• Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. (targetmol.com)
  • It's a lifesaver as a strong local anesthetic and antiarrhythmic agent, used to keep patients comfortable during painful procedures and in times of emergency. (pipelinemedical.com)
  • Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. (illnesshacker.com)
  • Sedef Atmaca Turkish Abstract Abstract Full Text PDF Similar Articles Mail to Editor Cardiovascular Properties of new Imidazolidin-2-one Derivatives with Local Anesthetic and Antiarrhythmic Activity #Librowski T. (actapharmsci.com)
  • Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias. (chemeurope.com)
  • As a doctoral candidate at Oxford University, Dr. Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). (chemeurope.com)
  • This study is created by ehealthme based on reports of 16 people who take lidocaine hydrochloride and xarelto from food and drug administration fda, and is updated regularly. (web.app)
  • It is most unlikely, even with misuse or excessive application of the gel, that the large amounts of lidocaine hydrochloride or cetylpyridinium chloride required to produce clinically-relevant toxic effects would be reached. (medthority.com)
  • Lidocaine should be used with caution in patients receiving other local anaesthetics or agents structurally related to amide-type local anaesthetics, e.g. antiarrhythmic drugs such as mexiletine, since the toxic effects may be additive. (medthority.com)
  • Mexiletine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • In patients with normal conduction systems, mexiletine has a minimal effect on cardiac impulse generation and propagation. (nih.gov)
  • Hemodynamic studies in a limited number of patients, with normal or abnormal myocardial function, following oral administration of mexiletine hydrochloride, have shown small, usually not statistically significant, decreases in cardiac output and increases in systemic vascular resistance, but no significant negative inotropic effect. (nih.gov)
  • Mild depression of myocardial function, similar to that produced by lidocaine, has occasionally been observed following intravenous mexiletine therapy in patients with cardiac disease. (nih.gov)
  • Lidocaine has additional medical applications as an antiarrhythmic agent for the treatment of cardiac arrhythmias. (pipelinemedical.com)
  • Lidocaine is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. (illnesshacker.com)
  • Flecainide and propafenone, like other antiarrhythmic drugs have been shown to increase the occurrence of arrhythmias (5.3% for propafenone, Teva physician prescribing information), primarily in patients with underlying heart disease. (cloudfront.net)
  • Propafenone differs from the prototypical class Ic antiarrhythmic in that it has additional activity as a beta-adrenergic blocker which can cause bradycardia and bronchospasm. (cloudfront.net)
  • In animal studies, mexiletine has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. (nih.gov)
  • Theoretically, therefore, mexiletine may be useful in the treatment of ventricular arrhythmias associated with a prolonged QT interval. (nih.gov)
  • Additionally, it is effective as an antiarrhythmic agent for the management of ischemic and myocardial infarction-related ventricular arrhythmias. (pipelinemedical.com)
  • Lidocaine is not only a useful local anesthetic, but also displays antiarrhythmic properties that are critical in the management of arrhythmias. (pipelinemedical.com)
  • Treatment of ventricular arrhythmias (e.g., sustained VT) that in the judgment of the clinician are life-threatening, but usually not the antiarrhythmic of first choice. (drugs.com)
  • Because of procainamide's arrhythmogenic potential, lack of evidence for improved survival for class I antiarrhythmic agents, and risk of serious, potentially fatal adverse hematologic effects (see Boxed Warning), particularly leukopenia or agranulocytosis, use for less severe arrhythmias not recommended. (drugs.com)
  • Lidocaine patch 5% should be used with caution in patients receiving class i antiarrhythmic drugs such as tocainide and mexiletine since the toxic effects are additive and potentially synergistic. (web.app)
  • because of higher risk of toxicity and proarrhythmic effects, antiarrhythmic agents generally reserved for patients who do not respond to or cannot be treated with AV nodal blocking agents (β-adrenergic blocking agents, verapamil, diltiazem). (drugs.com)
  • Mexiletine hydrochloride, USP is an orally active antiarrhythmic agent. (nih.gov)
  • Mexiletine hydrochloride is a local anesthetic, antiarrhythmic agent, structurally similar to lidocaine, but orally active. (nih.gov)
  • Antiarrhythmic agent pharmacologically similar to LIDOCAINE. (musc.edu)
  • 100 mg of mexiletine hydrochloride, USP is equivalent to 83.31 mg of mexiletine base. (nih.gov)
  • Each bisected, yellow, film-coated, oval biconvex tablet, with 'PA' engraved on one side and the strength engraved on the other side, contains paroxetine hydrochloride equivalent to 10 mg of paroxetine free base. (medbroadcast.com)
  • Mexiletine hydrochloride, at doses of 200-400 mg q8h, produced a significant reduction of ventricular premature beats, paired beats, and episodes of non- sustained ventricular tachycardia compared to placebo and was similar in effectiveness to the active agents. (nih.gov)
  • For economic and convenience reasons, some clinicians are starting certain antiarrhythmic agents in an outpatient setting for some patients. (cloudfront.net)
  • No consensus exists regarding the safety of this practice, and information is needed to determine which agents and which patients are appropriate for outpatient initiation of antiarrhythmic therapy. (cloudfront.net)
