MacularRetinal and choroidalOcularDevelopment of choroidal neovascularizationExperimental choroidal neovascularizationEndothelialPhotocoagulationRetrospectiveAngiographyDetection of choroidalSubfoveal choroidal thicknessAnti-VEGF agentsVEGFAtrophyVisual acuityPhotodynamic therapyVitroAntibodiesVisualizationAngiogenesisSecondaryCentral serous chorioretiSubretinalPatientsFindingsIntravitrealOccultNAMDLesionsPosteriorEtiologyIntraocularDiffuseGrowthTreatmentDisruptionHemorrhageTransscleralSensitivitySpectral-domainEyesOutcomes
Macular16
- Patients with angioid streaks are generally asymptomatic, unless the lesions extend towards the fovea or develop complications, such as macular choroidal neovascularization (CNV) [ 2 , 4 ]. (hindawi.com)
- Hence, this study is aimed at exploring the potential role of SIRT1 in choroidal neovascularization- (CNV-) induced age-related macular degeneration (AMD) development and the associated mechanism. (hindawi.com)
- Choroidal neovascularization (CNV), as the pathological process of the invasion of abnormal blood vessels into the subretinal space of the mammalian eye, is known as a feature of the age-related macular degeneration (AMD) [ 1 ]. (hindawi.com)
- To develop an optical coherence tomography (OCT) classification system that monitors the response of eyes treated with photodynamic therapy (PDT) with verteporfin for subfoveal choroidal neovascularization (CNV) from age-related macular degeneration (AMD). (qxmd.com)
- Quantitative optical coherence tomography angiography of type 3 neovascularization in age-related macular degeneration revealed significant regression of the microvascular morphology after a single anti-VEGF injection. (bmj.com)
- This prospective cross-sectional study reports the repeatability of swept-source optical coherence tomography derived retinal and choroidal thickness measurements in eyes with neovascular age related macular degeneration. (bmj.com)
- In this study, we investigated the role of hypoxia induced SIRT1 in choroidal neovascularization in relation to age-related macular degeneration. (molvis.org)
- PURPOSE: To determine whether different coagulation-balance genetic polymorphisms explain the variable clinical outcomes of photodynamic therapy with verteporfin (PDT-V) in Caucasian patients with occult subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). (unife.it)
- METHODS: In a multicentre, 2×2 factorial, non-inferiority randomised trial, we enrolled adults aged at least 50 years with active, previously untreated neovascular age-related macular degeneration and a best corrected distance visual acuity (BCVA) of at least 25 letters from 23 hospitals in the UK. (ox.ac.uk)
- Methods: Treatment-naïve eyes diagnosed with occult or minimally or predominantly classic CNV that commenced anti-VEGF treatment between January 2007 and December 2012 were identified from a registry of neovascular age-related macular degeneration (nAMD) treatment outcomes. (edu.au)
- Choroidal neovascularization (CNV) accounts for 90% of cases of severe vision loss in patients with advanced age-related macular degeneration. (elsevierpure.com)
- Methods RAINBOW ( Real life use of intravitreal Aflibercept In FraNce - oBservatiOnal study in Wet age-related macular degeneration) is an ongoing, observational, retrospective and prospective 4-year study to assess visual (primary), anatomical and safety outcomes following IVT-AFL treatment in wet AMD patients. (bmj.com)
- Purpose: To report three cases of choroidal neovascularization (CNV) that occurred following surgical disruption of Bruch membrane during macular surgery. (archive.org)
- PHP has the ability to identify visual changes earlier - when the lesions are smaller and according to the study, Functional and Morphologic Benefits in Early Detection of Neovascular Age Related Macular Degeneration Using the Preferential Hyperacuity Perimeter (RETINA 2011;Epub:1-7), "PHP has been shown to detect choroidal neovascularization with a sensitivity twice as high as the Amsler Grid. (enhancedvision.com)
- On December 12, Australia's Therapeutic Goods Administration approved anecortave acetate 15-mg suspension ( Retaane , made by Alcon, Inc) for the treatment of subfoveal choroidal neovascularization (CNV) due to exudative (wet) age-related macular degeneration (AMD) where there is a classic component. (medscape.com)
- Miller SA, Bresnick GH, Chandra SR. Choroidal neovascular membrane in Best's vitelliform macular dystrophy. (medscape.com)
Retinal and choroidal3
- They demonstrated their critical involvement in a rat model of retinal and choroidal neovascularization experimentally induced using ocular laser impacts. (molvis.org)
