While many bacteria have intrinsic, chromosomally encoded ARDs and the capability of increasing resistance through mutation, they can also enrich their resistance capabilities through the acquisition of exogenous ARDs located on mobile genetic elements (MGEs) such as plasmids, transposons or phages. (nature.com)
The set of MGEs in an organism is called a mobilome, which is composed of a large number of plasmids, transposons and viruses. (wikipedia.org)
These high-risk pathogens have developed mainly by acquiring different mobile genetic elements (MGEs), including plasmids and genomic islands (GIs) encoding an array of virulence and antibiotic resistance factors[ 2 ]. (biorxiv.org)
Two of the most common forms of MGEs are viruses and plasmids. (phys.org)
We searched mobile genetic elements (MGEs) among whole-genome sequences from 150 of those bacteria, leading to the discovery of 5 new tcdA - / tcdB + / cdtAB + putative plasmids among isolates that were cultivated from loose fecal samples of patients under clinical suspicion for C. difficile infections (CDIs): LIBA-6656, LIBA-7194, LIBA-7602, LIBA-7678, and LIBA-7697. (cdc.gov)
Mobile genetic elements (MGEs), especially multidrug-resistance plasmids, are major vehicles for the dissemination of antimicrobial resistance determinants. (uni-frankfurt.de)
These MGEs, most typically plasmids and integrative and conjugative elements (ICEs), are therefore important constituents of the accessory genome that imbue K . pneumoniae organisms with their distinct HA or CA clinical profiles. (biomedcentral.com)
This is thought to be related to the genetic determinants of phenotype traits, which are mostly located on mobile genetic elements (MGEs) (e.g., plasmids, phages, transposons, and insert elements) with the capability of horizontal gene transfer (HGT) [ 2 ]. (biomedcentral.com)
Genes5
An example of MGEs in evolutionary context are that virulence factors and antibiotic resistance genes of MGEs can be transported to share genetic code with neighboring bacteria. (wikipedia.org)
In addition, an increase in so-called mobile genetic elements (MGEs) in the vicinity of these resistance genes was found. (chemistryviews.org)
Genomic context is especially crucial for functions associated with horizontal gene transfer (HGT) via mobile genetic elements (MGEs), for example antimicrobial resistance genes (ARGs). (univr.it)
In this talk, I will present a method for comprehensive and accurate reconstruction of antimicrobial resistance genes (ARGs) and MGEs from metagenomic DNA, termed target-enriched long-read sequencing (TELSeq). (univr.it)
In Staphylococcus aureus, the phage-mediated acquisition of mobile genetic elements (MGEs) that encode virulence and antibiotic resistance genes largely contribute to its evolutionary adaptation and genetic plasticity. (bvsalud.org)
Mobile7
Mobile genetic elements (MGEs) sometimes called selfish genetic elements are a type of genetic material that can move around within a genome, or that can be transferred from one species or replicon to another. (wikipedia.org)
Mobile genetic elements (MGEs) drive extensive horizontal transfer in the gut microbiome. (mit.edu)
Mobile genetic elements (MGEs) are genetic entities that seek to replicate themselves and spread from cell to cell. (phys.org)
Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. (taylorfrancis.com)
Iro / iuc mobile genetic elements (MGEs) appear to be stably maintained at high frequency within known hypervirulent strains (ST23, ST86, etc.) but were also detected at low prevalence in others such as MDR strain ST258. (biomedcentral.com)
The antimicrobial resistance (AMR) and/or virulence determinants possessed by the associated bacteria are generally found on mobile genetic elements (MGEs) that transmit between K . pneumoniae cells via horizontal gene transfer (HGT) [ 4 ]. (biomedcentral.com)
These are called mobile genetic elements (or MGEs). (cdc.gov)
Virulence1
In contrast, mapping gaps corresponded to putative virulence factors (i.e., lectin-binding or cell wall-binding proteins), hypothetical proteins, and MGEs, such as class 2 introns and transposases (Figure 1, panel B). These findings imply that this group of chimeric molecules is undergoing nonhomologous recombination. (cdc.gov)
Genome2
In humans, approximately 50% of the genome is thought to be MGEs. (wikipedia.org)
Further investigations confirmed that these MGEs jump across the genome. (chemistryviews.org)
ARGs5
TELSeq uses bait enrichment, which is a new sequencing protocol that is becoming increasingly ubiquitous as it has been shown to successfully amplify regions of interest (such as MGEs and ARGs) in metagenomic samples. (univr.it)
Using the long reads generated by TELSeq was able to identify numerous MGEs flanking the low-abundance ARGs, indicating that these ARGs could be transferred across bacterial taxa via HGT. (univr.it)
The combined application of biochar and fertilizers reduced the occurrence of ARGs and MGEs to some extent, showing the remediation effect of biochar. (bvsalud.org)
MGEs are the key driver shaping ARGs dynamics. (bvsalud.org)
The variation of efflux pump ARGs was basically consistent with that of MGEs. (bvsalud.org)
Hunt and his team want to use a system dubbed Mountain Gravity Energy Storage (or MGES) . (bigthink.com)
Systems3
We have previously observed an overabundance of MTases (both solitary and belonging to R-M systems) in MGEs [1]. (sfbi.fr)
In other words, these MTases may serve as antidotes against R-M systems and thereby facilitate infection of new hosts and competition with other MGEs. (sfbi.fr)
Besidesï¼ high concentration of DADMAC C12 generally increased the abundances of MGEs in three denitrification systems, except extracellular MGEs in water. (bvsalud.org)
Regions1
MGEs can also cause mutations in protein coding regions, which alters the protein functions. (wikipedia.org)
Encode2
