Methods animal testing alternatives. Medical search. Frequent questions

Therefore, the aim of the study, published in the ACS' journal Chemical Research in Toxicology , was to develop an in vitro predictive test based on the analysis and integration of gene expression and intracellular signaling profiles of chemical-exposed skin-derived dendritic cells. (cosmeticsdesign.com)
There are more than 40 in vitro methods approved by international regulatory bodies. (pcrm.org)
Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation. (wikipedia.org)
The testing of cosmetic products directly onto an animal can be minimized or eliminated by the use of in vitro cell growth and development. (wikipedia.org)
In August 2010, the Organisation for Economic Co-operation and Development (OECD) published the Test Guideline 439 which describes the new procedure for in vitro hazard identification of irritant chemicals. (wikipedia.org)
Movia D, Prina-Mello A., Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models? (tcd.ie)
Movia D, Bruni-Favier S, Prina-Mello A., In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective. (tcd.ie)
UK-based Evocutis has been accepted as a member of the In Vitro Testing Industrial Platform (IVTIP) which will allow it to further its work: laboratory and clinical evaluations of skin care products. (cosmeticsdesign-europe.com)
BILTHOVEN, Netherlands, Sept. 19, 2023 (GLOBE NEWSWIRE) -- Intravacc, a Leading Contract Development and manufacturing Organisation for translational research and development of preventive and therapeutic vaccines together with MAT services at Sanquin Diagnostic Services, today announced the publication of a scientific article of an in vitro alternative assay to the replace rabbit pyrogen test for vaccines. (kfor.com)
The MAT is an in vitro assay that can replace the rabbit pyrogen test. (kfor.com)
An in vitro test for detecting eye irritants, the BCOP test method uses tissues obtained from slaughterhouses to replace the use of live animals. (aavs.org)
An in vitro test to determine skin corrosion, Corrositex® uses a biomembrane and chemical detection system that changes color when in contact with corrosive substances. (aavs.org)
Today, European and national regulatory authorities assess the safety of chemicals on the basis of a variety of information, including scientific literature as well as tests performed in vivo (on living organisms such as rodents, fish, amphibians), in vitro on isolated cells or tissues, and increasingly in silico (using computer models). (env-health.org)
As of today, using non-animal approaches such as in vitro tests on cells might be informative regarding certain elements of this definition, for instance to elucidate the endocrine mode of action of a chemical. (env-health.org)
However, in vitro tests alone do not allow us to assess complex adverse effects that chemicals may have on an organism, for example, effects on the brain or the metabolism across generations. (env-health.org)
That is why non-animal approaches such as in vitro tests cannot be used on their own to meet regulatory definitions of certain endpoints. (env-health.org)
Important progress is currently being made in the development of in vitro and in silico tests, but they will not be fit to address the complexity of the assessment of adverse effects on organisms before a long time. (env-health.org)
Alternative methods include laboratory tests that are performed in vitro. (essence.eu)
The group discussed needs for characterization of nanomaterial s and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. (cdc.gov)
In the interest of reducing animal use, in vitro alternatives for by Langerhans cells (LC) and the induction of specific T skin sensitization testing are under development. (cdc.gov)

A total of 12,800 animals died due to Splenda experimentation. (thepetitionsite.com)
That animal experimentation costs about $20 billion of taxpayer money annually. (caringconsumer.com)
According to those numbers from the Cruelty Free International report about animal experimentation, the top ten countries amount to using 69.7 million animals for animal experiments every year. (caringconsumer.com)
All that animal experimentation could be going to waste, however. (caringconsumer.com)
Every year in the United States, millions of animals including monkey's, rats, mice, rabbits, cats, and dogs suffer experimentation to test the biocompatibility of products before they are. (nova.edu)
Additionally, it has been debated that the results of animal experimentation are unreliable across a wide range of areas. (bartleby.com)
Therefore, the potential benefits of animal experimentation are greatly outweighed by the risks and collective harm of humans and animals which is why resources should be directed towards more human-based testing procedures. (bartleby.com)

16 National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. (nih.gov)
17 National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. (nih.gov)
In order to support non-animal testing, People for the Ethical Treatment of Animals (PETA) India, in 2022, announced a grant of 7 lakh rupees in order to advance animal-free methods for toxicology testing. (thebusinessresearchcompany.com)
In February 2008, three federal agencies, the National Human Genome Research Institute, the National Toxicology Program, and the Environmental Protection Agency, announced the establishment of a five-year plan to investigate new technologies that would allow for the rapid testing of large numbers of chemicals while also providing results more applicable to humans. (aavs.org)
The science of product testing and toxicology led to massive increases in product safety over the course of the 20th century. (acdlabs.com)
In this episode, we're going to be talking about the role of chemical predictions in toxicology and product testing. (acdlabs.com)
In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterial s. (cdc.gov)
Limited exposure and human health effect data are currently available concerning 1-BP, but the National Toxicology Program (NTP) has concluded that there is sufficient evidence of developmental and reproductive toxicity among animals exposed to 1-BP. (cdc.gov)

