Methods stroke ischemia time. Medical search. Frequent questions

Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
This method was implemented in an important study of reperfusion injury. (ucl.ac.uk)
The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)

The mechanism of action of Sanhua Decoction (SHD) in the treatment of ischemic stroke (IS) was analyzed based on the network pharmacology technology, and the pharmacodynamics and key targets were verified using the rat middle cerebral artery occlusion (MCAO) model. (hindawi.com)
IS refers to the stenosis or occlusion of cerebral blood vessels, leading to the blockage of cerebral blood flow, which in turn causes ischemia, hypoxia, softening, and even necrosis of brain tissue, thereby resulting in cerebrovascular dysfunction and irreversible brain damage [ 6 , 7 ]. (hindawi.com)
Admission National Institutes of Health Stroke Scale (NIHSS) score, onset-to-imaging time, CTA-SI Alberta Stroke Program Early CT Score, MCA M1 occlusion, cerebrovascular collaterals score, and CTA-SI lesion volume were correlated with 3- to 6-month follow-up modified Rankin Scale (mRS). We developed 2 stepwise regression models: one for patients with complete MCA M1 recanalization and one for patients without complete recanalization. (ajnr.org)
Methods In C57Bl/6 (wildtype, WT), \(hcn2^{+/+}\) and \(hcn2^{-/-}\) mice we used an in vivo model of cerebral ischemia (transient middle cerebral artery occlusion (tMCAO)) to depict a functional impact of HCN2 in stroke formation. (uni-wuerzburg.de)
The ischemic stroke accounts for the 87% of all cases, which results from the cerebral arteries occlusion due to thrombosis, atherosclerosis and platelets plug ( 3 ). (frontiersin.org)
Thus, we are investigating the common mechanism of inflammation in the middle cerebral artery occlusion (MCAO) model, a stroke model that affects both the brain and eye. (arvojournals.org)
This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
Methods: Six rats were subjected to permanent middle cerebral occlusion to induce focal ischaemia, and a consecutive cohort of acute stroke patients (n = 38) were recruited within 9 hours from symptom onset. (ox.ac.uk)
Cerebral vascular insufficiency, typically caused by extracranial or intracranial steno-occlusive disease (any arterial occlusion or severe extracranial or intracranial stenosis in symptomatic arterial territory), is the leading cause of ischemic stroke . (medscape.com)
Since there are no reports on the effects of nimesulide on permanent ischemic stroke and because most cases of human stroke are caused by permanent occlusion of cerebral arteries, the present study was conducted to assess the neuroprotective efficacy of nimesulide on the cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion (pMCAO) in the rat. (biomedcentral.com)
Ischemia was induced by permanent occlusion of the middle cerebral artery in rats, via surgical insertion of a nylon filament into the internal carotid artery. (biomedcentral.com)
Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)
This false lumen may extend into branches of the aorta in the chest or abdomen, causing malperfusion, ischemia, or occlusion with resultant complications. (medscape.com)
Currently, CABG-related MI is defined as (1) biomarker level elevations more than 5 times the upper reference limit plus either new pathological Q waves or new left bundle branch block (LBBB), (2) angiographically documented new graft or native coronary artery occlusion, or (3) imaging evidence of new loss of viable myocardium. (medscape.com)

A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)

This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. (wikipedia.org)
Thrombosis also form in cerebral venous, which is termed as cerebral venous thrombosis(CVT), a particular type of cerebrovascular disease, characterized by intracerebral hemorrhage and infarction, associated with increased intracranial pressure due to cerebrospinal fluid absorption and cerebral venous drainage, accounting for 0.5-1% of strokes ( 4 ). (frontiersin.org)
Even mild hyponatremia is associated with increased 30-day mortality after myocardial infarction, and it has recently shown to increase the 3-year mortality after a stroke. (nih.gov)
However, tissue progression from ischemia to infarction is variable, and some patients benefit from treatment up until 24 hours. (harvard.edu)
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. (cdc.gov)
[ 1 ] Cardiovascular end-organ damage may include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary edema, and/or aortic dissection. (medscape.com)
Prior myocardial infarction at any time prior to randomization, or c. (who.int)

