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Biliary Tract NeoplasmsCholangiocarcinomaBiliary Tract DiseasesBile Duct NeoplasmsBile Ducts, IntrahepaticBiliary TractMammaglobin BGallbladder NeoplasmsLithiasisCholelithiasisLiver NeoplasmsCarcinomaBile Ducts, ExtrahepaticCholecystitisSecretoglobinsVomiting, AnticipatoryBiliary Tract Surgical ProceduresGallstonesCholecystectomyDeoxycytidineGallbladderHepatectomyCholestasisBileCholestasis, ExtrahepaticCholangiopancreatography, Endoscopic RetrogradeCholestasis, IntrahepaticTegafurImmunohistochemistryCarcinoma, HepatocellularUracilPancreatitisMuscle NeoplasmsPrognosisCisplatinLymphatic MetastasisAdenoma, Bile DuctTreatment OutcomeRetrospective StudiesAntineoplastic Combined Chemotherapy ProtocolsTumor Markers, BiologicalCholangitisLiver DiseasesNeoplasm InvasivenessBile DuctsRespiratory Tract NeoplasmsKaplan-Meier EstimateSurvival RateRespiratory Tract Diseasesalpha-FetoproteinsHepatic Duct, CommonKlatskin's TumorAcute DiseaseUreteral NeoplasmsLiverLymph Node ExcisionNeoplasm StagingAmpulla of VaterCholangiographyCommon Bile DuctCell Line, TumorBile Duct DiseasesSurvival AnalysisCarcinoma, Squamous CellRespiratory Tract InfectionsPortasystemic Shunt, Transjugular IntrahepaticCholangitis, SclerosingOpisthorchiasisOpisthorchisCholedochostomyGene Expression Regulation, NeoplasticUrologic DiseasesRisk Factors
TumorCancersPancreatic cancerGastrointestinalCongenitalDuctsUnresectableAdenocarcinomaPancreasHepatomaSurgicalPrognosisDilatationAtresiaGallbladder cancerClinicalCholangiocellular carcinomaIncidencePatients with hepatocellular carcinomaObstruction of the biliarySquamousDrainageCancerAscending cholangitisIHCCBenignBile duct tumorsCirrhosisSubtypesComputed TomographyDiagnosisManagement of cholangiocarcinomaPreoperativeHepatocellular carcinomasCystsCommon bileChronicHilar CholangiocarcinomaEndoscopicICCAPathogenesisEpithelialCystPrimary liver tumorsPathophysiology
Tumor19
  • Patients with intrahepatic cholangiocarcinoma (cholangiocellular carcinoma) have a poor prognosis, and the tumor metastasizes early. (medscape.com)
  • Most patients with bile duct tumors present with jaundice due to obstruction of the biliary tree by the tumor. (medscape.com)
  • A biliary catheter (red tube) runs through the tumor volume and was used to deliver brachytherapy, which was given in addition to external-beam radiotherapy. (medscape.com)
  • Irving, TX, Jan. 15, 2015 - Caris Life Sciences® today announced the presentation of data from two studies in which Caris Molecular Intelligence™, the company's panomic, comprehensive tumor profiling service, yielded insights into the biology of hepatocellular and biliary tract carcinomas, while also identifying potential treatment options for patients living with these tumor types. (carislifesciences.com)
  • In a separate presentation, use of Caris Molecular Intelligence reportedly uncovered distinct targetable biomarkers in biliary tract carcinomas such as extrahepatic cholangiocarcinoma (EHCC), intrahepatic cholangiocarcinoma (IHCC), and gallbladder carcinoma (GBCA), while also suggesting the potential sensitivity of these rare, aggressive tumor types to novel and conventional therapies. (carislifesciences.com)
  • It is the most frequent malignant tumor of the biliary tract and is the second most common primary hepatic tumor after hepatoma. (medscape.com)
  • Biliary duct dilatation is easily demonstrated with US, but US seldom localizes the tumor mass. (medscape.com)
  • Cholangiocarcinoma is a tumor that arises as a result of differentiation of the cholangiocytes and can develop from anywhere in the biliary tree. (mdpi.com)
  • Undifferentiated carcinoma of liver and intrahepatic biliary tract is an extremely rare epithelial tumor of the liver and biliary tract which presents heterogenous histological findings and not yet fully defined clinicopathological characterisitcs. (nih.gov)
  • Primary hepatic ASC was defined as a liver tumor containing definite components of both adenocarcinoma and squamous cell carcinoma, and sometimes it was considered as a variant of cholangiocarcinoma [ 9 ]. (biomedcentral.com)
  • A total of 75 liver tumor patients, who had received liver resection (LR) during the period from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital, were picked out and included in this study. (biomedcentral.com)
  • Before their final diagnoses were made, each of these nine primary tumor patients had undergone imageological examination and hematological and blood biochemical determinations to preclude other primary tumor diseases. (biomedcentral.com)
