Methyltransferase gene. Medical search. Frequent questions

The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. (medlineplus.gov)
The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. (medlineplus.gov)
Other tissues, including the liver, kidneys, and blood, produce a shorter form of the enzyme called soluble catechol-O-methyltransferase (S-COMT). (medlineplus.gov)
In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters. (medlineplus.gov)
Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which organizes and coordinates information from other parts of the brain. (medlineplus.gov)
Catechol-O-methyltransferase helps maintain appropriate levels of these neurotransmitters in this part of the brain. (medlineplus.gov)
A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain. (medlineplus.gov)
Little is known, however, about the relationship between catechol-O-methyltransferase activity and the specific mental and emotional problems characteristic of this condition. (medlineplus.gov)
Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase. (medlineplus.gov)
The change affects the stability and activity of catechol-O-methyltransferase, which alters the enzyme's ability to break down neurotransmitters in the prefrontal cortex. (medlineplus.gov)
To produce sufficient amounts of recombinant catechol-O-methyltransferase (COMT) for structural and functional studies the coding regions of the rat liver and human placental COMT genes have been introduced into a bacterial expression vector pKEX14. (lu.se)
Variations in catechol-o-methyltransferase gene interact with parenting to influence attention in early development. (bvsalud.org)

The pentaamino acid sequence Pro-Cys-His-Arg-Val, the cysteine residue of which is the methyl acceptor site in Ada protein, was conserved in the 3 methyltransferase proteins. (elsevierpure.com)
How BES1/BZR1 and their interacting proteins function to regulate the large number of genes are not completely understood. (duke.edu)
In living organisms, gene expression is a complex process that results in the production of proteins from the genome in a time- and space-regulated manner. (cea.fr)
Methylation of key biological molecules and proteins plays important roles in numerous biological systems, including signal transduction, biosynthesis, protein repair, gene silencing and chromatin regulation (1). (gbiosciences.com)
[ 2 ] Histones are proteins that both provide structural support for DNA (DNA wraps around a core of histones to form nucleosomes) and are involved in the regulation of gene expression. (medscape.com)
These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA. (absoluteastronomy.com)
Living beings depend on genes, as they specify all proteins and functional RNA chains. (absoluteastronomy.com)
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. (fishersci.com)
It is caused by inactivating predominantly biallelic mutations involving >20 genes encoding proteins with roles in the FA/BRCA DNA repair pathway. (bvsalud.org)

Results suggesting that the promoter region of human klotho gene could be epigenetically controlled by DNA methylation have been reported. (tubitak.gov.tr)
Loss of expression is rarely due to deletion, mutation, or rearrangement of the MGMT gene, but methylation of discrete regions of the CpG island of MGMT has been associated with the silencing of the gene in cell lines. (aacrjournals.org)
We used methylation-specific PCR to study the promoter methylation of the MGMT gene. (aacrjournals.org)
DNA methyltransferase (DNMT)-triggered DNA methylation silences gene expression. (iasp-pain.org)
Blocking this upregulation prevented nerve injury-induced DNA methylation within the promoter and 5'-untranslated region of gene, rescued expression and total Kv current, attenuated hyperexcitability in the injured DRG neurons, and alleviated nerve injury-induced pain hypersensitivities. (iasp-pain.org)
This upregulation was responsible for nerve injury-induced DNA methylation within the promoter and 5'-untranslated region of the gene, reductions in expression and Kv current and increases in neuronal excitability in the injured DRG. (iasp-pain.org)

The DNA repair protein O 6 -methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O 6 position of guanine. (aacrjournals.org)
DNA methyltransferase ( MGMT , promotor-enhancer, can result in different dose-response relationships for 1099C/T). We also measured DNA damage (strand different groups of individuals. (cdc.gov)

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer. (cancerindex.org)
BACKGROUND The histone methyltransferase (HMT) family includes histone lysine methyltransferases (HKMTs) and histone/protein arginine methyltransferases (PRMTs). (cancerindex.org)