The plaque that builds up can lead to further complications such as stroke, as the plaque disrupts blood flow within the intracranial arterioles. (wikipedia.org)
Renal failure and respiratory failure were the most frequent complications (16.7%), while the rates of stroke and transient neurological dysfunction were 6.7% and 3.3%, respectively. (medscimonit.com)
Age >70 years, bypass time >140 min, distal ischemia time >55 min, and excessive blood or plasma transfusions were determinants of postoperative complications.Conclusions: Deep hypothermic circulatory arrest with left thoracotomy is a valid procedure with acceptable mortality rates in the management of aneurysms of distal arch and proximal descending aorta. (medscimonit.com)
This group was evaluated for the risk factors, presenting symptoms, killip class, type of acute coronary syndrome (STEMI vs NSTEMI), time to presentation to hospital, treatment received (medical management/thrombolysis/PCI/CABG), cardiac arrhythmias, mean ejection fraction, HRCT chest (CORADS grading), any complications and immediate outcome. (scialert.net)
Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)

Background In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. (unav.edu)
As the stenosis progresses, patients are unable to increase stroke volume, and as a result, they are unable to increase cardiac output so as to compensate for increases in myocardial oxygen demand. (medscape.com)

External counterpulsation for acute ischaemic stroke. (ecptherapy.com)
External counterpulsation (ECP) may improve cerebral blood flow, and it has been proposed as a potential therapy for patients with ischaemic stroke. (ecptherapy.com)
OBJECTIVES: To assess the efficacy and safety of ECP for acute ischaemic stroke. (ecptherapy.com)
Randomised controlled trials (RCTs) in which ECP (started within seven days of stroke onset) was compared with sham treatment or no treatment, or ECP plus routine treatment was compared with routine treatment alone, in patients with acute ischaemic stroke. (ecptherapy.com)
However, the use of standard MRI techniques in the investigation of the acute phases of cerebrovascular diseases such as stroke, has been hampered by impaired sensitivity to detect areas of ischaemic damage. (ucl.ac.uk)
Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. (ox.ac.uk)
Background and Objective: In hyperacute ischaemic stroke, T2 of cerebral water increases with time. (ox.ac.uk)
The median T2 difference (ΔT2) between lesion and contralateral non-ischaemic control region was determined by the newly-developed spherical reference method, and data compared to that obtained by the mirror reference method. (ox.ac.uk)
Conclusions: Data from the spherical reference method showed that the median T2 increase in the ischaemic lesion is correlated with stroke onset time in a rat as well as in a human patient cohort, opening the possibility of using the approach as a timing tool in clinics. (ox.ac.uk)
Particularly, ischaemic strokes account for 60-80 % of these strokes. (scielo.org.za)
7 In this article, we present our results on the synthesis, crystal structure and anti-ischaemic activity of new cinnamide derivative of (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1- yl}-3-(4-chlorophenyl)prop-2- en-1-one (5). (scielo.org.za)
I am particularly interested in developing novel MRI methodologies for examining brain function, investigating the role of sex and steroid hormones in ischaemic stroke/cognitive decline and increasing the translational relevance of experimental models of CNS injury and disease. (nottingham.ac.uk)
Anthraquinone glycosides extracted from rhubarb have been proven to have significant therapeutic effects on ischaemic stroke. (biomedcentral.com)

Rats were subjected to either endothelin-1-induced focal ischemia or sham surgery and subsequently designated to enriched-rehabilitation or standard-housing treatment groups starting 15 d after ischemia. (jneurosci.org)

Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. (ecptherapy.com)
An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
Ultrasound remains the ultimate method for real time functional cerebral blood flow imaging. (hindawi.com)