From the regulatory point of view, the main objective of acute toxicity testing is basically to classify chemicals according to their intrinsic toxicity as required by the EEC directive on the classification, packaging, and labelling of dangerous substances (Council Directive 67/548/EEC and subsequent amendments). (qima-lifesciences.com)
The law will make it unlawful for cosmetic manufacturers to sell any cosmetic in California if the final product or any component of the product was tested on animals after Jan. 1, 2020, with some exceptions for regulatory requirements. (pcrm.org)
But to be effective, S.1113 must drive regulatory science forward and ban animal testing for cosmetics. (pcrm.org)
however, it is estimated that cosmetics testing to satisfy Chinese regulatory requirements account for potentially 75 percent of animals killed for cosmetics testing globally. (pcrm.org)
It is of relevance to research scientists, academics, and those involved in regulatory affairs or in the field of animal ethics. (sagepub.com)
To eliminate unnecessary government-mandated animal testing and facilitate greater use of modern alternative methods, we request that the FDA develop and release Guidance for Industry on how alternatives to animal testing can be used to meet regulatory requirements. (house.gov)
This commitment continues today, in partnership with global regulatory agencies that manage cosmetic safety, with animal advocacy groups and with leading animal alternative researchers in an effort to gain global acceptance of these new approaches. (marykay.ca)
The agencies predict that success of these high throughput mechanisms would result in a "reduction or replacement of animals in regulatory testing. (aavs.org)
Regulatory accepted methods to assess skin sensitizing potential of chemicals are animal based tests, but increasing interest in animal welfare presses the development of animal-free methods. (tu-darmstadt.de)
To assess whether and how exposure to chemical substances can impact our health and the environment, European and national regulatory authorities rely on the results from several testing methods, including animal testing, when performing their safety assessment. (env-health.org)
All stakeholders involved in chemical regulatory discussions share the long-term goal of moving away from animal testing. (env-health.org)
As long as alternative methods validated and accepted for regulatory use are not available, and without the full implementation of a precautionary approach, animal tests are the only viable way to assess whether or not a chemical is hazardous to our health or the environment. (env-health.org)
United States regulatory and research agencies may rely upon skin sensitization test data to assess the sensitization hazards associated with dermal exposure to chemicals and products. (cdc.gov)

The webinar focuses on the standard information requirements for REACH registration, including the following endpoints: Skin corrosion and irritation Serious eye damage and eye irritation Skin sensitisation Acute toxicity The webinar explains recent developments in alternative methods and approaches to address these endpoints, including their recent REACH Annex revisions. (norecopa.no)
Companies can pursue a number of approaches to ensure their cosmetics are safe without testing on animals. (pcrm.org)
Moving toward species-relevant chemical safety assessments and away from animal testing requires access to reliable data to develop and build confidence in new approaches. (nih.gov)
These new ICE features allow users to explore the applications of an expanded data space and facilitate building confidence in non-animal approaches. (nih.gov)
The topics in this section provide information about approaches used to replace, reduce, or refine animal use while ensuring that the toxic potential of substances is appropriately characterized. (nih.gov)
ICCVAM and NICEATM have evaluated approaches for replacing and reducing animal use, and ICCVAM has issued recommendations. (nih.gov)
The report published by the EC stresses the continued commitment in Europe and worldwide to find alternative approaches. (cosmeticsdesign-europe.com)
The Humane Society is working to decrease the use of animals in laboratories by promoting the advancement of affective alternative approaches. (bartleby.com)
Its goal was to speed up the drug approval process, and to let scientists experiment with approaches methods that are more humane than testing on live subjects. (reason.com)
and whether data from non-animal alternative approaches are accepted by these US federal agencies. (cdc.gov)

The move away from animal tests-and the increased use of human-relevant methods to assess the safety of cosmetics and cosmetic ingredients-will ensure consumers can be assured safer cosmetics that are cruelty-free. (pcrm.org)
From simple cell cultures to 3D models of human skin, liver, and other organs, there are many methods available to assess cosmetic safety. (pcrm.org)
Much of the time this method of cosmetic testing is less time-consuming and less expensive than alternative choices. (wikipedia.org)
The US Environmental Protection Agency received $1.2 million in private sector research funding from global cosmetic company L'Oreal in a bid to determine if EPA's chemical toxicity forecaster (ToxCast) can be used in systemic toxicity tests and replace. (cosmeticsdesign-europe.com)
Industry body Cosmetics Europe, formerly known as Colipa, says it has secured an additional €8m in funding for the research programme aimed at finding viable alternatives to testing cosmetic ingredients on animals. (cosmeticsdesign-europe.com)
In Australia, a ban on cosmetic testing on animals has been in effect since July 2020. (alv.org.au)
The Cosmetics Directive prohibits animal testing in the EU of finished cosmetic products since 2004, and animal testing of ingredients of cosmetic products is prohibited since 2009. (cosmeticsdesign-europe.com)
A marketing ban is also in place in the EU which prohibits selling cosmetic products containing ingredients which have been tested on animals irrespective of the place of the testing after March 2009. (cosmeticsdesign-europe.com)
For many of the tests needed to ensure the safety of cosmetic products, the EC claims alternative methods are developed and validated by now. (cosmeticsdesign-europe.com)
The partnership with Poietis allows BASF to secure its strategic advantage in better understanding the skin mechanisms which support the development and testing of advanced cosmetic bioactives for skin care applications. (basf.com)
Union ban on in vivo testing of cosmetic and toiletry that allowed a ranking of reactivity as minimal, low, moderate, ingredients following the publication of the Seventh Amend- and high. (cdc.gov)

