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Protein Kinase CProtein KinasesCyclic AMP-Dependent Protein KinasesCDC2 Protein KinaseProtein-Serine-Threonine KinasesCalcium-Calmodulin-Dependent Protein KinasesPhosphorylationMitogen-Activated Protein KinasesProtein Kinase InhibitorsMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesPhosphatidylinositol 3-Kinasescdc25 Phosphatasescdc42 GTP-Binding ProteinEnzyme ActivationMitogen-Activated Protein Kinase 1Protein Kinase C-alphaMitogen-Activated Protein Kinase KinasesProtein Kinase C-deltaMitogen-Activated Protein Kinase 3Signal TransductionJNK Mitogen-Activated Protein KinasesAMP-Activated Protein KinasesCdc20 ProteinsProtein Kinase C-epsilonIsoenzymesProtein Kinase C betasrc-Family KinasesTetradecanoylphorbol AcetateMolecular Sequence DataCyclic GMP-Dependent Protein KinasesProtein-Tyrosine KinasesEnzyme InhibitorsAmino Acid SequenceCell LineCyclic AMPCasein Kinase IIp21-Activated KinasesMAP Kinase Kinase KinasesCells, CulturedCalcium-Calmodulin-Dependent Protein Kinase Type 2KineticsCell Cycle ProteinseIF-2 KinaseProtein BindingCDC2-CDC28 KinasesCyclin-Dependent KinasesMAP Kinase Kinase 1MutationSerineExtracellular Signal-Regulated MAP KinasesTransfectionRibosomal Protein S6 KinasesBlotting, WesternCalciumProto-Oncogene Proteins c-aktPhosphoproteinsProto-Oncogene ProteinsCasein KinasesMAP Kinase Kinase 4Substrate SpecificityDiglyceridesPhorbol 12,13-DibutyrateBase SequenceIntracellular Signaling Peptides and ProteinsCDC28 Protein Kinase, S cerevisiaeStaurosporineRecombinant ProteinsIsoquinolines1-(5-Isoquinolinesulfonyl)-2-MethylpiperazinePhorbol EstersMaleimidesRNA, MessengerBinding SitesCreatine KinaseRecombinant Fusion ProteinsDNA-Activated Protein KinaseGlycogen Synthase Kinase 3Phosphoprotein PhosphatasesIndolesApoptosisPhosphotransferases (Alcohol Group Acceptor)Cell CycleCyclic AMP-Dependent Protein Kinase Type IIProtein Structure, Tertiary3-Phosphoinositide-Dependent Protein KinasesSequence Homology, Amino AcidTumor Cells, CulturedPyruvate KinaseReceptor Protein-Tyrosine KinasesTyrosineThreonineFlavonoidsrho-Associated KinasesGene Expression Regulation, EnzymologicCell Line, TumorCell DivisionDose-Response Relationship, DrugImmunoblottingMitogen-Activated Protein Kinase 8

Cyclin dependSerineInhibitoryGeneFamilyExpressionCellEffect

Cyclin depend4

• CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs). (biomedcentral.com)
• PCNA is a co-factor of cyclin-D and it makes a complex with cyclin-D, a cyclin dependent kinase (CDK), and a cyclin dependent kinase inhibitor (CDKI). (biomedcentral.com)
• Cyclin-dependent kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity of CDKs. (biomedcentral.com)
• Cdk5 is named after its structural similarity to members of the serine/threonine cyclin-dependent kinase family. (frontiersin.org)

Serine2

• Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene. (wikipedia.org)
• Cyclins and CDKs assemble into complexes with one another as cells progress through G1 phase, cyclins being required to activate the serine-threonine kinase activity of their catalytic partners. (biomedcentral.com)

Inhibitory1

• More important, the combination of FZKA and gefitinib enhanced the inhibitory effect on EZH2, Snail and EGFR proteins. (bvsalud.org)

Gene1

• Western Blot and qRT-PCR were used for protein and gene expression test. (bvsalud.org)

Family1

• The progression of cells through the cell cycle is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs). (biomedcentral.com)

Expression3

• The in situ expression of protein was measured by cell immunofluorescence. (bvsalud.org)
• Moreover, FZKA significantly decreased EZH2 mRNA and protein expression, FZKA reversed the resistance of gefitinib by down-regulation of EZH2 protein. (bvsalud.org)
• We found that the expression level of Ki-67 protein in lung metastatic tumor tissues of mice treated with JFK was significantly reduced, while the infiltration level of CD8+ T lymphocytes and NK cells was significantly increased. (bvsalud.org)

Cell1

• Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). (biomedcentral.com)

Effect1

• Inhibition of Cdk5 by olomoucine enhanced phosphorylation of kinesin, suggesting that the effect was mediated by negative regulation of other kinases. (frontiersin.org)