  • Based on the anatomical location of tumor along the biliary tree, CCA can be further characterized into either intrahepatic or extrahepatic CCA (iCCA/eCCA) [ 1 ]. (springer.com)
  • ROLE OF IMAGING BEFORE PALLIATIVE BILIARY DRAINAGE Because the method of management of malignant biliary obstruction depends on the resectability of the underlying tumor, patients should undergo accurate staging of the disease. (kipdf.com)
  • Cholangiocarcinoma (CCa) is a tumor that originates from the neoplastic transformation of the epithelial cells of the intrahepatic or extrahepatic bile ducts. (ganzemedizin.at)
  • The clinical implications of tumor-infiltrating T cell subsets and their spatial distribution in biliary tract cancer (BTC) patients treated with gemcitabine plus cisplatin were investigated. (e-crt.org)
  • In extrahepatic cholangiocarcinoma, there was a higher density of T cell subsets in the tumor core and regulatory T cells in all regions. (e-crt.org)
  • Minimally invasive liver resection is recommended based on tumor location, size, proximity to major vascular and biliary structures. (iswantosucandyliversurgery.com)
  • In about 15% of patients, minimally invasive liver resection cannot be offered mainly due to tumor size, location, and proximity to or involvement of major vascular/biliary structures. (iswantosucandyliversurgery.com)
Cancers5
  • In a presentation at the 2015 Gastrointestinal Cancers Symposium in San Francisco, Calif., the researchers reported that Caris Molecular Intelligence revealed the molecular heterogeneity of hepatocellular carcinoma (HCC) and facilitated identification of potential therapies targeting molecular subtypes of this disease, for which treatment options have heretofore been extremely limited. (carislifesciences.com)
  • Biliary Tract Cancers Biliary Tract Cancers: Extrahepatic Management CHAPTER 15 TARUN SABHARWAL and ANDREAS ADAM INTRODUCTION Interventional radi. (kipdf.com)
  • Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa. (cancerindex.org)
  • This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. (ucbraid.org)
  • It's not common that treatment for most health problems, including most cancers, needs to start immediately after diagnosis. (surgerysecondopinion.com)
Pancreatic cancer2
  • Irinotecan hydrochloride is under development for the treatment of small cell lung cancer (SCLC), triple-negative breast cancer (TNBC), pancreatic cancer, metastatic adenocarcinoma of biliary tract, including intrahepatic cholangiocarcinoma (IHCC), extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma, HER2 negative breast cancer and metastatic adenocarcinoma of the pancreas. (pharmaceutical-technology.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
Gastrointestinal1
  • The Ziegler laboratory is investigating the role of the epithelial cytokines TSLP and IL-33 in regulating protective responses at mucosal barrier surfaces such as the respiratory and gastrointestinal tracts. (benaroyaresearch.org)
Congenital3
Ducts14
  • Malignant neoplasm of liver and intrahepatic bile ducts. (wikipedia.org)
  • Cholangiocarcinomas , the most important primary tumors of the bile ducts, may involve either the intrahepatic or the extrahepatic biliary ducts. (medscape.com)
  • On the basis of the site of origin, cholangiocarcinoma can be classified as intrahepatic (arising proximally to the second-order bile ducts, in the context of liver parenchyma), perihilar (originating between second-order bile ducts and the insertion of the cystic duct into the common bile duct), and extrahepatic or distal (below the insertion of common bile duct). (medscape.com)
  • [ 1 ] The classification of bile duct tumors has changed to include intrahepatic tumors of the bile ducts and extrahepatic tumors (perihilar and distal) of the bile ducts. (tri-kobe.org)
  • The biliary system consists of a network of ducts that carry bile from the liver to the small bowel and is classified by its anatomic location (Figure 1 ). (tri-kobe.org)
  • The bile ducts located within the liver are called intrahepatic bile ducts. (tri-kobe.org)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (tri-kobe.org)
  • They include part of the right and left hepatic ducts that are outside the liver, the common hepatic duct, and the common bile duct. (tri-kobe.org)
  • The majority of strictures of the mid and lower common bile ducts, which are mainly caused by carcinoma of the head of the pancreas, can be drained effectively by the endoscopic approach.5 Many hilar biliary strictures are difficult to treat endoscopically, however, and are best dealt with interventional radiologic techniques.6 The indications for PTBD are summarized in Table 15.1. (kipdf.com)
