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  • human
  • Recent data demonstrate highly significant correlations between DNA methylation and the most important risk factors of T2D, including age and body mass index, in blood and human tissues relevant to insulin resistance and T2D. (frontiersin.org)
  • This Review will address the most recent associations between DNA methylation and diabetes-related traits in human tissues and blood. (frontiersin.org)
  • Peptide
  • Employing this protein consisting of 158 amino acid residues of the main chain plus 40 residues of the fusion peptide. (ajou.ac.kr)
  • The identity of each modified lysine residue was confirmed by fragmentation pattern analysis of the peptide mass spectra. (nih.gov)
  • A synthetic peptide containing an identified tri-methylated lysine, which corresponds to a previously identified LipL32 epitope, demonstrated significantly reduced immunoreactivity with serum collected from leptospirosis patients compared to the peptide version lacking the tri-methylation. (nih.gov)
  • While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S -adenosyl methionine (SAM) as cofactor. (sciencemag.org)
  • peptides
  • Backbone N-methylation of peptides enhances their protease resistance and membrane permeability, a property that holds promise for applications to medicinal chemistry. (sciencemag.org)
  • We found that methylation of N τ residue of imidazole ring (balenine) or trimethylation of carnosine backbone at N τ residue of imidazole ring and terminal amine group dimethyl balenine (DMB) abolishes the ability of these peptides to react with HNE. (springer.com)
  • patterns
  • Altered DNA methylation patterns in coding strands lead to epigenetic modification. (omicsonline.org)
  • Prior research by the UCLA team found that methylation patterns in antiretroviral-naive adults indicate that their epigenetic age exceeds their chronological age by 14 years . (natap.org)
  • Because antiretroviral-treated people run an increased risk of age-related diseases, these investigators hypothesized that "ART initiation does not restore HIV-perturbed epigenetic patterns to age-appropriate levels, and that DNA methylation ages stay advanced in treated HIV-infected adults compared to chronologically age-matched controls. (natap.org)
  • To test those hypotheses, the UCLA researchers compared methylation patterns in lymphocyte subsets of 15 HIV-positive antiretroviral-treated men (all with an undetectable viral load) and 15 HIV-negative men in the MACS, an ongoing observational study of men who have sex with men (MSM). (natap.org)
  • The UCLA team used Horvath's epigenetic clock to compare DNA methylation patterns in these PBMC sets. (natap.org)
  • Together with the finding that ART does not restore age-appropriate DNA methylation patterns after 2 years of treatment, these results "suggest that HIV-induced age acceleration, partially mediated through epigenetic changes, may be directly associated with the earlier functional and clinical decline observed in virally suppressed HIV-infected adults on ART. (natap.org)
  • Acceleration of age-associated methylation patterns in HIV-1-infected adults. (natap.org)
  • DNMTs are responsible for setting and maintaining DNA methylation patterns. (novusbio.com)
  • alters
  • Methylation of these sites prevents or abolishes the aldehyde reactivity of carnosine, alters its metal-chelating property, and diminishes its ability to prevent electrophilic injury. (springer.com)
  • mammalian
  • We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of thousands of m(6)A residues in mammalian mRNA with single-nucleotide resolution. (jax.org)
  • strands
  • In contrast, DNMT1, the most prevalent methyltransferase in mammals, ensures the maintenance of methylation tags onto new DNA strands during replication. (novusbio.com)
  • abnormalities
  • This paper attempts to review genetic changes attributed to abnormalities in DNA methylation which in turn activate tumoriogenic potential of cells further leading to cancer. (omicsonline.org)
  • Chemical
  • Moreover, as a validation test of this approach, we compare our theoretical computations of the 13 C ε chemical-shift values against existing experimental data, obtained from NMR spectroscopy, for methylated and acetylated lysine residues with good agreement within ∼1 ppm. (peerj.com)
  • We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions. (stanford.edu)
  • cell
  • These CD8-cell subsets were significantly associated with DNA methylation age. (natap.org)
  • Even after 1 and 2 years of ART, all four CD8-cell subsets remained elevated compared to the HIV-negative group, and all remained significantly associated with DNA methylation age. (natap.org)
  • turn
  • Key residues contributing to K36me specificity on histone H3 are G33 and G34 (positioned within a narrow channel), P38 (a turn residue), and Y41 (inserts into its own pocket). (stanford.edu)