Metastatic prostate cancer lung cancer adenocarcinoma. Medical search. Frequent questions

Multiple, large autopsy series suggest that, in order of decreasing frequency, lung (40%), breast (20%), melanoma (10%), and enteric cancers (6%) are the most common primary tumors to metastasize to the brain. (medscape.com)
NEW YORK - By profiling genomic and clinical features in tumors from tens of thousands of cancer patients, a team led by investigators at Memorial Sloan Kettering Cancer Center has uncovered features that may help predict a tumor's metastatic potential and organ sites it may affect. (genomeweb.com)
As they reported in Cell on Thursday, the researchers analyzed targeted panel sequence data for 15,632 primary and 10,143 metastatic tumors from a total of 25,755 metastatic cancer patients in the MSK-MET cohort, including patients who had matched primary and metastatic tumor samples sequenced. (genomeweb.com)
In contrast to prior studies that centered on either primary or metastatic tumors as a group, the team set out to characterize integrated genomic and clinical features of metastatic disease in the context of cancer type and anatomic site of metastasis. (genomeweb.com)
Together with molecular data across 341 to 468 cancer genes profiled with the MSK-IMPACT clinical sequencing assay , these insights made it possible to compare molecular features found in tumors from primary or metastatic sites in individuals with or without metastases. (genomeweb.com)
The team's results revealed alterations that were relatively common in certain cancer types or in metastatic tumors springing up at specific target sites. (genomeweb.com)
The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
Metastatic bone tumors of the skeleton are caused when cancer from another part of the body spreads to the bones. (massgeneral.org)
Cancer spreading to the bones from elsewhere is much more common than cancer that begins in the bones (primary bone tumors). (massgeneral.org)
The most common kinds of metastatic bone tumors of the skeleton begin with prostate, breast, thyroid, lung, or kidney cancer. (massgeneral.org)
In children, metastatic skeletal tumors are usually due to neuroblastoma, leukemia or Ewing's sarcoma. (massgeneral.org)
Metastatic tumors from the kidney or thyroid are usually very vascular (made of blood vessels) whereas tumors from prostate, breast and lung are less so. (massgeneral.org)
Lung and breast tumors are the most common primary malignancies to affect the skull. (medscape.com)
Cancer is a disease in which tumors form and spread to nearby tissues (metastasis). (brachytherapy.net)
Cancer is an umbrella term encompassing many conditions that impact tissues and organs throughout the body, typically developing when cells proliferate uncontrollably, damaging healthy tissues while spreading to other parts of the body where they continue to divide unchecked to form tumors or form masses (known as nodules). (brachytherapy.net)
Cancers in these connective tissues generally form painless lumps (tumors). (brachytherapy.net)
Cancer occurs when changes (mutations) to the DNA inside cells occur, leading them to proliferate uncontrollably and create abnormal cells which build up and form into tumors over time. (brachytherapy.net)
We used immunohistochemistry to detect OPN in a selection of 350 human tumors and 113 normal tissues, from a variety of body sites, using stage-oriented human cancer tissue arrays. (aacrjournals.org)
Although OPN expression was identified in a good number of bladder, prostate, and brain tumors, the majority of 6 skin cancers, 11 of 14 salivary gland cancers, 2 thyroid carcinomas, and 23 of 26 breast cancers revealed low OPN positivity or were negative. (aacrjournals.org)
Ablation is an increasingly recognized alternative to surgery for liver tumors in patients with impaired liver function, associated extrahepatic disease, lesions inaccessible to surgical resection, extensive bilobar metastatic disease or concurrent medical conditions precluding an operation 1 . (nature.com)
No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
Lung tumors include small cell cancer. (medscape.com)
it is usually higher in large, metastatic, and well-differentiated tumors. (medscape.com)
Our 2022 achievements reaffirm our belief that using our viral immunotherapies to mobilize the patient's immune system to fight cancer represents a promising approach for the treatment of solid tumors," said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. (tmcnet.com)
These cancers are classified as T1 tumors and further categorized as T1a if less than 5% of the prostate tissue is observed to be highly proliferative. (paperroni.com)
The T1a tumors are estimated to progress as cancer within 15 years, while T1b tumors are quicker, only involving a progression of fewer than 5 years. (paperroni.com)
Prostate tumors that are detected through palpation of the rectum are classified as T2 tumors. (paperroni.com)
Prostate tumors that go beyond the covering epithelial tissue of the prostate gland are classified as T3 tumors. (paperroni.com)
Prostate tumors that have spread towards the seminal vesicles and lymph nodes, it is also expected that cancer has metastasized by 50% (Eastham, p. 23). (paperroni.com)

