• The rats were injected with methy-lazoxymethanol acetate (MAM) in saline solution at 25 mg/kg body weight once a week for 3 weeks and fed a diet containing 1% quercetin for the following 459days. (go.jp)
  • We found that administration of the mitotoxin methylazoxymethanol acetate (MAM) to rats at gestational day 17 leads to adult rats that exhibit neuroanatomical, pharmacological, and behavioral characteristics consistent with schizophrenia. (uthscsa.edu)
  • Another study found that mice whom methylazoxy-methanol acetate was administered on 16th gestational day, but not those whom it was adminitred on GD17 showed decreased parvalbumin expression in hippocampus and prefrontal cortex, and schizophrenia-like characteristics. (wikipedia.org)
  • Methylazoxymethanol acetate, MAM, is a neurotoxin which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and epilepsy. (wikipedia.org)
  • In particular, the methylazoxymethanol acetate (MAM) model relies upon disruption of neurodevelopment resulting in neuroanatomical effects on frontal and temporal cortices resembling those in schizophrenia. (ukri.org)
  • The effects of gestational date (13, 14, 15, and 17 days) of administration of methylazoxymethanol acetate (20 mg/kg) on the cortical synaptic chemistry and morphology of the rat has been examined in adult offspring. (johnshopkins.edu)
  • This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. (cdc.gov)
  • Johnston, MV, Carman, AB & Coyle, JT 1981, ' Effects of Fetal Treatment with Methylazoxymethanol acetate at Various Gestational Dates on the Neurochemistry of the Adult Neocortex of the Rat ', Journal of Neurochemistry , vol. 36, no. 1, pp. 124-128. (johnshopkins.edu)
  • Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. (nih.gov)
  • This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. (cdc.gov)
  • Prenatal administration of methylazoxymethanol acetate mitotoxin, a DNA-alkylating agent, has been used in rodents to model neurodevelopmental disruption in schizophrenia. (medscape.com)
  • Citation: McMahon TF, Cunningham ML. Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium His G46. (nih.gov)
  • An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methylazoxymethanol acetate (592-62-1). (nih.gov)
  • Another study found that mice whom methylazoxy-methanol acetate was administered on 16th gestational day, but not those whom it was adminitred on GD17 showed decreased parvalbumin expression in hippocampus and prefrontal cortex, and schizophrenia-like characteristics. (wikipedia.org)
  • We show that the brains of adult C57BL6 wild-type mice treated with a single systemic dose of MAM acetate display DNA damage (O⁶-methyldeoxyguanosine lesions, O⁶-mG) that remains constant up to 7 days post-treatment. (nih.gov)
  • Methylazoxymethanol acetate, MAM, is a neurotoxin which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and epilepsy. (wikipedia.org)