Metastatic prostate cancer metastatic adenocarcinoma. Medical search. Frequent questions

Multiple, large autopsy series suggest that, in order of decreasing frequency, lung (40%), breast (20%), melanoma (10%), and enteric cancers (6%) are the most common primary tumors to metastasize to the brain. (medscape.com)
Prostate cancer should always be considered in the differential diagnosis of elderly men presenting with metastatic epithelial tumors even in unusual sites. (hindawi.com)
Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
Consistent with this evidence, Trop-2 expression is found to be increased in metastatic prostate tumors of Transgenic Adenocarcinoma of Mouse Prostate mice and to strongly correlate with α5β1 integrin levels. (jefferson.edu)
NEW YORK - By profiling genomic and clinical features in tumors from tens of thousands of cancer patients, a team led by investigators at Memorial Sloan Kettering Cancer Center has uncovered features that may help predict a tumor's metastatic potential and organ sites it may affect. (genomeweb.com)
As they reported in Cell on Thursday, the researchers analyzed targeted panel sequence data for 15,632 primary and 10,143 metastatic tumors from a total of 25,755 metastatic cancer patients in the MSK-MET cohort, including patients who had matched primary and metastatic tumor samples sequenced. (genomeweb.com)
In contrast to prior studies that centered on either primary or metastatic tumors as a group, the team set out to characterize integrated genomic and clinical features of metastatic disease in the context of cancer type and anatomic site of metastasis. (genomeweb.com)
Together with molecular data across 341 to 468 cancer genes profiled with the MSK-IMPACT clinical sequencing assay , these insights made it possible to compare molecular features found in tumors from primary or metastatic sites in individuals with or without metastases. (genomeweb.com)
The team's results revealed alterations that were relatively common in certain cancer types or in metastatic tumors springing up at specific target sites. (genomeweb.com)
Benign, or noncancerous tumors (e.g. leiomyoma), can occur in the prostate, but these are rare. (vin.com)
This study drug treatment will be evaluated to see if it is effective in shrinking and destroying prostate cancer tumors prior to surgery and to further evaluate its safety prior to prostate cancer surgery. (survivornet.com)
METHODS: Eighty-two bladder cancer fresh samples were collected via transurethral resection of bladder tumors. (bvsalud.org)
Metastatic bone tumors of the skeleton are caused when cancer from another part of the body spreads to the bones. (massgeneral.org)
Cancer spreading to the bones from elsewhere is much more common than cancer that begins in the bones (primary bone tumors). (massgeneral.org)
The most common kinds of metastatic bone tumors of the skeleton begin with prostate, breast, thyroid, lung, or kidney cancer. (massgeneral.org)
In children, metastatic skeletal tumors are usually due to neuroblastoma, leukemia or Ewing's sarcoma. (massgeneral.org)
Metastatic tumors from the kidney or thyroid are usually very vascular (made of blood vessels) whereas tumors from prostate, breast and lung are less so. (massgeneral.org)
The JNK-deficient progenitor cells display increased proliferation and tumorigenic potential compared with progenitor cells from control prostate tumors. (mssm.edu)
No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
Lung tumors include small cell cancer. (medscape.com)
it is usually higher in large, metastatic, and well-differentiated tumors. (medscape.com)

Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). (snmjournals.org)
Prostate-specific antigen (PSA) was determined every 4 wk. (snmjournals.org)
Prostate-specific membrane antigen (PSMA) is a promising target for directing new therapies. (snmjournals.org)
Participants will undergo regular testing for signs of disease progression using computed tomography (CT) scans, magnetic resonance imaging (MRI), bone scans, and prostate-specific antigen (PSA) blood tests. (uclahealth.org)
Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
Here, we present the case of a 67-year-old male patient with incidental findings of mediastinal and retroperitoneal masses which were found to be due to metastatic prostate adenocarcinoma based on histopathology and immunohistochemical studies and later on supported by the significantly elevated Prostate Specific Antigen (PSA) levels. (hindawi.com)
At that time, his Prostate Specific Antigen (PSA) level was around 77.2 ug/L, but no prostate biopsy was done. (hindawi.com)
Older age is the main risk factor, but, since the introduction of the serum Prostate Specific Antigen (PSA) as a screening test in the late 1980s, prostate cancer has been diagnosed at younger ages and earlier stages. (hindawi.com)
Trial Description: This study will evaluate the safety and efficacy of a prostate cancer vaccine named Proscavax ( Prostate -specific antigen(PSA) / Interleukin-2(IL-2) / Granulocyte-macrophage colony-stimulating factor(GM-CSF)) in patients with localized prostate cancer . (dana-farber.org)
There was only a slight decrease in prostate-specific antigen (PSA) level and pelvic disease post treatment. (jpalliativecare.com)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
Data obtained from patients with androgen- independent prostatic carcinoma have revealed that prostate-specific antigen (PSA) correlates with survival in patients with normal bombesin levels. (cancernetwork.com)
Prostate cancer treatment options are historically based on clinical stage, prostate specific antigen ( PSA ) blood test, and tumor grade. (survivornet.com)
To determine the median time to prostate-specific antigen (PSA) progression by Prostate Cancer Clinical Trials Working Group 3 (PCWG3) criteria. (ucsf.edu)
Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided. (justia.com)
In one aspect, there is provided a use of an antigen-binding protein, or an antigen-binding fragment thereof as defined herein in the manufacture of a medicament for treating cancer. (justia.com)
In general, immunohistochemical staining for prostate-specific acid phosphatase (PSAP) was more intense than for prostate-specific antigen (PSA), in contrast to several other reports using these antisera. (citationimpact.com)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)

