This medication has virtually replaced the older medication propylthiouracil or PTU because methimazole is effective without as much tendency for side effects. (vin.com)
Given the risk of liver toxicity from propylthiouracil, methimazole is considered the preferred treatment for hyperthyroidism, especially during breastfeeding (Karras 2009, 2010 and 2012, Azizi 2011, Serrano 2014, Hudzik 2016). (e-lactancia.org)
If doses greater than 30 mg of methimazole are required, switching to propylthiouracil to control hyperthyroidism can be tried (doses up to 450 mg/day while breastfeeding have shown to be safe), or continuing with methimazole but with clinical and analytical monitoring (T4 and TSH) of the infant every 2 weeks at first. (e-lactancia.org)
Antithyroid drugs such as: thiouracil/propylthiouracil and carbimazole/methimazole. (en-academic.com)
Carbimazole or methimazole is the treatment of choice in the non-pregnant population driven by its more favourable pharmacokinetic and adverse effect profile over propylthiouracil. (onegravesvoice.com)
The most common medication prescribed to treat feline hyperthyroidism is called methimazole (trade name Tapazole or Felimazole). (vin.com)
Frenais R, Rosenberg D, Burgaud S et al: Clinical efficacy and safety of a once-daily formulation of carbimazole in cats with hyperthyroidism, J Small Anim Pract 50:510, 2009. (everycat.org)
Beta-blockers also help blood vessels open up to improve blood flow" are prescribed or antithyroid drug therapy such as carbimazoleCarbimazole "the most commonly used medicine for hyperthyroidism. (thyroiduk.org)
In December 2018, based on the assessment of epidemiological studies and case reports, the European Medicines Agency (EMA) has concluded that there is a strong association of carbimazole or methimazole (also known as thiamazole, the active form of carbimazole) with congenital malformation when administered during pregnancy, particularly at high doses and during the first trimester of pregnancy. (npra.gov.my)
Longhofer S, Martin-Jimenez T, Soni-Gupta J: Serum concentrations of methimazole in cats after a single oral dose of controlled-release carbimazole or sugar-coated methimazole (thiamazole), Vet Ther 11:E1, 2010. (everycat.org)
Medication3
The facial itching resolves with anti-itch medication and discontinuing methimazole, but cats with this side effect can be expected to have it again if medication is restarted, so another form of treatment should be given for the thyroid disease. (vin.com)
This toxicity can be expected to resolve after discontinuing the medication, but again, alternative therapy for the thyroid will be needed if the cat cannot tolerate methimazole without developing liver disease. (vin.com)
Carbimazole - Smoking can interfere with how your body uses this medication. (mednhealth.com)
Kidney problems can be minimized by starting with a lower dose of methimazole and working up over weeks or months so as not to cause as abrupt a change in kidney blood flow. (vin.com)
To minimize infant exposure, the dose of methimazole should be taken immediately after feeding (Hudzik 2016). (e-lactancia.org)
At the start of treatment with carbimazole, the total daily dose may be taken in two or three divided doses. (pharmacycode.com)
You must keep your regular appointment with your doctor, as they might need to adjust the dose of carbimazole you are taking and to keep a check on your condition. (pharmacycode.com)
Recently, a large amount of data has been collected on long-term ATDs for GD, and low-dose methimazole (MMZ) is expected to be a good option for remission. (e-jyms.org)
This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. (everycat.org)
In general, the pharmacokinetic values for the two treatments were similar when differences in effective methimazole dose were taken into consideration. (everycat.org)
An initial dose of methimazole is 2.5 mg to 5 mg and is divided into two equal amounts to be given daily. (bioguardlabs.com)
Liver1
Potentially serious liver disease results in an extremely small number (less than 2%) of cats taking methimazole. (vin.com)
Synthesis1
B) A simple and facile one-pot synthesis of carbimazole ( 12 ) and its methyl analogue ( 13 ) by using heterocyclic carbenes generated in situ from the corresponding imidazolium salts. (mugesh-iisc.in)
Radioiodine treatment2
Carbimazole is also used in the preparation of patients for thyroidectomy (part or total removal of the thyroid gland) and before radioiodine treatment. (pharmacycode.com)
Medical management with the antithyroid drug methimazole has become a popular option, either before surgery (thyroidectomy) or radioiodine treatment, or for long-term medical management. (everycat.org)
Doses3
Based on available evidence, carbimazole and methimazole may cause congenital malformations when administered during pregnancy, particularly in the first trimester of pregnancy and at high doses. (npra.gov.my)
Given that a small, but detectable, amount of both PTU and MMI are transferred into breast milk, the lowest effective doses of MMI/CM (carbimazole) or PTU should always be administered. (medscape.com)
It works by reducing the amount of thyroid hormones which your thyroid gland makes" or metabolite methimazole Metabolite methimazole "an anti-thyroid drug" , usually in low doses. (thyroiduk.org)
Methimazole accumulates in the thyroid gland so that antithyroid effects extend beyond (possibly up to 24 hours) the duration of elevated plasma levels. (everycat.org)
Agranulocytosis1
In less than 5% of treated cats, methimazole may have adverse effects such as agranulocytosis and thrombocytopenia. (bioguardlabs.com)
NPRA has received 332 reports with 593 adverse events suspected to be related to carbimazole and four (4) reports with five (5) adverse events with methimazole. (npra.gov.my)
Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. (everycat.org)
Careful benefit/risk assessment should be carried out prior to treatment with carbimazole or methimazole during pregnancy. (npra.gov.my)
Treatment3
EMA requested the product registration holders of carbimazole and methimazole to update the product information to include further advice for women of childbearing potential to use effective contraception during treatment. (npra.gov.my)
Before having any kind of surgery, including dental and emergency treatment, tell your doctor, dentist or surgeon you are taking carbimazole. (pharmacycode.com)
If a patient develops acute pancreatitis after the administration of carbimazole or methimazole, these drugs should be discontinued immediately. (npra.gov.my)
The main antithyroid action of the drugs PTU, methimazole, and carbimazole is through the inhibition of the organification of intrathyroid iodine as well as inhibition of the coupling of iodotyrosine molecules to form T3 and T4. (forexsignal300.com)
Effects3
It is important to understand what the potential side effects of methimazole and its relatives are and the monitoring that is generally recommended. (vin.com)
Laboratory studies in rats and mice have shown evidence of teratogenic and embryotoxic effects of methimazole. (petsupplies4less.com)
Administration2
That said, however, methimazole can be readily made into a flavored liquid or chewable for easier administration by a compounding pharmacy, or it may even be possible to convert methimazole into a gel administered on the hairless inner surface of the cat's ear (see below). (vin.com)
Bone marrow changes can also result from methimazole administration. (vin.com)
Symptoms2
Speak with your doctor for more specific information regarding any symptoms that you may experience when taking methimazole. (canadaprescriptionsplus.com)
The child was started on carbimazole and propranolol and gradual improvement in symptoms noted. (iap-kpj.org)