- We tested whether an antibody-drug conjugate (ADC) - an engineered monoclonal antibody linked to a cytotoxic agent - could selectively ablate pericytes and suppress retinal and choroidal neovascularization.Methods: Immunoblotting, flow cytometry, cell viability test, and confocal microscopy were conducted to assess the internalization and cytotoxic effect of ADC targeting mPDGFRbeta in an in vitro setting. (stanford.edu)
- OCTA is a recent advance in OCT technology that allows accurate visualization of retinal and choroidal vascular flow. (marcorispoli.it)
Ocular9
- Choroidal and retinal neovascularization plays an essential role in various ocular diseases. (molvis.org)
- The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. (justia.com)
- METHODS: Healthy adult volunteers were examined for ocular fatigue before and after watching videos for. (koreamed.org)
- Specific ablation of PDGFRbeta-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models. (stanford.edu)
- Background: Crosstalk between pericytes and endothelial cells is critical for ocular neovascularization. (stanford.edu)
- Immunofluorescence staining of whole-mount retinas and retinal pigment epithelium-choroid-scleral complexes, electroretinography, and OptoMotry test were used to evaluate the effect and safety of ADC targeting mPDGFRbeta in the mouse models of pathologic ocular neovascularization.Results: ADC targeting mPDGFRbeta is effectively internalized into mouse brain vascular pericytes and showed significant cytotoxicity compared with the control ADC. (stanford.edu)
- To evaluate the efficacy of ranibizumab in the treatment of choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome. (qxmd.com)
- Ranibizumab appears to be a safe and effective treatment option for choroidal neovascularization secondary to the presumed ocular histoplasmosis syndrome. (qxmd.com)
- Colored microsphere technique was used for in vivo experiments to determine the choroidal blood flow in ocular hypertensive (40 mmHg) rabbit eyes. (openophthalmologyjournal.com)
Development of choroidal neovascularization2
- Optical coherence tomography angiography can identify choroidal neovascularization in posterior uveitis associated with development of choroidal neovascularization. (bmj.com)
- The most common home test for the development of choroidal neovascularization is the use of the Amsler Grid. (enhancedvision.com)
Experimental choroidal neovascularization1
- The purpose of this study was to evaluate the effect of TNP-470-PVA conjugate on the proliferation of endothelial cells in vitro and on experimental choroidal neovascularization (CNV) in vivo. (arvojournals.org)
Endothelial4
- This study aimed to evaluate the long-term effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) injections in the treatment of choroidal neovascularization (CNV) associated with angioid streaks. (hindawi.com)
- Choroidal endothelial cells (RF/6A) were maintained in a semiconfluent state and hypoxia was induced by exposing the cells to cobalt chloride for 24 h. (molvis.org)
- However, its role has not been evaluated in hypoxic choroidal endothelial cells (CECs), the precursor of VEGF-mediated choroidal angiogenesis. (molvis.org)
- Purpose: To compare 5-year real-world outcomes of eyes with classic and occult choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (anti-VEGF) injections. (edu.au)
Photocoagulation1
- Choroidal neovascularization was induced in C57BL/6J mice using laser photocoagulation. (elsevierpure.com)
Retrospective5
- METHODS: This retrospective, observational case series included 57 eyes (29 patients). (koreamed.org)
- METHODS: A retrospective analysis was performed using the medical. (koreamed.org)
- The results of long-term extension trials following landmark randomized clinical studies and other long-term retrospective studies will also be compared to studies using a fixed interval dosing or the TAE/TES method. (intechopen.com)
- Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. (elsevierpure.com)
- Methods: A retrospective case series was compiled. (archive.org)
Angiography8
- As observed on angiography, the numbers of choroidal and retinal blood vessels were significantly increased (principally on the seventh day) after the laser impacts. (molvis.org)
- D Dioptres, AL Axial length, FA Fluorescein angiography, OCTA Optical coherence tomography angiography, SD-OCT Spectral domain optical coherence tomography, mCNV Myopic choroidal neovascularisation. (medscape.org)
- The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). (unifesp.br)
- To report a patient presenting a retinal pigment epithelial tear in which optical coherence tomography angiography enabled the visualization of subfoveal choroidal neovascularization (CNV) not evidenced by the fluorescein angiography . (bvsalud.org)
- OCT-Angiography was observed to have high sensitivity and specificity for the detection of choroidal neovasculariasation in myopic eyes. (bmj.com)