In contrast, rats fed maternal LP and postnatal HF diets showed no increase in subc-AT mt copy number, oxygen consumption rate, FGF21, PRDM16 and CD137 mRNA, whereas protein expression of an inhibitor for FGF21 transcription (histone methyltransferase, G9a) increased. (nih.gov)
Arginine methyltransferase inhibitor 1 (AMI-1) was used to pharmacologically block PRMT1 in resistant breast cancer cells (MCF7/adr). (oncotarget.com)
PRMT1 may be an important co-activator of PXR in activating MDR1 gene during acquired resistance, and PRMT1 inhibitor combined with chemotherapy drugs may be a new strategy for overcoming tumor MDR. (oncotarget.com)
The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression. (rwth-aachen.de)

By selecting hybrid plasmids that confer an increased resistance to alkylating agents of E. coli ada - mutant cells, the B. subtilis gene dat, which encodes O 6 -methylguanine-DNA methyltransferase, was cloned. (elsevierpure.com)
This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)
KMT2A gene encodes a transcriptional coactivator that plays an crucial role in regulating gene expression during early development and hematopoiesis. (atlasgeneticsoncology.org)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Only two mutations were found in isoniazid resistance (INH R ) strain for Rv3919c (T to G in codon 341) and Rv1392 (G to A in codon 97) genes. (ac.ir)
For example, loss of function mutations of the EZH2 gene are seen in around 10% of MDS/MPN cases and are associated with poor prognosis. (medscape.com)
Splicing factor mutations alter splicing in different ways and affect the expression of different genes involved in RNA splicing, protein synthesis, and mitochondrial function, suggesting common mechanisms of action in MDS. (medscape.com)
Interestingly, mutations in any DC-causal gene will cause telomere dysfunction and subsequent p53 activation to further promote the repression of p53-DREAM targets. (bvsalud.org)
Molecular diagnosis of FA is challenging due to the wide spectrum of the contributing gene mutations and structural rearrangements. (bvsalud.org)
mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E. (bvsalud.org)
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. (lu.se)

Seven putative mycobacterial MTase genes ( Rv0645c , Rv2966c , Rv1988 , Rv1694 , Rv3919c , Rv2756c , and Rv3263 ) and Rv1392 as SAM synthase were selected for analysis. (ac.ir)
Streptomyces viridochromogenes Tü57 is the principal producer of avilamycin A. aviG1 , a putative methyltransferase gene, was detected in the avilamycin biosynthetic gene cluster. (microbiologyresearch.org)

Overexpression of the thiostrepton resistance genes from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2′-methyltransferase in the GTPase centre of 23S ribosomal RNA. (microbiologyresearch.org)
We screened Salmonella and Escherichia coli isolates, collected 2004-2008 in the United Kingdom, for 16S rRNA methyltransferases. (cdc.gov)
Six types of 16S rRNA methyltransferase genes conferring resistance to these antimicrobial agents, armA , rmtA , rmtB , rmtC , rmtD , and npmA , have been identified ( 2 , 3 ). (cdc.gov)
Despite large surveys performed to identify 16S rRNA methyltransferases, the rmtC gene has been detected in only 2 Proteus mirabilis clinical isolates from Japan and Australia in 2006 and 2008, respectively ( 3 , 6 , 7 ). (cdc.gov)
In this study, 81,632 Salmonella and 10,700 Escherichia coli isolates obtained from the Health Protection Agency (HPA) Centre for Infections culture collection (isolated from January 2004 through December 2008) were screened for the presence of 16S rRNA methyltransferases. (cdc.gov)
Because 16S rRNA methyltransferases confer high-level resistance to amikacin, 13 S. enterica isolates were selected on the basis of ability to grow on Isosensitest agar containing 500 µg/mL amikacin, whereas none of the E. coli isolates grew under these conditions. (cdc.gov)

For this purpose, the expression levels of DNMT3A and DNMT3B in HEK293 cells were artificially changed, and the effect on klotho gene promoter activity was investigated using a reporter gene. (tubitak.gov.tr)
The results of this research showed that DNMT enzymes have negative regulatory effects on klotho gene promoter organized as a chromatin structure, and they have an enhancing effect on promoter activity when it is located on plasmid DNA. (tubitak.gov.tr)
DNA fragments of Bacillus subtilis were inserted into a plasmid vector that can multiply in Escherichia coli cells, and foreign genes were expressed under the control of the lac promoter. (elsevierpure.com)
p53 downregulates several genes mutated in DC, either by binding to promoter sequences (DKC1) or indirectly via the DREAM repressor complex (RTEL1, DCLRE1B), and the p53-DREAM pathway represses 22 additional telomere-related genes. (bvsalud.org)

