• For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • I. To assess the recommended phase 2 dose of belinostat in combination with tremelimumab and durvalumab in advanced solid tumors harboring ARID1A mutations with focus on urothelial carcinoma. (bcan.org)
  • Heterogeneous tumor-immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti-PD-L1 antibody therapy. (go.jp)
  • Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma. (go.jp)
  • Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
  • Scintigraphy with indium-111 diethylenetriamine pentaacetic acid (DTPA) octreotide (In-111 DTPA Octr), or OctreoScan, localizes the primary carcinoid and eventual recurrences, as well as other neuroendocrine tumors, with high sensitivity and specificity. (medscape.com)
  • Because CXCR2 is ubiquitously expressed by neuroendocrine cells in prostate cancer of all stages, targeting CXCR2 may particularly benefit patients whose tumors are advanced, recurrent, and resistant to currently available therapies," Huang says. (futurity.org)
  • Prostate cancer should always be considered in the differential diagnosis of elderly men presenting with metastatic epithelial tumors even in unusual sites. (hindawi.com)
  • The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
  • In neuroendocrine tumors (NETs), liver metastases (LM) represent the most crucial prognostic factor, irrespective of the primary tumor site. (oaepublish.com)
  • At diagnosis, about 65-95% of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show hepatic metastasis. (oaepublish.com)
  • Neuroendocrine tumors (NETs) are rare neoplasms originating from diffuse neuroendocrine cells. (oaepublish.com)
  • [ 2 ] Well- to moderately differentiated neuroendocrine neoplasms (WMD-NEN) are a highly heterogeneous group of tumors comprising low-grade (G1) and intermediate-grade (G2) NETs of the gastrointestinal tract, typical and atypical carcinoids of the lung and thymus, and other cancers such as medullary thyroid carcinoma and pheochromocytoma/paraganglioma. (oaepublish.com)
  • ABSTRACT: Pulmonary carcinoid tumors are a very rare type of neuroendocrine tumor, accounting for only 1% to 2% of all primary lung cancers. (bvsalud.org)
  • ABSTRACT: The role of 68 Ga-DOTATATE PET/CT in the evaluation of neuroendocrine tumors is well defined. (bvsalud.org)
  • Nevertheless, 68 Ga-DOTATATE uptake may be seen in some tumors other than neuroendocrine tumors as a reflection of tumor blood supply and somatostatin receptor expression. (bvsalud.org)
  • The name was chosen to separate these tumors from ordinary malignancies (carcinomas), but by the 1950s, the fact that carcinoids could be malignant was obvious, thanks to Erspamer and Asero (1952), who identified serotonin production by carcinoid tumors. (medscape.com)
  • In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)
  • Participants must have histologically or cytologically confirmed metastatic small cell carcinoma of the bladder (SCCB) or other high grade neuroendocrine tumors (HGNETs) of the urinary tract (which includes renal pelvis, ureter, and urethra, and excludes neuroendocrine tumors of the prostate). (who.int)
  • For patients with liver metastases, transplantation is indicated only for neuroendocrine tumors without extrahepatic growth after removal of the primary tumor. (msdmanuals.com)
  • As a senior consultant of oncology specialized in endcrine tumors and radionuclide therapy, my research focuses on optimizing peptide receptor radionuclide therapy for patients with neuroendocrine tumors. (lu.se)
  • The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors. (cdc.gov)
  • conceptualized carcinogenesis of hepatocellular carcinoma (HCC) as a multistep process involving parenchymal arterialization, sinusoidal capillarization, and development of unpaired arteries (a vital component of tumor angiogenesis). (wikipedia.org)
  • Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. (ispub.com)
  • Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor thought to be derived from a specialized epithelial cell, the Merkel cell. (ispub.com)
  • In early-stage prostate cancer, they constitute no more than 1% of all tumor cells, but their numbers are much larger in late-stage and metastatic disease, and they make up almost all of a particularly lethal form of prostate cancer called small cell neuroendocrine carcinoma. (futurity.org)
  • But not only do hormone therapies leave neuroendocrine tumor cells untouched, the researchers found, they actually enrich the neuroendocrine cell population. (futurity.org)
  • This occurs because a receptor on the surface of neuroendocrine cells called CXCR2, which creates the optimal environment for prostate tumor cells to proliferate and spread, drives tumor growth. (futurity.org)
  • In another study presented at the GI Cancers Symposium, researchers from the Research Institute and Hospital at the National Cancer Center in Goyang, South Korea, found that S-1 plus irinotecan (Camptosar) and oxaliplatin (Eloxatin) (TIROX) induced marked tumor reduction in both primary and metastatic tumor sites in MGC. (cancernetwork.com)
  • A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. (biomedcentral.com)
  • A neuroendocrine tumor (NET) is characterized by production and secretion of peptide hormones, amines, or the presence of secretory granules. (biomedcentral.com)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • New frontiers in imaging including radiomics updates for pancreatic neuroendocrine neoplasms. (nih.gov)