however, PTEN loss is a lead mechanism for prostate cancer resistance to AR directed therapy and development of castrate resistant prostate cancer. (survivornet.com)
SEAL BEACH, Calif.-( BUSINESS WIRE )-Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, today announced publication of results from its PROCEED registry, which evaluated real-world use of PROVENGE ® (sipuleucel-T) in men with asymptomatic or minimally symptomatic metastatic castrate-resistant prostate cancer (mCRPC). (gabio.org)
Episode 4: New Metastatic Castrate-Resistant Prostate Cancer Therapies Drs Sandhya Srinivas and Oliver Sartor discuss the VISION study, new therapies for patients with metastatic castrate-resistant prostate cancer, and PSMA biomarker-based imaging. (medscape.com)

Metastasis to the brain is the most feared complication of systemic cancer and the most common intracranial tumor in adults. (medscape.com)
Even though it is less sensitive than MRI in tumor detection and characterization, non-contrast CT imaging is commonly performed as the first screening modality in emergent situations where a patient presents with new-onset neurologic symptoms, because it is highly sensitive in detecting the acute life-threatening complications (ie, hemorrhage, hydrocephalus, and herniation) of metastatic disease. (medscape.com)
The study is enrolling people who have metastatic castration-sensitive prostate cancer and have an inherited or tumor mutation in one of the following genes involved in DNA damage repair: BRCA2, BRCA1, BRIP1, CHEK2, FANCA, PALB2, RAD51B and RAD54L. (facingourrisk.org)
Radiotherapy is a standard treatment for localized prostate cancer, for palliative management of mCRPC, and even radiopharmaceuticals targeting the surrounding bone matrix instead of the tumor itself can improve survival ( 5 ). (snmjournals.org)
Another hematologic or solid tumor ≥ stage 1 malignancy that completed surgery, last dose of radiotherapy, or last dose of systemic anti-cancer therapy ≤ 2 years from first dose of study treatment. (uclahealth.org)
Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. (dana-farber.org)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
Our work shows that genomic alterations identified in tumor samples can inform our understanding of a tumor's potential to metastasize, at least in some cancer types ," senior author Nikolaus Schultz, a researcher at MSKCC, said in an email. (genomeweb.com)
With insights from more than 99,400 metastatic events identified in 21,546 metastatic cancer patients, they flagged genomic patterns corresponding to metastases from dozens of cancer types that affected 21 different organs, along with suspicious primary tumor changes in individuals with metastatic disease. (genomeweb.com)
Even though most cancer deaths are due to metastatic disease, predicting whether or not an early-stage tumor will metastasize - as well as what organs will be eventually affected by metastases - remains a formidable challenge," Schultz explained. (genomeweb.com)
On the other hand, they found that high-grade serous ovarian or colorectal cancers were more often marked by copy number changes linked to relatively early stages in the tumor development process. (genomeweb.com)
MSK investigators are now gearing up to do related research focused on treatments that target metastatic tumor drivers through the newly-funded Marie- Jos é e and Henry R. Kravis Cancer Ecosystems Project. (genomeweb.com)
We hope that [MSK-MET] will be a valuable resource for the community and will stimulate further research and applications in cancer care," the authors wrote, adding that "more integrated studies are needed to fully investigate the impact of tumor cell-extrinsic effects, such as cancer therapy, target-organ microenvironment, and systemic factors. (genomeweb.com)
Although hormonal treatment is an important palliative measure in the management of patients with advanced prostate carcinoma, the vast majority of cases end in relapse due to overgrowth of androgen-independent tumor cell populations [1]. (cancernetwork.com)
High-risk prostate cancers treated surgically commonly exhibit loss of the phosphatase and tensin homologue (PTEN) tumor suppressor gene, which leads to increased activity of the AKT signaling pathway. (survivornet.com)
Eligible patients with high-risk prostate cancer exhibiting 10% PTEN staining by IHC will be exposed to a 4-week run-in of iADT, followed by dedicated research biopsy of the tumor to be used for correlative research, then treated with 16 weeks of combined iADT with AKT inhibition (capivasertib). (survivornet.com)
Participants must be willing to undergo metastatic tumor biopsy during Screening. (ucsf.edu)
Bone metastases, or bone mets, occur when cancer cells from a primary tumor spread to the bone. (massgeneral.org)
Game Changer': Health Professionals' Views on the Clinical Utility of Circulating Tumor DNA Testing in Hereditary Cancer Syndrome Management. (cdc.gov)
Prostate Cancer e-Tumor Boards: Case 5: Favorable Intermediate Risk CaP This case focuses on a patient in his early 60s diagnosed with clinically localized prostate cancer. (medscape.com)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)

