Metastatic colorectal cancer metastatic undifferentiated adenocarcinoma. Medical search. Frequent questions

The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
This study investigated the expression levels of lncRNAs PCAT19 and CKMT2-AS1 in colorectal tumors and normal tissues. (bvsalud.org)
Then, the expression levels of lncRNAs PCAT19 and CKMT2-AS1 were detected in 35 colorectal tumors and paired adjacent tissues using qRT-PCR. (bvsalud.org)
Experimental analysis showed that the expression level of lncRNA PCAT19 was decreased in colorectal tumors (p (bvsalud.org)
While the expression level of lncRNA CKMT2-AS1 did not change in tumor tissues, it decreased in non-metastatic tumors compared to normal tissues (p = 0.04). (bvsalud.org)
The significantly downregulation of lncRNA PCAT19 expression in both metastatic and non-metastatic colorectal tumors compared to normal tissue suggests that PCAT19 may play a role in the carcinogenesis and progression of colorectal cancer and may provide potential therapeutic targets for colorectal cancer. (bvsalud.org)
Mismatch repair-deficient tumors do not respond well to chemotherapy applied in the neoadjuvant, adjuvant, or metastatic settings. (cancer.gov)
It is now accepted that the formation of solid tumors requires the proliferation of stromal cells to support cancer cell growth, invasion, and metastasis [ 5 ] and that the stromal cell compartment comprises a heterogeneous mix of cell types responsible for the formation of blood vessels as well as supporting a microenvironment commensurate with tumor growth and proliferation. (hindawi.com)
New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
The Pathwork ® Tissue of Origin Test (Pathwork Diagnostics, Redwood City, CA, USA) is a gene expression test to aid in the diagnosis of metastatic, poorly differentiated and undifferentiated tumors. (biomedcentral.com)
This study demonstrates the accuracy of the Tissue of Origin Test when applied to predict the tissue of origin of metastatic brain tumors. (biomedcentral.com)
Metastatic tumors to the brain are the most common central nervous system (CNS) neoplasm and occur in about 15% of all cancer patients. (biomedcentral.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Studies have shown that epithelial ovarian cancer is not a single disease but is composed of a diverse group of tumors that can be classified based on distinctive morphologic and molecular genetic features [ 1 ]. (biomedcentral.com)
Type I tumors include low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas and type II include high-grade serous, high-grade endometrioid and undifferentiated carcinomas. (biomedcentral.com)
In terms of origin of ovarian cancer, many of researchers and gynecologic oncologists have traditionally understood that the various different ovarian tumors are all derived from the ovarian surface epithelium (mesothelium) and that subsequent metaplastic changes lead to the development of the different cell types (Table 2 ). (biomedcentral.com)
Heterogeneity in solid tumors is not limited to the differences between neoplastic cancer cells. (por-journal.com)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Tumors or cancer of the SKIN. (lookformedical.com)
Tumors or cancers of the KIDNEY. (lookformedical.com)

Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)
Large cell (undifferentiated) carcinomas can be found anywhere in the lungs. (mvasi.com)
The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
La Rosa S, Marando A, Furlan D, Sahnane N, Capella C: Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: Insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers. (edu.pl)
Background Microsatellite lack of stability (MSI) resulting from inactivation of the DNA mismatch fix program (MMR) characterizes a highly immunological subtype of colorectal carcinomas. (immune-source.com)