Recanalization status did, however, affect which variables in addition to CTA-SI volume significantly impacted clinical outcome: time with complete recanalization and NIHSS with incomplete recanalization. (ajnr.org)
Identifying predictors of clinical outcome after thrombolytic therapy for acute ischemic stroke may improve patient selection. (ajnr.org)
We sought to characterize the role of admission CTA-SI and other relevant clinical variables in determining clinical outcome among acute stroke patients who undergo attempted recanalization. (ajnr.org)
The collateral status varies among patients with acute ischemic stroke (AIS) and determines the final infarct size and clinical outcome. (ajnr.org)
Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice? (uni-wuerzburg.de)
Lampinen B, Lätt J, Wasselius J, van Westen D, Nilsson M. Time Dependence in Diffusion MRI Predicts Tissue Outcome in Ischemic Stroke Patients . (harvard.edu)
Here, it was hypothesized that time dependence in diffusion MRI may predict tissue outcome in ischemic stroke. (harvard.edu)
CONCLUSIONS: Diffusion time dependence predicted tissue outcome in ischemic stroke more accurately than the ADC, and may be useful for predicting reperfusion benefit. (harvard.edu)
Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively. (ecptherapy.com)
Hypoperfusion is related to unfavorable functional outcome, further strokes and long-term mortality. (ecptherapy.com)
Preliminary investigations suggested that ECP may improve the clinical outcome of stroke patients. (ecptherapy.com)
BACKGROUND: Neuroserpin has shown neuroprotective effects in animal models of cerebral ischemia and has been associated with functional outcome after ischemic stroke. (linc-stg.eu)
However, despite the objective of improving tissue oxygen delivery, hyperoxic ventilation can accentuate ischemia and impair that outcome. (normalbreathing.com)

Mortality from all causes, coronary heart disease, stroke, and alcohol related causes over 21 years of follow up related to units of alcohol consumed per week. (bmj.com)
A strong positive relation was seen between alcohol consumption and risk of mortality from stroke, with men drinking 35 or more units having double the risk of non-drinkers, even after adjustment. (bmj.com)
4 - 7 Risk of mortality from stroke has shown variable associations with alcohol consumption. (bmj.com)
Stroke is a major cause of disability and mortality worldwide and the second leading cause of death in the United States ( 1 , 2 ). (frontiersin.org)
This is the first study to demonstrate that hyponatremia is associated with acute mortality and poorer discharge dispositions and to confirm that higher mortality occurs in these patients, even after 12 months after a stroke. (nih.gov)
There was no significant difference in presenting NIHSS score, average time to presentation, average mRS at 90 days, or 90 day mortality between the two groups. (bmj.com)
Background:The purpose of this article is to describe our experience on distal arch and proximal descending aortic aneurysm repair, and to evaluate retrospectively the determinants of mortality and morbidity.Material/Methods: Between 1994 and 2002, 30 patients (mean age 53.4 years) underwent repair of distal arch or proximal descending aortic aneurysm approached through left thoracotomy with deep hypothermic circulatory arrest. (medscimonit.com)
In China, stroke is the second-highest cause of mortality in all diseases. (scielo.org.za)
It was the aim of the present study to characterize mortality and time-course of pathophysiological changes in the acute phase after experimental SAH using different filament sizes. (openaccessjournals.com)
Atrial fibrillation (AF) is the most common arrhythmia in the general population and is associated with an increased risk of stroke and mortality[ 1 - 2 ]. (jafib.com)

Based on the etiology, stroke can be classified into ischemic or hemorrhagic subtypes, which ranks second among the leading causes of death. (frontiersin.org)
All hemorrhagic strokes were excluded. (nih.gov)
In addition, the delicate new vessels that are formed as part of MMD are at risk for leaking into the brain and causing hemorrhagic stroke. (medscape.com)
The danger posed by an aneurysm is that blood might leak or burst out through the weak area, causing a hemorrhagic stroke. (medscape.com)
The section of the artery with the aneurysm can then be completely shut down, safely preventing hemorrhagic stroke. (medscape.com)
It may occur as the result of 1 or more of the following processes: thrombotic stroke, embolic stroke, hemorrhagic stroke , and reversible ischemic stroke . (medscape.com)

Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
Hypoxia and ischemia of the brain are key pathophysiological mechanisms of ischemic stroke ( 5 , 6 ). (frontiersin.org)
When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
The Ca 2+ -related activation of intracellular second messenger systems, the increase in reactive oxygen species formation, as well as hypoxia itself triggers the expression of a large number of pro-inflammatory genes following cerebral ischemia. (biomedcentral.com)