  • Treatment landscape of advanced high-grade neuroendocrine neoplasms. (nih.gov)
  • Highly aggressive, poorly differentiated neoplasms were defined as Grade-3 neuroendocrine carcinomas (NECs) when originating from the gastrointestinal tract, or as small- or large-cell NECs when appearing in the lung. (oaepublish.com)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
  • These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
  • Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
  • The metastatic workup showed multiple retroperitoneal lymphadenopathies with liver metastases. (ispub.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Unusual prostate carcinoma metastases are usually encountered in the presence of known advanced disease but rarely as the first presentation. (hindawi.com)
  • Twenty-two of 26 metastases were high grade and often were not histologically suggestive of prostate carcinoma. (citationimpact.com)
  • citation needed] Transcatheter arterial chemoembolization has most widely been applied to hepatocellular carcinoma for patients who are not eligible for surgery. (wikipedia.org)
  • Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)
  • Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). (pharmaceutical-technology.com)
  • Transarterial Chemoembolization in Children to Treat Unresectable Hepatocellular Carcinoma. (stanford.edu)
  • pubMedId':'29707868','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/29707868','publicationId':'464438','title':'Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. (stanford.edu)
  • These criteria plus the absence of extrahepatic and major vessel involvement satisfy the Milan criteria, used to assess suitability of liver transplantation for patients who have cirrhosis and hepatocellular carcinoma. (msdmanuals.com)
  • The median survival period from diagnosis of brain metastasis was 8.1 months, and the major cause of death was aggravation of the primary lesion or metastatic lesions in other organs. (biomedcentral.com)
  • A history of prior squamous cell carcinoma , malignant melanoma , or malignant fibrous histiocytoma suggests intraglandular metastasis or metastasis to parotid lymph nodes. (medscape.com)
  • The terms related to NETs, including "carcinoid", "endocrine", "neuroendocrine", "small cell carcinoma" and "large cell neuroendocrine carcinoma (LCNEC)", were searched among histopathological diagnoses of all neoplasm specimens obtained during surgical procedures at Tokyo Medical University Hospital during the 6 years between January 2008 and December 2013. (biomedcentral.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • According to the WHO classification, SCNs are classified into microcystic SCA, macrocystic SCA, solid serous adenoma, von Hippel-Lindau-associated serous cyst neoplasm, and mixed serous-neuroendocrine neoplasm (2). (spg.pt)
  • Microcystic serous cystadenoma mimicking pancreatic neuroendocrine neoplasm: report of a resected case with preoperative diagnostic difficulty and review of the literature. (spg.pt)
  • [ 3 - 5 ] Metastatic spread to the liver may be accompanied by a wide spectrum of clinical presentations, from asymptomatic disease incidentally discovered during radiologic workup for other reasons, to debilitating symptoms caused by acid hypersecretion, serotonin syndrome, or carcinoid syndrome. (oaepublish.com)
  • Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. (biomedcentral.com)
  • A few studies have reported that SOX2 is overexpressed in cervical squamous cell carcinoma (SCC), and plays an important role in the progression from squamous dysplasia to SCC. (biomedcentral.com)
  • Japanese patients with histologically confirmed ATC and locally advanced or metastatic MTC were enrolled from April to September 2014. (nih.gov)
  • Histologically confirmed urothelial carcinoma with metastatic disease or with unresectable, locally advanced disease. (bcan.org)
  • Arvind N. Dasari, MD, and Cathy Eng, MD, discuss clinical trial data that may support the FDA approval of fruquintinib in metastatic colorectal cancer, and how it may impact the standard of care. (cancernetwork.com)
  • This phase I/II trial is designed to efficiently identify the regimen limiting toxicity (RLT) and recommended phase 2 dose (RP2D) for the combination of the immunotherapeutic agent indoximod when administered in combination with standard of care chemotherapy gemcitabine plus nab-paclitaxel in subjects with metastatic adenocarcinoma of the pancreas. (stanford.edu)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • Here, we present the case of a 67-year-old male patient with incidental findings of mediastinal and retroperitoneal masses which were found to be due to metastatic prostate adenocarcinoma based on histopathology and immunohistochemical studies and later on supported by the significantly elevated Prostate Specific Antigen (PSA) levels. (hindawi.com)
  • Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy. (nih.gov)
  • We present the case of a 52-year-old man who had a metastatic esophageal adenocarcinoma showing 68 Ga-DOTATATE uptake. (bvsalud.org)
  • a poorly differentiated Neuroendocrine Cancer, Grade 3 by default. (ronnyallan.net)
  • Pretreated patients with metastatic gastric cancer experienced a boost in overall survival after treatment with everolimus (Afinitor), according to the results of a phase II trial presented at the 2010 Gastrointestinal Cancers Symposium. (cancernetwork.com)