The goal of the study is to determine if vaccine administration results in a change in the rate of prostate cancer progression when compared to a no-treatment control group of active surveillance patients. (dana-farber.org)
Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression," the authors wrote. (genomeweb.com)
This review will examine the evidence for the neuroendocrine progression of prostate cancer and the clinical utility of chemothera- peutic agents that are being investigated for the management of late stage disease. (cancernetwork.com)
Preliminary data suggests that these markers may contribute to prostate cancer progression. (cancernetwork.com)
Thus, FOXA1 mutations alter its pioneering function and perturb normal luminal epithelial differentiation programs, providing further support for the role of lineage plasticity in cancer progression. (escholarship.org)
This is a Phase 1b/2 study evaluating FOR46 in combination with enzalutamide in patients with metastatic castration resistant prostate cancer (mCRPC) after prior progression on abiraterone. (ucsf.edu)
Andrew Armstrong, MD, ScM, Duke Cancer Institute, Durham, N.C. and an investigator in the trial, said, 'Preventing or delaying radiographic progression is an important clinical endpoint in assessing cancer treatment and is very important to patients, their caregivers and their families. (yahoo.com)
These data demonstrate that the JNK and PTEN signaling pathways can cooperate to regulate the progression of prostate neoplasia to invasive adenocarcinoma. (mssm.edu)
The purpose of the study is to compare progression-free survival in chemotherapy-naïve, post-abiraterone-treated metastatic castration-resistant prostate cancer patients treated with enzalutamide and LY2157299 versus enzalutamide alone. (hopkinsmedicine.org)

The incidence of brain metastasis is rising with the increase in survival of cancer patients. (medscape.com)
Brain metastasis affects up to one third of adults with cancer and carries a historically bleak prognosis. (medscape.com)
Penile metastasis of prostatic adenocarcinoma. (urotoday.com)
Bone-targeting properties of (223)Ra could also potentially be used for treating skeletal metastasis from other primary cancers. (researchgate.net)
Here, we report a case of prostate cancer in 28-year-old male who presented with bone metastasis. (jpalliativecare.com)
The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age. (jpalliativecare.com)
Using electronic health record data, the researchers searched for patients with metastatic disease and information about the timing of metastasis. (genomeweb.com)
PTEN loss is associated with higher rates of prostate cancer recurrence, metastasis, and cancer mortality. (survivornet.com)
Although prostate cancer has a propensity to metastasize to the bone, metastasis to the mandible is rare. (bezmialem.edu.tr)
Because of their uncommon incidence, the diagnosis of mandibular metastasis, especially those originating from the prostate, may represent a challenge both for urologists and dentists. (bezmialem.edu.tr)
A 72 years old female that 8 years ago was diagnosed with adenocarcinoma of the sigma with liver metastasis. (doctorsmedicalopinion.com)
The histologic subtype, metastasis site, and certain patient characteristics can offer clues to the cancer primary. (medscape.com)
This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)

Cancer patients now live longer as a result of important advances in cancer diagnosis and management-particularly, the widespread use of magnetic resonance imaging (MRI) to detect small metastases. (medscape.com)
Pure small cell carcinoma of the prostate (SCPCa) is a very rare condition usually with poor survival after diagnosis. (karger.com)
The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)
A veterinary pathologist will look at the cells from the tissue sample to diagnosis the cancer. (vin.com)
Dave Fredrickson, executive vice president, oncology business unit, AstraZeneca, said, 'There is a critical unmet need for new first-line treatment options for patients with BRCA m mCRPC, and this approval underscores the importance of BRCA testing at metastatic diagnosis. (yahoo.com)
Of these, 9 men and 2 women had presented diagnosis of mouth's cancer. (bvsalud.org)

Prostate biopsy performed on 05/23/2016 showed bilateral adenocarcinoma, Gleason 4+5 equals 9 disease. (cancer.org)
A biopsy (i.e. or removal of a tissue sample) of the prostate is the only sure way to confirm that an abnormal prostate is cancerous. (vin.com)
His biopsy was bilaterally positive, so both the left and the right side contained cancer. (medscape.com)

