• Small bowel metastasis from malignant tumors is generally rare and underreported. (karger.com)
  • Metastatic tumors involving colon are rare, accounting for only 0.338% of all colorectal malignancies in a large multi-institutional study, when lymphoproliferative diseases, direct invasion, and mesenteric and peritoneal spreading are excluded [ 1 ]. (hindawi.com)
  • By contrast, 90.5% of the mice which received MCA followed by MWCNT had bronchiolo-alveolar adenomas and adenocarcinomas with an average of 2.9 tumors per mouse 17months after exposure. (cdc.gov)
  • The real incidence of pineal metastasis is not clear, studies have reported a prevalence of 0.4 to 3.8% in patients with metastatic solid tumors 1 . (radiopaedia.org)
  • Metastatic bone tumors of the skeleton are caused when cancer from another part of the body spreads to the bones. (massgeneral.org)
  • The most common kinds of metastatic bone tumors of the skeleton begin with prostate, breast, thyroid, lung, or kidney cancer. (massgeneral.org)
  • In children, metastatic skeletal tumors are usually due to neuroblastoma, leukemia or Ewing's sarcoma. (massgeneral.org)
  • Metastatic tumors from the kidney or thyroid are usually very vascular (made of blood vessels) whereas tumors from prostate, breast and lung are less so. (massgeneral.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • HO-1 expression was higher in human primary and metastatic tumors compared with noncancerous tissue. (jci.org)
  • These results establish HO-1 as a mediator of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential targets for therapeutic intervention in solid tumors. (jci.org)
  • Using AI to Detect Lymph Metastases from Urologic Tumors: Yes, No, or Maybe? (medpagetoday.com)
  • A study explored the use of an AI-based diagnostic model for detecting lymph node metastases on pathology slides of urological tumors, noting potential clinical application for improving diagnostic accuracy and reducing review times. (medpagetoday.com)
  • Investigators suggest basing personalized therapeutic choices for urothelial cancers on global assessments, rather than focusing on primary tumors, because of the high degree of genomic variability and discordance in metastatic disease. (medpagetoday.com)
  • Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. (iiarjournals.org)
  • Neoplastic CES may arise from cauda equina primary tumors or secondary metastases, which may involve the vertebral bones, resulting in fracture and external nerve compression ( 5 ). (iiarjournals.org)
  • Sister Joseph (1856-1939), superintendent of St. Mary's Hospital, was credited with making the observation of lymphatic metastases to the umbilical region in metastatic tumors of intra-abdominal origin, hence the name "Sister Joseph's nodule. (aafp.org)
  • 2 - 4 Additionally, there are rare reports of primary tumors outside the abdominal cavity with metastasis to the umbilicus, including breast, lung and penis. (aafp.org)
  • New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
  • Secondary or metastatic tumors appear to be less common and may result from local extension (e.g., nasal adenocarcinoma) or metastases from primary tumors elsewhere. (vin.com)
  • Secondary tumors reported to occur in the brain of cats include pituitary macroadenomas macrocarcinomas, and metastatic carcinomas. (vin.com)
  • Local extension in cats may be either from tumors such as squamous cell carcinoma of the middle ear cavity, or from nasal adenocarcinoma. (vin.com)
  • Secondary tumors are metastasis from a primary tumor located outside the nervous system, or occur by local invasion from adjacent non- neural tissues (e.g., bone). (vin.com)
  • Consecutive patients with metastatic CRC who had both primary and metastatic tumors diagnosed at our institution in January 2008 through December 2016 were identified. (jnccn.org)
  • Immunohistochemistry was used to test the MMR status of both primary and matched metastatic tumors, and PCR analysis was performed to test MSI in patients with deficient MMR (dMMR) status. (jnccn.org)
  • Of the 46 patients with MSI-high primary tumors, 37 (80.4%) also had MSI-high metastatic tumors, whereas 9 (19.6%) had microsatellite stable (MSS) metastatic tumors. (jnccn.org)
  • the median overall survival of MSI-high and MSS metastatic tumors was 21.3 and 21.6 months, respectively ( P =.774). (jnccn.org)
  • The tumor initially spreads via a hematogenous route to the pulmonary arterioles and capillaries with retrograde spread from hilar nodal metastases or upper abdominal tumors, but subsequently extends through the vascular walls, invades the low resistant peribronchovascular lymphatics, and spreads along the lymphatics. (medscape.com)
  • No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
  • In addition, patients with cancer of unknown primary origin are defined as patients with histologically proven metastatic malignant tumors in which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
  • Volume-rendered 3-dimensional CT scan shows a metastatic mass in the trachea from squamous cell carcinoma of the lung. (medscape.com)
  • Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. (nih.gov)
  • Anal squamous-cell carcinoma (ASCC) and rectal adenocarcinoma are typically indistinguishable on MRI, and a biopsy prior to imaging is necessary to accurately stage the tumor and determine the treatment approach. (bvsalud.org)