We retrospectively reviewed the clinical and imaging findings of consecutive acute stroke patients who presented to 2 centers with symptoms of proximal middle cerebral artery (MCA) ischemia within 6 hours of symptom onset, underwent admission unenhanced head CT and CTA evaluation, had recanalization status assessed by hospital day 2, and ultimately received follow-up brain imaging to confirm the diagnosis. (ajnr.org)
The new method may prove ideal for the prompt detection of ischemic onset, and can offer substantial insights into the neurobiology of various neurological disorders. (compamed-tradefair.com)
Their reported novel method shows precisely the onset and course of ischemic stroke, the severity of which can be investigated by a three-dimensional MR image reconstruction. (compamed-tradefair.com)
Given that the physiological changes in damaged brain tissue occur rather fast, the method may prove ideal for the prompt detection of ischemic onset, and can offer substantial insights into the neurobiology of various neurological disorders. (compamed-tradefair.com)
The average time from onset to puncture was 7.8 h. (bmj.com)
METHODS: Diffusion MRI data were acquired with multiple diffusion times in five non-reperfused patients at 2, 9, and 100 days after stroke onset. (harvard.edu)
Quantifying this change may be informative of the extent of tissue damage and onset time. (ox.ac.uk)
Our objective was to develop a user-unbiased method to measure the effect of cerebral ischaemia on T2 to study stroke onset time-dependency in human acute stroke lesions. (ox.ac.uk)
mean age, 72.4 ± 9.6 years) not treated with tPA within 12 hours (h) of symptoms onset (mean time, 4.7 ± 2.1 h). (linc-stg.eu)
The RAPID study is a multicenter, prospective, non-interventional study designed to compare the time from onset to first physician's evaluation of AHRE episode with arrhythmic burden ≥5% (72 minutes) for pacemaker recipients without atrial fibrillation history, between patients followed with RM or conventionally with annual in-hospital visits. (jafib.com)
The objective of this study is to evaluate the time from onset to first physician's evaluation of AHRE with arrhythmic burden ≥5% (72 minutes) in ordinary clinical practice for pacemaker patients without documented AF history and compare it between patients followed with RM or conventionally with annual in-hospital visits. (jafib.com)
Secondary objectives include: time to first investigator evaluation of AHRE episodes, regardless of its duration, time to anticoagulant therapy onset, time to any medical reaction related to the treatment of new onset atrial arrhythmia, time to cerebral ischemia, and time to first hospitalization due to cardiovascular issues [ Table 1 ]. (jafib.com)

However, in certain patients, a paradoxical vasoconstriction event ensues (4) such that this technique actually carries a risk of coronary ischemia. (escardio.org)
Numerous methods for evaluating the peripheral arterial system have emerged as alternatives to coronary endothelial function testing. (escardio.org)
To demonstrate the superiority of inclisiran compared to placebo in reducing the risk of 4P-MACE (composite of CV death, non-fatal MI, non-fatal ischemic stroke, and urgent coronary revascularization)Timepoint: Time to the first occurrence of 4P-MACE at every visit. (who.int)

Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. (nottingham.ac.uk)

The commonly used imaging techniques for ischemia diagnosis, such as ultrasonography or computed tomography, often lack the necessary sensitivity to detect ischemia at an early stage," comments Goran Angelovski, the principal investigator of this study. (compamed-tradefair.com)
This review summarizes the pathophysiological mechanisms, etiology, epidemiology, symptomatology, diagnosis, and treatment heterogeneity of venous thrombosis and compares it with arterial stroke. (frontiersin.org)
The aim is to provide a reference for a comprehensive understanding of venous thrombosis and a scientific understanding of various pathophysiological mechanisms and clinical features related to venous thrombosis, which will contribute to understanding the pathogenesis of intravenous stroke and provide insight into diagnosis, treatment, and prevention. (frontiersin.org)
We reviewed all patients admitted between 2004 and 2011 with the diagnosis of acute ischemic stroke. (nih.gov)
Although most abdominal aortic aneurysms are asymptomatic at the time of diagnosis, the most common complication remains life-threatening rupture with hemorrhage. (medscape.com)