- Purpose To evaluate the morphological structure of illdefined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). (elsevierpure.com)
- Fluorescein angiography remains a vital tool for assessing the activity of neovascular lesions, while indocyanine green angiography is the preferred option for choroidal vessel imaging in neovascular AMD. (marcorispoli.it)
- Choroidal neovascularization (CNV) was induced in brown Norway (BN) rats using a 532 nm diode argon laser and the CNV induction was assessed using fluorescein angiography. (mechentel.de)
Detection of choroidal1
- Early detection of choroidal neovascularization (wet AMD) means early treatment which translates into less vision loss. (enhancedvision.com)
Subfoveal choroidal thickness2
- Thick-choroid CSC was defined as mean subfoveal choroidal thickness more than 300.0 μ m. (plos.org)
- Eyes with CNV exhibited a larger myopic refractive error, inflammatory lesions confined within the posterior pole, and a decreased final subfoveal choroidal thickness compared with eyes without CNV. (elsevierpure.com)
Anti-VEGF agents1
- Purpose: To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. (birmingham.ac.uk)
VEGF2
- Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. (ox.ac.uk)
- The Inhibition of VEGF in Age-related choroidal Neovascularisation (IVAN) trial was designed to compare these drugs and different regimens. (ox.ac.uk)
Atrophy2
- Late AMD was defined as geographic atrophy or choroidal neovascularization. (arvojournals.org)
- It is the final stages of geographic RPE atrophy with possible development of choroidal neovascular membrane that is associated with further deterioration in acuity. (medscape.com)
Visual acuity1
- The main outcome measures included best-corrected visual acuity (BCVA), presence of choroidal neovascularization (CNV), and optical coherence tomography findings. (elsevierpure.com)
Photodynamic therapy3
- Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization. (qxmd.com)
- Photodynamic therapy (PDT) with verteporfin has been previously shown to be beneficial and safe as one of the standard therapies for subfoveal choroidal neovascularization (CNV). (dovepress.com)
- PURPOSE: The aim of this study is to discuss the effect and outcome of a combined photodynamic therapy and intravitreal injection of bevacizumab (1.25 mg) in occult and classic choroidal neovascularisation (CNV) due to AMD. (tum.de)
Vitro1
- In this study, we investigated the role of SIRT1 in choroidal angiogenesis in vitro and analyzed the mechanism by which SIRT1 may regulate the initiation of neovascularization. (molvis.org)
Antibodies2
- As such, lipid binding may not be uniquely required for MPER-targeting broadly neutralizing antibodies, as alternative methods to increase local concentration can achieve similar improvements in potency. (stanford.edu)
- The laser CNV model and a choroidal sprouting assay were used to test the effect of PS-targeting antibodies on choroidal angiogenesis. (elsevierpure.com)
Visualization1
- ICG has a peak absorption and fluorescence in the near infrared range, which allows visualization of choroidal pathology through overlying serosanguineous fluid, pigment, or a thin layer of hemorrhage that usually blocks visualization during FA. (medscape.com)
Angiogenesis1
- Results were confirmed using the choroid sprouting assay, an ex vivo model of choroidal angiogenesis. (elsevierpure.com)
Secondary1
- Choroidal neovascularisation secondary to Best's disease in a 13-year-old boy treated by intravitreal bevacizumab. (medscape.com)
Central serous chorioreti1
- In a study of 29 patients presenting with acute or chronic central serous chorioretinopathy, differential choroidal vessel dilation patterns were observed between acute and chronic disease. (bmj.com)
Subretinal2
- Indeed, when appropriate parameters are used for laser ray administration, the laser impacts break Bruch's membrane and induce subretinal neovascularization. (molvis.org)
- [ 1 ] Choroidal neovascularization (CNV) involves the growth of new blood vessels that originate from the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium (sub-RPE) or subretinal space. (medscape.com)
Patients12
- Excluded patients with other retinal or choroidal diseases, or dense cataracts. (medscape.org)
- This technique can provide a less invasive method of diagnosis and can help guide treatment of these patients. (bmj.com)
- METHODS: The medical records of patients who underwent vitrectomy to. (koreamed.org)
- METHODS: Medical records of 22 patients who were diagnosed with CL-LSCD between 2014 and. (koreamed.org)
- METHODS: In a pilot study involving 23 patients, intravitreal injections of bevacizumab were administered within 12 to 24 hours after standard PDT to reduce the post-PDT increase of proangiogenic and inflammatory factors. (tum.de)
