• This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. (cdc.gov)
  • Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. (nih.gov)
  • This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. (cdc.gov)
  • Citation: McMahon TF, Cunningham ML. Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium His G46. (nih.gov)
  • An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methylazoxymethanol acetate (592-62-1). (nih.gov)
  • Prenatal administration of methylazoxymethanol acetate mitotoxin, a DNA-alkylating agent, has been used in rodents to model neurodevelopmental disruption in schizophrenia. (medscape.com)
  • 2022 ) Increased Presynaptic Dopamine Synthesis Capacity Is Associated With Aberrant Dopamine Neuron Activity in the Methylazoxymethanol Acetate Rodent Model Used to Study Schizophrenia-Related Pathologies. (neurotree.org)
  • We show that the brains of adult C57BL6 wild-type mice treated with a single systemic dose of MAM acetate display DNA damage (O⁶-methyldeoxyguanosine lesions, O⁶-mG) that remains constant up to 7 days post-treatment. (nih.gov)
  • We measured global gene expression in immature cerebellar neurons (i.e., granule cells) after treatment with two distinct alkylating agents, methylazoxymethanol (MAM) and nitrogen mustard (HN2). (nih.gov)
  • Models of neural dysplasia in rats include treatment with methylazoxymethanol acetate followed by induction of epileptiform seizures by pilocarpine. (nih.gov)