To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1H nuclear magnetic resonance. (dovepress.com)
With two examples, poly( N -isopropyl acrylamide) brushes and poly(ethylene glycol) microgels on Si surfaces, the simulation as well as the application of the simulation to the GINSES data analysis are presented. (iucr.org)
Poly(ethylene glycol) methyl ether methacrylate (PEGMA) is a nonlinear analog of polyethylene glycol (PEG). (sigmaaldrich.com)
Comparison of modification of a bacterial uricase with N-hydroxysuccinimide esters of succinate and carbonate of monomethoxyl poly(ethylene glycol). (bvsalud.org)
Epoetin5
Methoxy polyethylene glycol-epoetin beta, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease. (wikipedia.org)
Methoxy polyethylene glycol-epoetin beta is made from erythropoietin by chemically linking the N-terminal amino group or the ε-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. (wikipedia.org)
The Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/109352/all/methoxy_polyethylene_glycol_epoetin_beta. (unboundmedicine.com)
Several ESA classes are available for anemia treatment (epoetin alfa, epoetin beta, darbepoetin alfa, methoxy polyethylene glycol-epoetin beta as well as biosimilar ESAs) but whether these drugs have differing benefits and harms is uncertain. (doki.net)
Molecular weight3
We offer several molecular weight Methoxy Polyethylene Glycols (mPEGs) as key starting raw material for development of PEG-Lipids that support to create hydration shell around the fragile LNPs. (clariant.com)
Evonik's new offering of poly(DL-lactide) (PLA) and polyethylene glycol (PEG) di-block copolymers are used for controlled release applications and feature different molecular weight fractions. (industryintel.com)
By adjusting the molecular weight of the mPEG (methoxy-PEG) and PLA blocks, the excipient attributes and formulation properties can be modified. (industryintel.com)
Conjugate1
In this study, we developed a bioreducible methoxy polyethylene glycol (mPEG)-triphenylphosphonium (TPP) conjugate (i.e., mPEG-(ss-TPP) 2 conjugate) as a vehicle for mitochondrial drug delivery. (acs.org)
mPEG-O-C16 is a linear methoxy PEG with one C16 alkyl through an ether bond. (creativepegworks.com)
20001
To investigate the photo-induced hydrophilicity of TiO 2 films and its durability, a series of TiO 2 films containing polyethylene glycol (PEG) 2000 with different contents are prepared. (pku.edu.cn)
Biocompatible1
We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted stealth analog and target-specific biotin-PEG- b -PMLABe one. (frontiersin.org)
Surface1
PEGMA can be used in the surface modification of poly(ether sulfone) based ultrafiltration (UF) membrane as a foul-resistant material. (sigmaaldrich.com)
Ethylene3
Neutron reflection was used to characterize the adsorbed layer structure for lysozyme conjugated at the N-terminus with a single perdeuterated methoxy poly(ethylene glycol) chain at the silica/water interface. (nist.gov)
Polyethylene glycol (PEG) also known as polyoethylene ethylene or polyoxy, is an oligopoly or polymer of ethylene oxide. (dongkeunited.com)
Embryos were exposed to aqueous suspensions of CdSe(core)/ZnS(shell) QDs functionalized with either poly-L-lysine or poly(ethylene glycol) terminated with methoxy, carboxylate, or amine groups. (nih.gov)
Mircera2
Methoxy polyethylene glycol-epoetin beta, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease. (wikipedia.org)
Methoxy polyethylene glycol-epoetin beta is made from erythropoietin by chemically linking the N-terminal amino group or the ε-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. (wikipedia.org)
Using methoxy polyethylene glycol-epoetin beta injection may increase the risk that blood clots will form in or move to the legs and lungs. (medlineplus.gov)
Before having any surgery, even dental surgery, tell your doctor or dentist that you are being treated with methoxy polyethylene glycol-epoetin beta injection, especially if you are having coronary artery bypass graft (CABG) surgery or surgery to treat a bone problem. (medlineplus.gov)
Your doctor will adjust your dose of methoxy polyethylene glycol-epoetin beta injection so that your hemoglobin level (amount of a protein found in red blood cells) is just high enough that you do not need a red blood cell transfusion (transfer of one person's red blood cells to another person's body to treat severe anemia). (medlineplus.gov)
