• Adenoid cystic carcinoma (ACC) is a subtype of malignant salivary gland tumors (MSGT), in which 90% of cases express cKIT. (nih.gov)
  • The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians. (biomedcentral.com)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Using paclitaxel (Taxol), another antimicrotubule drug, alone has had moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma. (medscape.com)
  • This is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody , as single agent and in combination with pembrolizumab in participants with advanced or metastatic solid tumors and non-small cell lung cancers. (ucbraid.org)
  • 1) The Part A study is a dose-finding rapid titration, Phase I trial of ONC-392 as a single agent in patients with advanced or metastatic solid tumors with various histology. (ucbraid.org)
  • The aim of this trial is to define the recommended Phase II dose for ONC-392 monotherapy (RP2D-M). (2) The Part B study is a dose-finding phase with ONC-392 in combination with a standard dose of 200 mg pembrolizumab in patients with advanced or metastatic solid tumors. (ucbraid.org)
  • A phase 1/2 open-label multicenter study will be performed with an initial dose escalation part to determine the MTD and/or the RP2D of MCLA-129 as monotherapy in patients with NSCLC, HNSCC, GC/GEJ, ESCC, or other solid tumors and who have progressed after receiving prior therapy for advanced/metastatic disease. (uci.edu)
  • This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation. (uci.edu)
  • Although other tumors may have a similar clinical presentation because of their location at the thoracic inlet, the most common cause is believed to be a bronchogenic carcinoma arising in or near the superior sulcus and invading adjacent extrathoracic structures by direct extension. (medscape.com)
  • Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
  • Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
  • Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
  • A Phase 2 Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma. (ucsfhealth.org)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
  • Solid-Basaloid Adenoid Cystic Carcinoma of the Breast: An Aggressive Subtype Enriched for Notch Pathway and Chromatin Modifier Mutations With MYB Overexpression. (ucsf.edu)
  • Although patient survival for breast cancer has been improved in recent decades[ 9 ], the outcome of patients with metastatic breast cancer remains poor with a median overall survival time of 2 to 3 years[ 10 ]. (biomedcentral.com)
  • The poor outcome of metastatic breast cancer patients underscores the importance of defining molecular factors responsible for cancer metastasis. (biomedcentral.com)
  • It is a commonly prevailing form of breast cancer with 80 percent breast cancers of the invasive type being that of ductal carcinoma. (healthresource4u.com)
  • MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. (sncrf.org)
  • In ambiguous cases, it is used as a phenotypic marker of lobular subtype of breast carcinoma. (iiarjournals.org)
  • The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. (iiarjournals.org)
  • Material and Methods: We processed 88 invasive breast carcinomas of NST type and their paired LNM. (iiarjournals.org)
  • Retrospective review of HPR of invasive breast carcinoma resections from 2016-2020. (waocp.com)
  • The study was conducted by retrospective review of HPR of invasive breast carcinoma resections over a period of 5 years from January 2016 to December 2020. (waocp.com)
  • breast carcinoma. (slideshare.net)
  • Ca breast ug lecture ajay khanna department of surgery. (slideshare.net)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uci.edu)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • Lymph node involvement is typically rare for eccrine carcinoma but distal metastasis is not uncommon [ 4 ]. (biomedcentral.com)
  • However, thyroid metastasis of ccRCC combined with papillary thyroid carcinoma (PTC) is rarely reported. (spandidos-publications.com)
  • After the operation, the pathological examination results suggested the following: Renal clear cell carcinoma, pT1aN0M0, the tumor sized ~4.0×4×3.5 cm 3 , with no lymph node cancer metastases or distant metastasis. (spandidos-publications.com)
  • However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. (oncotarget.com)
  • Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression for multiply tumor types. (biomedcentral.com)
  • Metastasis-associated in colon cancer-1 (MACC1) was first identified to be overexpressed in primary and metastatic tumor specimens of colon cancer as compared to normal colon mucosa and was found to be indicative of metastasis as well as poor survival of the patients. (biomedcentral.com)
  • In addition, p63 and Ki-67 expression levels were associated with myoepithelial carcinoma recurrence and metastasis. (cyberleninka.org)
  • Conclusions: Recurrence and metastasis in myoepithelial carcinomas are more frequent in p63-positive and Ki-67-positive EMCs, and poor prognosis is associated with overexpression of p63. (cyberleninka.org)
  • Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer. (kreftfri.no)
  • Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck. (mdanderson.org)
  • He studies how to improve the efficacy of immune checkpoint inhibitors (drugs that turn off the ability of some cancer cells to evade detection by immune system cells) with combination approaches to treating head and neck squamous cell carcinomas. (ucsfhealth.org)
  • Studies find that the levels of CMTM2 protein in hepatocellular carcinoma tissues of patients are lower higher than their levels in normal liver tissues. (wikipedia.org)
  • CMTM2 protein levels were also lower in the hepatocellular carcinoma tissues that had a more aggressive pathology and therefore a possible poorer prognosis. (wikipedia.org)