Our consortium aims to investigate novel non-invasive tools to quantify microvascular health and rarefaction in both organs, as well as surrogate biomarkers for cerebral and/or cardiac rarefaction (via sublingual capillary health, vascular density of the retina, and RNA content of circulating extracellular vesicles), and to determine whether microvascular density relates to disease severity.Methods/design: The clinical research program of CRUCIAL consists of four observational cohort studies. (unav.edu)
Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)

Local intra-arterial thrombolysis is the preferred treatment option for acute lower limb ischaemia (ALLI) in many vascular centres. (springer.com)
arterial transit time). (unav.edu)
Stroke is caused not only by arterial thrombosis but also by cerebral venous thrombosis. (frontiersin.org)
Arterial stroke is currently the main subtype of stroke, and research on this type has gradually improved. (frontiersin.org)
The molecular pathological hallmarks of arterial stroke and cerebral venous thrombosis. (frontiersin.org)
Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? (mcmaster.ca)
We demonstrate this increased risk of blood clots by comparing rates of venous and arterial clotting events in 4400 hospitalized COVID-19 patients in a large multisite clinical network in the United States examined from April through June of 2020, to patients hospitalized for non-COVID illness and influenza during the same time period and in 2019. (plos.org)

Background Brain ischemia is known to include neuronal cell death and persisting neurological deficits. (uni-wuerzburg.de)
In neurons, TASK channels carrying hyperpolarizing \(K^+\) leak currents, and the pacemaker channel HCN2, carrying depolarizing Background Brain ischemia is known to include neuronal cell death and persisting neurological deficits. (uni-wuerzburg.de)

The second goal was to devise a non-invasive method to demonstrate that G-CSF was delivered to the brain and expressed at therapeutic levels. (neurosciencenews.com)
We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke. (ecptherapy.com)
However, well-designed clinical studies exploring the therapeutic effects of ECP in ischemic stroke are very limited. (ecptherapy.com)
Hypothermia attenuated both the optical increase in intensity after MMPSense750 and the increase in MMP-9 protein expression supporting the proof of concept that NIRF imaging using MMPSense can be used to assess potential therapeutic strategies for stroke treatment. (biomedcentral.com)
In later experiments we investigated the therapeutic time window of protection of nimesulide by delaying its first administration 0.5-4 h after the ischemic insult. (biomedcentral.com)
These findings have important implications for the therapeutic potential of using COX-2 inhibitors in the treatment of stroke. (biomedcentral.com)
Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)

Chronic impairment of forelimb and digit movement is a common problem after stroke that is resistant to therapy. (jneurosci.org)
In this work, we investigated both acute and chronic clinical outcomes after a stroke in hyponatremic patients. (nih.gov)
21% O2) is widely used in medical practice for resuscitation, stroke intervention, and chronic supplementation. (normalbreathing.com)
Notably, chronic and severe headaches account for affected by age, sex, race, geography and socioeconomic a significant share of headache-related productive time status, and varies according to the population being evaluated ( 6,7 ). (who.int)
Over time, chronic pressure overload and compensatory LV hypertrophy result in reduced compliance of the LV, with the subsequent development of diastolic dysfunction and increased LV end-diastolic pressure (LVEDP). (medscape.com)

citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. (hindawi.com)
In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions. (hindawi.com)

Conclusions Here, we hypothesized that the absence of HCN2, an important functional counter player of TASK channels, affects neuronal survival during stroke-induced tissue damage. (uni-wuerzburg.de)
Conclusions ADAPT is an effective method to achieve good clinical and angiographic outcomes, and serves as a useful firstline method for revascularization. (bmj.com)