N-acetylserotonin O-methyltransferase-like protein is an enzyme that in humans is encoded by the ASMTL gene. (wikipedia.org)
Two versions of this enzyme are made from the gene. (medlineplus.gov)
This unique evolutionary paradigm for functional divergence of genes post-duplication underscores a divergent role for an enzyme singularly associated with methanogenic metabolism in other aspects of cell physiology. (illinois.edu)
The G-Biosciences' SAM Methyltransferase Assays are continuous enzyme coupled assays that can continuously monitor SAM-dependent methyltransferases (3) without the use of radioactive labels or endpoint measurements. (gbiosciences.com)
The SAM510™: SAM Methyltransferase Assay is a continuous kinetic enzyme coupled assay that can continuously monitor purified SAM-dependent methyltransferases without the use of radioactive labels or endpoint measurements. (gbiosciences.com)

It is essential to exhaustively interrogate complex mRNA isoforms of protein-coding genes with an unified data resource. (nature.com)
In order to investigate representative mRNA transcript isoforms to be utilized as transcriptome analysis references, we utilized GTEx data to establish a top-ranked transcript isoform expression data resource for human protein-coding genes. (nature.com)
Distinctive tissue specific expression profiles and modulations could be observed for individual top-ranked transcripts of protein-coding genes. (nature.com)
One major difficulty confronted is complex alternatively spliced transcript isoforms in human protein-coding genes. (nature.com)
Therefore, information regarding reference annotated mRNA transcripts of respective human protein-coding genes would be beneficial for biomedical researches and pathological sequence variation analyses. (nature.com)
These studies provided us more information on the spliced transcript isoforms of protein-coding genes as well as more understanding on their expression profiles and translated protein products in human tissues and diseases. (nature.com)

Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug. (oncotarget.com)
Pregnane x receptor (PXR) - activated overexpression of the multidrug resistance 1 (MDR1) gene is an important way for tumor cells to acquire drug resistance. (oncotarget.com)
Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia. (cancercentrum.se)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Therefore, elucidation of the control of klotho gene expression has become more important. (tubitak.gov.tr)
In contrast, a study revealing whether a change in the expression level of DNMT enzymes in the cells affects klotho gene expression has not been found. (tubitak.gov.tr)
Herein, the effects of DNMT3A and DNMT3B enzymes on the expression of klotho gene, an important genetic factor relating to the aging process and some human cancer types, were investigated. (tubitak.gov.tr)
These results elucidate the control mechanism of human klotho gene expression. (tubitak.gov.tr)
The 2 -ΔΔCt method was employed to calculate the relative expression levels of these genes. (ac.ir)
Kodama, KI, Nakabeppu, Y & Sekiguchi, M 1989, ' Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada - cells ', Mutation Research-DNA Repair , vol. 218, no. 2, pp. 153-163. (elsevierpure.com)
Scholars@Duke publication: Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. (duke.edu)
BRs signal through receptors localized to the plasma membrane and other signaling components to regulate the BES1/BZR1 family of transcription factors, which modulates the expression of thousands of genes. (duke.edu)
Here we report that histone lysine methyltransferase SDG8, implicated in histone 3 lysine 36 di- and trimethylation (H3K36me2 and me3), is involved in BR-regulated gene expression. (duke.edu)
BES1 interacts with SDG8, directly or indirectly through IWS1, a transcription elongation factor involved in BR-regulated gene expression. (duke.edu)
Global gene expression studies demonstrated that, while BR regulates about 5000 genes in wild-type plants, the hormone regulates fewer than 700 genes in sdg8 mutant. (duke.edu)
Based on these results, we propose that SDG8 plays an essential role in mediating BR-regulated gene expression. (duke.edu)
Our results thus reveal a major mechanism by which histone modifications dictate hormonal regulation of gene expression. (duke.edu)
However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene expression data processing and interpretation. (nature.com)
Protein-coding transcripts or genes do occupy much higher expression fraction in transcriptome data. (nature.com)
In order to enhance berry coloration of bright-red grape cultivars, the effects of abscisic acid (ABA) treatment on the quantity and composition of anthocyanins as well as the expression of genes related to flavonoid biosynthesis in the berry were examined. (scirp.org)
Studies carried out by scientists at IRIG, in collaboration with the University of Geneva, on the fruit fly model Drosophila melanogaster have revealed the role of Pcif1 in the control of gene expression, despite the fact that this protein has completely lost its RNA methyltransferase activity compared to its mammalian counterpart PCIF1. (cea.fr)
This study highlights an important contribution for Pcif1 in gene expression and physiology of the organism independently of any catalytic activity. (cea.fr)
In mice, mutation of PCIF1 encoding gene causes deregulation of the expression of a set of genes and a reduced body weight. (cea.fr)
The work of the scientists shows that mutation of Pcif1 gene in Drosophila results in a deregulation of the expression of a set of genes, reduced body weight and a significant drop in fertility which indicates an important role for this protein in the physiology of the organism. (cea.fr)
In agreement with these observations, the Pcif1 protein is distributed all along the polytene chromosomes at the level of active transcription sites and interferes with chromatin-dependent gene expression regulation. (cea.fr)
The lack of catalytic activity of Pcif1 in Drosophila reveals a new mechanism of gene expression regulation. (cea.fr)
Regulation of Gene Expression for L-Isoaspartyl O-Methyltransferases by Cis-Elements Associated with ?Heat-Shock Polytene Chromosome Puffing Formation? (kpfu.ru)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
For information on therapeutic regulation of gene expression, see therapeutic gene modulation.Regulation of gene expression includes the processes that cells and viruses use to regulate the way that the information in genes is turned into gene products. (absoluteastronomy.com)
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. (absoluteastronomy.com)
We show here that DNMT1, a canonical maintenance methyltransferase, acts as the DNMT and is required for neuropathic pain genesis likely through repressing at least DRG gene expression in male mice. (iasp-pain.org)
Peripheral nerve injury upregulated DNMT1 expression in the injured DRG through the transcription factor cAMP response element binding protein-triggered transcriptional activation of gene. (iasp-pain.org)
Since pharmacological inhibition or genetic knockdown of DRG DNMT1 alleviated nerve injury-induced pain hypersensitivities, DRG DNMT1 contributes to neuropathic pain genesis partially through repression of DRG gene expression. (iasp-pain.org)
We view the activity of TAZVERIK ® and its epigenetic mechanism in controlling the expression of certain genes as highly complementary and potentially synergistic with our broad portfolio of novel oncology assets," said Mr. Christian Hogg, CEO of HUTCHMED. (businesswire.com)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. (nih.gov)
With the exceptions of armA and rmtB in porcine Escherichia coli from Spain and the People's Republic of China, respectively ( 4 , 5 ), all methyltransferase genes described have been identified in human clinical samples, for which a possible role for food in transmission of these determinants remains largely unknown. (cdc.gov)
Recombinant COMT was produced in Escherichia coli up to 10% of total bacterial protein after the induction of the T7 RNA polymerase gene with isopropyl-β-d-thiogalactopyranoside. (lu.se)

1. Cheng, X. & Blumenthal, R.M. (1999) S-Adenosylmethionine Dependent Methyltransferases World Scientific, Singapore. (gbiosciences.com)

Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1The GenBank accession number for the sequence reported in this paper is AF333038. (microbiologyresearch.org)
The presence of erythromycin A in the culture supernatant of the complemented mutant indicated that L-mycarose biosynthesis could be restored and that AviG1 could take over the function of the C-methyltransferase EryBIII. (microbiologyresearch.org)
Quantitative real-time PCR analysis revealed that ABA treatment around véraison resulted in the upregulation of genes encoding enzymes responsible for both general flavonoid and anthocyanin biosynthesis. (scirp.org)
Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessive disorder of creatine biosynthesis due to pathogenic variants in the GAMT gene that lead to cerebral creatine deficiency and neurotoxic levels of guanidinoacetate. (cdc.gov)

Intriguingly, some of the top-ranked transcripts are noncoding splicing isoforms, which imply diverse gene regulation mechanisms. (nature.com)
gene loci structures and their regulation. (nature.com)