Prior chemotherapy treatment for castration-sensitive or castration-resistant prostate cancer (docetaxel or cabazitaxel). (orlandohealth.com)
Despite recent approval of some novel drugs, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease and additional treatment options are still needed. (snmjournals.org)
The study will enroll participants with metastatic castration-resistant prostate cancer (mCRPC) previously treated with one prior androgen receptor axis-targeted therapy (ARAT). (uclahealth.org)
Received 1 prior ARAT for metastatic or non-metastatic, castration-sensitive or castration-resistant prostate cancer. (uclahealth.org)
For metastatic castration-resistant prostate cancer, the recommended dose of TAXOTERE is 75 mg/m 2 every 3 weeks as a 1-hour intravenous infusion. (drugs.com)
and with cisplatin for unresectable, locally advanced or metastatic untreated NSCLC (1.2), 3 Castration-Resistant Prostate Cancer (CRPC): with prednisone in metastatic castration-resistant prostate cancer (1.3), 4 Gastric Adenocarcinoma (GC): with cisplatin and fluorouracil for untreated, advanced GC, including the gastroesophageal junction (1.4), 5 Squamous Cell Carcinoma of the Head and Neck (SCCHN): with cisplatin and fluorouracil for induction treatment of locally advanced SCCHN (1.5). (hipaaspace.com)
This phase I/II trial studies the best dose and side effects of olaparib and how well it works with radium Ra 223 dichloride in treating patients with castration-resistant prostate cancer that has spread to the bone and other places in the body. (endourology.ph)
Giving olaparib and radium Ra 223 dichloride may work better at treating castration-resistant prostate cancer. (endourology.ph)
78-years-old male with poorly differentiated hormone resistant prostate cancer. (doctorsmedicalopinion.com)
Episode 2: Castration-Resistant Prostate Cancer Treatment Options Drs Sandhya Srinivas and Shilpa Gupta discuss castration-resistant prostate cancer and the sequence, method of therapy, and specific patient populations in which these drugs will be most effective. (medscape.com)

For locally advanced or metastatic breast cancer after failure of prior chemotherapy, the recommended dose of TAXOTERE is 60 mg/m 2 to 100 mg/m 2 administered intravenously over 1 hour every 3 weeks. (drugs.com)

Participants must have ≥ 1 metastatic lesion that is present on magnetic resonance imaging (MRI), computed tomography (CT), or bone scan obtained ≤ 28 days prior to initiation of study treatment. (uclahealth.org)
The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)
patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic adenocarcinoma metastatic to bone is reported. (scienceopen.com)
The use of more reliable prognostic tools or staging systems may overcome this difficulty and a nonhistological prostate cancer staging system has already shown that patients with visceral involvement but minimal bone disease have the highest chance of responding to a combination of doxorubicin, mitomycin-C, and 5-fluorouracil. (cancernetwork.com)
The bone is a common site for metastatic disease. (massgeneral.org)
In patients with a history of cancer, a bone scan will show any additional sites of skeletal involvement. (massgeneral.org)
metastatic disease radiographically documented by CT/MRI or bone scan. (hopkinsmedicine.org)
Episode 1: Androgen Deprivation Therapy and Prostate Cancer Drs Sandhya Srinivas and Rana R. McKay discuss bone health and survivorship, including risk factors and potential side effects with androgen deprivation therapy in patients with prostate cancer. (medscape.com)

Brain metastases are an increasingly important cause of morbidity and mortality among cancer patients. (medscape.com)
With regard to screening for intracranial metastases, no consensus has been reached concerning when CT or MRI should be used for initial staging evaluation of a patient with cancer. (medscape.com)
Unusual prostate carcinoma metastases are usually encountered in the presence of known advanced disease but rarely as the first presentation. (hindawi.com)
These cancers were also less likely to show metastases-associated chromosomal stability. (genomeweb.com)
The researchers also found associations between primary cancer subtypes and the body sites that were later impacted by metastatic disease, including an overrepresentation in liver metastases among patients with metastatic forms of lung neuroendocrine cancer and an uptick in ovarian or peritoneum metastases in individuals with advanced lobular breast cancer. (genomeweb.com)
Metastases after age 30 are usually adenocarcinoma (a type of cancer that involves the cells lining the walls of different organs in the body). (massgeneral.org)
Twenty-two of 26 metastases were high grade and often were not histologically suggestive of prostate carcinoma. (citationimpact.com)
Blastic metastases are seen in patients with primary prostate cancer or in patients who have undergone treatment for breast cancer. (medscape.com)
The potential for improved outcome in patients with hepatic metastases from colon cancer: A population-based study. (cancercentrum.se)

Participants who had curative therapy for non-melanomatous skin cancer or for localized malignancy are eligible. (uclahealth.org)
CA 125 is useful for evaluating pelvic masses in postmenopausal women, monitoring response to therapy in women with ovarian cancer, and detecting recurrence of this malignancy. (aafp.org)
PSA is used to screen for prostate cancer, detect recurrence of the malignancy, and evaluate specific syndromes of adenocarcinoma of unknown primary. (aafp.org)
Prostate cancer, the most commonly diagnosed malignancy, has become the second leading cause of cancer-related deaths among men in the United States [ 1 ]. (jcancer.org)
Most prostate cancers from the TZ exhibit relatively low malignancy. (jcancer.org)
However, the underlying mechanisms for the differential cancer origination and malignancy remains unknown [ 3 ]. (jcancer.org)
Prostate cancer is one of the commonest types of malignancy in males. (bezmialem.edu.tr)