The dramatic reduction in brain atrophy in mice, if verified in humans, could lead to highly effective emergency treatments for stroke and other diseases that often cause brain damage such as heart attack. (neurosciencenews.com)
Delivering the G-CSF gene at multiple time points after the induced blockage led to significant reduction in deaths, cerebral atrophy, and neurological deficits as measured by behavioral testing of the treated mice. (neurosciencenews.com)
For control mice, which did not receive G-CSF in eye drops, the MRI technique identified brain areas with reduced metabolic activity and eventual cerebral atrophy as the result of ischemia. (neurosciencenews.com)
On average, following ischemia, mouse brain striatum size was reduced more than 3-fold, from 15 square millimeters in normal mice to less than 5 square millimeters. (neurosciencenews.com)
The results showed that compound 5 significantly prolonged the survival time of mice subjected to acute cerebral ischaemia at all doses tested and exhibited potent neuroprotective activity. (scielo.org.za)
An alternative surgical approach reduces variability following filament induction of experimental stroke in mice Disease Models & Mechanisms. (nottingham.ac.uk)
[ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)

and global ischemia, which encompasses wide areas of brain tissue. (wikipedia.org)
The researchers reported observations from high-resolution imaging of the changing amount of calcium in the brain tissue during stroke. (compamed-tradefair.com)
Cerebral ischemia is characterized in conditions of a reduced blood supply to the brain tissue, causing a deprivation of oxygen and glucose delivery and a production failure of adenosine triphosphate (ATP), a key energy carrier. (compamed-tradefair.com)
Cerebral revascularization is surgery that restores blood flow to the brain, decreasing the chance of stroke or other damage to brain tissue. (medscape.com)
Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)

It is a sub-type of stroke along with subarachnoid hemorrhage and intracerebral hemorrhage. (wikipedia.org)

An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Over time, inflammation, atherosclerosis and calcification thicken the aortic valve leaflets and restrict mobility. (medscape.com)

Computed tomography (CT) In the context of imaging cerebral atherosclerosis, multidirectional computed tomography (MDCT) is often superior to regular CT scans, because it can provide a higher spatial resolution and it has a shorter acquisition time. (wikipedia.org)
In this paper, we consider a modified 3D UNet architecture to improve the quality of stroke segmentation based on 3D computed tomography images. (it.pt)
Our architecture may simply be extended to ischemia segmentation and computed tomography image identification by selecting relevant hyperparameters. (it.pt)
Of brain computed tomography scans of 17 patients, 3 showed cerebral and/or cerebellar atrophy and 2 confirmed strokes. (cdc.gov)
Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)