This study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. (hindawi.com)
Alone, colorectal cancer (CRC) is responsible for 600,000 mortalities annually and approximately 1.2 million new cases are reported each year [ 1 ]. (hindawi.com)
A Practical Overview of the Stool DNA Test for Colorectal Cancer Screening. (cdc.gov)
We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal cancer. (biomedcentral.com)
The diagnostic value of whole blood NEAT1 expression was evaluated in test ( n = 60) and validation ( n = 200) cohorts of colorectal cancer patients and normal controls (NCs). (biomedcentral.com)
Whole blood NEAT1 expression was significantly higher in colorectal cancer patients than in NCs. (biomedcentral.com)
NEAT1_v1 and NEAT1_v2 expression were highly accurate in distinguishing colorectal cancer patients from NCs (area under the curve: 0.787 and 0.871, respectively). (biomedcentral.com)
Whole blood NEAT1 expression is a novel diagnostic and prognostic biomarker of overall survival in colorectal cancer. (biomedcentral.com)
In the present study, we determined the diagnostic and prognostic significance and of whole blood NEAT1 in patients with colorectal cancer. (biomedcentral.com)
Both experience high rates of lung and colorectal cancer. (healthandenvironment.org)
These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)

Metastasis to the brain is the most feared complication of systemic cancer and the most common intracranial tumor in adults. (medscape.com)
The incidence of brain metastasis is rising with the increase in survival of cancer patients. (medscape.com)
Brain metastasis affects up to one third of adults with cancer and carries a historically bleak prognosis. (medscape.com)
Using electronic health record data, the researchers searched for patients with metastatic disease and information about the timing of metastasis. (genomeweb.com)
Here, we report a case of prostate cancer in 28-year-old male who presented with bone metastasis. (jpalliativecare.com)
The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age. (jpalliativecare.com)
This protein enhances cell motility, invasion and metastasis of cancer cells. (cancer-genetics.org)
It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
The histologic subtype, metastasis site, and certain patient characteristics can offer clues to the cancer primary. (medscape.com)
Purpose: The aim of this study was to determine whether modified citrus pectin, a complex polysaccharide rich in galactosyl residues, could inhibit spontaneous metastasis of prostate adenocarcinoma cells in the rat. (johnshopkins.edu)
Conclusions: We present a novel therapy in which oral intake of modified citrus pectin acts as a potent inhibitor of spontaneous prostate carcinoma metastasis in the Copenhagen rat. (johnshopkins.edu)
Implications: Further investigations are warranted to determine the following: 1) the role of galectin-3 in normal and cancerous prostate tissues and 2) the ability of modified citrus pectin to inhibit human prostate metastasis in nude mice. (johnshopkins.edu)
Johnsson A, Kiani NA, Gernaat SAM, Wilking U, Shabo I, Hedayati E. Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study. (cancercentrum.se)

Even though it is less sensitive than MRI in tumor detection and characterization, non-contrast CT imaging is commonly performed as the first screening modality in emergent situations where a patient presents with new-onset neurologic symptoms, because it is highly sensitive in detecting the acute life-threatening complications (ie, hemorrhage, hydrocephalus, and herniation) of metastatic disease. (medscape.com)
Our work shows that genomic alterations identified in tumor samples can inform our understanding of a tumor's potential to metastasize, at least in some cancer types ," senior author Nikolaus Schultz, a researcher at MSKCC, said in an email. (genomeweb.com)
With insights from more than 99,400 metastatic events identified in 21,546 metastatic cancer patients, they flagged genomic patterns corresponding to metastases from dozens of cancer types that affected 21 different organs, along with suspicious primary tumor changes in individuals with metastatic disease. (genomeweb.com)
Even though most cancer deaths are due to metastatic disease, predicting whether or not an early-stage tumor will metastasize - as well as what organs will be eventually affected by metastases - remains a formidable challenge," Schultz explained. (genomeweb.com)
On the other hand, they found that high-grade serous ovarian or colorectal cancers were more often marked by copy number changes linked to relatively early stages in the tumor development process. (genomeweb.com)
MSK investigators are now gearing up to do related research focused on treatments that target metastatic tumor drivers through the newly-funded Marie- Jos é e and Henry R. Kravis Cancer Ecosystems Project. (genomeweb.com)
We hope that [MSK-MET] will be a valuable resource for the community and will stimulate further research and applications in cancer care," the authors wrote, adding that "more integrated studies are needed to fully investigate the impact of tumor cell-extrinsic effects, such as cancer therapy, target-organ microenvironment, and systemic factors. (genomeweb.com)
Bone metastases, or bone mets, occur when cancer cells from a primary tumor spread to the bone. (massgeneral.org)
This can be due to the tumor pressing on a nerve or cancer that has spread to your bones. (healthline.com)
The heterogeneity of driver alterations in a tumor type presents a major challenge to the efforts to develop a comprehensive toolbox of targeted therapies to extend personalized cancer medicine driven by genomics information. (biomedcentral.com)
MiR-133a has been reported on several occasions to be downregulated in cancers when compared to normal adjacent tissue, and it has been implemented as a tumor suppressor targeting several oncogenes. (hindawi.com)
MiR-133a targets FSCN1 in bladder cancer and CAV1 in head and neck squamous cell carcinoma functioning as a tumor suppressor [ 9 , 10 ]. (hindawi.com)
Game Changer': Health Professionals' Views on the Clinical Utility of Circulating Tumor DNA Testing in Hereditary Cancer Syndrome Management. (cdc.gov)
Although hormonal treatment is an important palliative measure in the management of patients with advanced prostate carcinoma, the vast majority of cases end in relapse due to overgrowth of androgen-independent tumor cell populations [1]. (cancernetwork.com)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
Compared with general treatments, nanomedicines greatly increase the efficiency of therapy (e.g., the increased loading compacity, prolonged circulation of drug and combined therapies, etc.) and limit side effects (e.g., encapsulated anti-cancer drugs and specific tumor targeting, etc. (frontiersin.org)
To identify the origin of NEAT1, its expression was analyzed in blood, matched primary tumor tissues, para-tumor tissues, metastatic tissues, and also immune cells from patients or NCs. (biomedcentral.com)
For example, breast cancer that spreads to and forms a metastatic tumor in the lung is metastatic breast cancer, not lung cancer. (healthandenvironment.org)
It is caused either by tumor production of humoral factors [humoral hypercalcemia of malignancy (HHM)] or by locally enhanced bone resorption associated with metastatic lesions of solid cancers [ 1 ]. (biomedcentral.com)
The number of MAT-LyLu tumor colonies in the lungs were counted. (johnshopkins.edu)
More specifically, data from our CAN-2409 clinical trial demonstrated robust evidence of local and systemic anti-tumor activity in patients with non-small cell lung cancer who had an inadequate response to immune checkpoint inhibitors. (tmcnet.com)
This system employs tumor grades which play a major role in the prognostication of prostate cancers. (paperroni.com)
Such tumor grades are strongly associated with poor prognosis because the patient usually presents sporadic metastatic events. (paperroni.com)
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)

