AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Carcinoma, EndometrioidCarcinomaEndometrial NeoplasmsNeoplasms, Unknown PrimaryAdenocarcinoma, Clear CellOvarian NeoplasmsCystadenocarcinoma, SerousCarcinoma, Squamous CellNeoplasm MetastasisCarcinoma, HepatocellularImmunohistochemistryTumor Markers, BiologicalAdenocarcinomaCystadenocarcinoma, PapillaryEndometrial HyperplasiaLymphatic MetastasisLiver NeoplasmsSea LionsGenital Neoplasms, MaleKeratinsAdenocarcinoma, MucinousCarcinoma, Ductal, BreastBreast NeoplasmsNeoplasm InvasivenessPrognosisMucin-1Carcinoma, PapillaryMeningiomaLung NeoplasmsFrozen SectionsCarcinoma in SituMixed Tumor, MullerianKeratin-7Krukenberg TumorUterine NeoplasmsPleural Effusion, MalignantHysterectomyNeoplasm StagingEndometriosisKeratin-20Lymph NodesMeningeal NeoplasmsCholangiocarcinomaRetrospective StudiesBone NeoplasmsColonic NeoplasmsCarcinosarcomaFatal OutcomeStomach NeoplasmsGene Expression Regulation, NeoplasticTissue Array AnalysisBiopsyNeoplastic Cells, CirculatingCarcinoma, AdenosquamousMesotheliomaBiopsy, Fine-NeedlePTEN PhosphohydrolaseCarcinoma, Basal CellNeoplasms, Glandular and EpithelialAntibodies, NeoplasmAntigens, CD15Carcinoembryonic AntigenTreatment OutcomeCystadenocarcinoma, MucinousNeoplasmsDilatation and CurettageAntigens, NeoplasmEndometriumNeoplasm GradingNeoplasms, Cystic, Mucinous, and SerousVimentinOvarian CystsCell Line, TumorPredictive Value of TestsSensitivity and SpecificityCarcinoma, Transitional CellPancreatic NeoplasmsDNA, NeoplasmNeoplasms, Multiple Primarybeta CateninBiopsy, NeedleSalpingectomyCarcinoma, BronchogenicTumor Suppressor Protein p53Carcinoma, Intraductal, NoninfiltratingTomography, X-Ray ComputedCarcinoma, Adenoid CysticEpididymal Secretory ProteinsMicrosatellite InstabilityCarcinoma, Small CellFluorouracilImmunoenzyme TechniquesProstatic NeoplasmsCarcinoma, MedullaryAntineoplastic Combined Chemotherapy ProtocolsSurvival RateKidney NeoplasmsCarcinoma, LobularPrecancerous ConditionsNeoplasm Proteins
TumorsAdenocarcinomaSubtypesTumorHistologicallyPrognosisSquamousCancersPapillary serousUrothelial CarcinomaOvaryRecurrentCell carcinomaPatients with metastaticTransitionalInvasiveMalignantHistological typesProgressionChemotherapyMalignancyOvariesHigh-gradeCervical cancerSurvivalPulmonaryCancerClear cell
Tumors19
  • subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
  • Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
  • However, 56.2% of reported metastatic meningiomas originated from benign (Grade I) and intermediary (Grade II) tumors, as in our case [2]. (amjcaserep.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
  • The most frequent histologic type was represented by high-grade serous carcinoma Rare primary ovarian tumors were represented by: adult granulosa cell tumor, clear cell carcinoma, sarcoma cancer by age serous-mucinous carcinoma and undifferentiated pleomorphic sarcoma 1. (metin2kiss.ro)
  • The earliest age of all patients with ovarian tumors was 31 years old for the mixed serous-mucinous carcinoma. (metin2kiss.ro)
  • Admixtures of other surface epithelial tumors (serous, endometrioid) are common, thus, the transitional cell component must comprise over 50% of the tumor to be diagnosed as transitional cell carcinoma. (surgpath4u.com)
  • These IHC stuides have lead most authors to conclude that TCCs are a poorly-differentiated adenocarcinoma akin to other surface epithelial ovarian tumors such as serous and endometrioid types. (surgpath4u.com)
  • The natural progression of these tumors also lend support to this theory, as Brenner tumors (even borderline and malignant) have a much better prognosis than transitional cell carcinomas of the ovary. (surgpath4u.com)
  • Transitional cell carcinoma represent a more aggressive neoplasm compared to malignant Brenner tumors. (surgpath4u.com)
  • Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. (surgpath4u.com)
  • Reidel I, Czernobilsky B, Lifschitz-Mercer B. Brenner tumors but not transitional cell carcinomas of the ovary show urotehlial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. (surgpath4u.com)
  • Its prevalence was high, particularly in metastatic tumors and metastatically transformed cancer cell lines, making it a potential pan-marker for metastatic progression. (biomedcentral.com)
  • Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
  • Notable was the almost complete absence of Ki-ras mutations in an aggressive form of endometrial cancer, UPSC, when compared to the usual endometrioid tumors. (medmuv.com)
  • Ovarian cancer is a rare disease, with carcinomas comprising approximately 90% of tumors and germ cell and stromal tumors accounting for the remainder. (uofmhealth.org)
  • 10 ] Further, among carriers of deleterious mutations in BRCA1 or BRCA2, increasing evidence suggests that many tumors previously classified as ovarian high-grade serous carcinoma may develop from malignant cells arising in the tubal epithelium (serous tubal intraepithelial carcinoma [STIC]), although these tumors continue to be referred to as ovarian cancers in most writings. (uofmhealth.org)
  • Reported rates of mucinous carcinoma diagnoses have declined dramatically, but expert pathology reviews suggest that this reflects increased recognition of metastases from occult gastrointestinal primary tumors to the ovary, rather than a true decline in rates of ovarian primary tumors. (uofmhealth.org)
Adenocarcinoma6
Subtypes6
  • 8 ] [ 11 ] The median survivals of stage III and IV MOC disease are only up to 15 to 33 months compared with 50 months for advanced stage serous and endometrioid subtypes of EOC. (thieme-connect.de)
  • Three cytological subtypes (endocervical, endometrioid and intestinal subtypes) of AIS were also analyzed. (cytojournal.com)
  • The recognition of infrequent AIS subtypes (endometrioid and intestinal subtypes) is also important. (cytojournal.com)
  • 15] revealed that SOD2 is more strongly expressed in ovarian clear cell carcinoma than in other epithelial ovarian cancer subtypes and that SOD2 is a pro-tumorigenic or metastatic factor. (bibf1120.com)
  • The category of ovarian borderline tumor or tumor of low-malignant potential, which historically had been considered in the context of ovarian cancer, is now generally considered a nonmalignant entity, although it has a postulated relationship with the development of some histological subtypes of low-grade ovarian carcinomas. (uofmhealth.org)
  • The association of endometriosis with ovarian cancer is stronger for nonserous subtypes, especially clear cell carcinoma and endometrioid subtypes. (uofmhealth.org)
Tumor8
  • In most cases of metastatic meningiomas, surgical resection of the original tumor was followed by progression within 5 years of diagnosis [4], leading to the hypothesis that surgical resection might initiate meta-static spread [2]. (amjcaserep.com)
  • Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. (biomedcentral.com)
  • Due to its heterogeneities, 90% of ovarian carcinoma are epithelial ovarian cancer (EOC), while the rest could be classified as non-EOC, including asexual cell tumor, ovarian yolk cystic tumor, granulosa cell tumor, metastatic OC, etc. (amegroups.org)
  • To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. (hindawi.com)
  • However, because the data source highly depends upon the entire occurrence of tumor types, the provisional and final analyses of ovarian cancers have primarily focused on serous ovarian adenocarcinomas, rather than on EAOC including clear cell and endometrioid ovarian carcinomas. (bibf1120.com)
  • Noted are areas of endometrioid differentiation, though a majority of the tumor is high grade with no evidence of specific cell line differentiation. (healthdrugpdf.com)
  • The category of 'transitional cell carcinoma of the ovary' represents primary ovarian carcinomas in which definite urothelial features are identified, but no benign or borderline proliferating Brenner tumor are found. (surgpath4u.com)
  • Compared to endometrial endometrioid carcinoma, MLA showed larger tumor size, deeper myometrial invasion, increasingly advanced-stage disease, and more frequent lymphovascular space invasion. (iiarjournals.org)
Histologically4
  • Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (uclahealth.org)
  • Participant must have histologically documented, platinum resistant, advanced (metastatic and/or unresectable) high-grade serous/endometrioid ovarian, primary peritoneal, or fallopian tube cancer. (uclahealth.org)
  • Histologically, most of them are serous or mucinous, but endometrioid, clear cell, Brenner (transitional cell) or mixed histotypes can be also seen. (intechopen.com)