  • Additionally, adolescents with locally advanced unresectable or metastatic solid malignancies will also be enrolled. (pharmaphorum.com)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • pancreatic neuroendocrine tumours (tumours of the hormone-producing cells in the pancreas) that have spread or cannot be removed with surgery. (europa.eu)
  • For pancreatic neuroendocrine tumours, Sunitinib Accord is given at a dose of 37.5 mg once a day without a rest period. (europa.eu)
  • However, it's true to say that the prognosis for differentiated Neuroendocrine Carcinomas (NEC) is generally poorer than the less aggressive Neuroendocrine Tumours (NET).Surgery can be of benefit for localized disease after extensive preoperative imaging. (ronnyallan.net)
  • This phase I trial studies the side effects and best dose of belinostat when given together with tremelimumab and durvalumab in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and has spread to nearby tissue or lymph nodes (locally advanced). (bcan.org)
  • Pure small cell carcinoma of the prostate (SCPCa) is a very rare condition usually with poor survival after diagnosis. (karger.com)
  • The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)
  • This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and study results. (ronnyallan.net)
  • The researchers isolated the neuroendocrine cells from fresh human prostate cancer tissue and studied them in the lab. (futurity.org)
  • Mediastinum and retroperitoneum are exceedingly rare sites for metastatic prostate cancer to occur. (hindawi.com)
  • Prostate carcinoma is the second most common malignant disease in men. (hindawi.com)
  • Being aware of this unusual and rare presentation of metastatic prostate carcinoma might decrease diagnostic delay and allow earlier treatment. (hindawi.com)
  • Less frequently, patients present initially with metastatic prostate cancer. (hindawi.com)
  • Metastatic prostate carcinoma should be ruled out by using immunoperoxidase for PSA and PSAP in all men over 45 presenting with carcinoma of unknown primary origin in left-sided supradiaphragmatic lymph nodes, even in the absence of bony disease, elevated serum acid phosphatase (SAP), abnormal rectal examination, and a histologic picture suggesting prostate carcinoma. (citationimpact.com)
  • Data from a phase 1 trial highlight a clinically acceptable safety profile for BI 764532 in patients with extensive-stage small cell lung cancer and extrapulmonary neuroendocrine carcinomas. (cancernetwork.com)
  • Cabometyx is indicated for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible. (pharmaceutical-technology.com)
  • It was also under development for the treatment of relapsed/refractory multiple myeloma, salivary gland, cancer and adenoid cystic carcinoma (ACC). (pharmaceutical-technology.com)
  • You'll note the title of this post is 'World Neuroendocrine Cancer Day' and that is because (so called) 'NET Cancer Day' is not good awareness. (ronnyallan.net)
  • One of the many observations I make in my private Neuroendocrine Cancer Facebook group is the misunderstandings caused by the use of non-standard terminology combined with a lack of understanding of what is up to date or not. (ronnyallan.net)
  • Neuroendocrine Cancer - normally slow but don't be fooled! (ronnyallan.net)
  • One such sneaky disease is the lesser-known type of cancer that infiltrated my body - Neuroendocrine Cancer. (ronnyallan.net)
  • BACKGROUND: Prognostic markers in metastatic renal cell cancer (mRCC) are still insufficient. (bvsalud.org)
  • Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
  • Sorafenib seems to be effective in the treatment of advanced MTC but not ATC, and could be a new treatment option for locally advanced or metastatic MTC and radioactive iodine-refractory DTC. (nih.gov)
  • Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
  • Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan, even though vandetanib for MTC and lenvatinib for MTC and ATC have been approved. (nih.gov)
  • Transcatheter arterial chemoembolization plays a palliative role in patients with metastatic colon carcinoma. (wikipedia.org)
  • Pathological classification of the primary lesion was NET Grade 2 (Ki-67: 3 to 20 %) in 3 patients and neuroendocrine carcinoma (NEC, Ki-67: ≥21 %) in 26 patients. (biomedcentral.com)
  • The associations of SOX2 and/or high-risk (HR)-HPV RNA in situ hybridization (RISH) levels with clinicopathological characteristics and prognostic outcomes for 88 neuroendocrine carcinoma (NEC) cases were analyzed. (biomedcentral.com)
  • PURPOSE: To investigate the relationship between 18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) parameters and outcomes in mRCC, and to define a revised International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model for the intermediate-risk group. (bvsalud.org)
  • Carboplatin in combination with etoposide is recommended as first-line treatment for metastatic disease. (ronnyallan.net)
  • Participants must have metastatic disease defined as new or progressive lesions. (who.int)
  • Metastatic pheochromocytoma and paraganglioma: Somatostatin receptor 2 expression, genetics and therapeutic responses. (cdc.gov)
  • The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with MCC. (springeropen.com)
  • The rare case of metastatic infiltration of the thyroid gland by a MCC based on histological and immunohistochemical findings was described. (springeropen.com)
  • Treatment strategies for neuroendocrine carcinoma of the upper digestive tract. (nih.gov)