Novo synthesis1
- Folic acid is needed for the de novo synthesis of the nucleoside thymidine, required for DNA synthesis. (the-medical-dictionary.com)
Inhibits2
- Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. (lookformedical.com)
- Methotrexate competetively and reversibly inhibits dihydrofolate reductase (DHFR), an enzyme that is part of the folate synthesis metabolic pathway. (the-medical-dictionary.com)
Cancer4
- Antimetabolites that are useful in cancer chemotherapy. (lookformedical.com)
- formerly known as amethopterin ) is an antimetabolite drug used in treatment of cancer and autoimmune diseases. (the-medical-dictionary.com)
- Methotrexate originated in the 1940s when Sidney Farber at Children's Hospital Boston was testing the effects of folic acid on cancer. (the-medical-dictionary.com)
- The higher doses of methotrexate often used in cancer chemotherapy can cause toxic effects to the rapidly-dividing cells of bone marrow and gastrointestinal mucosa. (the-medical-dictionary.com)
Drug4
- That inspired chemists at the drug company Lederle to start looking for antimetabolites resembling folic. (the-medical-dictionary.com)
- Methotrexate gained FDA approval as an oncology drug in 1953. (the-medical-dictionary.com)
- Methotrexate is a highly teratogenic drug and categorized in Pregnancy Category X by the FDA. (the-medical-dictionary.com)
- Methotrexate users were increased to 22.5 mg of the drug per week, while those assigned to cyclosporine were increased to a dosage of 5 mg per kg per day. (the-medical-dictionary.com)