It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma. (globaldata.com)
There are three main subtypes of NSCLC which are adenocarcinoma (~40% of cases), squamous cell carcinoma (~25-30% of cases), and large-cell carcinoma (~10-15% of cases). (hindawi.com)
The most common types of non-small cell lung cancer are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. (msdmanuals.com)

However, brain MRI for patients with primary cancers that frequently metastasize to the brain (eg, bronchogenic carcinoma) is probably cost-effective. (medscape.com)
Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
It was also under development for the treatment of relapsed/refractory multiple myeloma, salivary gland, cancer and adenoid cystic carcinoma (ACC). (pharmaceutical-technology.com)
Data obtained from patients with androgen- independent prostatic carcinoma have revealed that prostate-specific antigen (PSA) correlates with survival in patients with normal bombesin levels. (cancernetwork.com)
Among all cancers, lung, breast, and prostate carcinoma are the three most fatal cancers. (frontiersin.org)
One third of patients with cancer of unknown primary origin have poorly or undifferentiated carcinoma. (medscape.com)
The presence of galectin-3 in rat MAT-LyLu cells and human prostate carcinoma was demonstrated by immunoblotting and immunohisto-chemistry. (johnshopkins.edu)
Sometimes called oat cell carcinoma, this cancer accounts for about 15% of all lung cancers. (msdmanuals.com)

Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided. (justia.com)
In one aspect, there is provided a use of an antigen-binding protein, or an antigen-binding fragment thereof as defined herein in the manufacture of a medicament for treating cancer. (justia.com)
There was only a slight decrease in prostate-specific antigen (PSA) level and pelvic disease post treatment. (jpalliativecare.com)
There has been a downward "age migration" in the PSA (prostate-specific antigen) era such that the median age of diagnosis is now approximately 60 years old. (science-medic.com)
Another technique that is important in the detection of prostate cancer is the screening for prostate-specific antigen (PSA). (paperroni.com)

The researchers also found associations between primary cancer subtypes and the body sites that were later impacted by metastatic disease, including an overrepresentation in liver metastases among patients with metastatic forms of lung neuroendocrine cancer and an uptick in ovarian or peritoneum metastases in individuals with advanced lobular breast cancer. (genomeweb.com)
Neuroendocrine differentiation has been foundin 50% to 100% of prostate neoplasms of all stages. (cancernetwork.com)
Thus, neuroendocrine-specific growth factors such as bombesin represent novel therapeutic targets and may also be important in the selection of patients for aggressive chemotherapy, which has been rather ineffective in prostate cancer. (cancernetwork.com)
This review will examine the evidence for the neuroendocrine progression of prostate cancer and the clinical utility of chemothera- peutic agents that are being investigated for the management of late stage disease. (cancernetwork.com)
However, the proportion of neuroendocrine differentiation was found to be much higher in follow-up studies and it is now thought that 50% to 100% of all prostate neoplasms (including benign prostatic tissue) contain at least some neuroendocrine cells [3,5]. (cancernetwork.com)
Combined with observations of neuroendocrine enrichment in cases of poor clinical response to androgen deprivation therapy, these findings support the notion that the clonal expansion of AR-negative neuroendocrine cells may play a critical role in the development of androgen-insensitive metastatic prostate cancer. (cancernetwork.com)
The clinical relevance of immunohistological detection of neuroendocrine tissue in prostate cancer patients has been the focus of many investigators. (cancernetwork.com)
mCRPC with pathological confirmation of adenocarcinoma without small-cell or neuroendocrine features. (who.int)