  • To be eligible for the open-label, single-arm trial, patients needed to have histologically confirmed and metastatic endometrial carcinoma measurable by immune-related RECIST. (oncnursingnews.com)
Prognosis4
  • In earlier research, high SOD2 manifestation is connected with poor prognosis in a few carcinomas [10C12]. (bibf1120.com)
  • In renal very clear cell carcinomas Specifically, which display pathological commonalities with very clear cell ovarian carcinomas, high SOD2 manifestation demonstrates better mitochondrial ROS and function level of resistance, and improved SOD2 manifestation correlates with poor prognosis [14]. (bibf1120.com)
  • Ovarian clear cell carcinomas have poor prognosis because of resistance to current chemotherapy protocols, based on platinum and taxane [19]. (bibf1120.com)
  • Chromosome 17p is frequently involved, which contains the p53 gene known to confer a poor prognosis in endometrial cancers when mutated or deleted, and which plays an important role in the transition to carcinoma from atypical hyperplasia. (medmuv.com)
Squamous1
Cancers11
  • Secondary malignancies of the broad ligament include metastatic cancers from endometrial, cervical, and ovarian carcinoma. (medscape.com)
  • Fallopian tube carcinomas comprise 1% of all gynecologic cancers. (medscape.com)
  • EAOC, especially ovarian clear cell carcinomas, is well recognized to have greater resistance to platinum-based chemotherapy, a more aggressive clinical course, and more malignant behavior than other types of ovarian cancers [19C21]. (bibf1120.com)
  • Although most of these cancers are responsive to initial chemotherapy, relapse from remission frequently occurs, resulting in death from widespread metastatic disease. (biomedcentral.com)
  • Kirsten (Ki)-ras activating point mutations in codons 12 and 13 have been implicated in the development of atypical endometrial hyperplasias and endometrioid carcinomas in Japanese women, as well as in colon cancers. (medmuv.com)
  • Endometrioid cancers arising in Japanese women tend to be high grade and deeply invasive, are less common than in the United States , and are not generally associated with hormonal exposure. (medmuv.com)
  • Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
  • ces cancers ont ete diagnostiques au stade avance d'ou les difficultes dans leur prise en charge chirurgicale. (bvsalud.org)
  • En consequence notre objectif a ete d'etudier la place et les caracteres de la chirurgie dans la prise en charge de ces cancers. (bvsalud.org)
Papillary serous1
Urothelial Carcinoma1
  • Gender-specific counselling of patients with upper tract urothelial carcinoma and Lynch syndrome. (cdc.gov)
Ovary1
  • A Brenner component was lacking, a feature of the diagnosis of transitional cell carcinoma of the ovary. (surgpath4u.com)
Recurrent2
  • OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. (knowcancer.com)
  • Limited treatment options are available to patients with recurrent or metastatic endometrial cancer. (onclive.com)
Cell carcinoma4
Patients with metastatic1
  • For instance, the 5-year relative survival rate for patients with metastatic CRC is about 11%, while that for patients with stage III CRC ranges from 53% to 89% ( https://www.cancer.org ). (biomedcentral.com)
Transitional2
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • The majority of transitional cell carcinomas are poorly-differentiated and foci of necrosis are common. (surgpath4u.com)
Invasive3
  • Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) contribute to invasive and metastatic abilities of ovarian cancer (OC) cells. (oncotarget.com)
  • All 16 had serous tubal intraepithelial carcinoma, and 8 of 16 had invasive HGSC into the underlying lamina propria. (medscape.com)
  • Loss of epithelial and gain of dedifferentiated mesenchyme-like phenotype enable CRC cells to develop invasive and metastatic growth characteristics [ 22 ]. (biomedcentral.com)
Malignant4
  • It was under development for the treatment of relapsed or refractory multiple myeloma, glioblastoma multiforme, blood cancer, metastatic non-small cell lung cancer and malignant pleural mesothelioma. (pharmaceutical-technology.com)
  • however, some show a malignant behavior that can lead to metastatic disease [2]. (amjcaserep.com)