Given that is a key player in neuropathic pain, our findings suggest that DRG DNMT1 may be a potential target for neuropathic pain management.In the present study, we reported that DNMT1, a canonical DNA maintenance methyltransferase, is upregulated via the activation of the transcription factor CREB in the injured DRG after peripheral nerve injury. (iasp-pain.org)
La DNMT1 metila residuos CpG, con preferencia por el ADN hemimetilado y se asocia a los sitios de replicación del ADN en la FASE S para mantener el patrón de metilación en la hebra recién fabricada, lo que resulta esencial en los PROCESOS EPIGENÉTICOS. (bvsalud.org)

The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. (nih.gov)
A Chromatin Immunoprecipitation (ChIP) experiment showed that H3K36me3 is reduced in BR-regulated genes in the sdg8 mutant. (duke.edu)

Similarly, ribosomal dysfunction and DNA lesions cause p53 activation, and p53-DREAM targets include the DBA-causal gene TSR2, at least 9 FA-causal genes, and 38 other genes affecting ribosomes or the FA pathway. (bvsalud.org)

Based on the nucleotide sequence of the gene, it was deduced that the protein comprises 165 amino acids and that the molecular weight is 18 779. (elsevierpure.com)
The presumptive amino acid sequence of Dat protein is homologous to the sequences of the E. coli Ogt protein and the C-terminal half of the Ada protein, both of which carry O 6 -methylguanine-DNA methyltransferase activity. (elsevierpure.com)
Subsequently, through comparative sequence analyses, we show that functional divergence of paralogs is primarily mediated by divergent evolution of the 5′ regulatory region, despite frequent gene conversion within the coding sequence. (illinois.edu)
The following METTL17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
Following duplication events, the resulting stretches of homologous sequence can promote recombination between gene copies. (elifesciences.org)
or the transmembrane protein gene cassettes of some pathogenic bacteria ( Santoyo and Romero, 2005 ), gene conversion can also generate sequence diversity. (elifesciences.org)
Sequence variations in a number of genes for DNA repair in occupational toxicology for a more accurate risk and phase I/phase II metabolising enzymes have recently assessment of groups of workers. (cdc.gov)

This major gene polymorphism may now be studied using biochemical and molecular genetic techniques. (elsevierpure.com)

On the other hand, the gene expressions of enzymes involved in proanthocyanidin synthesis were drastically decreased at véraison and remained extremely low even with ABA treatment. (scirp.org)
one includes structural genes encoding enzymes that directly participate in the formation of anthocyanins and other flavonoids, and the other comprises regulatory genes controlling the transcription of structural genes. (scirp.org)

The chromosomal region that is typically deleted contains 30 to 40 genes, including the COMT gene. (medlineplus.gov)
As a result of the deletion, people with this disorder have only one copy of the COMT gene in each cell instead of the usual two copies. (medlineplus.gov)
Variations in the COMT gene also may be associated with mental illness in people without 22q11.2 deletion syndrome. (medlineplus.gov)
Researchers have looked extensively at the potential connection between changes in the COMT gene and the risk of developing schizophrenia. (medlineplus.gov)
Other changes in the COMT gene may also contribute to these differences. (medlineplus.gov)
Variations in the COMT gene are among many factors under study to help explain the causes of schizophrenia. (medlineplus.gov)

Detects human Glycine N-methyltransferase/GNMT in direct ELISAs and Western blots. (rndsystems.com)
Detection of Human Glycine N-methyltransferase/GNMT by Western Blot. (rndsystems.com)
PVDF Membrane was probed with 1 µg/mL of Human Glycine N-methyltransferase/GNMT Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6526) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
A specific band was detected for Glycine N-methyltransferase/GNMT at approximately 33 kDa (as indicated). (rndsystems.com)
GNMT (glycine N-methyltransferase) is a cytoplasmic homotetramer of 33 kDa units that converts S-adenosylmethionine to N-methylglycine (sarcosine), also producing S-adenosylhomocysteine. (rndsystems.com)

Overview of all the structural information available in the PDB for UniProt: O95671 (Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein) at the PDBe-KB. (wikipedia.org)
The structural similarity of these methyltransferases suggests possible evolution from a single ancestral gene. (elsevierpure.com)