Cancer patients now live longer as a result of important advances in cancer diagnosis and management-particularly, the widespread use of magnetic resonance imaging (MRI) to detect small metastases. (medscape.com)
Brain metastases are an increasingly important cause of morbidity and mortality among cancer patients. (medscape.com)
With regard to screening for intracranial metastases, no consensus has been reached concerning when CT or MRI should be used for initial staging evaluation of a patient with cancer. (medscape.com)
These cancers were also less likely to show metastases-associated chromosomal stability. (genomeweb.com)
Metastases after age 30 are usually adenocarcinoma (a type of cancer that involves the cells lining the walls of different organs in the body). (massgeneral.org)
Blastic metastases are seen in patients with primary prostate cancer or in patients who have undergone treatment for breast cancer. (medscape.com)
Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
Early publications examined the relationship between specific genetic alterations in lung cancer and clinically relevant applications including differential drug sensitivity, differentiation of metastases from second primary cancers, and application of patient-specific mutations as epitopes for immunotherapy. (dukecancerinstitute.org)
001, respectively) reductions in lung metastases. (johnshopkins.edu)

For metastatic castration-resistant prostate cancer, the recommended dose of TAXOTERE is 75 mg/m 2 every 3 weeks as a 1-hour intravenous infusion. (drugs.com)

circ_0000567/miR-421/TMEM100 Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis. (cdc.gov)
GATA3 is frequently found mutated in breast cancer, and downregulation of the protein has been linked to poor prognosis of the disease. (ms-validatedantibodies.com)
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent neoplastic disease of the pancreas, with high metastatic potential, accounting for more than 90% of all pancreatic malignancies and is a highly devastating disease with poor prognosis and rising incidence. (biospace.com)

STIL has associated with various cancers including lung cancer, colon cancer, pancreatic cancer, prostate adenocarcinoma, and ovarian cancer. (wikipedia.org)
However, the exact mechanism of miRNA dysregulation in CRC pathogenesis is not fully understood, but unique sets of miRNA expression profiles have been identified in a vast array of cancers, for example, ovarian, breast, and prostate. (hindawi.com)
Practice guidelines for BRCA1/2 tumour testing in ovarian cancer. (cdc.gov)

