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  • Structures
  • According to the protein knot server (http://knots.mit.edu/), which confirmed that this structure has a knot, there are only 40 similar structures in the PDB, including several SpoU-like RNA methyltransferases. (ssgcid.org)
  • Liver
  • Castro C, Millian N, Garrow T. Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. (labome.org)
  • Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT) is a transferase enzyme (EC 2.1.1.17) which converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. (wikipedia.org)
  • cofactor
  • The 1.5 A crystal structure of RrmJ in complex with its cofactor S-adenosylmethionine revealed that RrmJ has a methyltransferase fold. (ebi.ac.uk)
  • The structure of HhaI methyltransferase (M.HhaI) has been resolved to 2.5 A: the molecule folds into 2 domains - a larger catalytic domain containing catalytic and cofactor binding sites, and a smaller DNA recognition domain. (wikipedia.org)
  • COMT
  • Several features of the structure like this folding lip suggest that PNMT is a recent adaptation to the catecholamine synthesizing enzyme family, evolving later than COMT, but before other methyltransferases like GNMT. (wikipedia.org)