Cancers on the right side of the large intestine (ascending colon and cecum) tend to be exophytic, that is, the tumor grows outwards from one location in the bowel wall. (wikipedia.org)
Fungating carcinoma of the colon Edges and margins of an intestinal tumor Adenocarcinoma is a malignant epithelial tumor, originating from superficial glandular epithelial cells lining the colon and rectum. (wikipedia.org)
Exosomal miRNAs can reflect tumor progression and metastasis, and are effective biomarkers for cancer diagnosis. (bvsalud.org)
First, Using GEPIA2 database, we compared the expression level of target lncRNAs between primary colon adenocarcinoma tumor and normal tissues. (bvsalud.org)
MATERIALS AND METHODS: An intrasplenic injection-induced liver metastatic model was established to examine the efficiency of ECH on tumor metastasis in vivo. (bvsalud.org)
Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
The development of targeted therapies in pancreatobiliary cancers has been hampered by the difficulty in obtaining biopsies with sufficient tumor cell content for genomic sequencing analyses. (aacrjournals.org)
These findings demonstrate the feasibility and accuracy of cfDNA sequencing in detecting tumor-derived mutations in advanced pancreatobiliary cancers and suggest that this approach may improve personalized treatment of this deadly disease. (aacrjournals.org)
Preclinical studies demonstrated that LOXO-101 inhibited the proliferation of cancer cell lines harboring oncogenic TRK fusions in a dose-dependent manner and resulted in suppression of tumor growth in vivo , consistent with previous studies. (aacrjournals.org)
Gender differences in tumor behavior exist in patients with colon cancer [ 5 ], but the exact mechanisms are unknown. (hindawi.com)
This study investigated the levels of CXCL10, which were recently been reported to play an important role in the outcome of tumor treatment, secreted by colon cancer cells. (bslonline.org)
Despite recent advances in medicine nearly 50% of patients with colorectal cancer show tumor recurrence. (biomedcentral.com)
Although the reason for this is not fully understood, the presence of chemotherapy-resistant cancer stem (CSCs) is thought to be one the primary causes for tumor recurrence [ 3 ]. (biomedcentral.com)
Metastatic brain cancers are the most common intracranial tumor and occur in about 15% of all cancer patients. (biomedcentral.com)
Fifteen fresh-frozen metastatic brain tumor specimens of known origins met specimen requirements. (biomedcentral.com)
Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). (mdpi.com)
Over the past three decades, surgical tumor debulking, followed by platinum-based chemotherapy is the standard treatment for advanced ovarian cancer. (biomedcentral.com)
In this review article we aimed to emphasize the importance of single-cell analyses by presenting tumor heterogeneity and the limitations of conventional investigational approaches, followed by an overview of the whole single-cell analytic workflow from sample isolation to amplification, sequencing and bioinformatic analysis and a review of recent literature regarding the single-cell analysis of colorectal cancers. (por-journal.com)
There are two not mutually exclusive models explaining tumor heterogeneity: the cancer stem cell and the clonal evolution model. (por-journal.com)
Cancer-associated fibroblasts, which have a constantly activated phenotype are the main components of tumor stroma [ 11 ]. (por-journal.com)
Their exact origin and functions are not fully understood, but it is hypothesized that they can enhance tumor growth and progression, invasion, and metastatic potential as well [ 12 ]. (por-journal.com)

The most common form of colon cancer is adenocarcinoma, constituting between 95% and 98% of all cases of colorectal cancer. (wikipedia.org)
In 2020, there were an estimated 1.93 million new cases of colorectal cancer and 935,173 deaths. (cancer.gov)
Lynch Syndrome Lynch syndrome is an autosomal dominant disorder responsible for 2 to 3% of cases of colorectal cancer ( 1). (msdmanuals.com)

Undifferentiated prostate cancer, squamous cell carcinoma, and ductal transitional carcinoma also occur infrequently. (msdmanuals.com)
What is Non-Squamous Non-Small Cell Lung Cancer? (mvasi.com)
Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) MVASI®, in combination with carboplatin and paclitaxel, is approved to treat advanced non-squamous non-small cell lung cancer (NSCLC) in people who have not received chemotherapy for their advanced disease. (mvasi.com)
Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
Avastin, in combination with carboplatin and paclitaxel, is indicated for the first‑line treatment of patients with unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer. (avastin.com)
Zhang KY, Aurit S, Silberstein P. Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database analysis. (creighton.edu)
Gootee J, Patel M, Aurit S, Silberstein P. The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database. (creighton.edu)
Cox proportional hazards models were used to estimate HRs relating air pollutant exposures to all-cause mortality overall and stratified by stage (localised only, regional and distant site) and histology (squamous cell carcinoma, adenocarcinoma, small cell carcinoma, large cell carcinoma and others) at diagnosis, adjusting for potential individual and area-level confounders. (bmj.com)