The sensitizing potential of chemicals is currently assessed using animal models. (cosmeticsdesign.com)
Other tests assessing the effects of chemicals on internal systems involve force-feeding mice or rats chemicals for weeks, months, or their entire lives. (pcrm.org)
Tests for lung effects require forcing animals to inhale airborne chemicals or particles by shoving them into tiny tubes exactly the size of their bodies for hours a day, for weeks or months. (pcrm.org)
Regardless of the clear mandate from the public and international governments on this issue, the European Commission (EC) and the European Chemicals Agency (ECHA) are insisting on testing the chemicals used in cosmetics for which there's a possibility of workforce exposure during manufacturing processes. (peta.org.uk)
Yet across Europe, hundreds of animals, such as rats, mice, rabbits and guinea pigs, are used in toxicity (or "poison") tests for chemicals used in household products. (peta.org.uk)
In these tests, chemicals are applied to or injected into animals' skin or forced down their throats via a tube to check for side effects such as vomiting, tremors, organ failure, paralysis and even death. (peta.org.uk)
These technologies replace animal testing in end-use industries including pharmaceuticals, medical devices, chemicals and pesticides, food, and others. (thebusinessresearchcompany.com)
Despite the fact that ECVAM recommended the Rat Skin TER Assay for use in all corrosivity tests, ICCVAM deemed this method unreliable in testing certain classes of chemicals, and suggested that traditional animal studies still be used. (aavs.org)
Evaluating the safety of chemicals most often requires the use of tests on animals. (greenfacts.org)
The aim of this work was the development, establishment and validation of several alternative methods to animal testing to predict the skin sensitizing potential of chemicals. (tu-darmstadt.de)
Millions of animals involved in animal testing live out their days, kept in small cages, forced fed chemicals, injected with drugs, and deprived of anything natural and normal. (bartleby.com)
The same is true when it comes to testing, whether it's chemicals or pharmaceuticals. (acdlabs.com)
High-throughput transcriptomics can be used to investigate biological perturbations induced by chemical exposures and to compare similarities and differences in biological potencies across chemicals, filling data gaps more quickly and at lower cost than animal testing. (pcrm.org)
While all stakeholders engaged on chemicals share the goal to progressively eliminate tests performed on animals and core pieces of EU legislation on chemicals refer to this goal, it is unfortunately currently not possible to fully do without them for several reasons that are detailed further below. (env-health.org)
In this context, chemicals, pesticides, or drugs are tested on animals for market approval. (aerzte-gegen-tierversuche.de)
Allergic contact dermatitis (ACD) resulting from skin have undertaken recently the development of chemical re- sensitization is a critical toxicological endpoint evaluated for activity screening methods for aiding in the assessment of all new chemicals developed for consumer and/or occupational a chemical's skin sensitization potential (Aptula et al. (cdc.gov)

Every year countless animals, including thousands of dogs and puppies, are used in painful and deadly toxicity tests performed to earn FDA approval for new drugs and medical devices. (house.gov)
Using rodent cells to estimate starting doses for in vivo acute oral toxicity tests, this 3T3 basal cytotoxicity test is a reduction method that minimizes the number of animals used in each procedure. (aavs.org)
This NHK basal cytotoxicity method uses human cells to estimate starting doses for in vivo acute oral toxicity tests, reducing the number of animals used for each test. (aavs.org)

CORe Building - Elevator Testing, Tuesday, September 19, 2023 at 8:00 a.m. to Wednesday, September 20, 2023 at 5:00 p.m. (uwindsor.ca)
The global non-animal alternatives testing market size grew from $1.78 billion in 2022 to $1.94 billion in 2023 at a compound annual growth rate (CAGR) of 9.2% . (thebusinessresearchcompany.com)

5 ). In addition, the World Organisation for Animal during the March-June 2020 COVID-19 epidemic in Health defi ned COVID-19 as an emerging disease in Italy and 100 serum samples, 65 from dogs and from animals and began promoting surveys on the preva- 35 cats, collected in different regions of Italy before lence of SARS-CoV-2 infections among animals ( 6 ). (cdc.gov)

ATLA is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and toxicity testing. (sagepub.com)
According to the US-based foundation of Biomedical Research, animal testing has made a major advance within the last century- for veterinary health and humans. (bartleby.com)

Allowing the pharmaceutical industry and government agencies to utilize high-tech alternatives to wasteful and inhumane animal tests will save time, money, and animals' lives. (house.gov)
Animal testing is an inhumane process of the past that has no place in the forward thinking society of today. (bartleby.com)
The testing of animals is deemed to be cruel and inhumane. (bartleby.com)

What could be more beautiful than cruelty-free wrinkle creams, eye shadows, and shampoos that protect both humans and animals? (pcrm.org)
SARS-CoV-2 seroprevalence was higher among cats humans and animals. (cdc.gov)
CoV-2 infection in humans and animals. (cdc.gov)
As a result, research ethics directly derived from medical research on humans and animals do not apply. (lu.se)

Several tissue culture methods that measure the rate of chemical absorption by the skin have been approved by the OECD. (wikipedia.org)
The 3T3 Neutral Red Uptake (NRU) Phototoxicity Test, approved by the OECD, detects the viability of 3T3 cells after exposure to a chemical in the presence or absence of light. (wikipedia.org)
Bioaccumulation is assessed on the partition coefficient (n-octanol/water), usually reported as log K ow (also log P ow ) where substances with log K ow ≥ 4.5 are assessed as having a high potential for bioaccumulation (OECD test 107 or 117). (janusinfo.se)

In addition to replacement, the journal also features research that aims to reduce or refine in vivo experiments that are still carried out, as well as advocating for changes to global animal use policies. (sagepub.com)
In addition to the replacement of animals, it also covers work that aims to reduce the number of animals used and refine the in vivo experiments that are still carried out. (sagepub.com)
Used to estimate acute oral toxicity, the UDP is an in vivo test that reduces the number of rodents used. (aavs.org)
For instance, under the EU regulation on classification, labelling and packaging (CLP) regulation, the identification of hazards such as carcinogenicity, endocrine disruption, or reproductive toxicity includes the requirement for positive evidence coming from tests performed in vivo . (env-health.org)

Instead, companies have developed new, humane testing methods to ensure that their products don't harm humans or animals. (peta.org.uk)
PETA and its affiliates are determined to uphold the public's opposition to cosmetics testing and support the advancement of innovative, humane testing methods by pushing the ECHA to fulfil the spirit of the law by never testing cosmetics ingredients on animals - no matter what the circumstances are. (peta.org.uk)
As Humane Society International highlights, for example, over 12 million animals are experimented on within Europe every year, particularly for medical research. (caringconsumer.com)
Studies show that modern non-animal drug testing methods like organs-on-chips are more effective, economical, and humane. (house.gov)

