a heavily glycosylated, β 2 m-associated protein in transfected lines as well as in fresh mouse CD1-expressing cells. (jimmunol.org)
  • The gene encoding the C18-defined antigen was identified as a mutated form of a mouse mitogen-activated protein kinase, ERK2, and a peptide incorporating the resulting amino acid substitution (lysine to glutamine) was efficiently recognized by C18. (pnas.org)
  • Extensive efforts to isolate antigen-loss variants of CMS5 were unsuccessful, suggesting that the mutated mitogen-activated protein kinase is essential for maintenance of the malignant phenotype. (pnas.org)
  • Using a CMS5-specific CTL clone to screen a cDNA library, we identified a mutated form of mitogen-activated protein kinase as the source of the CMS5-specific antigen. (pnas.org)
  • Table II ⇓ reflects several novel mouse CD homologues that have been identified via cloning, Abs, or protein probes, such as the use of ligand-Ig fusion proteins. (jimmunol.org)
  • The antigens used in this study were the N protein and a deletion mutant of the Gn glycoprotein.Transformed lines were analysed for specific mRNA and protein content by RT-PCR and Westernblotting, respectively. (diva-portal.org)
  • Prolactin Mouse protein is fused to a 23 amino acid His tag at N-terminus and is purified by standard chromatography. (prospecbio.com)
  • Like many tumor-associated antigens, generating robust immune responses to the WT1 protein has been difficult as endogenous WT1 expression may delete or render anergic most of the high avidity T cell repertoire capable of recognizing WT1 expressing tumors. (washington.edu)
  • locus
  • The mouse CD1 locus contains a pair of highly homologous genes, CD1.1 and CD1.2, that encode conserved MHC-like β 2 -microglobulin (β 2 m 3 )-associated molecules that are the homologues of CD1d, one of five human CD1 isotypes ( 1 , 2 , 3 , 4 , 5 ). (jimmunol.org)
  • alleles
  • Suzanne L. Zebedee, Diana S. Barritt, and William C. Raschke, "Comparison of Mouse Ly5 a and Ly5 b Leucocyte Common Antigen Alleles," Developmental Immunology , vol. 1, no. 4, pp. 243-254, 1991. (hindawi.com)
  • murine
  • Using a well-characterized murine model of adoptive T cell immunotherapy for established malignancy, we have demonstrated the feasibility of eliminating disseminated leukemia using T cells genetically modified by TCR gene transfer.We next examined the potential of targeting a clinically relevant tumor antigen, the transcription factor WT1, for which the expression patterns in normal and malignant cells are similar in mouse and man. (washington.edu)
  • We have transfected the mouse CD4 gene into a beef insulin (BI)-specific murine T helper hybridoma that lacks CD4 surface expression. (rupress.org)
  • sequence
  • In addition to differences in DNA sequence, evolutionary divergence between mice and humans may also be manifested in Ag distribution. (jimmunol.org)
  • restriction
  • We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. (hindawi.com)
  • immunology
  • The molecular basis of the polymorphic tumor rejection antigens of chemically induced sarcomas of inbred mice remains a mystery, despite the discovery of these antigens over 40 years ago and their critical importance to the foundation of tumor immunology. (pnas.org)
  • The finding that sarcomas induced by cancer carcinogens are immunogenic in inbred strains of mice is one of the major milestones in the field of tumor immunology. (pnas.org)
  • Several novel markers mentioned may prove useful in mouse immunology research. (jimmunol.org)
  • challenge
  • Both IL-25 and IL-33 are critical for induction of Th2-type cytokine-mediated allergic airway eosinophilia, but not Th17-type cytokine-mediated airway neutrophilia, at the local sites of lungs in the challenge phase of mice sensitized EC with OVA. (sigmaaldrich.com)
  • basis
  • On the basis of experimental data, a hypothesis was advanced that thre eloci in the IXth linkage group are involved in genetic control of the response to ϑ-AKR antigen. (jimmunol.org)