To mobilize DNA, most MGEs encode an enzyme called the transposase that orchestrates a series of molecular events such as DNA recognition, its cleavage, and integration, all mediated by a large nucleoprotein complex called the transpososome. (nih.gov)
Later thinks about have appeared that prophages, conjugative components, their parasites (phage satellites and mobilizable components), and other ineffectively depicted MGEs encode defense frameworks homologous to those of microscopic organisms. (alliedacademies.org)
Mobile5
Mobile genetic elements (MGEs) sometimes called selfish genetic elements are a type of genetic material that can move around within a genome, or that can be transferred from one species or replicon to another. (wikipedia.org)
We searched mobile genetic elements (MGEs) among whole-genome sequences from 150 of those bacteria, leading to the discovery of 5 new tcdA - / tcdB + / cdtAB + putative plasmids among isolates that were cultivated from loose fecal samples of patients under clinical suspicion for C. difficile infections (CDIs): LIBA-6656, LIBA-7194, LIBA-7602, LIBA-7678, and LIBA-7697. (cdc.gov)
Genomes of halophilic archaea typically contain multiple loci of integrated mobile genetic elements (MGEs). (pasteur.fr)
Currently available databases of bacterial mobile genetic elements (MGEs) contain both "core" and accessory MGE functional modules, the latter of which are often only transiently associated with the element. (biorxiv.org)
These are called mobile genetic elements (or MGEs). (cdc.gov)
Bacteria1
A network model was used to analyze the potential host bacteria of T-ARGs and MGEs. (mammal.cn)
Genomes4
In general, the reorganization of genomes by MGEs has had a huge impact on the evolution of many organisms. (nih.gov)
Some MGEs can deliver large DNA segments and integrate these in the genomes of a variety of different cell types. (nih.gov)
Homology searches showed that IntSNJ2-type integrases are widespread in haloarchaeal genomes and are associated with various integrated MGEs. (pasteur.fr)
Intragenomic coevolution can create genomes comprising multiple replicons that together provide high-level, low-cost resistance, but the resulting co-dependence may limit the spread of coadapted MGEs to other lineages. (york.ac.uk)
Defense2
As components of MGEs, these defense frameworks have probably advanced to supply them, not the cell, versatile capacities. (alliedacademies.org)
To overcome this limitation, we analysed 10,776,212 protein sequences derived from seven MGE databases to compile a comprehensive database of 6,140 manually curated protein families that are linked to the "life cycle" (integration, excision, replication/recombination/repair, transfer, and stability/defense) of all major classes of bacterial MGEs. (biorxiv.org)
A detailed mechanistic understanding of how they work could open up a variety of different avenues to modify and optimize MGEs so that clinicians will have them available in the future to treat patients using genetic tools. (nih.gov)
Elements1
Therefore, resistome risk stratification can be advanced if AMR profiles are considered in light of the flanking mobilizable genomic milieu (e.g., plasmids, integrative conjugative elements (ICEs), phages, and other MGEs). (frontiersin.org)
Play2
MGEs play a distinct role in evolution. (wikipedia.org)
Whereas the interface of the have and MGEs are adjusted when they confront a common danger such as an contamination by a harmful phage, cautious capacities carried by MGEs might moreover play more narrow minded parts to battle off other opposing MGEs or to ensure their upkeep within the cell. (alliedacademies.org)
Program6
The report is a direct extension of Taylor's work with the Master of Art in Art, Gallery Management & Exhibits Specialization (MGES) degree at Western, for which he is the program director. (western.edu)
Furthermore, it will be a point of prestige for Western, for the MGES program and for our graduates. (western.edu)
It's an enormous opportunity for the MGES program and for Western. (western.edu)
While studying in Western's M. A. in Art: Gallery Management & Exhibits Specialization (MGES, now MGMM) program, Sloane found employment at Art Omi, a contemporary art center, international artists residency and 120-acre Sculpture and Architecture Park in New York's Hudson Valley. (western.edu)
Her participation in the MGES program continued to open doors for her in her career. (western.edu)
Through the MGES (now MGMM) program, Sloane completed her required curatorial internship under the curator and project manager of Art Omi, which led to a promotion to curatorial assistant. (western.edu)
Management1
MGES management agreed to retain, the editorial board of all the journals with minor changes till 30th August 2022. (mgesjournals.com)
Work2
The current focus of the lab is to understand the molecular details of how certain MGEs work and armed with this knowledge to redesign them so they can be part of our gene therapy toolkit. (nih.gov)
Peterson/Gordon Architects of Winston-Salem prepared the site plan, and MGES Civil Engineering & Land Surveying did the survey work, according to the planning documents on file with the town, but no general contractor has been chosen for the project. (mecktimes.com)
Education2
It is to inform you that Gyandhara International Academic Publications (GIAP Journals) has been completely acquired by Maya Global Education Society (MGES), Prayagraj, India. (mgesjournals.com)
I use my MGES education on a daily basis, whether I am conducting collections research and preparing title text for the park, or purchasing fabrication materials and assisting with physical installation. (western.edu)
Potential1
One of the most exciting thing about MGEs is their potential application in gene therapy. (nih.gov)
Cell1
In contrast, mapping gaps corresponded to putative virulence factors (i.e., lectin-binding or cell wall-binding proteins), hypothetical proteins, and MGEs, such as class 2 introns and transposases (Figure 1, panel B). These findings imply that this group of chimeric molecules is undergoing nonhomologous recombination. (cdc.gov)