Evidence suggests that minimally invasive stereotactic radiosurgery (SRS) can be a safe treatment option for patients with up to 10 brain metastatic nodules. (medscape.com)
[ 3 ] The radiologist plays a primary role in management of cancer by providing accurate information on number, size, and locations of metastatic lesions, which is crucial for selecting the most appropriate treatment method for patients. (medscape.com)
In addition, approximately 20% of patients with solitary metastatic lesions on CT show multiple lesions on MRI. (medscape.com)
The decision to perform imaging for patients with other cancers is made on the basis of the clinical evaluation. (medscape.com)
By publicly releasing clinical and genomic data from more than 25,000 patients," he added, "we hope that this will become a valuable resource for the community that will empower researchers and facilitate the study of metastatic disease. (genomeweb.com)
Cabometyx is indicated for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible. (pharmaceutical-technology.com)
In patients with a history of cancer, a bone scan will show any additional sites of skeletal involvement. (massgeneral.org)
Chemotherapy, use of hormones and palliative radiation therapy, that is radiation to treat the symptoms not cure, are other options used to care for patients with metastatic disease. (massgeneral.org)
Metastatic disease is very serious, but advances in cancer care mean that many patients still have significant amounts of quality time for themselves and their families. (massgeneral.org)
These patients living with metastatic disease have a phenomenal amount of inner strength and hope. (massgeneral.org)
The radiologist plays a primary role in the management of cancer patients by helping detect, localize, and diagnose the lesion. (medscape.com)
Association of Family History of Cancer with Clinical and Pathological Outcomes for Prostate Cancer Patients on Active Surveillance. (cdc.gov)
Metastatic Adenocarcinoma of Prostate in a 28-Year-Old Male: The outcome is poor in young patients? (jpalliativecare.com)
Prostate cancer is common in older patients. (jpalliativecare.com)
Most of the published data has reported poor outcome in younger patients with metastatic prostate cancer. (jpalliativecare.com)
Aidexi is indicated for the treatment of locally advanced or metastatic gastric cancer (including gastroesophageal junction adenocarcinoma) with HER2 over-expression in patients who have received at least two types of systemic chemotherapy. (pharmaceutical-technology.com)
The use of more reliable prognostic tools or staging systems may overcome this difficulty and a nonhistological prostate cancer staging system has already shown that patients with visceral involvement but minimal bone disease have the highest chance of responding to a combination of doxorubicin, mitomycin-C, and 5-fluorouracil. (cancernetwork.com)
Should this be confirmed, this may add to the routine histological grading in patients with progressive prostate cancer [6]. (cancernetwork.com)
The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. (hindawi.com)
For instance, the five-year survival rate for patients with (stage IA) after surgical resection is close to 70% but the five-year survival rate for patients with stage IV (metastatic disease) is as low as 2% [ 4 ]. (hindawi.com)
1. A major theme throughout my career has been the biology of and improving outcomes for patients with lung cancer. (dukecancerinstitute.org)
More recently, I have been an active member of the Respiratory Committee of CALGB/Alliance including serving as principal investigator on a trial testing the addition of irinotecan to treatment of patients with small cell lung cancer. (dukecancerinstitute.org)
This led to opportunities to utilize the vast and detailed clinical data sets of nearly 1 million patients with cancer to address questions that have been difficult to study either through randomized trials or in less robust datasets. (dukecancerinstitute.org)
With the support of various diagnosis technologies including positron emission tomography (PET), magnetic resonance imaging (MRI), and computed tomography (CT), surgery, radiotherapy, chemotherapy, and hormone therapy are generally applied to treat patients with cancer, including those three deadliest carcinomas. (frontiersin.org)
A large number of cancer patients show central nervous system (CNS) involvement. (medscape.com)
[ 7 ] The first report of a paraneoplastic syndrome has been attributed to a French physician, M. Auchè, who described peripheral nervous system involvement in cancer patients in 1890. (medscape.com)
Between January 2015 and December 2017, 163 patients with 286 lesions were treated with SMWA in our institution, a certified cancer center. (nature.com)
We aimed to identify microRNA (miRNA) expression patterns in the serum of prostate cancer (CaP) patients that predict the risk of early treatment failure following radical prostatectomy (RP). (oncotarget.com)
While recent cancer breakthrough therapies, most notably anti-PD-1 antibodies, have led to dramatic improvements in outcomes in many cancer settings, this is not the case for pancreatic cancer, which remains a devastating diagnosis for patients. (biospace.com)
Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. (health.am)
As expected, there was a lower lung cancer death risk seen for those patients who quit smoking earlier in life, and the risk for those who were former smokers was significantly lower than for those who continued to smoke. (health.am)
NEEDHAM, Mass., March 30, 2023 (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (Candel or the Company) (Nasdaq: CADL), a clinical stage biopharmaceutical company focused on developing and commercializing viral immunotherapies to help patients fight cancer, today reported financial results for the fourth quarter and full year ended December 31, 2022 and provided a corporate update. (tmcnet.com)
We remain confident in our belief that our investigational medicines have the potential to improve the lives of patients living with cancer. (tmcnet.com)
In September 2021, the Company completed enrollment of 711 evaluable patients in its pivotal, placebo-controlled, randomized phase 3 clinical trial of CAN-2409 in combination with valacyclovir in localized intermediate/high-risk prostate cancer. (tmcnet.com)
The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)

In particular, an increase in chromosomal instability turned up in metastatic forms of lung or prostate adenocarcinomas and in hormone receptor- and HER2-positive breast carcinomas originating in the duct, the researchers reported. (genomeweb.com)
High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometrial carcinomas, 70% of esophageal carcinomas, 58% of squamous cell carcinomas of the head and neck, and 59% of ovarian carcinomas. (aacrjournals.org)

14 Cancers increasing in the US include lung cancer (especially in women), melanoma, non-Hodgkin lymphoma and myeloma. (healthandenvironment.org)

Mol Cancer Ther (2022) 21 (6): 948-959. (aacrjournals.org)
In 2022, the American Cancer Society estimated that 236,740 new cases of lung cancer will be diagnosed in the United States (118,830 in women and 117,910 in men), and 130,180 people will die from the disease. (msdmanuals.com)

For gastric adenocarcinoma, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion, followed by cisplatin 75 mg/m 2 , as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the cisplatin infusion. (drugs.com)
Gastric cancer represents a significant global health concern, necessitating the exploration of novel therapeutic options. (bvsalud.org)
However, the potential anticancer effect of diosmetin in gastric cancer and its underlying mechanism have yet to be elucidated. (bvsalud.org)
In this study, we aimed to investigate the impact of diosmetin on cell proliferation, migration, cell cycle progression and apoptosis in human gastric cancer HGC-27 cells. (bvsalud.org)