  • These findings suggest that CMTM2 protein suppresses the development and/or progression of hepatocellular carcinoma and therefore that the CMTM2 gene acts as a tumor suppressor in this cancer. (wikipedia.org)
  • These findings suggest that the CMTM2 gene may act as a tumor suppressor not only in hepatocellular carcinoma but also in linitis plastica and salivary gland adenoid cystic carcinoma. (wikipedia.org)
  • Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). (pharmaceutical-technology.com)
  • Renal cell carcinoma (RCC) is the most common solid lesion within the kidney and accounts for ~90% of all kidney malignancies. (spandidos-publications.com)
  • Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. (sncrf.org)
  • Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
  • INTRODUCTION: Morphologic and molecular data for staging of multifocal lung squamous cell carcinomas (LSCCs) are limited. (bvsalud.org)
  • In a two-stage design, patients with progressive, recurrent/metastatic ACC (+cKIT) and non-ACC MSGT (separate cohort) were treated with dasatinib 70 mg p.o. b.i.d. (nih.gov)
  • And, the CMTM2 gene has been found to be more highly expressed in the salivary gland adenoid cystic carcinoma tissues of patients who did not develop tumor recurrences or perineural invasion of their carcinomas compared to the expression of this gene in patients whose adenoid cystic carcinoma tissues went on to develop these complications. (wikipedia.org)
  • This is a Phase 1, open-label, non-randomized, multicenter study investigating REM-422, a potent, selective, and oral small molecule mRNA degrader that reduces expression of the MYB transcription factor for patients with recurrent or metastatic ACC. (ucsf.edu)
  • The purpose of the Dose Escalation Phase is to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of REM-422 in patients with recurrent or metastatic ACC. (ucsf.edu)
  • Cabometyx is indicated for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible. (pharmaceutical-technology.com)
  • Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
  • The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
  • The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)
  • Pancreatic Cancer Cohort, ONC-392 monotherapy, will enroll advanced/metastatic pancreatic cancer patients who have progressive disease after first and second lines of systemic treatment. (ucbraid.org)
  • Arm B: TNBC Cohort, ONC-392 monotherapy, will enroll advanced/metastatic TNBC patients who have progressive disease after prior systemic treatments, including checkpoint inhibitor immunotherapy. (ucbraid.org)
  • Arm C: NSCLC Mono Cohort 1, ONC-392 monotherapy, will enroll advanced/metastatic NSCLC patients with EGFR or ALK mutations who have progressive disease after prior systemic treatments, including targeted therapy or checkpoint inhibitors. (ucbraid.org)
  • Thus, PKM2 deregulation plays an important role in TSCC and may serve as a biomarker of metastatic potential or as a therapeutic target in patients with TSCC. (oncotarget.com)
  • Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published correction appears in CA Cancer J Clin. (msdmanuals.com)
  • These cancers have cystic and glandular features. (healthresource4u.com)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
  • Selective loss of E-cadherin can cause de-differentiation and invasiveness in human carcinomas, leading this marker to be classified as a tumor suppressor ( 5 ). (iiarjournals.org)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Morphologic, immunophenotypic, and molecular features of these neoplasms are largely similar to salivary gland tumours elsewhere, and therefore the exclusion of metastatic disease requires clinical and radiologic correlation. (bvsalud.org)
  • Overall, salivary gland type-tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high-grade variants exist for many of these tumour types. (bvsalud.org)
  • AIMS: Thymic epithelial tumours (TET), including thymomas and thymic carcinomas and thymic neuroendocrine neoplasms, are malignant neoplasms that can be associated with morbidity and mortality. (bvsalud.org)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • In addition, in 2017 the Union for International Cancer Control (UICC) / American Joint Committee on Cancer (AJCC) published the 8th Edition Staging Manual which, for the first time, includes a TNM staging that is applicable to thymomas, thymic carcinomas, and thymic neuroendocrine neoplasms. (bvsalud.org)
  • Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
  • Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12/19/2017) 24. (sncrf.org)
  • Have locally advanced or metastatic ACC. (ucsf.edu)
  • The overwhelming majority of cases of Pancoast syndrome are non-small cell lung carcinoma (NSCLC), with more than 95% located in the superior sulcus. (medscape.com)
  • Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. (ucsf.edu)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Carcinomas in the superior pulmonary sulcus produce Pancoast syndrome, thus causing pain in the shoulder and along the ulnar nerve distribution of the arm and hand. (medscape.com)
  • CA Cancer J Clin 68(6):394-424, 2018. (msdmanuals.com)
  • CA Cancer J Clin 73(1):17-48, 2023. (msdmanuals.com)
  • At the age of 86, "Peanuts" producer Lee Mendelson lost his battle to cancer and passed away at his home in Hillsborough, California, on Dec. 25. (wonderwall.com)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018) 7. (sncrf.org)
  • Squamous cell carcinoma variants of the genitourinary (GU) system 19. (sncrf.org)
  • Other lesions reported with BSS include parotid basal cell adenomas, organoid nevi, syringomas, and basal cell carcinomas. (medscape.com)