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  • nitric oxide
  • After the rhythmic bladder contractions stabilized, L-arginine, a nitric oxide (NO) substrate (100 mg/kg), was administered intravenously in both groups. (readbyqxmd.com)
  • As the nitrogen donor in nitric oxide (NO∙) synthesis, arginine and its metabolic products are integrally linked to vascular health and inflammation. (omicsonline.org)
  • biological
  • Arginine is unique among amino acids as its guanidino group contains five potential hydrogen bond donors that are positioned for favorable interactions with biological hydrogen bond acceptors. (mdanderson.org)
  • citrulline
  • Targeted metabolomic analysis of arginine metabolites in plasma was performed by isotope dilution LC/MS including asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), N-mono-methylarginine (NMMA), arginine and citrulline. (omicsonline.org)
  • CKD mice had high levels of citrulline and arginine, but ADMA levels had no correlation with either of these metabolites. (omicsonline.org)
  • The conversion of arginine to citrulline, an atypical amino acid that lacks arginine's positive charge, is accomplished by a member of the peptidylarginine deiminase (PAD) 3 family of enzymes, PAD4 ( 5 ). (jimmunol.org)
  • symmetric
  • Mutation in an Arabidopsis symmetric arginine dimethyltransferase, AtPRMT5, causes pleiotropic developmental defects, including late flowering, but the underlying molecular mechanism is largely unknown. (pnas.org)
  • region
  • The primary structure of G3BP2, similar to its G3BP1 isoform identified previously ( Bikkavilli and Malbon, 2011 ), has an N-terminal nuclear transport factor 2-like domain (NTF2), an RNA recognition motif (RRM domain) and a glycine-arginine-rich (GAR) region ( Fig. 1B ). (biologists.org)
  • mass
  • We developed a targeted metabolomic platform to profile quantitatively arginine metabolites in plasma by liquid chromatography tandem mass spectrometry (LC/MS). Male low-density lipoprotein receptor deficient (LDLr-/-) mice at age 6 weeks were subjected to sham or 5/6 nephrectomy surgery to induce CKD. (omicsonline.org)
  • domain
  • B ) Schematic of the organization of G3BP2 and G3BP1 showing a conserved NTF2-like domain, an RNA recognition motif, a glycine-arginine-rich motif and SH3-binding motifs. (biologists.org)
  • cells
  • Importantly, E2F‐1 is methylated in tumour cells, and a reduced level of methylation is evident under DNA damage conditions that allow E2F‐1 stabilization and give rise to apoptosis. (embopress.org)