  • formerly known as primary biliary cirrhosis) is an autoimmune liver disorder characterized by the progressive destruction of intrahepatic bile ducts, leading. (msdmanuals.com)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • Biliary atresia is a condition in which the intra‐ and extrahepatic biliary ducts fibrose, resulting in liver cirrhosis and death in the first year of life [ 3 , 4 ]. (radiologykey.com)
  • Primary biliary cirrhosis: This autoimmune disease affects the bile ducts in the liver. (cancercenter.com)
  • The branchings of the bile ducts resemble those of a tree, and indeed the term " biliary tree " is commonly used in this setting. (wikidoc.org)
Unresectable7
  • Unfortunately, many patients present with unresectable disease. (medscape.com)
  • A study of 66 patients with unresectable intrahepatic cholangiocarcinoma treated with hypofractionated radiation therapy reported 2-year outcomes of 84% local control and 58% overall survival. (medscape.com)
  • In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)
  • METHODS: The analysed population included patients with unresectable, locally advanced or metastatic adenocarcinoma of the biliary tract treated with durvalumab in combination with gemcitabine and cisplatin at 17 Italian centres. (bvsalud.org)
  • After the Milan criteria were published in the 1990s, liver transplantation became the standard of care for patients with unresectable hepatocellular carcinoma who fit strict criteria. (miamitransplantinnovation.org)
  • Taking together, the clinical preoperative diagnosis of intrahepatic perihilar CCA with S7 metastasis was made and it was unresectable. (oncologyradiotherapy.com)
  • 1 year in cases of unresectable disease. (e-crt.org)
Adenocarcinoma7
  • The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (tri-kobe.org)
  • Irinotecan hydrochloride is under clinical development by CSPC Pharmaceutical Group and currently in Phase II for Metastatic Adenocarcinoma of The Pancreas. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Metastatic Adenocarcinoma of The Pancreas have a 42% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. (cancercentrum.se)
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (ucbraid.org)
  • Primary Intrahepatic Adenosquamous Carcinoma (iASC) is a very rare subtype of Cholangiocarcinoma (CCA), with a worse prognosis than adenocarcinoma. (oncologyradiotherapy.com)
Pancreas3
  • Most patients with malignant obstructive jaundice caused by carcinoma of the gallbladder, carcinoma of the pancreas, and cholangiocarcinoma present with advanced disease2,3 and only 20% to 30% of such tumors are resectable at the time of diagnosis.2,4 Palliation of the malignant obstruction relieves the patient of itching and jaundice, reduces the risk of infection and septicemia, and generally improves the quality of life. (kipdf.com)
  • Re Carcinoma of head of pancreas - does that mean they have better prognosis if diagnosed earlier? (imperial.ac.uk)
  • Left untreated, choledochal cyst frequently leads to recurrent biliary infection, biliary stasis, or pancreatitis (inflammation of the pancreas) and ultimacalltoy causes biliary cancer from the chronic inflammatory state. (iswantosucandyliversurgery.com)
Hepatoma1
Surgical8
  • Topics discussed during lectures represent an integral part of the program and are the subject of evaluation during exams, including knowledge of tissue fixation and of pathology reporting (biopsies, surgical specimens, autopsies). (unibo.it)
  • Complete surgical resection is the only therapy to afford a chance of cure for cholangiocarcinoma. (medscape.com)
  • If diagnosed early these can be resected, but most cases of intrahepatic cholangiocarcinoma present late in the disease course where surgical resection is not an option. (mdpi.com)
  • There were just nine patients who suffered from histologically proven primary hepatic SCC (three patients) or ASC (six patients) had surgical treatment during the 14 years in our hospital, and all of them were included as the primary SCC/ASC group. (biomedcentral.com)
  • Surgical, endoscopic, and interventional radiologic (IR) percutaneous techniques are available for biliary drainage. (kipdf.com)
  • Because of the lower morbidity and mortality associated with ERC and percutaneous transhepatic biliary drainage (PTBD) compared to surgical methods, surgery is now rarely employed for palliative purposes. (kipdf.com)
  • Factors influencing recurrence after surgical treatment for T2 gallbladder carcinoma. (cancercentrum.se)