For locally advanced or metastatic breast cancer after failure of prior chemotherapy, the recommended dose of TAXOTERE is 60 mg/m 2 to 100 mg/m 2 administered intravenously over 1 hour every 3 weeks. (drugs.com)
For the adjuvant treatment of operable node-positive breast cancer, the recommended TAXOTERE dose is 75 mg/m 2 administered 1 hour after doxorubicin 50 mg/m 2 and cyclophosphamide 500 mg/m 2 every 3 weeks for 6 courses. (drugs.com)
Contribution of large genomic rearrangements in PALB2 to familial breast cancer: implications for genetic testing. (cdc.gov)
Understanding Racial and Ethnic Inequities in Uptake and Outcomes Following Multigene Prognostic Testing in Early Breast Cancer: The Promise of Real-World Data. (cdc.gov)
Breast Cancer Phenotype Associated With Li-Fraumeni Syndrome: A Brazilian Cohort Enriched by TP53 p.R337H Carriers. (cdc.gov)
Disitamab vedotin is under clinical development by RemeGen and currently in Phase I for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer). (pharmaceutical-technology.com)
According to GlobalData, Phase I drugs for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer) have an 84% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. (pharmaceutical-technology.com)
Cancers are named for the organ or tissue where they first manifest, most frequently breast, lung and colorectal. (brachytherapy.net)
for example, breast cancer that has metastasized to the lungs continues to look and behave similarly to when it originated in breast tissue. (brachytherapy.net)
Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. (hindawi.com)
Therefore, these recent bioresponsive nano-platforms that have been investigated in lung, breast, and prostate cancer theranostics are highlighted in the current review. (frontiersin.org)
Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)
most breast, colon and prostate cancers are adenocarcinomas. (healthandenvironment.org)
Not surprisingly, men experience higher rates of prostate cancer, while women experience higher rates of breast cancer. (healthandenvironment.org)
In the United States, the leading cause of cancer death in men is lung cancer, with lung cancer continuing to surpass breast cancer as the leading cause of cancer death in women. (health.am)
The number of prostate cancer around the globe is significantly huge, that it even occurs at a higher frequency than that of breast cancer among women. (paperroni.com)
Medical and surgical postoperative complications after breast conservation versus mastectomy in older women with breast cancer: Swedish population-based register study of 34 139 women. (cancercentrum.se)
Proteogenomics decodes the evolution of human ipsilateral breast cancer. (cancercentrum.se)
R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
Based Short-Term Risk Model for Breast Cancer. (cancercentrum.se)
Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)
Breast Cancer Association Consortium and MINDACT Collaborators. (cancercentrum.se)
Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973-2017: A population-based matched study. (cancercentrum.se)
F, Humphreys K, Easton D, Hall P, Czene K. Prediction of breast cancer risk for sisters of women attending screening. (cancercentrum.se)
Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)

There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)

Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression," the authors wrote. (genomeweb.com)
The changes in this profile during therapeutic response and disease progression provide the potential for the advancement in cancer treatments [ 6 ]. (hindawi.com)
Preliminary data suggests that these markers may contribute to prostate cancer progression. (cancernetwork.com)

AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)

Clinical and genomic data generated for participants from the MSK-MET cohort so far is available online via the cBioPortal for Cancer Genomics database. (genomeweb.com)
Cabometyx is under clinical development by Exelixis and currently in Phase II for Bladder Cancer. (pharmaceutical-technology.com)
2. A second area of continuing interest in lung cancer is the conduct of therapeutic and prevention clinical trials. (dukecancerinstitute.org)
Over the next few quarters of 2023, we anticipate multiple additional clinical data readouts as well as topline data in the fourth quarter of 2024 from our phase 3 clinical trial in early localized prostate cancer. (tmcnet.com)

Men with a large component of benign prostatic hyperplasia often present with bladder outlet obstruction unrelated to their prostate cancer. (science-medic.com)
The majority of prostate cancers involve the abnormal proliferation of the prostatic glandular acini, resulting in adenocarcinomas. (paperroni.com)

Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. (cdc.gov)
Cancers may be caused by genetic mutations or physical and chemical carcinogens such as radiation exposure. (brachytherapy.net)
I led a study that demonstrated that tubulin mutations are uncommon in lung cancer and described the artifactual detection of pseudogenes as the origin of a prior report claiming association of tubulin mutation with taxane sensitivity, thus correcting the scientific record. (dukecancerinstitute.org)
As cancer cells continue to grow and divide, they accrue more mutations, are less able to function as normal cells and displace healthy cells. (healthandenvironment.org)
In these people, the reason why they develop lung cancer is unknown, but certain genetic mutations may be responsible. (msdmanuals.com)

Gemcitabine (Gem) is widely used as chemotherapy for pancreatic cancer (PaCa), but its effect is not fully satisfactory. (cancerindex.org)

Even so, the American Cancer Society expects about 34,700 people to die from prostate cancer in 2023. (healthline.com)
J Natl Cancer Inst 2023 May 27;djad101. (cancercentrum.se)

When cancer spreads to your lymph nodes, they can't drain as easily. (healthline.com)
When a cancer spreads from its primary location, it is renamed metastatic cancer. (healthandenvironment.org)
At subsequent prostate cancer stages such as metastatic conditions, cancer spreads to the bones and lungs. (paperroni.com)