Colorectal carcinoma with desmoplastic reaction (*) Dirty necrosis Determining the specific histopathologic subtype of colorectal adenocardinoma is not as important as its staging (see #Staging section below), and about half cases do not have any specific subtype. (wikipedia.org)
Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
It was also under development for the treatment of relapsed/refractory multiple myeloma, salivary gland, cancer and adenoid cystic carcinoma (ACC). (pharmaceutical-technology.com)
Recently, especially in Japan, several researchers have suggested that colorectal cancer can develop not only through an adenoma-carcinoma sequence but also from normal mucosa via a de novo pathway, and that these de novo cancers have more aggressive malignant potential. (biomedcentral.com)
Metastatic Renal Cell Carcinoma (mRCC) MVASI®, used with interferon alfa, is approved to treat metastatic kidney cancer (mRCC). (mvasi.com)
Human gastric cancer cell lines BGC-823 and SGC-7901, oesophageal cancer cell line CaEs-17, hepatocellular carcinoma cell lines SMMC-7721, QGY-7701 and HepG2, pancreatic cancer cell line Panc-1 and colon cancer cell lines LoVo and Ls174T were obtained from the Shanghai Institute of Cell Biology (Shanghai, China). (iiarjournals.org)
Grabowski P, Schönfelder J, Ahnert-Hilger G, Foss HD, Stein H, Berger G, Zeitz M, Scherübl H: Heterogeneous expression of neuroendocrine marker proteins in human undifferentiated carcinoma of the colon and rectum. (edu.pl)
Hepatocellular carcinoma (HCC)is a common type of liver cancer with a poor prognosis, especially in patients with advanced stages or underlying liver disease. (bvsalud.org)
BACKGROUND: Primary hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLM) represent the liver's two most common malignant neoplasms. (bvsalud.org)

H&E stained sections: (A) Serrated adenocarcinoma: epithelial serrations or tufts (thick blue arrow), abundant eosinophilic or clear cytoplasm, vesicular basal nuclei with preserved polarity. (wikipedia.org)
Ovarian Cancer (OC) MVASI®, in combination with carboplatin and paclitaxel, followed by Avastin alone, is used for the treatment of patients with advanced (Stage III or IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer following initial surgery. (mvasi.com)
MVASI®, in combination with paclitaxel, pegylated liposomal doxorubicin or topotecan, is approved to treat platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer in women who received no more than two prior chemotherapy treatments. (mvasi.com)
MVASI®, either in combination with carboplatin and paclitaxel or with carboplatin and gemcitabine, followed by Avastin alone, is approved for the treatment of patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. (mvasi.com)
Growing evidence supports the contention that epithelial cancers including colorectal cancer, the incidence of which increases with aging, are diseases driven by the pluripotent, self-renewing cancer stem cells (CSCs). (biomedcentral.com)
Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
However, a number of groups have recently reported that mesenchymal-epithelial transition (MET) is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. (mdpi.com)
Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. (biomedcentral.com)
The origin and pathogenesis of epithelial ovarian cancer (EOC) have long been investigated but still poorly understood. (biomedcentral.com)
The increased incidence of cancer with age is thought to be attributable to: At least 70% of cancers occur in epithelial cells which are constantly exposed to external, ingested or inhaled substances. (boghammar.se)