  • Early diagnosis of biliary atresia and surgical intervention is imperative for optimal outcome. (radiologykey.com)
Prognosis4
Dilatation2
  • A) Axial T2-weighted Magnetic Resonance Image (MRI) and (B) coronal T2-weighted MRI show a hyperintense mass (black arrow) located at the perihilar area, with marked intrahepatic biliary dilatation in the adjacent liver (the metastatic lesion at segmental VII of the liver was not shown here). (oncologyradiotherapy.com)
  • This type presents as a fusiform dilatation of a portion or entire common bile duct, with normal intrahepatic duct. (iswantosucandyliversurgery.com)
Atresia4
  • Other common indications are evaluation of gallbladder ejection fraction (as an indicator of chronic cholecystitis), bile leak, and biliary atresia [1] . (radiologykey.com)
  • In the neonate or infant with prolonged cholestatic jaundice, imaging plays an important role in differentiating between obstructive causes such as biliary atresia versus hepatocellular causes. (radiologykey.com)
  • In assessing for biliary atresia, no single modality is perfectly accurate, so a combination of tests aids in early diagnosis. (radiologykey.com)
  • Importantly, a normal US does not rule out biliary atresia. (radiologykey.com)
Gallbladder cancer3
Clinical12
  • Invasive growth, hight metastatic potential and a rapid clinical course are typically associated. (nih.gov)
  • Clinical treatment of cholangiocarcinoma: an updated comprehensive review. (nih.gov)
  • To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study. (biomedcentral.com)
  • We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China. (biomedcentral.com)
  • However, it was observed to have more aggressive clinical and pathological features than cholangiocarcinoma [ 10 ]. (biomedcentral.com)
  • Objective: Here we report the updated survival results of 11 patients with locally advanced or metastatic IDH1-mutated CCA who received ivosidenib in clinical practice. (bvsalud.org)
  • Since then, improved diagnostic imaging techniques, significant developments in interventional radiology, and the results of clinical trials have revolutionized and clearly defined the role of percutaneous biliary interventions. (kipdf.com)
  • A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (lookformedical.com)
  • In a clinical study, Alecensa (alectinib) treatment resulted in objective radiographic response in 50% (2/4) and stable disease in 25% (1/4) of non-small cell lung carcinoma patients harboring RET rearrangement ( PMID: 27544060 ). (jax.org)
  • In a clinical study, analysis of patients with RET-rearranged non-small cell lung cancer treated with RET inhibitors demonstrated a response rate of 37% (7/19), with complete response in 5% (1/19) and partial response in 32% (6/19) of patients, and stable disease in 26% (5/19) of patients following Cometriq (cabozantinib) treatment ( PMID: 28447912 ). (jax.org)
  • ERCP -guided stone extraction or CBD stenting ) may be performed at the same time as urgent biliary drainage in stable patients with mild cholangitis or deferred until clinical improvement in patients with severe cholangitis. (amboss.com)
  • Clinical trials are studying cancer from a variety of angles, including prevention and treatment. (benaroyaresearch.org)
Cholangiocellular carcinoma1
Incidence3
  • Biliary cytadenoma or mucinous cystic neoplasm of the liver is an uncommon premalignant cystic lesion, which accounts for less than 5% of all intrahepatic biliary cysts and occurs primarily in middle aged women with a peak incidence in the 50s. (drpapoulas.com)
  • 1 , 2 , 4 , 5 Incidence and mortality rates for intrahepatic CC have risen steeply and steadily across the world over the past few decades with concomitant falls in extrahepatic CC rates. (bmj.com)
  • The incidence rate of the disease is also increasing exponentially. (cancercenter.com)
Patients with hepatocellular carcinoma1
  • INTRODUCTION: The aim of this retrospective proof-of-concept study was to compare different second-line treatments for patients with hepatocellular carcinoma and progressive disease (PD) after first-line lenvatinib or atezolizumab plus bevacizumab. (bvsalud.org)
Obstruction of the biliary1
  • INTRODUCTION Interventional radiologists first became involved in the management of malignant obstruction of the biliary tree in the late 1960s, when Kaude et al.1 introduced nonsurgical biliary drainage. (kipdf.com)
Squamous6
Drainage11
  • Adequate biliary drainage can be achieved in a high percentage of cases. (medscape.com)
