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  • PBP2a
  • PBP2a has an elevated rate constant for dissociation and decreased acylation rate constant and these together significantly decrease the acylation of PBP2a, producing b-lactam resistance . (scribd.com)
  • 1940s
  • The introduction of penicillin in the early 1940s dramatically improved the prognosis of patients with staphylococcal infection. (jci.org)
  • genes
  • Emergence of resistance often begins with a large pathogen population in which a tiny fraction is naturally resistant to the antibiotic, either through spontaneous changes or through the acquisition of resistance genes from other microbes. (informit.com)
  • In contrast, the resistance to non-b-lactams is due to the presence of transposons and other genes. (scribd.com)
  • The most common mechanism for such resistance is target site modification mediated by erm genes, which can be expressed either constitutively ( c MLS B phenotype) or inducibly ( i MLS B phenotype). (biomedcentral.com)
  • phenotypes
  • Of particular interest is the ability of bacterial signaling systems to confer reversible resistance phenotypes, an act that saves precious cellular energy because they respond to host assaults only when the threat is present. (springer.com)
  • Here we searched for novel proteins binding to the mec operator, in an attempt to identify new factor(s) controlling methicillin resistance phenotypes. (uzh.ch)
  • microbes
  • It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them," Fleming warned in 1945 when he received the Nobel Prize in medicine or physiology , together with Florey and Chain, "and the same thing has occasionally happened in the body. (harvardmagazine.com)
  • sepsis
  • Although it is recognised as an important cause of morbidity and mortality by infectious disease practitioners, there are limited data on the incidence of serious S. aureus sepsis in Australia, and only two regional studies on patient outcomes in patients with methicillin-resistant S. aureus sepsis. (health.gov.au)
  • staphylococcal
  • The patient, a policeman suffering from a severe staphylococcal infection, died a month later-supplies of penicillin had run out after just five days-but his initial improvement had been remarkable. (harvardmagazine.com)
  • genetic
  • To investigate the genetic basis for increased resistance and transmissibility, the TW20 genome was completely sequenced, assembled, and finished and annotated as described previously ( 16 , 25 ). (asm.org)
  • hospital
  • As members of the Australian Group on Antimicrobial Resistance, 17 hospital laboratories from each state and territory of Australia participated in the collection of anonymous data on cases of S. aureus bacteraemia from January 2005 to December 2006 over periods ranging from 5 to 24 months. (health.gov.au)