However, the accuracy of exosomal miRNA-based cancer diagnosis is limited by the low sensitivity and complicated RNA extraction of traditional approaches. (bvsalud.org)
In a study of peritoneal cancer (PC) diagnosis, investigators found that the administration of carbonated water for dual-time point imaging may improve the accuracy of FDG PET/CT scanning for PC in patients previously diagnosed with colorectal cancer (CRC). (medscape.com)
Symptoms, initial diagnosis, and treatment are similar to other forms of colorectal. (msdmanuals.com)
While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
Despite advances in diagnosis and treatment, the morbidity and mortality of lung cancer remains to mount up. (intechopen.com)
The purpose of this study was to evaluate the performance of the Tissue of Origin Test in the diagnosis of primary sites for metastatic brain cancer patients. (biomedcentral.com)
Recent epidemiological studies have addressed the incidence of cancer in patients with AIP and/or IgG4-RD. Surprisingly, a significant number of AIP patients were detected with cancer at or within one year of the diagnosis of AIP. (go.jp)
However, a substantial proportion of gastric adenocarcinomas are advanced or metastatic disease at the time of diagnosis. (biomedcentral.com)
A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
In most cancer centres, the issue is not whether, but how and when, to inform patients of diagnosis and prognosis. (boghammar.se)
An important component of the nurse's role is The risk of cancer recurrence is always present when a diagnosis has been given. (boghammar.se)
Rationale Exposure to ambient air pollutants has been associated with increased lung cancer incidence and mortality, but due to the high case fatality rate, little is known about the impacts of air pollution exposures on survival after diagnosis. (bmj.com)
Conclusions These epidemiological findings support the hypothesis that air pollution exposures after lung cancer diagnosis shorten survival. (bmj.com)
Does exposure to ambient air pollution after diagnosis of lung cancer affect survival? (bmj.com)
Patients with lung cancer, with higher average ambient NO 2 , PM 2.5 and PM 10 exposures since diagnosis, had shorter survival, with the largest differences in survival for patients with early-stage non-small cell cancers (particularly adenocarcinomas). (bmj.com)
This is the first study to link individual-level estimates of air pollution exposures after lung cancer diagnosis to survival, and the study population was the population-based sample of 352 053 patients with newly diagnosed lung cancer during 1988-2009 in California, as ascertained by the California Cancer Registry. (bmj.com)
It's not common that treatment for most health problems, including most cancers, needs to start immediately after diagnosis. (surgerysecondopinion.com)

and family history of some hereditary breast and ovarian cancers. (msdmanuals.com)
Ovarian cancer (OC) is the 5th most common cancer among European women. (cancerindex.org)
Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
Ovarian cancer is the most lethal gynecologic malignancy. (biomedcentral.com)
One of the most investigated and promising molecular targeted drugs in ovarian cancer is bevacizumab, a monoclonal antibody directed against VEGF. (biomedcentral.com)
A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway. (biomedcentral.com)
These findings suggest that these two different types of ovarian cancers develop along different molecular pathways. (biomedcentral.com)

Compared to metastatic MCC, a higher proportion of metastatic FCC patients ranged over 60 years of age, black race, treated without chemotherapy, and insurance, while the primary site was located on the right side. (hindawi.com)
Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
Chemotherapy is an indispensable element of treatment for gastric cancer patients, and fluoropyrimidines, platinum-containing agents, taxanes, alone or in combinations, are the most effective and commonly used chemotherapy regimens ( 1 ). (iiarjournals.org)
Personalised chemotherapy based on pharmacogenetics and pharmacogenomics has shown a promising predictive role to achieve superior outcomes in cancer treatment ( 4 - 7 ). (iiarjournals.org)
The present study established a docetaxel-resistant gastric cancer cell line and evaluated the alteration of mRNA expression levels globally by microarray, in an attempt to obtain novel predictive biomarkers for docetaxel chemotherapy. (iiarjournals.org)
A randomized clinical trial REGATTA which aimed to evaluate whether the addition of gastrectomy to chemotherapy improves survival for advanced gastric cancer patients with a single non-curable factor was terminated ahead of time due to the negative results from the interim analysis [ 2 ]. (biomedcentral.com)
Park H, Imoto S , Miyano S. Comprehensive information-based differential gene regulatory networks analysis (CIdrgn): Application to gastric cancer and chemotherapy-responsive gene network identification. (google.com)

Though ECH has inhibitory activity against aggressive colorectal cancer (CRC) cells, its anti-metastasis effect in vivo and the action mechanism is undetermined. (bvsalud.org)
AIM OF THE STUDY: The purpose of this study was to investigate the impact of ECH on colorectal cancer liver metastasis in vivo and its potential mechanisms. (bvsalud.org)
We report a case of aggressive colon cancer resulting in systemic metastasis despite small tumour size. (biomedcentral.com)
The most common site of metastasis of these cancers is the liver, followed by the lung. (biomedcentral.com)
Herein, we report a rare case of a small colon cancer with a depressed component and aggressive malignant potential with systemic metastasis, where the chief complaint was cervical lymph node swelling. (biomedcentral.com)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)