  • PDT is effective in restoring biliary drainage and improving quality of life in patients with nonresectable disseminated cholangiocarcinomas. (medscape.com)
  • Palliative measures such as resection, radiation therapy (e.g., brachytherapy or external-beam radiation therapy), or stenting procedures may maintain adequate biliary drainage and allow for improved quality of life. (tri-kobe.org)
  • BILIARY DRAINAGE FOR MALIGNANT STRICTURES Biliary obstruction is potentially fatal because of the adverse pathologic effects including depressed immunity, impaired phagocytic activity, reduced Kupffer cell function, and paucity of bile salts reaching the gut, with consequent endotoxemia, septicemia, and renal failure. (kipdf.com)
  • Because most patients undergo endoscopic retrograde cholangiopancreaticogram (ERCP) during the diagnostic workup for obstructive jaundice endoscopic insertion of biliary endoprostheses is performed more often than percutaneous drainage. (kipdf.com)
  • In patients with strictures below the hilum of the liver, endoscopic drainage achieves a high rate of success, is associated with fewer complications than percutaneous intervention, and avoids the discomfort of a percutaneous biliary catheter. (kipdf.com)
  • Preoperative Percutaneous Transhepatic Biliary Drainage The practice of PTBD prior to surgery is controversial. (kipdf.com)
  • Either internal/external biliary drainage catheters or more plastic stents are inserted 2 to 6 weeks prior to elective surgery. (kipdf.com)
  • Hepatobiliary scintigraphy assesses liver uptake and biliary drainage through the use of bile‐like radiotracers technetium‐99m ( 99m Tc)‐bromo‐2,4,6‐trimethylacetanilido iminodiacetic acid ( 99m Tc‐mebrofenin) or 99m Tc‐2,6‐diisopropylacetanilido iminodiacetic acid ( 99m Tc‐disofenin). (radiologykey.com)
  • Empiric antibiotic therapy and urgent biliary drainage (e.g. (amboss.com)
  • ERCP + papillotomy , EUS -guided biliary drainage) within 48 hours of presentation are the mainstays of treatment. (amboss.com)
Cancer27
  • Cancer of the bile duct (also called cholangiocarcinoma) is extremely rare. (tri-kobe.org)
  • The size of the mass can vary from 1-20 cm in diameter and the risks of malignant transformation into hepatocellular carcinoma liver cancer increases significantly at 4 cm. (drpapoulas.com)
  • Hepatocellular carcinoma (HCC) is the most common primary liver cancer.Hepatocellular carcinoma is a major cause of morbidity and mortality in patients with background liver disease. (drpapoulas.com)
  • Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. (springer.com)
  • Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. (springer.com)
  • Cholangiocarcinoma (CCA) is an aggressive type of liver cancer, which arises from the epithelium of the biliary tract. (springer.com)
  • BACKGROUND: The TOPAZ-1 phase III trial reported a survival benefit with the anti-programmed death cell ligand 1 (anti-PD-L1) durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer. (bvsalud.org)
  • Liver cancer includes two major types: hepatocellular carcinoma (HCC) and intrahepatic bile duct cancer. (oncolink.org)
  • For information about bile duct cancer, see Bile Duct Cancer (Cholangiocarcinoma) Treatment. (oncolink.org)
  • All adult female patients coming to Department of Oncology with reports of breast cancer biopsy and receptor status were included. (cancerindex.org)
  • Novel therapeutic options, based on an improved understanding of underlying biology and response to therapy, are urgently needed for patients presenting with advanced biliary tract cancer (ABC). (nature.com)
  • Rectal cancer in Albania: treatment outcome and prognostic factors of disease progression. (postersessiononline.eu)
  • Patients with cholangiocarcinoma, hepatocellular carcinoma, or non-resectable metastatic colon cancer to the liver can now be treated outside of the previous criteria and be considered for a liver transplant. (miamitransplantinnovation.org)
  • There are exciting changes in survival rates for patients with cholangiocarcinoma of the liver, also known as bile duct or biliary tract cancer. (miamitransplantinnovation.org)
  • There was an urgent need to improve outcomes for these patients, and there have now been rapid advances in the treatment paradigm for biliary tract cancer. (miamitransplantinnovation.org)
  • Patients with metastatic colon cancer to the liver have had limited treatment options. (miamitransplantinnovation.org)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • Combining BAY 1895344 with chemotherapy treatment (cisplatin, or cisplatin and gemcitabine) may be effective for the treatment of advanced solid tumors, including urothelial cancer. (ucbraid.org)