Prostate carcinoma is the second most common malignant disease in men. (hindawi.com)
Prostate cancer is the second most common noncutaneous malignant disease in men worldwide. (hindawi.com)
More than two-thirds of patients with ovarian cancer are diagnosed with advanced disease, and approximately 50-70% of these patients die within five years. (merck.com)
The Phase 3 PAOLA-1 trial evaluated LYNPARZA in combination with bevacizumab as first-line maintenance therapy in patients with advanced ovarian cancer, who were without evidence of disease after surgery or following response to platinum-based chemotherapy. (merck.com)
By publicly releasing clinical and genomic data from more than 25,000 patients," he added, "we hope that this will become a valuable resource for the community that will empower researchers and facilitate the study of metastatic disease. (genomeweb.com)
The goal is that early precision treatment of aggressive disease will result minimal residual cancer at the time of prostatectomy, and subsequently improved cancer outcomes. (survivornet.com)
Staging studies are usually done to determine the extent of the metastatic disease and plan the most appropriate treatment. (massgeneral.org)
Chemotherapy, use of hormones and palliative radiation therapy, that is radiation to treat the symptoms not cure, are other options used to care for patients with metastatic disease. (massgeneral.org)
Metastatic disease is very serious, but advances in cancer care mean that many patients still have significant amounts of quality time for themselves and their families. (massgeneral.org)
These patients living with metastatic disease have a phenomenal amount of inner strength and hope. (massgeneral.org)
Radiation therapy plays an important role in the management of these diverse malignancies, including its use prior to surgery, as definitive treatment with chemotherapy and for palliation of local or metastatic disease. (rochester.edu)
Metastatic prostate carcinoma should be ruled out by using immunoperoxidase for PSA and PSAP in all men over 45 presenting with carcinoma of unknown primary origin in left-sided supradiaphragmatic lymph nodes, even in the absence of bony disease, elevated serum acid phosphatase (SAP), abnormal rectal examination, and a histologic picture suggesting prostate carcinoma. (citationimpact.com)

A prostate MRI performed on 05/17/2016 showed metastatic bilateral iliac lymphadenopathy and right femoral osseous metastatic lesion. (cancer.org)
If there is no safely accessible metastatic lesion, this requirement will be waived. (ucsf.edu)
The radiologist plays a primary role in the management of cancer patients by helping detect, localize, and diagnose the lesion. (medscape.com)

Histologically confirmed adenocarcinoma of the prostate without evidence of neuroendocrine differentiation, signet cell, or small cell features. (uclahealth.org)
Neuroendocrine differentiation has been foundin 50% to 100% of prostate neoplasms of all stages. (cancernetwork.com)
However, the proportion of neuroendocrine differentiation was found to be much higher in follow-up studies and it is now thought that 50% to 100% of all prostate neoplasms (including benign prostatic tissue) contain at least some neuroendocrine cells [3,5]. (cancernetwork.com)

RAHWAY, N.J.--(BUSINESS WIRE)-- AstraZeneca and Merck, known as MSD outside of the United States and Canada, today announced long-term follow-up results from the Phase 3 PAOLA-1 and SOLO-1 trials in first-line advanced ovarian cancer, which represent the longest-term data for any PARP inhibitor in this setting. (merck.com)
Ovarian cancer is one of the most common gynecologic cancers and has the worst prognosis and highest mortality rate. (merck.com)
p=0.4118) in patients with newly diagnosed advanced ovarian cancer. (merck.com)
Practice guidelines for BRCA1/2 tumour testing in ovarian cancer. (cdc.gov)

Of those, 95% were treated with PROVENGE as first-line therapy for mCRPC as recommended by the National Comprehensive Cancer Network (NCCN). (gabio.org)
In the U.S., prostate cancer is the second most common cancer in men, and despite an increase in the number of available therapies for patients with mCRPC, five-year survival remains low. (yahoo.com)

Beyond these, it was found one patient of buccal melanoma and one patient of a metastatic adenocarcinoma of prostate origin. (bvsalud.org)

Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)

For the adjuvant treatment of operable node-positive breast cancer, the recommended TAXOTERE dose is 75 mg/m 2 administered 1 hour after doxorubicin 50 mg/m 2 and cyclophosphamide 500 mg/m 2 every 3 weeks for 6 courses. (drugs.com)
CA 27.29 is highly associated with breast cancer, although levels are elevated in several other malignancies ( Table 1 ) . (aafp.org)
Oligometastatic breast cancer treated with hypofractionated stereotactic radiotherapy: Some patients survive longer than a decade. (rochester.edu)
Contribution of large genomic rearrangements in PALB2 to familial breast cancer: implications for genetic testing. (cdc.gov)
Understanding Racial and Ethnic Inequities in Uptake and Outcomes Following Multigene Prognostic Testing in Early Breast Cancer: The Promise of Real-World Data. (cdc.gov)
Breast Cancer Phenotype Associated With Li-Fraumeni Syndrome: A Brazilian Cohort Enriched by TP53 p.R337H Carriers. (cdc.gov)
The risk of distant recurrence in breast cancer patients is difficult to prognostic indices, such as the Nottingham Prognostic Index (6, 7), assess with current clinical and histopathological parameters, and have proven valuable in identifying patients with poor prognosis. (lu.se)
However, a simple way to screened 240 sera from 64 patients with primary breast cancer. (lu.se)
The risk of developing distant strated enough prognostic accuracy in breast cancer (10). (lu.se)
The samples were collected from breast cancer patients rent procedures. (lu.se)
Survival from breast cancer has improved during the past dec- markerserumlevelshavebeenusedpreviously,e.g.,incalculating ades in the Western world. (lu.se)