This occurs in mucinous adenocarcinoma, in which cells are poorly differentiated. (wikipedia.org)
Depending on glandular architecture, cellular pleomorphism, and mucosecretion of the predominant pattern, adenocarcinoma may present three degrees of differentiation: well, moderately, and poorly differentiated. (wikipedia.org)
The tumour cells with oval to round nuclei with prominent nucleoli were found to be showing partial ductal structures, leading us to suspect poorly differentiated adenocarcinoma. (biomedcentral.com)

Within cohorts of soft tissue diagnoses assembled by tissue type (liposarcoma, leiomyosarcoma, undifferentiated sarcoma, and other), endosialin expression was significantly correlated with a better outcome. (hindawi.com)
An oncogenic LMNA-NTRK1 fusion gene was detected in a patient with metastatic soft-tissue sarcoma. (aacrjournals.org)
A 41-year-old woman who presented with undifferentiated soft-tissue sarcoma and lung metastases was found to harbor a gene fusion consisting of the 5′ region of lamin A/C ( LMNA ) and the 3′ region of neurotrophic tyrosine kinase receptor type 1 ( NTRK1 , encoding TRKA). (aacrjournals.org)
Treatment patterns, and survival of patients with metastatic undifferentiated pleomorphic sarcoma: A National Cancer Database (NCDB) study. (creighton.edu)

Cabometyx is under clinical development by Exelixis and currently in Phase II for Bladder Cancer. (pharmaceutical-technology.com)
Importantly, five cancers including breast, lung, liver, cervical, and colon cancer from 64 patients are distinguished with 99% accuracy by testing exosomal miRNAs in clinical plasma. (bvsalud.org)
This simple, accurate, and sensitive biosensor holds the potential to be expanded into clinical non-invasive cancer diagnostic tests. (bvsalud.org)
The identification of a mechanism of MET-driven resistance to BRAF/EGFR blockade in a patient with BRAF -mutant colorectal cancer indicates that MET inhibitors may warrant further investigation in biomarker-driven clinical trials in combination with BRAF inhibition or with dual EGFR and BRAF inhibition. (aacrjournals.org)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Emphasis on screening for colon cancer in women and additional clinical care should be paid for, especially for patients with FCC with metastatic liver cancer. (hindawi.com)
With recent developments in medical technology, the introduction of the Clinical Pathway [CP], and the hospital's efforts to increase the surgical bed turnover rate, the period of hospitalization and treatment for colorectal cancer patients is becoming shorter. (bslonline.org)
Ganti AK, Subbiah SP, Kessinger A, Gonsalves WI, Silberstein PT, Lobriza FR Jr. Association between Race and Survival of Patients with Non-Small Cell Lung Cancer in The United States Veterans Affairs Population:Clinical Lung Cancer-2014 Mar;15(2):152-8. (creighton.edu)
In gastric cancer, the efficacy of docetaxel combined with cisplatin/fluorouracil remains unsatisfactory, with a clinical response rate of 37%, and some patients suffer form adverse effects without any benefit ( 3 ). (iiarjournals.org)
Background - Cancer of unknown primary origin (CUP) is defined by the presence of pathologically identified metastatic disease without clinical or radiological evidence of a primary tumour. (ices.on.ca)
To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)

The Lauren system classifies gastric cancer pathology as either type I (intestinal) or type II (diffuse). (medscape.com)
The aim of this study was to explore predictive genes involved in docetaxel sensitivity of gastric cancer. (iiarjournals.org)
Histoculture drug response assay (HDRA) was used to examine docetaxel sensitivity, while qRT-PCR was used to measure the mRNA levels of the genes in 25 surgically dissected gastric cancer specimens. (iiarjournals.org)
Results: Only CXCR4 mRNA levels in gastric cancer tissues were correlated with docetaxel sensitivity (R 2 =0.23, p=0.019) and significantly higher in resistant specimens (p=0.038). (iiarjournals.org)
Conclusion: CXCR4 mRNA expression levels may be a potential predictive biomarker in gastric cancer. (iiarjournals.org)
It results in the arrested growth of tumour cells at G 2 -M phase in a variety of tumours, including non-small cell lung cancer (NSCLC), hormone-refractory prostate cancer, advanced gastric cancer and breast cancer ( 2 ). (iiarjournals.org)
Human gastric cancer cell lines MKN-45, Kato III and AGS were preserved in our laboratory. (iiarjournals.org)
Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. (biomedcentral.com)
Adenocarcinoma accounts for the majority of gastric cancer diagnoses, and patients with gastric adenocarcinoma often experience relatively short survival times. (biomedcentral.com)
Surgery provides a curative opportunity for a number of patients and is considered the foundation of multimodal management of gastric cancer. (biomedcentral.com)
A previous systematic review and meta-analysis of 14 studies comprising 3003 patients with incurable advanced gastric cancer revealed that palliative gastrectomy significantly improved overall survival [ 9 ]. (biomedcentral.com)
Moreover, a recent study based on the Surveillance, Epidemiology, and End Results Program (SEER) data demonstrated a survival benefit for palliative gastrectomy in gastric cancer patients with stage IV disease after balancing baseline characteristics using propensity score matching analysis [ 10 ]. (biomedcentral.com)

Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). (e-ce.org)
A meta-analysis of four studies in which pathologists were blinded to the knowledge of the primary site showed that even an extensive IHC workup correctly identified the primary site for only 66% of all metastatic specimens [ 9 ]. (biomedcentral.com)

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)
From the abstract: 'Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). (cdc.gov)

Adenocarcinomas make up about 40% of lung cancers. (mvasi.com)

Pancreatic cancer (PC) is a lethal disease and a major cause of cancer-related deaths worldwide. (e-ce.org)

The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
Cox multivariate regression analysis showed that the risk ratio was higher in metastatic FCC patients compared to those without metastases. (hindawi.com)
A recently proposed algorithm for immunohistochemical evaluation of the common types of brain metastases recommends the use of 18 antibodies to distinguish 10 cancer types [ 7 ]. (biomedcentral.com)

In order to resist cancer dissemination, more effective therapeutic strategies are clearly required. (intechopen.com)

Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
P =0.04) and more likely to have mucinous adenocarcinomas ( P= 0.003), and tended to survive longer ( P =0.11) than those with sporadic cases. (oncotarget.com)

The histopathology of colorectal cancer of the adenocarcinoma type involves analysis of tissue taken from a biopsy or surgery. (wikipedia.org)
Immunohistochemical reevaluation showed the cervical lymph node biopsy specimen to be positive for CDX2 and CK20 and negative for CK7 expression, leading us to suspect the presence of a primary colorectal cancer. (biomedcentral.com)
Malignant lymphoma (ML) was first suspected, but aspiration cytology and biopsy of the lymph node suggested metastatic adenocarcinoma resulting from breast cancer. (biomedcentral.com)

The purpose of this study was to compare the metastatic pattern and prognosis of female colon cancer (FCC) to that of male colon cancer (MCC) to ascertain the independent factors impacting the prognosis of patients with FCC. (hindawi.com)

The non-polypoid gross appearance of the tumour suggested that it can originate de novo , thus providing a valuable case in support of the aggressive malignant potential of a de novo colorectal cancer pathway. (biomedcentral.com)
Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)

Material and Methods - The researchers used the Ontario Cancer Registry (OCR) and the Same-Day Surgery and Discharge Abstract Database (SDS/DAD) to identify patients diagnosed with CUP in Ontario between 1 January 2000, and 31 December 2005. (ices.on.ca)
From the abstract: ' Cancer immunogenomics is an emerging field that bridges genomics and immunology. (cdc.gov)

Deaths: 52,550 (rectal and colon cancers combined). (cancer.gov)
These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)

20 - 25 ] A major pooled analysis evaluating the impact of T and N stage and treatment on survival and relapse in patients with rectal cancer who are treated with adjuvant therapy confirmed these findings. (cancer.gov)
In this case, immunohistochemical findings strongly suggested the existence of a colorectal cancer. (biomedcentral.com)

In 2012, researchers at The Cancer Genome Atlas Network published their work on the comprehensive molecular biological characterization of human colorectal cancers (CRC) [ 1 ]. (por-journal.com)
We summarize new insights by IOTN researchers, some of which are ripe for translation for several types of cancers. (cdc.gov)

