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  • toxicity
  • 3. Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity have been reported with concomitant administration of methotrexate (usually in high dosage) along with some non-steroidal anti-inflammatory drugs (NSAIDs). (nih.gov)
  • NSAIDS
  • Very bad and sometimes deadly bone marrow problems and stomach or bowel problems have happened when methotrexate injection was taken with NSAIDs like ibuprofen or naproxen. (drugs.com)
  • bone
  • Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. (medhelp.org)
  • Very bad side effects like bone marrow problems, liver problems, lung problems, infections, and skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) can happen with methotrexate injection (subcutaneous). (drugs.com)
  • Stomach
  • And also, I read under methotrexate that it can cause stomach ulcers, which I think I already have before even starting this med. (medhelp.org)
  • treatment
  • A drug called leucovorin (folinic acid) can be given as a "rescue" treatment to protect a person from the toxic effects of methotrexate. (labtestsonline.org)
  • Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. (medhelp.org)
  • Methotrexate is a first-line drug in RA treatment. (labcorp.com)
  • 1 Because arthritic diseases can be steadily progressive diseases, the time to arrive at an effective treatment is important for each patient, many of whom will have different medication blood levels on the same methotrexate dosage schedule. (labcorp.com)
  • Discontinue methotrexate first and, if the lymphoma does not regress, appropriate treatment should be instituted. (nih.gov)
  • Recently, use of methotrexate in combination with anti-TNF agents has been shown to be effective for the treatment of ulcerative colitis. (wikipedia.org)
  • patients
  • In general, patients taking methotrexate should have the tests monthly. (arthritis.org)
  • 2. Methotrexate elimination is reduced in patients with impaired renal function, ascites, or pleural effusions. (nih.gov)
  • 8. Like other cytotoxic drugs, methotrexate may induce "tumor lysis syndrome" in patients with rapidly growing tumors. (nih.gov)
  • Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. (cigna.com)
  • Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities. (wikipedia.org)
  • Young acute lymphoblastic leukemia patients with methotrexate-induced leukoencephalopathy appear asymptomatic. (wikipedia.org)
  • cancer
  • Methotrexate was made in 1947 and initially came into medical use to treat cancer, as it was less toxic than the then-current treatments. (wikipedia.org)
  • Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. (medhelp.org)
  • In cancer, methotrexate works by interfering with the synthesis of DNA and RNA. (hubpages.com)
  • Not all methotrexate products are used to treat cancer. (drugs.com)
  • Methotrexate belongs to the group of medicines known as antineoplastics (cancer medicines). (mayoclinic.org)
  • citation needed] In 1951, Jane C. Wright demonstrated the use of methotrexate in solid tumors, showing remission in breast cancer. (wikipedia.org)
  • Several years later at the National Cancer Institute, Roy Hertz and Min Chiu Li then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956, discovering that methotrexate alone could cure choriocarcinoma (1958), a germ-cell malignancy that originates in trophoblastic cells of the placenta. (wikipedia.org)
  • lymphoma
  • Methotrexate is a drug that has been in use since the 1960s to treat childhood acute lymphocytic leukemia , lymphoma , and cancers of the lung , head, neck, and breast . (labtestsonline.org)
  • Pregnancy
  • Use birth control to prevent pregnancy while you are using methotrexate, whether you are a man or a woman . (cigna.com)
  • If you are a man , use a condom to keep from causing a pregnancy while you are using methotrexate. (cigna.com)
  • Methotrexate with dilatation and curettage is used to treat molar pregnancy. (wikipedia.org)
  • Methotrexate is teratogenic and hence is not advised for either the prospective father to take it before or for the mother to take it before or during pregnancy (pregnancy category X) and for a period after birth. (wikipedia.org)
  • drug
  • Methotrexate is eliminated from the body by the kidneys, so any condition that decreases kidney function or interferes with drug clearance has the potential to increase blood concentrations. (labtestsonline.org)
  • Methotrexate is a powerful drug and definately needs to be thought over thoroughly. (medhelp.org)
  • Methotrexate - does this drug make you feel sick? (drugs.com)
  • X-rays also showed that the progress of the disease slowed or stopped in many people receiving methotrexate, with the progression being completely halted in about 30% of those receiving the drug. (wikipedia.org)
  • therapy
  • 10. Potentially fatal opportunistic infections, especially Pneumocystis carinii pneumonia, may occur with methotrexate therapy. (nih.gov)