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  • hydrolysis
  • Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. (string-db.org)
  • One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. (string-db.org)
  • 1. A hydrolase catalyzing the hydrolysis of an l-methionyl-amino acid to l-methionine and an amino acid. (lexic.us)
  • reaction
  • May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. (string-db.org)
  • ribosome
  • During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. (string-db.org)
  • PMID
  • Then, in a second, "editing" step, the ligase itself rapidly hydrolyses only the valylated products [ PMID: 9554847 , PMID: 10446055 ] as shown from the crystal structures. (ebi.ac.uk)