For decades, guinea pigs, rats, mice, and rabbits have been poisoned and killed in tests for the purpose of selling cosmetics. (pcrm.org)
Replacing the use of rabbits in skin corrosivity tests, the Rat Skin TER Assay utilizes rat skin samples instead. (aavs.org)
The test substance is also applied to the shaved skin of rats, mice, or rabbits, which can lead to burns and inflammation. (aerzte-gegen-tierversuche.de)

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. (cosmeticsdesign.com)
Fungi like Cunninghamella elegans can be used as a microbial model of mammalian drug metabolism thereby reducing the need for laboratory animals. (wikipedia.org)
PETA highlights that animal testing involves subjecting animals to painful experiments in a laboratory setting . (caringconsumer.com)
But there's no ambiguity about the suffering that laboratory animals go through in the name of research. (caringconsumer.com)
Alternatives to Laboratory Animals (ATLA) is an established peer-reviewed journal dedicated to the Three Rs - the reduction, refinement and replacement of animals in research and testing. (sagepub.com)
As of 2015, 200 to 225 million animals are said to used in laboratory research for the biomedical industry annually worldwide. (bartleby.com)
First off, the laboratory conditions that are instigated upon millions of animal models for the sake of medical research has been said to be unethical and cruel. (bartleby.com)
Henry's Clinical Diagnosis and Management by Laboratory Methods. (medlineplus.gov)

Typical tests involve daily administration of a substance by gavage directly into the stomach of mice, rats, or other animals. (aerzte-gegen-tierversuche.de)
Roughly ninety-five percent of all lab animals are special-bred mice and rats. (bartleby.com)

However, ethical and economic concerns and the recent European legislative framework triggered intensive research efforts in the development and validation of alternative methods. (cosmeticsdesign.com)
Dr Movia champions the reduction and replacement of animal testing via research and training of young scientists. (tcd.ie)
Her current research work focuses on developing new, non-animal methodologies (NAMs) that can replace animal studies in cancer and lung toxicity research. (tcd.ie)
Dr Movia has received support and funding from several organisations including the Irish Research Council (IRC), Science Foundation Ireland (SFI), Animal-Free Research UK, the Johns Hopkins Center for Alternatives to Animal Testing Award (CAAT), and the European Commission. (tcd.ie)
Dr Movia is part of the Scientific Advisory Panel of Animal-Free Research UK and FRAME. (tcd.ie)
The National Institute of Health (NIH), a medical research center, allows the public to volunteer to be tested on with it's Clinical Research Volunteer Program. (thepetitionsite.com)
The Canadian Centre for Alternatives to Animal Methods will promote human-centered research methods. (uwindsor.ca)
By optimizing the MAT for early-stage testing and demonstrating its comparability with RPT results, this research contributes to our ongoing efforts to create vaccines with optimal safety and efficacy profiles. (kfor.com)
Tests performed on animals for medical research and teaching are so common in Australia that in 2017, over 20 million animals were experimented on. (alv.org.au)
Consumers are fed up with animal testing, the gruesome practice of testing products with animal research for medical experiments, makeup testing, chemical testing, and more. (caringconsumer.com)
By standard, animal research involves removing animals from their natural environment. (caringconsumer.com)
In the sections below I've highlighted some startling statistics about the use of animals in scientific research. (caringconsumer.com)
Some are more regularly used in animal research than others. (caringconsumer.com)
According to the American Anti-Vivisection Society , guinea pigs are the most common research animals, representing 22% of all animal experiments. (caringconsumer.com)
This non-animal alternatives testing market research report provides a comprehensive view of everything you require, including an in-depth analysis of the industry's current and future scenario. (thebusinessresearchcompany.com)
All medicines and treatments go through stringent testing in the lab (pre-clinical research) and in small groups of patients (clinical research). (thebusinessresearchcompany.com)
By "alternatives" to the use of animals in research, Norecopa endorses the internationally accepted tenet of The Three R's (Replacement, Reduction, Refinement), developed by Russell and Burch in the UK in the 1950s. (norecopa.no)
A lot of companies are currently seeking non-animal test methods for their research processes in order to either eliminate animal use completely or to restrict it as much as possible. (prnewswire.com)
Despite this commitment and progress in research finding alternative methods for testing, the Commission says these remaining 'complex endpoints' will not be possible by the 2013 deadline. (cosmeticsdesign-europe.com)
This research and development has not only reduced the number of animals used in testing, it is at the same time yielding important results in terms of better science to the benefit of consumer safety. (cosmeticsdesign-europe.com)
Animal testing is required in drug development research and is crucial for assessing the efficacy and safety of medications before they are commercialized. (researchgate.net)
Eurogroup for Animals is working with its Member Organisations and the European Commission, on a research project which will outline selected key welfare issues affecting equines across Europe. (thefishsite.com)
First, we're going to be talking to Dr. Jarrod Bailey, director of science at Animal Free Research UK. (acdlabs.com)
He is the director of science for Animal Free Research UK, and he did his Ph.D. in genetics at Newcastle University. (acdlabs.com)
So I want to talk a little bit about your background and kind of how you came into the field of animal free research. (acdlabs.com)
Basic research has accounted for more than half of all animal experiments in Germany for years. (aerzte-gegen-tierversuche.de)
Animals are used by scientists to develop research for new medications and experiments daily. (bartleby.com)
Does federal law ensure that animals used in research are treated humanely? (bartleby.com)
The essential need for animal research and observation is supported by health agencies and medical associations around the world. (bartleby.com)
Animal experiments are used for scientific purposes, mostly within research in medicine and science. (lu.se)
Most of the medical research at Lund University is conducted in test tubes or using cell culture techniques. (lu.se)
However, there are research studies in which animal experiments provide us with knowledge that we are not yet able to acquire in any other way. (lu.se)
In order to conduct animal experiments in Sweden, researchers must first apply for permission to an animal experiment ethical review board, which will run an ethical review of the proposed research study. (lu.se)
The research is to be conducted according to a protocol which has been reviewed and approved by the regional animal experiment ethical review board in Malmö/Lund. (lu.se)
In some states, 1-BP is now being used as an alternative solvent within the dry cleaning industry in response to the restricted use of perchloroethylene, which is considered "probably carcinogenic to humans" by the International Agency for Research on Cancer (IARC). (cdc.gov)