If you receive enough methoxy polyethylene glycol-epoetin beta injection to increase your hemoglobin to a normal or near normal level, there is a greater risk that you will have a stroke or develop serious or life-threatening heart problems including heart attack, and heart failure. (medlineplus.gov)
Your doctor will monitor your blood pressure often during your treatment with methoxy polyethylene glycol-epoetin beta injection. (medlineplus.gov)
Your doctor will also order certain tests to check your body's response to methoxy polyethylene glycol-epoetin beta injection. (medlineplus.gov)
Your doctor may decrease your dose or tell you to stop using methoxy polyethylene glycol-epoetin beta injection for a period of time if the tests show that you are at high risk of experiencing serious side effects. (medlineplus.gov)
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methoxy polyethylene glycol-epoetin beta injection and each time you refill your prescription. (medlineplus.gov)
Talk to your doctor about the risks of receiving methoxy polyethylene glycol-epoetin beta injection. (medlineplus.gov)
Methoxy polyethylene glycol-epoetin beta injection should not be used to treat anemia caused by cancer chemotherapy. (medlineplus.gov)
Methoxy polyethylene glycol-epoetin beta injection is used to treat anemia (a lower than normal number of red blood cells) in people with chronic kidney failure (condition in which the kidneys slowly and permanently stop working over a period of time) in adults on and not on dialysis and in children 5 years of age and older on dialysis who have already received another treatment for anemia. (medlineplus.gov)
Methoxy polyethylene glycol-epoetin beta injection should not be used to treat anemia caused by cancer chemotherapy and should not be used in place of a red blood cell transfusion to treat severe anemia. (medlineplus.gov)
This research aimed to investigate the relation between resistance to the methoxy polyethylene glycol-epoetin beta (ME-β) and angiotensin-converting enzyme (ACE) gene polymorphism. (nih.gov)
Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109352/all/methoxy_polyethylene_glycol_epoetin_beta. (unboundmedicine.com)
In vitro studies presented by Michael Jarsch, MD, from Roche Diagnostics GmbH, in Penzberg, Bavaria, Germany, compared the binding and consumption of methoxy polyethylene glycol-epoetin beta and epoetin beta with the extracellular domain of the soluble human erythropoietin receptor using a surface plasma resonance assay. (medscape.com)
Using the equilibrium constant analysis, Jarsch and colleagues were able to calculate the binding affinity of epoetin beta and methoxy polyethylene glycol-epoetin beta, which showed that methoxy polyethylene glycol-epoetin beta had a lower binding affinity (K d ) than epoetin beta (approximately 140 nM vs approximately 2.9 nM, respectively). (medscape.com)
Furthermore, the surface plasma resonance binding kinetics showed that the dissociation rate from the receptor was approximately 1.5 times faster for methoxy polyethylene glycol-epoetin beta than epoetin beta, and the association rate of methoxy polyethylene glycol-epoetin beta from the soluble human erythropoietin receptor was slower. (medscape.com)
Therefore, the increase in K d seen with methoxy polyethylene glycol-epoetin beta can be attributed to methoxy polyethylene glycol-epoetin beta's lower association rate. (medscape.com)
Finally, using UT-7 cell consumption assays during a 120-hour incubation with 1000 pM methoxy polyethylene glycol-epoetin beta or 100 pM epoetin beta, methoxy polyethylene glycol-epoetin beta concentrations remained sufficient to stimulate cell proliferation after 120 hours vs epoetin beta, and epoetin beta concentration in supernatant declined significant vs methoxy polyethylene glycol-epoetin beta concentration in supernatant (did not change significantly at time points). (medscape.com)
In conclusion, methoxy polyethylene glycol-epoetin beta was found to be less rapidly consumed by target cells and thus remained at stimulating concentrations for longer periods. (medscape.com)
These findings support a different activity of methoxy polyethylene glycol-epoetin beta at the receptor level. (medscape.com)