The bone is a common site for metastatic disease. (massgeneral.org)
You may feel bone pain if prostate cancer has spread to your bones. (healthline.com)
Leukemia is an aggressive cancer that begins in blood and bone marrow cells. (brachytherapy.net)
Lymphoma is an infection-fighting cancer originating in lymphocytes found in lymph nodes, thymuses, spleens and bone marrow. (brachytherapy.net)
The bone is one of the most common metastatic sites for lung cancer [ 8 , 9 ]. (hindawi.com)
Bone cancer is osteosarcoma. (healthandenvironment.org)
Brain CT was normal, bone scan with 99m Tc-MDP showed no evidence of metastatic bone disease, and parathyroid scan with 99m Tc-MIBI double phase was unremarkable. (biomedcentral.com)

Your provider will also evaluate the grade of your sarcoma, which measures how similar its cancer cells resemble normal cells. (brachytherapy.net)

According to GlobalData, Phase II drugs for Bladder Cancer have a 31% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
OPN score and stage were also significantly correlated for specific cancer sites including bladder ( P = 0.01), colon ( P = 0.004), kidney ( P = 0.0001), larynx ( P = 0.035), mouth ( P = 0.046), and salivary gland ( P = 0.011). (aacrjournals.org)
Locally advanced disease Bladder outlet obstruction is the most common sign of locally advanced prostate cancer. (science-medic.com)

Lung cancer is the second most common cancer and the leading cause of cancer related mortality in both men and women. (hindawi.com)
It is generally believed that the high mortality rate of lung cancer cases may be a result of the aggressiveness and invasive and metastatic potential of the disease and the fact that it is not easily detectable until it reaches advanced stages [ 2 ]. (hindawi.com)
While the incidence and mortality of all cancers combined is decreasing, specific cancers, including cancers among children, are on the rise. (healthandenvironment.org)
A recent American Cancer Society study clarified the risk of lung cancer mortality in smokers and former smokers. (health.am)
examined and compared absolute and relative lung cancer death risk in former smokers as a function of age at cessation.7 In a prospective cohort study with 6 years of follow-up, the absolute risk of lung cancer mortality was compared in individuals who had never smoked and current and former smokers. (health.am)
For current smokers at age 75, the annual lung cancer mortality is estimated at 1 per 100 for males and 1 per 200 for females. (health.am)

Computer tomography showed a large multinodular mass in the right lobe of the liver and smaller lesions in the right lung. (biomedcentral.com)

The fundamental basis of antibody-based cancer therapy is the fact that cancerous tissues express an array of antigens that may be overexpressed, selectively expressed or mutated compared to normal, non-cancerous tissue. (justia.com)
There are over 200 types of cancer, each named for the cells or tissues it starts in. (brachytherapy.net)
Although these nano-agents exhibit desirable anti-cancer function, the constantly active cytotoxicity would potentially cause indiscriminate damage to normal tissues due to the off-target effect. (frontiersin.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Here are some symptoms showing that your prostate cancer may be in its final stages. (healthline.com)
Microarray and Q-RT-PCR analyses identified 43 miRNAs as differentiating disease stages within 14 prostate cell lines and reflectedpublically available patient data. (oncotarget.com)
Many stages of the metastatic cascade involve cellular interactions mediated by cell surface components, such as carbohydrate-binding proteins, including galactoside-binding lectins (galectins). (johnshopkins.edu)
It is often difficult to detect prostate cancer at its early stages because the symptoms are usually not noticeable early on because it generally involves cellular changes in the cells that make up the periphery of the prostate gland. (paperroni.com)

most frequently found in lungs, pancreas and prostate. (brachytherapy.net)

Cancers can occur in most parts of the body and can be classified by the area of the body in which they arise or by the type of tissue or cell that formed them. (healthandenvironment.org)
Cancer of the prostate glands first extends to the lymph nodes and other adjacent structures such as the outer tissue of the prostate glands, the seminal vesicle, and rectum, and later spread to other farther organs. (paperroni.com)
A PSMA-positive metastatic lesion should not correspond to a normal tissue structure or benign lesion. (who.int)

Computer tomography (CT) revealed a large multinodular mass in the right lobe of the liver consistent with neoplastic disease (Figure 1 ) and smaller nodules in the right lung. (biomedcentral.com)

Clear info, support, survivors and treatment of secondary liver cancer. (metastaticlivercancer.org)
Erbitux: fighting secondary liver cancer with antibodies! (metastaticlivercancer.org)

Approximately 40% of intracranial neoplasms are metastatic. (medscape.com)

For patient education information, see the Cancer Center , as well as Lung Cancer , Lymphoma , and Carcinoid Syndrome . (medscape.com)

Early screening for prostate cancer means that doctors find most cases early, leading to a high survival rate. (healthline.com)
And despite the high survival rate, it's still the second leading cause of cancer death in people assigned male at birth in the United States. (healthline.com)
These findings are important for cancer treatment planning and help professionals to seek greater survival. (bvsalud.org)

Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)
Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)