He says that testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans. (cosmeticsdesign.com)
Fortunately, experiments on animals for cosmetics products and their ingredients have been consigned to the history books in many parts of the world. (peta.org.uk)
Major companies have turned their backs completely on animal testing and no longer use ingredients that were tested on animals - and a number of animal tests have been completely replaced with superior, cheaper and more effective non-animal methods. (peta.org.uk)
The 2013 ban was the culmination of a vigorous and long-standing public campaign against animal-tested cosmetics - not just for finished products but also for their ingredients, which was critical. (peta.org.uk)
Despite the remarkable progress that's been made, ingredients used in cosmetics may still be tested on animals in the EU under REACH , the world's largest chemical testing programme. (peta.org.uk)
This means that animals will, in fact, continue to suffer and die in tests for cosmetics ingredients. (peta.org.uk)
There are thousands of ingredients that have already been proved safe for use in household products as well as an increasing number of alternative testing methods for new ingredients that don't use animals and are more reliable. (peta.org.uk)
PETA is urging the UK government to end these animals' suffering by banning all animal-testing for household products and their ingredients. (peta.org.uk)
The ingredients themselves often come from exploited and slaughtered animals. (alv.org.au)
Fat from slaughtered cows and sheep, shark liver, crushed bugs, lanolin from sheep in the wool industry, snail mucus and ground up animal hooves are all ingredients found in make-up and skin-care products. (alv.org.au)
Testing cosmetics on animals is not performed domestically, and the ban prohibits the importation of new ingredients tested on animals overseas. (alv.org.au)
However, ingredients previously tested are still permissible, as well as multi-purpose ingredients tested for other purposes like cleaning products. (alv.org.au)
The non-animal alternatives testing is testing products and services that do not involve testing on animals to determine the safety and efficacy of products and ingredients used in any industry sector. (thebusinessresearchcompany.com)
Mary Kay is committed to the elimination of animal testing and is a strong advocate of utilizing alternative methods to substantiate the safety of our ingredients and products. (marykay.ca)
We do not conduct animal testing on our products or ingredients, nor do we ask others to do so on our behalf, except when absolutely required by law. (marykay.ca)
Since essence has been on the market, we have never commissioned any testing on animals - neither for our products nor for the ingredients and neither in Germany nor anywhere else in the world. (essence.eu)
And since 2009, products with ingredients that have been tested on animals especially for cosmetics are also forbidden. (essence.eu)
By law, medical ingredients can and must still be tested on animals to prove that they are safe for use. (essence.eu)
The important thing is: the ingredients are not allowed to be tested on animals especially for cosmetics purposes. (essence.eu)
The reason for this is that ingredients may, for example (as already mentioned in question 1), have already been tested on animals for medical purposes. (essence.eu)

Establishment and validation of the methods was performed with 54 test substances of known sensitizing potential, and the findings were compared to available human patch test data and murine local lymph node assay data. (tu-darmstadt.de)

In 2013, the European Union banned the testing of cosmetics on animals in the EU, and the marketing or sale of cosmetics that have been tested on animals outside the EU. (pcrm.org)
Although companies can't sell animal-tested cosmetics in Europe, they can continue to test cosmetics on animals outside Europe and sell them in other markets. (peta.org.uk)

This paper shows that the MAT is a valuable assay to assess reactogenicity levels of OMV based vaccines at multiple stages of vaccine development and the data presented could help to substantiate the switch from small animal testing to cellular assays at several stages of vaccine development. (kfor.com)
By combination of different assays or more specifically the combination of the outcome of different assay into a testing strategy or testing battery predictivities were increased and allowed the prediction of sensitizing and non-sensitizing substances with high probability. (tu-darmstadt.de)
The combinations of assays showed that predictivity compared to single assays can be increased and that for the number of tested substances these combinations are comparable to the local lymph node assay, the current gold standard to assess skin sensitizing potential. (tu-darmstadt.de)

Johns Hopkins University and the University of Konstanz in Brussels have announced they are to hold an open workshop on the 'Human Toxome Project' for alternatives to animal testing (CAAT) on the 15th of this month. (cosmeticsdesign-europe.com)

The European Union has announced it is to put Roche's xCELLigence System, an alternative animal testing technology through the paces as part of its SEURAT (Safety Evaluation Ultimately Replacing Animal Testing) initiative to see if it can be safely applied. (cosmeticsdesign-europe.com)

2) By Method: Cellular Assay, Biochemical Assay, In Silico. (thebusinessresearchcompany.com)

However, ICCVAM recommended that EpiDermTM be used only as part of a tiered assessment strategy, which may or may not involve animals. (aavs.org)
Instead the Commission is currently assessing the impact of the entry into force of the ban in 2013 without alternatives and will decide on next steps on the basis of the full impact assessment. (cosmeticsdesign-europe.com)
However, it is still currently assessing the impacts of the implementation of the full marketing ban by 2013 (environmental, animal welfare, economic and social) and on the basis of that assessment the EC will decide whether or not to make a proposal in relation to the marketing ban. (cosmeticsdesign-europe.com)
The group proposed elements of a potential testing scheme for nanomaterial s that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. (cdc.gov)
Cyanobacteria , blue-green algae, are recommended for effects testing of antimicrobials in environmental risk assessments according to the European guidelines for risk assessment of medicinal products for human use (EMEA/CHMP/SWP/4447/00 corr 2). (janusinfo.se)

