The vertebrate head is a complex tapestry of morphological features woven together during embryonic development from a varied array of specialized cell types. (frontiersin.org)
We have studied Platynereis orthologs of the most important vertebrate neural bHLH genes, i.e. achaete-scute, neurogenin, atonal, olig , and NeuroD genes, the latter two being genes absent of the Drosophilagenome. (biomedcentral.com)
Vertebrates2
These transcription factors have been studied in many metazoans, especially in vertebrates but also in early branching metazoan clades such as the cnidarians and sponges. (biomedcentral.com)
The NOTCH1 cell signaling mechanism is conserved in most multicellular organisms including all metazoans (and thus vertebrates). (atlasgeneticsoncology.org)
Transmembrane3
Presenilin is the catalytic component of the γ-secretase complex that is responsible for the cleavage of the transmembrane protein, amyloid precursor protein (APP) (reviewed in D e S trooper 2003 ). (genetics.org)
These four transmembrane proteins constitute the γ-secretase core complex, yet little is known about its regulation and activity. (genetics.org)
272,500 Da) consists of a large extracellular unit which associates in a calcium-dependent, non-covalent interaction with a second unit consisting of the following: a small extracellular region, a single transmembrane spanning region, and a small intracellular region. (atlasgeneticsoncology.org)