Of 44 patients undergoing CT/CTA within 6 hours of developing symptoms of proximal MCA ischemia, 19 patients achieved complete proximal MCA (MCA M1) recanalization. (ajnr.org)
Because CT is faster, less expensive, and more universally available than MR imaging, evidence supporting the accurate characterization of stroke physiology with advanced CT imaging could widely impact the management of patients with ischemic stroke. (ajnr.org)
All of the patients were referred for imaging by a stroke neurologist who determined an initial National Institutes of Health Stroke Scale (NIHSS) score. (ajnr.org)
At presentation, patients with DM had a lower degree of ischemia judged by the Rutherford classification, compared to those without DM (p = 0.023). (springer.com)
Assessment of the collateral status has been emphasized for appropriate treatment decisions in patients with acute ischemic stroke. (ajnr.org)
From a prospectively maintained registry of acute ischemic stroke, MR imaging data of patients with acute ischemic stroke caused by steno-occlusive lesions of the unilateral ICA and/or the M1 segment of the MCA were analyzed. (ajnr.org)
70% of patients have ischemic stroke and the recurrence rate is as high as 17.7% ( 1 , 2 ). (spandidos-publications.com)
A total of 3585 patients with stroke were identified. (nih.gov)
Hyponatremic patients had higher National Institutes of Health Stroke Scale (NIHSS) score on admission (P = .032) and at discharge (P = .02). (nih.gov)
However, when tested in a human trial in more than 400 stroke patients, G-CSF did not improve treatment outcomes, so enthusiasm about it diminished. (neurosciencenews.com)
Palliative care experts use narrative medicine often on a daily basis - giving patients and family members time to explore their illness through storytelling, and eliciting their goals and values in the process. (pallimed.org)
Methods Retrospective analysis of a database was gathered on patients undergoing stroke thrombectomy with ADAPT at a stroke center. (bmj.com)
1 Recently, multiple randomized clinical trials were completed demonstrating improved outcomes in patients with ischemic stroke who undergo endovascular thrombectomy compared with intravenous thrombolysis alone. (bmj.com)
Conclusion - ECP is feasible for ischemic stroke patients with larger artery disease. (ecptherapy.com)
Currently, there is a growing body of evidence to suggest that external counterpulsation (ECP) may enhance the blood supply to the brain and thus may be beneficial to patients with ischemic stroke. (ecptherapy.com)
In patients, ΔT2 linearly increases by 1.6 ± 1.4 and 1.9 ± 0.9 ms/h in the lesion, as determined by the mirror reference and spherical reference method, respectively. (ox.ac.uk)
They concluded that cerebral revascularization may be done safely at high-volume cerebrovascular centers for high-risk patients for whom optimal medical therapy has failed, and that further research must be done to develop an improved method of risk stratification for patients with symptomatic atherosclerotic cerebrovascular steno-occlusive disease to determine which patients may benefit from intervention. (medscape.com)
Given the high risk of recurrent stroke in some patients and the fact that for some patients, medical therapy fails, surgical revascularization may offer the best method of ensuring good long-term outcomes with manageable up-front risks. (medscape.com)
The efficacy of CEA is well validated with a significant stroke risk reduction in patients with symptomatic internal carotid artery (ICA) stenosis [2,3]. (irispublishers.com)
We reviewed retrospectively over 12 years' time, six consecutive patients with symptomatic carotid disease who underwent PTP during CEA in the presence of a significantly tortuous ICA. (irispublishers.com)
Fever was present at the time of presentation in only 8 (32%) patients. (scialert.net)
A hospital in New York City reported a rate of 1.7% of imaging-confirmed VTE among 921 COVID-19 patients admitted during the city's first wave of the pandemic, as well as 11 patients with ischemic stroke and 2 with limb ischemia [ 17 ]. (plos.org)
METHODS: We used electronic health records for asthma patients aged 2-17 years from a regional, urban, children's hospital in Ohio during 2011-2015. (cdc.gov)
Cranial imaging of 3 encephalitic patients documented changes consistent with cerebral atrophy ( 3 ), meningoencephalitis ( 4 ), and areas of diffusion restriction suggesting ischemia ( 4 , 5 ). (cdc.gov)

RESULTS: Positive values of k were observed within stroke lesions on day 2 (P = .001) and on day 9 (P = .023), indicating diffusional exchange. (harvard.edu)
Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions. (cdc.gov)

Experimental & Translational Stroke Medicine 2013, 5:16. (uni-wuerzburg.de)
The combination of simple delivery and non-invasive monitoring has the potential to contribute to improved studies of experimental gene therapy in animal models of stroke, Alzheimer's dementia, Parkinson's disorder, and ALS. (neurosciencenews.com)
This thesis describes the implementation of these two techniques in experimental studies of cerebral ischaemia. (ucl.ac.uk)
The combination of these two MRI techniques has provided unique insights into experimental cerebral ischaemia. (ucl.ac.uk)

Add RAGs, detect the RAGs and the corresponding anthraquinone aglycones by HPLC-UV at different time points. (biomedcentral.com)

We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)

We use the ISLES 2018 (Ischemic Stroke Lesion Segmentation Challenge 2018) open dataset to train and test the proposed model. (it.pt)
During my time at Leicester I was Head of the School for Psychology (2013-2017) and deputy Head of the College of Life Sciences before moving to the University of Nottingham in 2018. (nottingham.ac.uk)

The retina represents an additional avenue that can be explored when using the MCAO model to investigate stroke and its potential treatments. (arvojournals.org)

In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least partially recovered. (wikipedia.org)
However, it is now generally accepted that the mammalian brain may be more resistant to ischemia than previously thought. (biomedcentral.com)