If you're not already fed up with how cruel-and potentially wasteful -animal testing is, keep reading. (caringconsumer.com)

There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. (wikipedia.org)
Refinement refers to methods that alleviate or minimize potential pain, suffering, or distress, and enhance animal welfare for the animals used. (wikipedia.org)

Until China removes these testing requirements, companies large and small are trying strategies to remain cruelty-free, such as manufacturing in China, avoiding manufacture of some kinds of cosmetics, creating separate product lines for the Chinese market, or avoiding selling their products in China altogether. (pcrm.org)
It closed the final loophole: in 2009, these abhorrent tests were banned in Europe, but products tested elsewhere could still be imported. (peta.org.uk)
Because of this, the only way to be completely sure that you aren't indirectly supporting animal testing is to continue to purchase products only from companies that don't test on animals. (peta.org.uk)
Following the ban on animal-tested cosmetics in Europe, ending animal tests for household products is the next logical step - and would save countless lives. (peta.org.uk)
However, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as serum or cells. (wikipedia.org)
Johnson & Johnson supply to those that require animal testing on products by law. (thepetitionsite.com)
There are new alternatives to testing products for consumers. (thepetitionsite.com)
Avon has landed in hot water, alongside Estee Lauder and Mary Kay, after being slapped with a class action lawsuit for allegedly deceiving American consumers with false and misleading representations relating to animal testing of their products. (cosmeticsdesign-europe.com)
All parenteral vaccine products must be tested for pyrogen/endotoxins to ensure an acceptable safety profile. (kfor.com)
It is estimated that 500,000 animals suffer and die for the sake of beauty products every year worldwide. (alv.org.au)
Check PETA's comprehensive database to search for companies that do not test their products on animals. (alv.org.au)
Federal agencies have accepted ICCVAM's recommendation to use this test for identification of products that may cause severe or permanent eye damage. (aavs.org)
The contracts with our suppliers state that they must manufacture products according to EU law, and this clearly excludes animal testing. (essence.eu)
To us, this is a matter of course, and always has been on a voluntary basis - because we know that we can manufacture good and safe products without making animals suffer. (essence.eu)
So, it could happen that an ingredient has been tested on animals somewhere in the world - but since 2013, not for a cosmetics company that markets its products in Europe. (essence.eu)
The law allows drug companies to find alternative methods of assessing their products, without testing them on animals or human beings. (reason.com)
Additionally, NIOSH is working with a major manufacturer of 1-BP products to better understand their extent of use, proper methods for handling the material, and practices that will minimize worker exposure. (cdc.gov)

Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. (wikipedia.org)

Unfortunately, the Murine LLNA uses mice as a substitute to test substances topically. (aavs.org)

Guiding principles for more ethical use of animals in testing are the Three Rs (3Rs) first described by Russell and Burch in 1959. (wikipedia.org)
The study showcases a significant step forward in vaccine safety testing, offering the potential to enhance the efficiency and ethical standards of vaccine development. (kfor.com)
The main ethical concern that receives the most criticism from activists and animal welfare groups is the overall treatment of animals. (bartleby.com)
The second factor to take into consideration consists on the ethical considerations of animal experiments, as animals have the ability to suffer just like humans do. (bartleby.com)
Animal testing should be outlawed due to animal rights, ethical issues, alternative ways and its unreliability. (bartleby.com)

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) develops and evaluates alternatives to animal use for chemical safety testing. (nih.gov)
Companies experiment on animals to test the safety of their product. (thepetitionsite.com)
However, vaccine safety is of paramount importance, and researchers are continually exploring innovative methods to ensure that new vaccines are both effective and safe. (kfor.com)
The use of this test may contribute to a significant reduction in the use of animals, currently the standard for vaccine safety profiles. (kfor.com)
Stringent regulations related to safety, efficacy, and quality are projected to act as a major challenge for players operating in the non-animal alternative testing market. (thebusinessresearchcompany.com)
Congresswoman Titus has a long history of fighting for animal welfare in Congress and will continue to prioritize their safety. (house.gov)
Animal-free strategies in food safety & nutrition: What are we waiting for? (ilsi.org)
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force. (ilsi.org)
In a typical year, Mary Kay spends millions of dollars and conducts more than 300,000 tests to ensure that Mary Kay ® product meets the highest standards of quality, safety and performance. (marykay.ca)
For more than two decades, we have been a global leader in helping to develop alternative testing methods for product safety. (marykay.ca)
While the federal validation of non-animal alternative test methods continues to be a slow and frustrating process, new laws and public concerns about safety, have pushed the need for better and cheaper alternative methods. (aavs.org)
Promote the development and use of non-animal methods when testing the safety of food produced using nanotechnologies. (thefishsite.com)
We will talk to experts in the science of animal testing, and the use of QSAR in product safety. (acdlabs.com)
Animals are not sufficiently predictive of humans with regards to toxicity and to safety. (acdlabs.com)
However, completely getting rid of animal tests for chemical safety assessments overnight would constitute a serious threat to our health as well as wildlife. (env-health.org)
Why is animal testing still being used for chemical safety testing today, while alternative methods already exist and more are being developed? (env-health.org)
The US Consumer Product Safety Commission, the US Environmental Protection Agency, the US Food and Drug Administration, the Occupational Safety and Health Administration, the National Institute for Occupational Safety and Health, and the US Department of Defense are member agencies of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). (cdc.gov)

Reduction refers to methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals. (wikipedia.org)
Of the twelve remaining members, one half are researchers, animal experiment technicians or animal experiment staff. (lu.se)

Avoid giving donations to medical and hospital charities that conduct animal testing. (alv.org.au)