I also have expertise in stereotactic body radiation therapy for the treatment of primary and metastatic gastrointestinal malignancies. (rochester.edu)

The association between CALN1 methylation percentage and clinicopathological variables of all cases and intravesical recurrence of non-muscle-invasive bladder cancer (non-MIBC) cases were analyzed. (bvsalud.org)
Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer. (cancercentrum.se)
Loco-regional recurrence from colon cancer: A population-based study. (cancercentrum.se)

Thus, neuroendocrine-specific growth factors such as bombesin represent novel therapeutic targets and may also be important in the selection of patients for aggressive chemotherapy, which has been rather ineffective in prostate cancer. (cancernetwork.com)

Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme" (PDF). (wikipedia.org)
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. (uchicagomedicine.org)
Association of Family History of Cancer with Clinical and Pathological Outcomes for Prostate Cancer Patients on Active Surveillance. (cdc.gov)
Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
Impact of a surgical training programme on rectal cancer outcomes in Stockholm. (cancercentrum.se)

Combined with observations of neuroendocrine enrichment in cases of poor clinical response to androgen deprivation therapy, these findings support the notion that the clonal expansion of AR-negative neuroendocrine cells may play a critical role in the development of androgen-insensitive metastatic prostate cancer. (cancernetwork.com)
Prostate cancer (PC) patients receiving androgen deprivation therapy (ADT) were treated as exposed. (springer.com)

Besides the PATCH trial, the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial, also in the United Kingdom, added a high-dose transdermal estradiol patches arm with approximately 2,000 men in July 2017. (wikipedia.org)
No other systemic anti-cancer therapies administered other than LHRH analogue within 14 days or, 5 half-lives, whichever is shorter, prior to initiation of study treatment. (ucsf.edu)

In particular, an increase in chromosomal instability turned up in metastatic forms of lung or prostate adenocarcinomas and in hormone receptor- and HER2-positive breast carcinomas originating in the duct, the researchers reported. (genomeweb.com)
Economic Analysis of Exclusionary EGFR Test Versus Up-Front NGS for Lung Adenocarcinoma in High EGFR Mutation Prevalence Areas. (cdc.gov)
Targeted RNA sequencing for upfront analysis of actionable driver alterations in non-small cell lung cancer. (cdc.gov)
circ_0000567/miR-421/TMEM100 Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis. (cdc.gov)

It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma. (globaldata.com)
Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine? (lu.se)
Cancer Epidemiol Biomarkers Prev 2008;17:3062- to pancreatic cancer. (who.int)

Trial Description: The IMPACT study is an international targeted prostate screening study of men at increased prostate cancer risk due to the presence of known pathogenic mutations in BRCA1 and BRCA2 genes. (dana-farber.org)
Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown 1-9 . (escholarship.org)
Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the forkhead domain: Wing2 (around 50% of all mutations) and the highly conserved DNA-contact residue R219 (around 5% of all mutations). (escholarship.org)
Wing2 mutations are detected in adenocarcinomas at all stages, whereas R219 mutations are enriched in metastatic tumours with neuroendocrine histology. (escholarship.org)
Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. (cdc.gov)

The prostate gland surrounds the opening of his urinary bladder, which collects urine, as well as the urethra, a tube-like structure that sends urine from the bladder to outside the body. (vin.com)
Cancers that have spread from elsewhere in the body are also uncommon but can include lymphoma, which is associated with the immune system, and transitional cell carcinoma, a common cancer found in and around the bladder. (vin.com)
We investigated the usefulness of the methylation status of CALN1 as a biomarker for bladder cancer using methylation-sensitive restriction enzyme (MSRE)-quantitative polymerase chain reaction (qPCR). (bvsalud.org)
CONCLUSION: Our findings suggest that CALN1 methylation percentage could be a useful molecular biomarker for bladder cancer. (bvsalud.org)
S2 Episode 3: Personalized Medicine in Bladder Cancer: Inflection Point Drs Cheryl Lee and Tom Powles talk about ctDNA and personalized medicine approaches for advanced bladder cancer as we sit at the precipice of change. (medscape.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