However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
9% of cancers of uterine corpus, however is associated with more aggressive behavior and a poorer prognosis. (medscape.com)
Furthermore, patients with liver metastatic FCC have a worse prognosis than those with MCC. (hindawi.com)
We conducted cross-sectional and longitudinal studies of patients with metastatic FCC to determine their clinicopathological characteristics and differences from patients with metastatic MCC and identify independent factors that affect the prognosis of patients with FCC. (hindawi.com)
Although clear cell type is categorized in indolent type, it is known to show relatively strong resistance to carboplatin and paclitaxel regimen and thus poor prognosis compared to serous adenocarcinoma, especially in advanced stages. (biomedcentral.com)

Given that cancer cells and astrocytes in glioblastomas coexist in a hypoxic microenvironment, we examined whether astrocytes affect the adaptation of glioblastoma cells to hypoxia. (cancerindex.org)
The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. (bvsalud.org)

The types of non-small cell lung cancer are named for the kinds of cells in which they occur and how the cells look under a microscope. (mvasi.com)
They usually occur in smokers and they are also the most common lung cancer seen in nonsmokers. (mvasi.com)
He predicted that cancers occur upon activation of dormant embryonic-like cancerous cells present in mature tissues but not spontaneously [ 8 ]. (biomedcentral.com)

Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)

It is difficult to separate epidemiological considerations of rectal cancer from those of colon cancer because studies often consider colon and rectal cancer together (i.e., colorectal cancer). (cancer.gov)

Pietrantonio, Oddo, and colleagues identified a mechanism of resistance to dual EGFR and BRAF blockade in a patient with BRAF V600E -mutant metastatic colorectal cancer who developed resistance to the anti-EGFR antibody panitumumab plus the BRAF inhibitor vemurafenib. (aacrjournals.org)

Among all racial groups in the United States, Black individuals have the highest sporadic colorectal cancer incidence and mortality rates. (cancer.gov)
Colon cancer (CC) is the third most prevalent cancer in the United States, occurring in both men and women, and is also the third leading cause of mortality from cancer [ 1 ]. (hindawi.com)
Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to be on the rise. (academicjournals.org)
Preventive action will be taken only after the individual has balanced the benefits of that action against its physical, psychological and financial costs (, Despite recent debates about the quality of over 40 years of trials, it is generally agreed that there is a clear benefit and reduction in mortality from breast cancer from screening women over the age of 50 years by mammography every 2 years (IARC 2002). (boghammar.se)

Cabometyx is indicated for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible. (pharmaceutical-technology.com)

Fusions involving the tropomyosin-related kinase (TRK) family of neurotrophin receptor tyrosine kinases have been identified in various human cancers and suggested to function as oncogenic drivers. (aacrjournals.org)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)

Invasive neoplasms of the female pelvic organs account for almost 15% of all cancers in women. (medscape.com)

The most common metastatic sites were in the respiratory or digestive systems (n = 1,603), and the most common histology was adenocarcinoma (n = 939). (ices.on.ca)

Thus, AIP appears to be associated with cancer of other organs rather than the pancreas itself, which suggests that AIP is not a pre-cancerous condition of the pancreas. (go.jp)
Notch signaling dysregulation is involved in a variety of pathologies, including cancer and non-cancerous diseases. (spandidos-publications.com)
Cancerous cells are embedded into diverse tissues consisting of cancer-associated fibroblasts, extracellular matrix, vascular and lymphatic networks, and immune cells, among others. (por-journal.com)

Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
Even 10 years ago the comprehensive characterization of colorectal cancers by The Cancer Genome Atlas was based on measurements of bulk samples. (por-journal.com)
The establishment of large-scale genomic collaborative efforts along with the development of new single-cell transcriptomic techniques and multi-omics approaches have enabled characterization of the mutational and transcriptional profiles of many cancer types and helped to identify clinically actionable alterations as well as predictive and prognostic biomarkers. (cdc.gov)

This study aimed to determine whether ambient air pollutant exposures are associated with the survival of patients with lung cancer. (bmj.com)

MVASI®, in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is approved to treat persistent, recurrent, or metastatic cancer of the cervix. (mvasi.com)
Importantly, in the patient's recurrent GBM, we identified unique repeat sequences with TMZ mutational signature and demonstrated that their CRISPR targeting enables cancer-specific cell ablation. (bvsalud.org)