  • Immunohistochemical detection of glucose transporter GLUT1 in benign and malignant fallopian tube epithelia, with comparison to ovarian carcinomas. (medscape.com)
  • These IHC panels will be helpful in differentiating primary ovarian TCCs versus malignant Brenners versus metastatic bladder TCCs. (surgpath4u.com)
Histological types3
  • MLA had the lowest progression-free survival rate among different histological types of endometrial carcinoma. (iiarjournals.org)
  • Diverse growth patterns make it difficult to distinguish uterine MLA from more commonly encountered histological types of endometrial carcinoma, including endometrial endometrioid carcinoma (EC) ( 10 ), serous carcinoma (SC), and carcinosarcoma (CS). (iiarjournals.org)
  • Further, data suggest that the distinction of high-grade serous carcinomas from other histological types of high-grade carcinomas, particularly endometrioid carcinomas, is not reliable. (uofmhealth.org)
Progression3
  • Biochemical recurrence (eg, CA-125 in ovarian carcinoma) only is not considered as disease progression. (uclahealth.org)
  • Dr. Jean-Noel Billaud will present a poster on the application of Ingenuity Pathway Analysis (IPA) on endometrioid endometrial carcinoma metastatic progression analysis. (qiagen.com)
  • Real-World Evaluation of Disease Progression After CDK 4/6 Inhibitor Therapy in Patients With Hormone Receptor-Positive Metastatic Breast Cancer. (cdc.gov)
Chemotherapy1
  • The patient had a history of stage III endometrial carcinoma status post vaginal hysterectomy and bilateral salpingo-oophorectomy 3 months prior and chemotherapy with Taxol and carboplatin. (healthdrugpdf.com)
Malignancy2
  • Fallopian tube malignancy usually starts as a dysplasia or carcinoma in situ. (medscape.com)
  • The perinucleolar compartment (PNC) has been shown to be associated with malignancy and is considered a surrogate phenotypic marker for metastatic cancer cells. (biomedcentral.com)
Ovaries1
  • Khan MI, Waguespack SG, Habra MA, Broaddus R, Jimenez C. Acute-onset ectopic adrenocorticotropic hormone syndrome secondary to metastatic endometrioid carcinoma of the ovaries as a fatal complication. (foxchase.org)
High-grade6
  • Gilks et al indicate that most cases of incidental nonuterine high-grade carcinomas (HGSCs) arise in the fallopian tube fimbria. (medscape.com)
  • Incidental Nonuterine High-grade Serous Carcinomas Arise in the Fallopian Tube in Most Cases: Further Evidence for the Tubal Origin of High-grade Serous Carcinomas. (medscape.com)
  • Ovarian carcinomas consist of several histopathological types, with high-grade serous being both the most common and most lethal. (uofmhealth.org)
  • It is hypothesized that high-grade serous carcinomas among individuals who are not carriers of mutations in BRCA1 or BRCA2 may also develop in the fallopian tube, but few STICs have been identified among these women in the absence of concurrent high-stage disease. (uofmhealth.org)
  • Among these, high-grade serous ovarian carcinoma (HGSOC) represents the most frequent type, comprising about 70% of all advanced EOCs [ 4 ]. (biomedcentral.com)
  • HER2 IHC Expression and Gene Amplification in p53-aberrant High-grade Endometrial Endometrioid Carcinoma Suggests That This Population May Benefit From HER2 Testing and Targeted Therapy. (cdc.gov)
Cervical cancer1
  • The patient was then referred to radiology, where she received a PET/CT examination that revealed markedly hypermetabolic primary cervical cancer with metastatic lymph node involvement of a single right external iliac and two left external iliac lymph nodes. (healthdrugpdf.com)
Survival1
Pulmonary1
Cancer3
  • Ovarian cancer remains a major health problem for women as it is often diagnosed at a late stage with metastatic disease. (biomedcentral.com)
  • Additional studies are warranted to determine the efficacy of ML246 as an inhibitor of metastatic disease in ovarian cancer and to determine its precise mechanism of action. (biomedcentral.com)
  • En 11 annees (1er janvier 1998-31 decembre 2008) 9946 patientes ont ete operes dans notre servie dont 29 pour le cancer de l'ovaire soit 0;29. (bvsalud.org)
Clear cell1
  • This study confirmed the following findings: a novel therapeutic strategy for clear cell ovarian carcinomas and/or other EAOCs, in which SOD2 is strongly expressed, should be established. (bibf1120.com)