If the prostate is enlarged, it could be pressing on the colon, which collects feces (poop), making it difficult for him to poop. (vin.com)
This population-based study found an increased risk of CRC among PC patients exposed to ADT, specifically adenocarcinoma of the distal colon, which indicates an increased association between ADT (PC + ADT) and CRC but not a positive dose-response trend questioning a true causal effect. (springer.com)
Improved survival in cancer of the colon and rectum in Sweden. (cancercentrum.se)
Cancer staging and survival in colon cancer is dependent on the quality of the pathologists' specimen examination. (cancercentrum.se)
Colon cancer management and outcome in relation to individual hospitals in a defined population. (cancercentrum.se)
Segelman J, Singnomklao T, Hellborg H, Martling A. Differences in MDT assessment and treatment between patients with stage IV colon and rectal cancer. (cancercentrum.se)
Suggested citation for this article: Redwood D, Provost E, Asay E, Ferguson J, Muller J. Giant Inflatable Colon and Community Knowledge, Intention, and Social Support for Colorectal Cancer Screening. (cdc.gov)

The purpose of this study is to learn about how an investigational drug intervention completed before doing prostate surgery (specifically, radical prostatectomy with lymph node dissection) may help in treatment of high risk localized prostate cancer s that are most resistant to standard treatments. (survivornet.com)
abiraterone and leuprolide) with an AKT inhibitor (capivasertib) prior to radical prostatectomy among high-risk localized prostate cancers with PTEN loss. (survivornet.com)

In this study, we show that the transmembrane glycoprotein Trop-2 is up-regulated in human prostate cancer (PCa) with extracapsular extension (stages pT3/pT4) as compared to organ-confined (stage pT2) PCa. (jefferson.edu)

In one series, mediastinal adenopathy was reported as the initial presentation in only 0.8% of patients with prostate cancer [ 2 ]. (hindawi.com)
Hormone therapy for most patients with prostate cancer aims to remove or block the function of the male hormone androgen. (jcancer.org)
A retrospective medical record review of 66 patients with prostate cancer (PCa) was performed. (biomedcentral.com)
Episode 3: Prostate Cancer, Germline Testing, and PARP Inhibitors Drs Sandhya Srinivas and Heather Cheng discuss PARP inhibitors, clinical trials, and germline vs somatic testing for patients with prostate cancer, as well as the optimal time for this testing. (medscape.com)

The decision to perform imaging for patients with other cancers is made on the basis of the clinical evaluation. (medscape.com)
It seems to show different clinical features compared to other prostate cancer subtypes, specifically adenocarcinoma. (karger.com)
Larger clinical trials are warranted to study (223)Ra on the prevention of SREs and on overall survival in patients with hormone-refractory prostate cancer. (researchgate.net)
Zimberelimab is under clinical development by Arcus Biosciences and currently in Phase II for Esophageal Cancer. (pharmaceutical-technology.com)
Arcus Biosciences operates as a clinical-stage biopharmaceutical company focused on creating innovative cancer immunotherapies by leveraging underexploited biological opportunities. (pharmaceutical-technology.com)
Clinical and genomic data generated for participants from the MSK-MET cohort so far is available online via the cBioPortal for Cancer Genomics database. (genomeweb.com)
The clinical relevance of immunohistological detection of neuroendocrine tissue in prostate cancer patients has been the focus of many investigators. (cancernetwork.com)
Clinical stage T3 (resectable), per AJCC Cancer Staging Manual, 8th ed. (survivornet.com)

BACKGROUND & AIMS: Because malnutrition adversely affects the prognosis of patients with cancer, accurate nutritional status assessment is important. (bvsalud.org)

People with Metastatic Hormone Sensitive Prostate Cancer are asked to participate in a research study being conducted by Montefiore Medical Center. (brany.com)
Episode 5: Metastatic Hormone-Sensitive Prostate Cancer Therapies Drs Sandhya Srinivas and Tanya B. Dorff discuss metastatic hormone-sensitive prostate cancer, which patients are the best candidates for doublets vs triplets, and how we pick these patients. (medscape.com)

abstract = "The c-Jun NH2-terminal kinase (JNK) signal transduction pathway is implicated in cancer, but the role of JNK in tumorigenesis is poorly understood. (mssm.edu)

At present, most cases of prostate cancer are diagnosed on prostate needle biopsies performed either for elevated serum PSA levels or for abnormal prostate on digital rectal exam [ 1 , 3 ]. (hindawi.com)

ASTRO 2023: Exploring the Potential for SBRT Martin King, MD, PhD, offers insights on SBRT's potential to redefine treatment in prostate and renal cancer. (medscape.com)

AFP and β-hCG also may be useful in evaluating potential origins of poorly differentiated metastatic cancer. (aafp.org)
78 years old male patient diagnosed 6 years ago with poorly differentiated prostate cancer. (doctorsmedicalopinion.com)

Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)