  • Damage to the liver from illness or disease may increase the risk of liver cancer and impact treatment options for the diseases. (cancercenter.com)
  • The American Cancer Society estimates 41,210 new cases of liver cancer and intrahepatic bile duct cancer, which forms in the bile duct branches in the liver, will be diagnosed in the United States in 2023. (cancercenter.com)
  • Symptoms of liver cancer may not be noticeable until the disease has progressed to an advanced stage. (cancercenter.com)
  • Secondary liver cancer is metastatic , meaning it started somewhere else and moved into the liver. (cancercenter.com)
  • Choledochal cyst is a premalignant condition with substantial risk of malignant transformation into cholangiocarcinoma, bile duct cancer. (iswantosucandyliversurgery.com)
  • Laboratory scientists are investigating the connections between autoimmune diseases and the mechanisms that help cancer grow and spread without being detected by the immune system. (benaroyaresearch.org)
  • Cancer is an umbrella term for a variety of diseases in which abnormal cells divide uncontrollably. (benaroyaresearch.org)
  • The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders. (benaroyaresearch.org)
Ascending cholangitis1
IHCC1
  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
Benign5
  • Tumors of the biliary tract are uncommon but potentially serious problems, with a spectrum of of severity that ranges from benign tumors such as adenomas to malignant lesions such as adenocarcinomas. (medscape.com)
  • Each subtype has distinct imaging characteristics, as well as a variety of benign and malignant mimics, making accurate diagnosis of cholangiocarcinoma through imaging challenging. (medscape.com)
  • Benign neoplasm of liver include hepatic hemangiomas, hepatic adenomas , and focal nodular hyperplasia (FNH). (wikidoc.org)
  • low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromaffin-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)
  • The term neoplasm includes both benign and malignant "new growths) A carcinoma is a malignant neoplasm of epithelial cells. (imperial.ac.uk)
Bile duct tumors2
  • The anticipated course of most cases of bile duct tumors includes recurrent biliary obstruction with infectious complications, local spread, and death in 6-12 months. (medscape.com)
  • Traditionally, bile duct tumors located within the liver had been classified with hepatocellular carcinoma as primary liver tumors. (tri-kobe.org)
Cirrhosis4
  • This includes mostly drug-induced hepatotoxicity, (DILI) which may generate many different patterns over liver disease, including cholestasis necrosis acute hepatitis and chronic hepatitis of different forms, cirrhosis Effects of Acetaminophen (Tylenol) other rare disorders like focal nodular hyperplasia, Hepatic fibrosis, peliosis hepatis and veno-occlusive disease. (wikipedia.org)
  • Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or chronic toxic liver disease may cause liver failure and hepatorenal syndrome fibrosis and cirrhosis of liver Cirrhosis may also occur in primary biliary cirrhosis. (wikipedia.org)
  • Cirrhosis may also occur in primary biliary cirrhosis . (wikidoc.org)
  • In patients with cirrhosis, liver disease, or other risk factors for HCC, and with lesions greater than 1 cm, triple-phase, contrast-enhanced studies (dynamic computed tomography [CT] or magnetic resonance imaging [MRI]) can be used to establish a diagnosis of HCC. (oncolink.org)
Subtypes3
  • According to the World Health Organization classification, there are 2 subtypes of intrahepatic cholangiocarcinoma, small duct (SD) and large duct (LD), each with distinct clinicopathologic features. (medscape.com)
  • Cholangiocarcinoma presents as 3 separate morphologic subtypes: mass forming, periductal infiltrating, and intraductal growing. (medscape.com)
  • Subtypes of cholangiocarcinoma are differentiated based on their location in the biliary tree. (mdpi.com)
Computed Tomography2
  • Main international guidelines recommend computed tomography (CT) and/or magnetic resonance imaging (MRI) as the principal imaging modalities for the diagnosis of intrahepatic cholangiocarcinoma. (medscape.com)
  • Positron Emission Tomography/Computed Tomography (PET/CT) clearly demonstrated hotspots (SUV max: 7.7 for the primary mass and 4.2 for the metastatic lesion) at the same locations as the tumors detected by MRI, but no hot spots for lymph nodes and distant metastases were observed ( Figure 1D ). (oncologyradiotherapy.com)