The most common and painful are the Draize skin and eye tests. (pcrm.org)
Animals are regularly subjected to painful tests which will most often end in their death and dissection. (alv.org.au)
Animal Testing Imagine a life where the only thing you ever have known and ever will know is a metal cage, white lab coats, and numerous painful tests. (bartleby.com)

In addition to campaigning for the worldwide ban of animal-tested cosmetics, raising awareness of the cruelty that goes on in laboratories and putting pressure on governments and politicians to introduce compassionate legislation, PETA and its affiliates are also helping to develop non-animal testing methods that'll encourage companies to phase out horrific experiments on animals. (peta.org.uk)
If Johnson & Johnson value the opinion of their consumers and the lives of countless animals, Johnson and Johnson should completely stop conducting experiments on animals. (thepetitionsite.com)
Experiments on animals for medical purposes are not only cruel they are unreliable. (alv.org.au)
Experiments on Animals - Why Are They Still Done? (alv.org.au)
Due to experiments on animals we have treatments for diabetics, tuberculosis, breast cancer, malaria and brain injuries. (bartleby.com)

We don't want animals to suffer because of our love of make-up, and we strongly believe in "beauty without cruelty", which is fortunately also required by EU law. (essence.eu)

Alternatives include solutions such as the Irritation Assay System which is a simplified procedure in a test tube used for skin irritation, or even human skin culture. (prnewswire.com)
This method was first approved by ECVAM for use as a stand-alone assay. (aavs.org)

Charu Chandrasekera is the founding executive director of the Canadian Centre for Alternatives to Animal Methods. (uwindsor.ca)

Yet, a staggering 95% of drugs tested 'successfully' on animals fail in human trials because they don't work or are dangerous. (alv.org.au)
The NIH reports that 90 percent of drugs that pass these animal tests fail in human trials because they are toxic or ineffective. (house.gov)

In the United States, California passed the Cruelty-Free Cosmetics Act, but the federal government does not require animal testing for cosmetics. (pcrm.org)
Even before the introduction of the legal ban in the EU, we have exclusively produced cosmetics without animal testing - essence stands for cruelty-free cosmetics and is part of the official list of PETA Germany e.V. for cosmetics without animal testing. (essence.eu)

Some of these cruel and unnecessary tests have been funded by taxpayers. (house.gov)
Also, this kind of animal experiments is unnecessary. (aerzte-gegen-tierversuche.de)
Unless alternative action is taken, large and unnecessary expenditures will continue indefinitely. (cdc.gov)

Replacement refers to the preferred use of non-animal methods over animal methods whenever it is possible to achieve the same scientific aim. (wikipedia.org)
This method was first validated by the European Coalition on the Validation of Alternative Methods (ECVAM) as a complete replacement for animal tests. (aavs.org)

We conducted a serologic survey among dogs and cats million companion animals, health authorities were in Italy to detect antibodies against severe acute respi- ratory syndrome virus 2 (SARS-CoV-2). (cdc.gov)
The EC also pointed out that significant advances have been made in reducing the number of animals used in tests, for example in relation to acute toxicity. (cosmeticsdesign-europe.com)

The FDA's regulations related to animal testing no longer fully conform with applicable law," writes the Kentucky senator. (reason.com)
The FDA's regulations related to animal testing no longer fully conform with applicable law," writes Paul in a letter to FDA Commissioner Robert Califf. (reason.com)

In the U.S., the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) validates alternative methods, and recommends them for use to the scientific and federal regulators. (aavs.org)
The following are some of the validated alternatives approved by ICCVAM. (aavs.org)
In contrast, ICCVAM has validated EPISKINTM for reduction purposes, suggesting that some substances may need to be tested on animals after using this method. (aavs.org)
This test has been used for years prior to the passage of ICCVAM. (aavs.org)
ICCVAM seeks to identify opportunities for the use of non-animal replacements to satisfy these testing needs and requirements. (cdc.gov)

The development of new methods to predict the protein reactive potential of sensitizing substances indicated that such compounds are able to react with proteins on the cell surface and that this reaction impacts the detection of such proteins by antibody staining. (tu-darmstadt.de)

The ICE test method uses tissue obtained from slaughterhouses, which would otherwise be discarded, to detect eye irritants. (aavs.org)
The partnership also emphasizes bioprinted tissue models as an alternative to animal testing in cosmetics and dermopharmacy. (basf.com)
Dr. Sebastien Cadau, responsible for tissue engineering development at BASF, points out: "Compared to other bioprinting methods the laser-assisted technology provides higher resolution when it comes to the patterning of cells. (basf.com)
The exclusive use of this technology allows Poietis to produce more complex, robust and customizable tissues than the ones currently obtained by the conventional methods of cell culture and tissue engineering. (basf.com)

Now, drug companies will still have the option to start testing experimental drugs on animals, but they won't have to. (reason.com)

The Murine LLNA is used as an alternative to guinea pig tests that screen for allergic reactions on the skin. (aavs.org)

The practice of using animals for testing has been debated for many decades. (bartleby.com)
Low rates of pap smear testing and mammography were reported and breast self examination (BSE) practice is still unpopular among Saudi females. (who.int)

Serology for brucellosis is a blood test to look for the presence of antibodies against brucella. (medlineplus.gov)

Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. (wikipedia.org)
Another alternative is so-called microdosing, in which the basic behaviour of drugs is assessed using human volunteers receiving doses well below those expected to produce whole-body effects. (wikipedia.org)
Human skin equivalent tests can be used to replace animal-based corrosive and irritative studies. (wikipedia.org)
Animals of different species don't necessarily react the same as other animals or humans, and therefore a substance tested on an animal can have a completely different effect on a human. (alv.org.au)
Animals are not good models for predicting human clinical outcomes because of differences in physiology, metabolism and other differences between human and non-human animals. (alv.org.au)
The government organizations enforce laws and regulations, raise funds to support non-animal testing methods such as tests on human volunteers, and advanced computer-modeling techniques, and also fund studies with human volunteers. (thebusinessresearchcompany.com)
A model of reconstructed human epithelium, developed to test skin corrosion. (aavs.org)
You can never make an animal that you're testing human relevant enough. (acdlabs.com)
Typically defended by arguments of reliability and human health benefits, recently the question of ethics and values placed on animal testing have caused it to become a relevant and pressing topic that has been more widely discussed and debated. (bartleby.com)
Most individuals would be saddened knowing that animals were being harshly experimented on for human benefits. (bartleby.com)
Animal testing is not only beneficial to human but also animals, at least to those who are not used in the experiments, such as pets and endangered species. (bartleby.com)
Rand Paul: Why Is the FDA Still Requiring Human or Animal Testing For New Drugs? (reason.com)
Reason 's Elizabeth Nolan Brown aptly summarized the bill's achievements, noting that "previously, all drugs in development were required to undergo animal studies before being tested in human trials. (reason.com)
But companies currently submitting applications for drug approval still have to deal with FDA requirements that stipulate human or animal testing-at least on paper. (reason.com)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
In 1987, the Secretary of the U.S. Department of Health and Human Services established an Advisory Committee for Elimination of Tuberculosis* to provide recommendations for developing new technology, applying prevention and control methods, and managing state and local tuberculosis programs targeted at eliminating tuberculosis as a public health problem. (cdc.gov)

A team of scientists in Portugal are working on a new non-animal method of testing for skin sensitivity and help eliminate the need for animals in cosmetics testing once and for all. (cosmeticsdesign.com)

Validated alternative methods have been made available for the identification of corrosive substances, skin irritants and severe eye irritants, skin phototoxicity and skin penetration as well as to assess genotoxicity. (cosmeticsdesign-europe.com)

Neves explains that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. (cosmeticsdesign.com)

Though the average consumer may be vaguely aware of scientific or commercial testing on animals, as you read in the previous section, the realities are far worse than they can probably imagine. (caringconsumer.com)
Ensure that the following elements are included in the revision of the organic policy: higher animal welfare standards, the improved definition and harmonisation of minimum welfare standards and that the regulation considers scientific advice on the subject of animal welfare, as supported by relevant EFSA opinions. (thefishsite.com)
Thanks to scientific advancements, the age of animal testing may soon be in the past. (acdlabs.com)
He's going to explain the scientific argument against animal-based testing. (acdlabs.com)
Understanding this challenge is fundamental in order to understand why we are currently not able to identify critical hazards, such as endocrine disruption, according to established scientific knowledge without animal tests. (env-health.org)
The experiments do not serve the well-being of the animal, but aim to answer a wide variety of the researcher's scientific questions. (aerzte-gegen-tierversuche.de)
Animals are used to address even the most devious scientific inquiries, driven more by a sense of tradition than by any meaningfulness. (aerzte-gegen-tierversuche.de)
This is due to the fact that, as proven by many scientific studies, the transferability of findings from animal experiments to humans is by no means assured. (aerzte-gegen-tierversuche.de)

right to not be harmed although the Animal Welfare Act doesn't provide much protection. (bartleby.com)
But the Animal Welfare Act is by no means intended to protect animals from this pain, suffering, and harm. (aerzte-gegen-tierversuche.de)
In other words, animals can be harmed in almost any way under the guise of the Animal Welfare Act, without there being any medical benefit. (aerzte-gegen-tierversuche.de)

Support us in changing the ways of Johnson and Johnson to save the lives of millions of animals. (thepetitionsite.com)

The aim is to develop new drugs, new treatment methods or to increase our basic knowledge of how the body functions. (lu.se)

This complements the reduction in use of animal models due to the growing protests by people against their use. (prnewswire.com)

Uses specific strains of common bacteria to detect genetic changes caused by test substances. (aavs.org)

The remaining percentage of animal tests and clinical trials are split relatively evenly among the above animal species. (caringconsumer.com)
It is distressing to learn that when substituting an apparently "safer" alternative to perchlroethylene in the dry cleaning industry, we may have created a new clinical problem. (cdc.gov)

This week, Lush Cosmetics rolled out its largest-ever global anti-animal testing campaign, whereby staff staged protests and performance stunts in over 800 stores across 49 countries to coincide with World Week for Animals in Laboratories. (cosmeticsdesign-europe.com)
Under some circumstances, a major key issue of testing animals implicates pain and suffering, which is not considered by laboratories. (bartleby.com)

Anatomy14

Organisms17

Diseases6

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology4

Phenomena and Processes79

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Information Science13

Health Care26

Geographicals1

Vitro20

Experimentation7

Toxicology8

Regulatory13

Approaches10

Cosmetic11

Chemicals16

Toxicity Tests3

20232

20201

Biomedical research2

Inhumane3

Humans and animals4

OECD3

Vivo4

Humane4

Rabbits3

Laboratory8

Rats2

Research35

Ingredients20

Murine Local Lymph Node Assay1

Cosmetics on animals2

Assays3

CAAT1

Replacing Animal Testing1

Silico1

Assessment5

Wasteful1

Refinement2

Products17

Implementation1

Mice1

Ethical5

Safety17

Researchers2

Conduct animal1

Painful3

Experiments on animals5

Suffer1

Assay2

Centre1

Fail in human trials2

Cruelty-Free Cosmetics2

Unnecessary3

Replacement2

Acute2

FDA's2

ICCVAM5

Antibody1

Tissue4

Experimental1

Guinea1

Practice2

Antibodies1

Human16

Eliminate1

Assess1

Ethics1

Scientific8

Welfare Act3

Millions1

Drugs1

Reduction1

Substances1

Clinical2

Laboratories2