Loading...
  • phosphorylation
  • Octameric protein complexes called nucleosomes are responsible for the amount of supercoiling of DNA, and these complexes can be temporarily modified by processes such as phosphorylation or more permanently modified by processes such as methylation . (wikipedia.org)
  • protein
  • The diverse functions of histone and DNA modifications are brought about by large protein complexes that regulate a number of biological processes, ranging from DNA replication, transcription and repair to cellular division, differentiation and apoptosis. (embopress.org)
  • By increasing the affinity of the mouse primary antibody for the protein G bead, the Bridging Antibody for Mouse IgG can help improve the results of all ChIP, MeDIP and IP experiments that use Histone H2BK120ub1 antibody (mAb). (activemotif.com)
  • Chemical "tags" called histones, collections of protein molecules, influence the DNA molecule. (blogspot.com)
  • Our data indicate that expression of 41BBL and OX40L can indeed be epigenetically regulated, as inhibition of histone deacetylases and of DNA methyltransferases results in increased OX40L and 41BBL mRNA and protein expression. (biomedcentral.com)
  • DNMT 3L is a nuclear protein which has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. (abcam.com)
  • Histone acetyltransferase enzymes (HATs) such as CREB-binding protein also dissociate the DNA from the histone complex, allowing transcription to proceed. (wikipedia.org)
  • gene expression
  • Following the initial observation of DNA methylation as one of the most critical aspects for the stable maintenance of gene expression pattern, today epigenetic regulation has earned a notable place in scientific research on cellular and physiological response mechanism towards multiple external stimuli, particularly in disease biology. (mdpi.com)
  • cell
  • I agree with pcrman in that cloning and then sequencing clones might give you a better idea of what methylation frequency of your sites is-sites can be methylated or not within the same cell population. (protocol-online.org)