Diagnosis4
  • Granulomatous lung diseases: sarcoidosis and tuberculosis (and their differential diagnosis). (unibo.it)
  • Pathogenesis, diagnosis, and management of cholangiocarcinoma. (nih.gov)
  • Xanthogranulomatous cholecystitis (XGC) mimics Gallbladder carcinoma (GBC) in both preoperative and intra-operative settings and the patient may undergo an unnecessary radical cholecystectomy which is associated with a greater morbidityrather than a cholecystectomy alone.We postulated that a pre-operative diagnosis of XGC might benefit patients by avoiding radical procedures and attempted to identify the features of XGC which would differentiate it from GBC before and during surgery. (medicinelakex1.com)
  • A cystic dilation of the biliary tree is consistent with the diagnosis of choledochal cyst. (iswantosucandyliversurgery.com)
Management of cholangiocarcinoma2
Preoperative1
  • Debate exists about whether preoperative stenting is warranted, but most surgeons believe that preoperative biliary decompression does not alter the outcome of surgery. (medscape.com)
Hepatocellular carcinomas1
  • Solitary well-demarcated tumors are difficult to differentiate from primary hepatocellular carcinomas (HCCs). (medscape.com)
Cysts2
  • Abdominal enhanced Magnetic Resonance Imaging (MRI) and Magnetic Resonance Cholangiopancreatography (MRCP) revealed an irregular mass (approximately 48 mm × 44 mm in its dimensions) mainly located at segment VIII (S8) of the liver involving the hepatic hilum with mild delayed enhancement, a small metastatic lesion at segment VII (S7), and several small sporadic cysts in the liver ( Figure 1A-1C ). (oncologyradiotherapy.com)
  • There are 5 types of choledochal cysts, based on the location of cyst within the biliary tree . (iswantosucandyliversurgery.com)
Common bile1
Chronic4
  • Ischemic heart disease: pathogenesis and morphological features of angina pectoris, chronic ischemic heart disease, myocardial infarction (timing of the progression of ischemic necrosis in myocardial infarction: evaluation methods). (unibo.it)
  • Chronic restrictive diseases: classification of various types of histological patterns in interstitial lung disease (usual interstitial pneumonia, nonspecific interstitial pneumonia). (unibo.it)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • SD has been shown to develop more frequently in patients with chronic viral hepatitis without precursor lesions, whereas LD lesions have been found more frequently in patients with chronic bile duct disease. (medscape.com)
Hilar Cholangiocarcinoma2
Endoscopic2
  • Cholangiography via a transhepatic or endoscopic approach is required to define the biliary anatomy and the extent of the lesion. (medscape.com)
  • Stents can be placed via endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) to relieve biliary obstruction. (medscape.com)
ICCA1
  • Here, we report a case of multifocal intrahepatic CCa (iCCa) who achieved complete long-lasting remission on treatment with metronomic combination therapy of oral celecoxib, etoposide, and cyclophosphamide. (ganzemedizin.at)
Pathogenesis4
  • Valvular heart disease: morphology and pathogenesis of rheumatic heart disease, aortic stenosis, mitral valve prolapse, infective endocarditis, non-bacterial thrombotic endocarditis. (unibo.it)
  • Myocardial diseases: pathogenesis and morphological features of myocarditis and cardiomyopathies, dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy (amyloidosis) and arrhythmogenic cardiomyopathy. (unibo.it)
  • Pericardial disease: pathogenesis and morphological features of pericarditis and pericardial effusions. (unibo.it)
  • Results of epidemiologic studies have implicated bacteria-induced carcinogens derived from bile salts (eg, lithocholate) as a causative factor in the pathogenesis of cholangiocarcinomas . (medscape.com)
Epithelial1
  • The liver is an epithelial-mesenchymal outgrowth of the caudal part of the foregut, with which it retains its continuity by the biliary tree. (medscape.com)
Cyst2
  • Type IVa Choledochal Cyst: This type presents as multiple dilatations of the intrahepatic and extrahepatic biliary tree. (iswantosucandyliversurgery.com)
  • The standard treatment for choledochal cyst is via complete cyst resection with or without liver resection , depending on type of the choledochal cyst, followed by a reconstruction of the biliary tree. (iswantosucandyliversurgery.com)
Primary liver tumors1
Pathophysiology1
  • Presumably this is not common, but is this likely to be related to the 'IgG4 Related Diseases' or another pathophysiology entirely? (imperial.ac.uk)