In patients with pheochromocytoma, administration of metyrosine reduces catecholamine biosynthesis by 35-80%, as measured by urinary catecholamine levels. (medscape.com)
The therapeutic efficacy of Metyrosine can be increased when used in combination with Benazepril. (puvanameta.com.my)
They made a deal She sucks his big dick and he fucks h The free trial escape from tarkov efficacy of Metyrosine can be decreased when crossfire script no recoil in combination with Flunoxaprofen. (apcnet.org)
Catecholamine1
Metyrosine inhibits tyrosine hydroxylase, the rate-limiting step in catecholamine synthesis. (medscape.com)
DEMSER1
DEMSER 1 (Metyrosine) is (-)-α-methyl- L -tyrosine or (α-MPT). (nih.gov)
Capsule1
Each capsule contains 250 mg metyrosine. (nih.gov)
Sedation3
metyrosine and olopatadine intranasal both increase sedation. (medscape.com)
metyrosine and daridorexant both increase sedation. (medscape.com)
difelikefalin and metyrosine both increase sedation. (medscape.com)
Doses1
Plasma half-life of metyrosine determined over an 8-hour period after single oral doses was 3-3.7 hours in three patients. (nih.gov)
Drugs2
When Metyrosine is used preoperatively, alone or especially in combination with alpha-adrenergic blocking drugs, adequate intravascular volume must be maintained intraoperatively (especially after tumor removal) and postoperatively to avoid hypotension and decreased perfusion of vital organs resulting from vasodilatation and expanded volume capacity. (nih.gov)
This denatured agent [D,L-alpha-metyrosine] plus the 3 other repurposed drugs are designed to capitalize on that, such that they're going to -increase uptake of D,L-alpha--metyrosine into the cell, and hopefully that will result in cell death. (theoncologypharmacist.com)
Gastrointestinal1
Metyrosine is well absorbed from the gastrointestinal tract. (nih.gov)
Regimen1
A novel tumor metabolism-altering oral regimen that combines a tyrosine derivative (D,L--alpha-metyrosine) with 3 repurposed agents (sirolimus, phenytoin, and methoxsalen) has demonstrated promising activity in patients with previously treated metastatic pancreatic cancer. (theoncologypharmacist.com)
Adverse1
One patient in the D,L-alpha--metyrosine 460-mg twice--daily arm had 2 adverse events (ie, rash and arthralgia) that were considered to be dose--limiting toxicities, but the patient resumed treatment after successful management of the events. (theoncologypharmacist.com)
Effects3
These metabolites are probably not present in sufficient amounts to contribute to the biochemical effects of metyrosine. (nih.gov)
carbidopa increases effects of metyrosine by pharmacodynamic synergism. (medscape.com)
Furthermore, we observed that Cys466 of -catenin, located at the binding interface of the -cateninCTCF4 transcriptional complex, is essential for disruption of this complex by NO. Importantly, Cys466 of -catenin is necessary for the inhibitory effects of NO on Wnt3a-stimulated proliferation of Metyrosine endothelial cells. (physiciansontherise.org)
Patients3
In most patients, the duration of treatment has been two to eight weeks, but several patients have received Metyrosine for periods of 1 to 10 years. (nih.gov)
We don't have FDA-approved agents specifically for the third line, so the thought is if we can use D,L-alpha--metyrosine, which is well tolerated, there may be an opportunity to benefit patients. (theoncologypharmacist.com)
In part 1 of the trial, 38 patients were randomized to D,L-alpha-metyrosine 230 mg twice daily or 460 mg twice daily. (theoncologypharmacist.com)
Food and Drug Admin1
Because metyrosine is an approved agent, and the US Food and Drug Administration 505(b)(2) guidance states that any stereoisomer of an approved agent can be considered to be the same agent, this investigator-initiated trial was predicated on using the D,L-isomer as an unapproved use of an approved agent. (yamopharma.com)
Results1
Your search for METYROSINE did not return any results. (nih.gov)