  • Follow-up of patients from the controlled trials has demonstrated continued effectiveness of mexiletine in long-term use. (nih.gov)
  • Mexiletine decreased the effective refractory period (ERP) in Purkinje fibers. (nih.gov)
  • Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1. (musc.edu)
  • Mexiletine, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0. (nih.gov)
  • This work presents an updated solid form discovery approach to the polymorphism of the anti-arrhythmic drug mexiletine hydrochloride, in which experimental and computational techniques are combined to provide a rigorous characterisation of the solid-form landscape of this compound. (worktribe.com)
  • This approach reveals five solid form types of mexiletine hydrochloride. (worktribe.com)
  • Cloperastine ( INN ) or cloperastin , in the forms of cloperastine hydrochloride ( JAN ) (brand names Hustazol , Nitossil , Seki ) and cloperastine fendizoate , is an antitussive and antihistamine that is marketed as a cough suppressant in Japan , Hong Kong , and in some European countries. (cloudfront.net)
  • This graph shows the total number of publications written about "Mexiletine" by people in this website by year, and whether "Mexiletine" was a major or minor topic of these publications. (musc.edu)
  • Below are the most recent publications written about "Mexiletine" by people in Profiles. (musc.edu)
  • MEXITIL ® (mexiletine hydrochloride, USP) is an orally active antiarrhythmic agent available as 150 mg, 200 mg and 250 mg capsules. (nih.gov)
  • The antiarrhythmic effect of MEXITIL has been established in controlled comparative trials against placebo, quinidine, procainamide and disopyramide. (nih.gov)
  • Mexiletine (Mexitil)Green coffee contains caffeine. (nih.gov)
  • Mexiletine (Mexitil)Guarana contains caffeine. (nih.gov)
  • Mexiletine (Mexitil)Black tea contains caffeine. (nih.gov)
  • Mexiletine (Mexitil)Yerba mate contains caffeine. (nih.gov)
  • The antiarrhythmic efficacy of mexiletine hydrochloride (Mexitil) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia. (nih.gov)
  • Lidocaine is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. (illnesshacker.com)
  • Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. (illnesshacker.com)
  • Sedef Atmaca Turkish Abstract Abstract Full Text PDF Similar Articles Mail to Editor Cardiovascular Properties of new Imidazolidin-2-one Derivatives with Local Anesthetic and Antiarrhythmic Activity #Librowski T. (actapharmsci.com)
  • Amiodarone injection belongs to the group of medicines known as antiarrhythmics. (drugs.com)
  • Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias . (cloudfront.net)
  • Mexiletine is used to treat certain types of ventricular arrhythmias (abnormal heart rhythms). (nih.gov)
  • The overall arrhythmia suppression of ventricular premature contractions of 70% and greater was low and seen in only 22% of patients, with an additional 16% responding to a combination of mexiletine and an additional antiarrhythmic drug. (nih.gov)
  • The suppression of high-grade forms, couplets of 90% and greater, and complete abolition of nonsustained runs of ventricular tachycardia was achieved in 22% of patients, with 9% responding to the addition of another antiarrhythmic agent. (nih.gov)
  • Considering the known proarrhythmic properties of mexiletine and the lack of evidence of improved survival for any antiarrhythmic drug in patients without life-threatening arrhythmias, the use of mexiletine as well as other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmia . (drugs.com)
  • Each yellow, modified capsule shaped, biconvex, film-coated tablet, debossed with 'C 55' on one side and break line on the other side, contains 10 mg of paroxetine (as paroxetine hydrochloride hemihydrate). (mediresource.com)
  • The European Medicines Agency's (EMA's) Committee for Medicinal Products for Human Use (CHMP) has recommended marketing authorization for the antiarrhythmic drug mexiletine hydrochloride ( NaMuscla, Lupin Neurosciences) for adults with nondystrophic myotonia (NDM), a group of inherited muscle contraction disorders. (medscape.com)
  • The drug was poorly tolerated, with intolerable side effects developing in 49% of patients receiving mexiletine alone and in 57% of patients receiving a combination of antiarrhythmic agents. (nih.gov)
  • Mexiletine is a medicine that treats symptoms of myotonia congenita. (nih.gov)
  • Sotalol hydrochloride is a white, crystalline solid with a molecular weight of 308.8. (nih.gov)
  • Mexiletine, which was first authorized in Europe in the 1970s to restore normal heart rhythm, blocks channels for sodium ions in muscle cells, leading to a reduction in muscle contraction rate and stiffness. (medscape.com)
  • The composition of 1 ml of injection solution contains the active substance: bupivacaine hydrochloride - 5 mg. (abchealthonline.com)
  • Commonly reported side effects of mexiletine include: heartburn, nausea, and vomiting. (drugs.com)
  • Along with its needed effects, mexiletine may cause some unwanted effects. (drugs.com)
  • Some side effects of mexiletine may occur that usually do not need medical attention . (drugs.com)
  • The most common side effects associated with mexiletine therapy have been gastrointestinal and nervous system effects. (drugs.com)
  • A case of new first-degree AV heart block and left bundle branch block associated with elevated mexiletine serum levels (34 mcg/mL) was reported. (drugs.com)
  • Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC 50 values are 75.3 and 23.6 μ M for tonic and use-dependent block respectively). (tocris.com)
  • Mexiletine was continued following a dosage reduction and an increase in the dosing interval. (drugs.com)