Micrographs (H&E stain) Cancer - Invasive adenocarcinoma (the most common type of colorectal cancer). (wikipedia.org)
Worldwide, colorectal cancer is the third most common form of cancer. (cancer.gov)
The most common of these malignancies is uterine cancer. (medscape.com)
It is the fourth most common cancer, accounting for 7% of female cancers, following breast, lung, and colorectal cancer. (medscape.com)
Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in the United States and in most developed countries with access to sufficient health care. (medscape.com)
Colorectal cancer is the fourth most common form of cancer worldwide and ranks third among the cancer-related deaths in the US and other Western countries. (biomedcentral.com)
Colorectal cancer, the third most common cancer in women and the fourth in men, causes 610,000 deaths per year worldwide [ 1 ]. (biomedcentral.com)
Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. (oncotarget.com)
Lung cancer has been the most common cancer for decades. (bmj.com)

Cancer Sci , 2023 Jun 26. (google.com)

She was diagnosed with unknown primary cancer and referred to our hospital for further examination. (biomedcentral.com)
The lesion was found to have an intramucosal cancer component, demonstrating that this lesion represented primary colon cancer. (biomedcentral.com)
MVASI® is not approved for use after the primary treatment of colon cancer that has not spread to other parts of the body. (mvasi.com)
Dahl M, Aurit SJ, Silberstein PT, Gootee J. Primary Site and Other Prognostic Factors for Fibrosarcoma: An Analysis of the National Cancer Database. (creighton.edu)

In Uganda, literature has shown that, cervical cancer incidence and death rates was 45.6 and 25 per 100,000 women respectively. (academicjournals.org)

Invasive adenocarcinoma commonly displays: Varying degrees of gland formation with tall columnar cells Frequently desmoplasia Dirty necrosis, consisting of extensive central necrosis with granular eosinophilic karyorrhectic cell detritus. (wikipedia.org)
Uterine cancer is defined as any invasive neoplasm of the uterine corpus. (medscape.com)
Treatment trends of muscle invasive bladder cancer: Evidence from the Surveillance, Epidemiology, and End Results database, 1988 to 2013. (creighton.edu)
In addition to noting hair loss, the nurse also assesses the Through working partnerships with the community and the food industry, strategies to promote healthy eating include a national 'Five a Day' programme, improving accessibility to affordable fresh fruit and vegetables, and advocating five portions of these daily (see Ch. However, only 14% of cancer patients in the world are receiving palliativ … non-invasive - do not invade locally or metastasise. (boghammar.se)

RAC1 Alterations Induce Acquired Dabrafenib Resistance in Association with Anaplastic Transformation in a Papillary Thyroid Cancer Patient. (mdanderson.org)
Established cancer cell lines are widely used for developing biomarkers for the patient-specific treatment of colorectal cancer and predicting prognoses. (bslonline.org)

The tumour was only 12 mm in diameter, with a central depressed component and a severely thickened stalk, which suggested direct cancer invasion of the deep submucosa. (biomedcentral.com)

Current study aimed to develop and validate prognostic nomograms for patients with metastatic gastric adenocarcinoma treated with palliative gastrectomy. (biomedcentral.com)

Anatomy11

Organisms1

Diseases59

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Phenomena and Processes40

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science5

Named Groups1

Health Care40

Geographicals3

Tumors21

Carcinomas6

Tumor24

Cases of colorectal cancer3

Squamous8

Carcinoma9

Epithelial11

Diagnosis17

Ovarian10

Chemotherapy7

Metastasis6

Poorly3

Sarcoma4

Clinical12

Gastric cancer12

Specimens2

NSCLC3

Lung cancers1

Pancreatic cancer1

Metastases3

Therapeutic1

Mucinous2

Biopsy3

Factors impacting the1

Malignant2

Abstract2

Colon cancers2

Findings2

Researchers2

Prognosis5

Glioblastoma3

Occur3

HNPCC1

Epidemiological1

V600E1

Mortality4

Refractory1

Oncogenic1

Pathways1

Mismatch2

Neoplasms1

Histology1

Cancerous3

Characterization3

Survival of patients1

Recurrent2

Common10

20231

Primary4

Cervical Cancer1

Invasive4

Patient2

Invasion1

Prognostic1