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  • Metastasis
  • Metastasis to the forearm skeletal muscle from an adenocarcinoma of the colon: report of a case. (koreascience.or.kr)
  • This is because only a small population of cells in the primary tumor have the potential for metastasis, and these cells may have different microscopic features. (merckvetmanual.com)
  • Cutaneous metastasis is usually a feature of aggressive tumors and is associated with a guarded to poor prognosis. (merckvetmanual.com)
  • Specific cell type, size of tumor, extent of metastasis in brain and elsewhere. (healthtap.com)
  • Here, in a case of stage IV adenocarcinoma of the gastroesophageal junction, we report the successful genome wide analysis using array comparative genomic hybridization (CGH) of DNA from only fourteen tumor cells using a bead-based single cell selection method from a bone metastasis progressing during chemotherapy. (springer.com)
  • In a case of metastatic adenocarcinoma of the gastroesophageal junction, the progression of bone metastasis was observed during a chemotherapy regimen of epirubicin, oxaliplatin and capecitabine, whereas lung-, liver and lymph node metastases as well as the primary tumor were regressing. (springer.com)
  • A bone marrow aspirate sampled at the site of progressing metastasis in the right iliac bone was performed, and single cell molecular analysis using array-CGH of Epithelial Specific Antigen (ESA)-positive metastatic cells, and revealed two distinct regions of amplification, 12p12.1 and 17q12-q21.2 amplicons, containing the KRAS (12p) and ERBB2 (HER2/NEU) (17q) oncogenes. (springer.com)
  • ERBB2 was heterogeneously amplified by FISH analysis in the primary tumor, as well as liver and bone metastasis, but homogenously amplified in biopsy specimens from a progressing bone metastasis after three initial cycles of chemotherapy, indicating a possible enrichment of erbB2 positive tumor cells in the progressing bone marrow metastasis during chemotherapy. (springer.com)
  • Correspondingly, the erbB2 protein was found heterogeneously expressed by immunohistochemical staining of the primary tumor of the gastroesophageal junction, while negative in liver and bone metastases, but after three initial cycles of palliative chemotherapy with epirubicin, oxaliplatin and capecetabine, the representative bone metastasis stained strongly positive for erbB2. (springer.com)
  • Global analysis of genetic aberrations, as illustrated by performing array-CGH analysis on genomic DNA from only a few selected tumor cells of interest sampled from a progressing bone metastasis, can identify relevant therapeutic targets and genetic aberrations involved in malignant progression, thus emphasizing the importance and feasibility of this powerful tool on the road to more personalized cancer therapies in the future. (springer.com)
  • Krukenberg tumors account for about 15% of metastatic cancers that initially appear to have arisen in the ovary, and as such is less common than metastasis arising from ovarian epithelial and germ-cell tumors. (wikipedia.org)
  • There has been debate over the exact mechanism of metastasis of the tumor cells from the stomach, appendix or colon to the ovaries. (wikipedia.org)
  • LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. (wikipedia.org)
  • A liver metastasis is a malignant tumor in the liver that has spread from another organ affected by cancer. (wikipedia.org)
  • Tumor size also affects the prognosis, in that dogs with tumors greater than five centimeters have a greater chance of lymph node metastasis. (wikipedia.org)
  • Metastasis for any malignant mammary tumor is usually to the regional lymph nodes and lungs. (wikipedia.org)
  • Symptoms such as abdominal or back pain or pressure, diarrhea, indigestion, or yellowing of the skin and whites of the eyes can arise from the effects of a larger PanNET tumor, either locally or at a metastasis. (wikipedia.org)
  • Pancreatic neuroendocrine tumor staging (AJCC) Stage T1 Stage T2 Stage T3 Stage T4 Involvement of nearby lymph nodes - Stage N1 Metastasis - stage M1 In general, treatment for PanNET encompasses the same array of options as other neuroendocrine tumors, as discussed in that main article. (wikipedia.org)
  • Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. (wikipedia.org)
  • Over the course of time-particularly if the primary tumor is left untreated-smaller "satellite" tumors will appear at other places in the body, a phenomenon known as metastasis. (wikipedia.org)
  • After a detailed imaging and pathologic analysis, oncologists can tell their patients with CUP that metastasis does not always involve the formation of a primary tumor, and that their diagnostic evaluation is complete. (wikipedia.org)
  • lung tumors
  • According to the most recent revision (2004) of the World Health Organization (WHO) histological classification system for lung tumors ("WHO2004"), currently the most widely recognized typing scheme for pulmonary neoplasia, MCACL is considered a distinctive variant of adenocarcinoma. (wikipedia.org)
  • gastrointestinal tract
  • Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract. (bioportfolio.com)
  • A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. (wikipedia.org)
  • six years later these were shown to be of metastatic gastrointestinal tract origin. (wikipedia.org)
  • In 50% of all cases the primary tumor is of the gastrointestinal tract, other common sites include the breast, ovaries, bronchus and kidney. (wikipedia.org)
  • lymph node
  • In 1960, Klein and colleagues found that in mice, primary methylcholanthrene-induced sarcomas exhibited an antitumor immune response mediated by lymph node cells to cancer cells derived from the primary tumor. (wikipedia.org)
  • For instance, a woman in whom there is axillary lymphadenopathy (swelling in the lymph nodes of the armpit) it is likely that the cancer originated in the breast, and men with lymph node deposits in the mediastinum of the chest and/or retroperitoneal space of the abdomen may have a germ cell tumor. (wikipedia.org)
  • incidence
  • Dogs have an overall reported incidence of mammary tumors of 3.4 percent. (wikipedia.org)
  • An early survey found that the rate of tumor malignancy was 48% for girls and 67% for boys older than 2 months at the time of sacrococcygeal tumor diagnosis, compared with a malignant tumor incidence of 7% for girls and 10% for boys younger than 2 months at the time of diagnosis. (wikipedia.org)
  • biopsies
  • Further intrapatient tumor heterogeneity of these highlighted gene copy number changes was analyzed by fluorescence in situ hybridization (FISH) in all available primary and metastatic tumor biopsies, and ErbB2 protein expression was investigated by immunohistochemistry. (springer.com)
  • cutaneous
  • Florid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-TrĂ©lat may be highlighted as part of a continuum, with each having a common or similar pathogenic pathway due to an underlying malignancy that produces a factor epidermal growth factor-like activity. (wikipedia.org)
  • heterogeneity
  • The tumor microenvironment contributes to tumour heterogeneity. (wikipedia.org)
  • A study in 2014 argues the gap between these two controversial models can be bridged by providing an alternative explanation of tumor heterogeneity. (wikipedia.org)
  • But the existence of both biologically distinct non-CSC and CSC populations supports a more CSC model, proposing that both models may play a vital role in tumor heterogeneity. (wikipedia.org)
  • diagnosis
  • Goblet cell carcinoid (GCC) is an extraordinarily rare appendiceal tumor that is usually an incidental diagnosis on post-operative histology. (bioportfolio.com)
  • Other tumors can occur in the sacrococcygeal and/or presacral regions and hence must be ruled out to obtain a differential diagnosis. (wikipedia.org)
  • pulmonary
  • It can sometimes occur within a pulmonary bronchocele, and this tumor entity should be kept in mind after identification of a bronchocele with suspicious or non-prototypical imaging characteristics. (wikipedia.org)