- OCT findings in patients with occult and classic choroidal neovascularisation 1, 3 and 6 months after combination therapy showed a reduced retinal thickness compared to baseline. (tum.de)
- METHODS: In a pilot study involving 23 patients, intravitreal injections of. (tum.de)
- Methods: Fellow eyes of 516 patients enrolled in clinical trials of laser treatment of CNV were followed for 5 years. (johnshopkins.edu)
- METHODS: The clinical records of consecutive patients with AMD-related occult CNV, treated with PDT-V for evidence of disease progression, were retrospectively examined. (unife.it)
- About 15% of AMD patients switch to the wet form, characterized by choroidal neovascularization. (frontiersin.org)
- Purpose: To describe the clinical features and outcomes of punctate inner choroidopathy (PIC) in Korean patients Methods: We retrospectively reviewed the medical records of patients with PIC between 2004 and 2015. (elsevierpure.com)
- To describe the design and methods of the Multicenter Uveitis Steroid Treatment (MUST) trial and the baseline characteristics of enrolled patients. (entokey.com)
Findings1
- To investigate fundus autofluorescence (FAF) findings in eyes with myopic choroidal neovascularisation (CNV). (bmj.com)
Intravitreal2
- To evaluate the 12-month efficacy and safety of intravitreal conbercept for myopic choroidal neovascularization (CNV). (biomedcentral.com)
- AIMS: To evaluate whether ketorolac eyedrops and ranibizumab intravitreal injections would provide additional benefit over ranibizumab alone in the treatment of choroidal neovascularisation (CNV). (unibs.it)
Occult1
- Five-year real-world outcomes of occult and classic choroidal neovascularization: data from the Fight Retinal Blindness! (edu.au)
NAMD1
- Growth of choroidal neovascularization (CNV) in nAMD is the main cause of vision loss [ 5 , 6 ]. (ekjo.org)
Lesions1
- Choroidal neovascularization lesions costained for exposed PS and for intercellular adhesion molecule 2 (or isolectin B4) were imaged in flat mounts and in cross sections. (elsevierpure.com)
Posterior1
- Use of systemic corticosteroids-with immunosuppressive drugs when indicated-historically has been the primary method advocated for control of severe cases of intermediate uveitis, posterior uveitis, and panuveitis. (entokey.com)
Etiology1
- Although the precise underlying mechanisms of AMD are not fully understood, numerous lines of evidence have indicated that endoplasmic reticulum (ER) stress contributes to the etiology of RPE cell damage and neovascularization formation ( 5 - 7 ). (spandidos-publications.com)
Intraocular2
- We used Brown Norway rats, in which choroidal and retinal neovascularization was induced using intraocular laser impacts. (molvis.org)
- Choroidal melanoma is the most common primary malignant intraocular tumor and the second most common type of primary malignant melanoma in the body. (medscape.com)
Diffuse1
- Poorly-defined CNV is seen as a diffuse area of choroidal hyperreflectivity that blends into the normal contour of the normal RPE band. (medscape.com)
Growth1
- It upregulates angiogenic growth factors and promotes neovascularization. (molvis.org)
Treatment1
- More than 90% of eyes with successful use of Reynard and Hanscom's central retinal artery occlusion (CRAO) method [ 4 ], with some modifications, for have a sudden, painless decrease in visual the treatment of retinal artery occlusion. (who.int)
Disruption1
- During AMD progression, the RPE is damaged, accompanied by a disruption of the choroidal blood-eye barrier and degeneration of photoreceptors. (spandidos-publications.com)
Hemorrhage1
- Wet AMD is characterized by choroidal neovascularization (CNV) and the subsequent development of hemorrhage, exudation, scarring or retinal detachment. (spandidos-publications.com)
Transscleral2
- One objective of this study was to determine whether polymeric nanoparticles and/or microparticles sustain transscleral choroidal and retinal delivery of triamcinolone acetonide (TA ) for two months in therapeutically effective concentrations after single periocular administration. (mechentel.de)
- Study: Influence of choroidal neovascularization and biodegradable polymeric particle size on transscleral sustained delivery of triamcinolone acetonide. (mechentel.de)
Sensitivity1
- Some studies report 30% and 34% sensitivity for early detection of wet AMD using this method. (enhancedvision.com)
Spectral-domain1
- METHODS: Optic disc images were obtained from spectral-domain. (koreamed.org)
Eyes1
- METHODS: This was a pilot study of eyes with new-onset CNV. (unibs.it)
Outcomes1
- Research with all three is continuing to build on lessons learned from the first gene therapy trial in 1990, 2 with the goal of improving delivery methods and outcomes. (aao.org)