What began as a possible fiasco ended, in those brief hours of demonstration time, in every little thing Cajal had hoped for: the chance to current the evidence to the main authorities-he mentions His, Schwalbe, Retzius, Waldeyer, van Gehuchten, 'and particularly K�lliker' (Cajal, 1989)-and acquire their acceptance of his outcomes. (dnahelix.com)
Introduction The direct aspiration first pass technique (ADAPT) has been introduced as a simple and fast method for achieving good angiographic and clinical outcomes using large bore aspiration catheters for the treatment of acute ischemic stroke (AIS). (bmj.com)
It is widely accepted that faster recanalization of occluded vessels and reperfusion of ischemic territories has been associated with improved outcomes following acute stroke. (bmj.com)
8 , 9 The direct aspiration first pass technique (ADAPT) was recently introduced as an efficient and cost effective thrombectomy method for achieving excellent angiographic and clinical outcomes using large bore aspiration catheters. (bmj.com)

In acute middle cerebral artery (MCA) stroke, CT angiographic (CTA) source images (CTA-SI) identify tissue likely to infarct despite early recanalization. (ajnr.org)
However, the fact that retina and brain increases are not correlated may indicate a difference in the timing of the response or the responsiveness of the tissue. (arvojournals.org)

These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)

Thus, this study provides a feasible method to study the pharmacological mechanism of traditional Chinese medicine compound prescriptions and a theoretical basis for the development of SHD into a new drug for IS treatment. (hindawi.com)
For those with severe stenosis that are at risk for impending stroke endovascular treatment is used. (wikipedia.org)
In past studies in a number of animal models of brain disorders including stroke, Alzheimer's, and Parkinson's, G-CSF held promise as a potential treatment. (neurosciencenews.com)
MRI was also used to monitor the effectiveness of the treatment in experimentally induced brain ischemia. (neurosciencenews.com)
This is particularly important for stroke and cardiac arrest, where treatment within a few hours is critical. (neurosciencenews.com)
PURPOSE: Reperfusion therapy enables effective treatment of ischemic stroke presenting within 4-6 hours. (harvard.edu)
Despite the rapid progress in stroke prevention, effective acute stroke treatment except for thrombolysis is still lacking. (ecptherapy.com)
The impact of gender on stroke pathology and treatment. (nottingham.ac.uk)
Nimesulide (12 mg/kg) not only reduced infarct volume but also enhanced functional recovery when the first treatment was given up to 2 h after stroke. (biomedcentral.com)
These data show that nimesulide protects against permanent focal cerebral ischemia, even with a 2 h post-treatment delay. (biomedcentral.com)

Strong evidences showed that combined CEA and best medical therapy are superior when compared with medical therapy alone in the prevention of stroke recurrence [2-4]. (irispublishers.com)

Ischemic stroke (IS) is a common type of cerebrovascular disease with high morbidity and disability [ 4 ]. (hindawi.com)

Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
Prescriptions are commonly used to improve blood stasis in order to treat stroke, and these prescriptions include Xiexin Decoction (recorded in the Synopsis of the Golden Chamber ), Didang Decoction (recorded in the Treatise on Febrile Diseases ) and Dahuang Zhechong pill (recorded in the Synopsis of the Golden Chamber ), all of which use rhubarb as the main ingredient. (biomedcentral.com)

Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
This causes the downstream sections of the brain that would normally be supplied by the blocked artery to suffer from ischemia. (wikipedia.org)
Symptomatic peripheral artery disease (PAD) as evidenced by either intermittent claudication, previous revascularization, or amputation due to atherosclerotic disease at any time prior to randomization. (who.int)

Anatomy28

Organisms9

Diseases65

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment90

Phenomena and Processes31

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Named Groups2

Health Care41

Geographicals1

Reperfusion injury9

Occlusion14

Model of cerebral ischemia1

Infarction7

Complications5

Myocardial2

Ischaemic13

Focal ischemia1

Cerebral bloo3

Outcome13

Mortality10

Hemorrhagic6

Hypoxia4

Onset12

Coronary3

Rats1

Diagnosis5

Cohort2

Arterial7

Persisting neurological2

Therapeutic7

Chronic5

Pathological3

Conclusions2

Mice7

Brain tissue5

Subarachnoid1

Inflammation4

Computed tomography5

Patients24

Lesions2

Experimental4

Detect1

Humans1

20182

MCAO1

Mammalian2

Outcomes4

Tissue2

Blood-brain b1

Treatment10

Recurrence1

Cerebrovascular1

Diseases2

Artery4