Moreover, this mechanistic difference further supports extended administration intervals between methoxy polyethylene glycol-epoetin beta and traditional ESAs for anemia treatment. (medscape.com)
Allen Nissenson, MD, Professor of Medicine, Associate Dean and Director of the Dialysis Program at the David Geffen School of Medicine at University of California, Los Angeles, California, presented the results from a randomized, open-label trial to assess hemoglobin stability and dose changes in adult anemic patients on dialysis (hemodialysis or peritoneal dialysis ≥ 12 weeks) with intravenous (IV) methoxy polyethylene glycol-epoetin beta or IV epoetin alfa or beta. (medscape.com)
The starting dose of methoxy polyethylene glycol-epoetin beta was based on the epoetin dose administered during the week preceding the switch. (medscape.com)
Doses of methoxy polyethylene glycol-epoetin beta and epoetin beta were adjusted every 4 weeks to maintain hemoglobin within ± 1.0 g/dL of baseline levels and between 10 and 13.5 g/dL. (medscape.com)
Methoxy polyethylene glycol-epoetin beta: (Moderate) Androgens are known to stimulate erythropoiesis. (bootb.com)
High-molecular-weight1
PEG 8000 is a high-molecular-weight polyethylene glycol commonly used in pharmaceuticals and food products. (dongkeunited.com)
Encapsulation2
Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. (uct.ac.za)
The purpose of this study is to increase the aqueous solubility of astaxanthin by encapsulation into self-assembled methoxypolyethylene glycol-poly(ɛ-caprolactone) (MPEG-PCL) polymeric micelle. (confex.com)
Nanoparticles1
Selective size separation of AIS and AIS/ZnS hydrophilic nanoparticles was performed as well as the ligand exchange by thiolated methoxypolyethylene glycol molecules having an amphiphilic nature. (researchgate.net)
Conjugation1
The methoxy form of PEG (mPEG) is usually used for conjugation applications due to the single hydroxyl group that can be coupled with several other groups including small drugs, proteins, polymers, and lipids. (avantilipids.com)
Toxicity1
Toxicity prediction programs have projected that 2-methoxy-4-nitroaniline is a carcinogen in rodents, but there is no actual data on the chronic toxicity or carcinogenicity of this chemical. (nih.gov)
Lysine1
It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues. (drugbank.com)
Compound3
Given the concerns about other anisidines, findings that 2-methoxy-4-nitroaniline is mutagenic when metabolically activated raises concerns about the carcinogenic potential of this compound. (nih.gov)
Polyethylene glycol (PEG) is a versatile compound widely used in various industries,including pharmaceuticals, cosmetics, and food. (dongkeunited.com)
Polyethylene glycol (PEG) is a versatile compound that finds extensive use in the pharmaceutical, cosmetic, and food industries. (dongkeunited.com)
Findings1
Despite these findings, large quantities of 2-methoxy-4-nitroaniline appear to be in use worldwide. (nih.gov)
Molecules1
Energy transfer in hybrid structures based on colloidal quantum dots of CdSe/ZnS and molecules of tetra(p-trimethylamino)phenylporphin formed in polyethylene terephthalate track membranes is considered. (researchgate.net)
Cells1
2-Methoxy-4-nitroaniline was mutagenic to Salmonella typhimurium and Escherichia coli and produced chromosome aberrations in Chinese hamster lung cells. (nih.gov)
Water1
Department of Isopentenol in the production of Poly (carboxylic Acid water reducing agent, can be used for the preparation of precast concrete cast in situ concrete high-performance, flow-state, the self compacting concrete and mass, and concrete can widely be used in high speed railway, large bridges and water conservancy. (psp-vault.com)
Found1
Polyethylene glycol (PEG) has been found to minimize nonspecific adsorption of proteins onto NPs and to reduce their uptake by the liver ( 6 ). (nih.gov)
Products1
Polyolefins such as polyethylene (PE) and polypropylene (PP) may be used to manufacture a varied range of articles, including films, molded products, foams, and the like. (justia.com)
Names1
These three names are generally synonymous today, but historically polyethylene glycol often refers to hypocatries and polymers with a molecular mass of less than 20,000 g/mol. (dongkeunited.com)
Release1
An environmental assessment to determine the extent that 2-methoxy-4-nitroaniline is released into the environment and the hazards associated with this release. (nih.gov)