Finally, we show that the generated episignature includes CpG sites that do not undergo functional selective pressure, allowing diagnosis of FA in individuals with reverted phenotype due to gene conversion. (bvsalud.org)

A gene is a molecular unit of heredity of a living organism. (absoluteastronomy.com)

Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. (nih.gov)

Prediction of the coding sequences of unidentified human genes. (nih.gov)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)

Significantly, the evolutionary pressures leading to gene duplication and subsequent genome expansion have not been well investigated, especially with respect to biological methane production (methanogenesis), which is the key biological trait of these environmentally important organisms. (illinois.edu)

One important genetic factor associated with aging is klotho gene. (tubitak.gov.tr)
Gene duplication is long recognized as a potential source of genetic innovation ( Ohno, 1970 ). (elifesciences.org)

METT10D is a probable methyltransferase. (thermofisher.com)

With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. (nature.com)

A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)

Isolates resistant to neomycin bore the aac(6′)-Ib gene cassette, whereas the dfrA1 gene was responsible for resistance to trimethoprim. (cdc.gov)
The erythromycin resistance methylase ( erm ) gene commonly mediates resistance to macrolides, clindamycin , and quinupristin but not the oxazolidinones or dalfopristin. (msdmanuals.com)
The chloramphenicol -florfenicol resistance ( cfr ) gene mediates resistance to chloramphenicol , dalfopristin, clindamycin , and oxazolidinones, but tedizolid may retain susceptibility in some strains. (msdmanuals.com)

All isolates were clonally related and bore the rmtC gene on the bacterial chromosome. (cdc.gov)

3H2B: Crystal structure of the SAM-dependent methyltransferase cg3271 from Corynebacterium glutamicum in complex with S-adenosyl-L-homocysteine and pyrophosphate. (rcsb.org)
Transient B12-dependent methyltransferase complex revealed by small-angle X-ray scattering. (degruyter.com)

Sus scrofa methyltransferase like 17 (METTL17), mRNA. (genscript.com)

Furthermore, patients with BMFSs may exhibit brain abnormalities, and p53-DREAM represses 16 genes mutated in microcephaly or cerebellar hypoplasia. (bvsalud.org)

Three transcript variants encoding different isoforms have been found for this gene. (nih.gov)
The role of HMT gene variants in prostate cancer remains unknown. (cancerindex.org)
It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. (fishersci.com)
Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci. (elifesciences.org)
In order to expand our understanding of how recombination might influence virus variation during the course of adaptation, we focused on large DNA viruses, in which rapidly evolving populations can simultaneously harbor both adaptive gene copy number variation and beneficial single nucleotide variants (SNVs) at the same locus. (elifesciences.org)

Researchers at IRIG, in collaboration with the University of Geneva, focused on a RNA mammalian methyltransferase, the PCIF1 protein (homologous to the Drosophila Pcif1 protein), which adds an extra methyl group to m 6 A (m 6 adenosine) to form m 6 Am when the first transcribed nucleotide is an adenosine. (cea.fr)

Several intracellular metabolic pathways in which multiple genes have a role affect the aging process. (tubitak.gov.tr)
In this regard, the role of mycobacterial methyltransferases (MTases) in TB infection can be fundamental, though it has not been broadly deciphered. (ac.ir)

Anatomy9

Organisms11

Diseases1

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes45

Disciplines and Occupations1

Information Science4

Catechol-O-methyltransfera12

Proteins9

Methylation6

MGMT2

Lysine Methyltransferases2

Inhibitor4

Encodes3

Mutations8

Putative2

RRNA6

Promoter4

Enzyme5

Protein-codin6

Overexpression3

Expression32

Escherichia3

19991

Biosynthesis4

Regulation2

DNMT12

Chromatin2

Ribosomal1

Sequence7

Polymorphism1

Enzymes2

COMT6

GNMT5

Structural2

Phenotype1

Organism1

ASMTL1

Human genes2

Genome1

Genetic2

Probable1

Transcriptome1

Regulatory1

Resistance3

Chromosome1

Complex2

MRNA1

Abnormalities1

Variants5

Homologous1

Role2