To assess whether androgens play a role in explaining the sex related differences in the incidence of colorectal cancer (CRC). (springer.com)
Colorectal cancer (CRC) is the third most common cancer in men, the second most common cancer in women and the second most common cause of cancer death in both sexes when analyzed separately, accounting for 1 in 10 cancer cases and deaths globally [ 1 ]. (springer.com)
A Practical Overview of the Stool DNA Test for Colorectal Cancer Screening. (cdc.gov)
Registration and validity of surgical complications in colorectal cancer surgery. (cancercentrum.se)
Elective surgery for colorectal cancer in a defined population. (cancercentrum.se)
Colorectal cancer (CRC) is the second-leading cause of deaths from cancer in the United States. (cdc.gov)

PROVENGE is an autologous cellular immunotherapy indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant (hormone-refractory) prostate cancer. (gabio.org)

For gastric adenocarcinoma, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion, followed by cisplatin 75 mg/m 2 , as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the cisplatin infusion. (drugs.com)

The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)

We identified 26 cases of metastatic prostatic carcinoma in supradiaphragmatic lymph nodes from 1972-1987. (citationimpact.com)

the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)
Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)

BACKGROUND: DNA methylation in cancer is considered a diagnostic and predictive biomarker. (bvsalud.org)

Trial Description: This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. (dana-farber.org)

The Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) study is a large randomized controlled trial in the United Kingdom of high-dose transdermal estradiol patches versus gonadotropin-releasing hormone agonist therapy in the treatment of prostate cancer in men. (wikipedia.org)
Trial Description: This trial is testing whether molecularly targeted oral medications called talazoparib and tazemetostat can be safely combined for the treatment of prostate cancer , and whether the combination is effective in shrinking or preventing the growth of metastatic prostate cancer . (dana-farber.org)
PROVENGE is the only FDA-approved immunotherapy made from a patient's own immune cells for the treatment of prostate cancer. (gabio.org)

The median survival of four years following treatment with PROVENGE is meaningful," said Celestia S. Higano, M.D., FACP, lead author of the PROCEED analysis, and professor, Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center. (gabio.org)
I was drawn to gastrointestinal oncology because it is a challenging field, which includes some of the most lethal cancers. (rochester.edu)
Genomic sequencing in oncology: Considerations for integration in routine cancer care. (cdc.gov)

In summary, our findings show that Trop-2 promotes an α5β1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa. (jefferson.edu)
Here, we demonstrate that the JNK signaling pathway reduces the development of invasive adenocarcinoma in the phosphatase and tensin homolog (Pten) conditional deletion model of prostate cancer. (mssm.edu)

Antibiotics may be needed if urinary tract or prostate infections occur secondary to the cancer. (vin.com)
While seven cases had a history of prostate cancer, the rest presented with enlarged nodes alone or with simultaneous urinary obstructive symptoms. (citationimpact.com)

Research has shown that these men are at an increased risk of developing prostate cancer but more information is needed about the pathogenesis of prostate cancer in this defined group and the role of screening in these men. (dana-farber.org)
Prostate Cancer Screening Guidelines: To PSA or Not to PSA As primary care physicians, a large part of our role is to prevent or detect cancers early. (medscape.com)
Health Interview Survey and the National Cancer Institute's Health Information National Trends Survey (HINTS) show associations between CRC knowledge, awareness, and intention to screen and receiving screening (8-10). (cdc.gov)

Approximately 40% of intracranial neoplasms are metastatic. (medscape.com)

In early stages of prostate cancer, your dog may not show any symptoms at all. (vin.com)
The model depicted CRC stages from normal tissue to advanced adenocarcinoma and displayed signs with CRC prevention tips. (cdc.gov)

These glands and ducts are distributed in the prostate and surrounded by stromal tissues. (jcancer.org)
The fundamental basis of antibody-based cancer therapy is the fact that cancerous tissues express an array of antigens that may be overexpressed, selectively expressed or mutated compared to normal, non-cancerous tissue. (justia.com)

Anatomy13

Organisms4

Diseases53

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Psychiatry and Psychology2

Phenomena and Processes42

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science9

Named Groups2

Health Care34

Geographicals1

Tumors21

Antigen21

Castrate resistant prostate cancer3

Tumor22

Progression9

Metastasis13

Diagnosis6

Biopsy3

Resistant Prostate Cancer10

Locally advanced or metastatic1

Bone10

Metastases9

Malignancy7

Disease12

Lesion3

Neuroendocrine differentiation3

Ovarian cancer4

MCRPC2

Melanoma1

Epithelial2

Breast cancer11

Primary and metastatic1

Recurrence3

Chemotherapy1

Outcomes5

Androgen deprivation2

Systemic2

Lung4

Pancreatic3

Mutations5

Bladder6

Colon7

Radical Prostatectomy2

Human prostate1

Patients with prostate cancer4

Clinical8

Prognosis1

Hormone Sensitive2

Abstract1

Serum1

Renal1

Poorly differentiated2

Lymphadenopathy1

Colorectal6

Symptomatic1

Gastric1

Radiotherapy2

Prostatic carcinoma1

Cervical2

Biomarker1

Lymph node1

Treatment of prostate cancer3

Oncology3

Signaling pathway2

Urinary2

Screening3

Neoplasms1

Stages2

Tissues2