Race The highest incidence of prostate cancer in the world is found in Ameri- can black men, who have approximately a 9.8% lifetime risk of developing this cancer. (science-medic.com)
Black men have an incidence of prostate cancer that is 1.6 times that of whites. (science-medic.com)
Interestingly, although Japanese immigrants to the United Stateshave a higher incidence of prostate cancer than Japanese people living in Ja-pan, their rate is still about half that of American whites. (science-medic.com)
Geography The incidence of prostate cancer is highest in Scandinavian coun- tries (22 cases per 100,000 population) and lowest in Asia (5 per 100,000). (science-medic.com)
However, no definitive proof of its role their history of ejaculationfrequency by filling out serial Vasectomy Several large epidemiologic stud- ies suggest that vasectomy may increase the relative risk of prostate cancer by as much as incidence of prostate cancer inthe group. (science-medic.com)
In addition, it is also interesting to know that in the United States, African-Americans show a higher incidence of prostate cancer than Caucasians (Reis, p. 2). (paperroni.com)

However, a key challenge in developing candidate therapeutic antibodies for cancer is the identification of antigens suitable for antibody-based therapy. (justia.com)
RemeGen, a subsidiary of Yantai Rongchang Pharmaceutical Co Ltd, is a biopharmaceutical company that focuses on the discovery, development and commercialization of therapeutic antibody drugs such as antibody-drug conjugates (ADCs), antibody fusion proteins, monoclonal antibodies and bispecific antibodies for the treatment of cancer, autoimmune and eye diseases. (pharmaceutical-technology.com)
Although general therapeutic strategies and existent nanomedicine have been applied in relating cancer treatments, the side effects and potential damage induced by the off-target effect greatly lower the therapeutic efficiency. (frontiersin.org)
These nanomaterials could perform as anti-cancer agents by carrying effective cargos (e.g., anti-cancer drugs or monoclonal antibody, etc.) and processing directly therapeutic effects (e.g., photothermal and photodynamic therapy, etc. (frontiersin.org)

Despite the factthat this cancer will be diagnosed in an estimated 232,090 American men inthe year 2005 and will lead to the death of approximately 30,350 men, there isno universally agreed-upon strategic plan for its diagnosis and management. (science-medic.com)

The amount of PSA in the blood is often influenced by the administration of other urologic procedures such as prostate biopsies and TURP, and may also be correlated with urologic events such as infection of the prostate gland or prostatitis, decreased ability to urinate (urinary retention), and ejaculation during the administration of the procedure. (paperroni.com)

Data table showing topics related to specific cancers and associated disorders. (cancer-genetics.org)

Exelixis is a biopharmaceutical company that focuses on the development and commercialization of small molecule therapies for the treatment of cancer. (pharmaceutical-technology.com)
Staging studies are usually done to determine the extent of the metastatic disease and plan the most appropriate treatment. (massgeneral.org)
Antibody-based therapy has in recent years become an important treatment strategy for cancer. (justia.com)
It is anticipated that the information gathered might be useful in future efforts of optimizing lung cancer treatment strategies. (hindawi.com)
In spite of the advances in treatment of primary malignancy, cases of relapse and metastatic spread have created major hurdles to reaching the desired treatment outcome [ 7 ]. (hindawi.com)
The use of surgery to treat early stage non-small cell lung cancer is a standard treatment for which I observed a racial disparity. (dukecancerinstitute.org)
In a patient who is already receiving treatment for cancer, the onset of a paraneoplastic syndrome may be an indication of relapse. (medscape.com)
Few treatment options exist for metastatic pancreatic cancer, and response rates to the standard of care therapy of gemcitabine/nab-paclitaxel remain very low. (biospace.com)
The development of immune checkpoint blockers (ICB) aimed at enhancing antitumor T-cell responses has revolutionized cancer treatment. (aacrjournals.org)

It represents 3% of gastrointestinal tract cancers and its incidence is increased worldwide [ 2 ]. (biomedcentral.com)

Sources: CDC's National Program of Cancer Registries and National Cancer Institute's Surveillance, Epidemiology, and End Results program. (healthandenvironment.org)

Mutational analysis using next generation sequencing in pediatric thyroid cancer reveals BRAF and fusion oncogenes are common. (cdc.gov)

Anatomy10

Organisms3

Diseases50

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Psychiatry and Psychology2

Phenomena and Processes42

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups3

Health Care33

Geographicals3

Tumors31

Colorectal cancer11

Metastasis14

Tumor25

Squamous cell carc3

Carcinoma8

Antigen5

Neuroendocrine8

Metastases14

Castration-resistant prostate1

Prognosis3

Ovarian3

Patients36

Carcinomas2

Melanoma1

20222

Gastric4

Breast25

NSCLC1

Progression3

Various cancers1

Clinical4

Prostatic2

Mutations5

Chemotherapy1

20232

Spreads3

Bone7

Sarcoma1

Bladder3

Mortality6

Lesions1

Tissues4

Stages4

Pancreas1

Tissue3

Nodules1

Liver2

Neoplasms1

Lymphoma1

Survival3

Cervical3

Incidence of prostate cancer6

Therapeutic4

Diagnosis and management1

Urinary1

Specific cancers1

Treatment9

Gastrointestinal Tract1

Epidemiology1

Thyroid cancer1