  • PURPOSE: This review discusses the histology, MR technique, diagnosis, staging, and treatment of anal cancer, with a particular focus on the differences in TNM staging between anal squamous-cell carcinoma (ASCC) and rectal adenocarcinoma. (bvsalud.org)
  • Squamous cell carcinoma con- geal cancer is endemic in some regions other malignancies were considered as stituted 95% and adenocarcinoma 5% of Islamic Republic of Iran [3,4] and exclusion criteria. (who.int)
  • Typical sites of metastasis of endometrial carcinoma are pelvic and para-aortic lymph nodes, vagina, peritoneum, and lungs [ 2 ]. (karger.com)
  • Adenoid cystic carcinoma (ACC) is a tumor characterized by slow growth and late distant metastasis. (hindawi.com)
  • Metastatic adenoid cystic carcinoma (ACC) in the colon is rare, with only a few case reports available [ 2 - 4 ]. (hindawi.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • 4. Li J, Wang P, Wang B. Unique Case Report of Pineal Gland Metastasis From Bladder Carcinoma. (radiopaedia.org)
  • 1 ] Breast carcinoma is the most common cause of cutaneous metastasis, followed by carcinoma large intestine, lung, and ovaries in women. (lww.com)
  • Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. (ispub.com)
  • Metastases affecting the small bowel and originating from carcinoma of the lung are a rare occurrence, but recent reports suggest that they may be more frequent than previously thought as they rarely produce symptoms. (ispub.com)
  • The purpose of this study was to investigate the outcome, treatment related toxicity, and prognostic factors in cats with stage IV (metastatic) mammary carcinoma. (vin.com)
  • Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • A new study compared survival outcomes among patients with metastatic bladder urothelial carcinoma across racial/ethnic groups with predicted life expectancy, as derived from Social Security Administration life tables. (medpagetoday.com)
  • A new retrospective analysis suggests that urothelial carcinoma with glandular differentiation (UC-GD) is similar to urothelial carcinoma not otherwise specified (UC-NOS), while primary bladder and urachal adenocarcinomas are similar to colorectal adenocarcinomas. (medpagetoday.com)
  • The patient had no history of breast cancer, and mammography showed no evidence of breast carcinoma as a primary site for her metastatic disease. (aafp.org)
  • Multiple distant metastases are the major cause of mortality in lung cancer. (aging-us.com)
  • Of note, distant metastases occur most commonly in the brain, liver, adrenal glands and bones. (spandidos-publications.com)
  • Ready-to-use antibodies, which were not diluted, were purchased from Beijing Zhongshan Golden Bridge Biological Technology Co., Ltd. Whole-body CT examination revealed no distant metastases anywhere, including the brain. (spandidos-publications.com)
  • While a large number of patients with pulmonary metastases are asymptomatic at the time of diagnosis, some patients develop symptoms such as hemoptysis, cough, shortness of breath, chest pain, weakness, and weight loss. (medscape.com)
  • Here, we report a case of ACC metastatic to the colon 19 years after resection of the primary tumor, to broaden the differential diagnosis of colorectal malignancies and to better understand the clinical, histological, and molecular features of ACC. (hindawi.com)
  • Immunohistochemically, the tumor demonstrated epithelial-myoepithelial dual lineage differentiation, which confirmed the diagnosis of metastatic ACC. (hindawi.com)
  • Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma. (ispub.com)
  • The disease is often metastatic at the time of diagnosis, though metastases may be microscopic. (vin.com)
  • Cats were required to have a complete medical record including a histologic diagnosis of mammary adenocarcinoma, with metastatic disease confirmed based on physical exam (PE), ultrasound, radiographs or CT. (vin.com)
  • 75% of cats has a previous mammary surgery, while the remainder had distant metastasis at the time of initial diagnosis. (vin.com)
  • 19 cats had received chemotherapy prior to diagnosis of metastasis. (vin.com)
  • There was a very diffuse set of histories, with some cats receiving chemotherapy prior to diagnosis of metastasis, which may have contributed to drug resistance. (vin.com)
  • The diagnosis was an atypical presentation of cutaneous lymphangitis carcinomatosa from metastatic lung adenocarcinoma. (cdlib.org)
  • Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
  • Lung cancer is the leading cause of cancer-related death worldwide, with most patients presenting with metastases during diagnosis ( 1 ). (spandidos-publications.com)
  • Furthermore, the literature relevant to the occurrence, diagnosis and treatment of GI metastasis of lung cancer was reviewed. (spandidos-publications.com)
  • CASE PRESENTATION: Male, 60 years-old, presents to a surgical consult with the diagnosis of an adenocarcinoma of the sigmoid colon. (bvsalud.org)
  • 5. Verified diagnosis of colorectal adenocarcinoma (C18.5, C19, C20). (who.int)
  • MTA1 was first cloned by Toh, Pencil and Nicholson in 1994 as a differentially expressed gene in a highly metastatic rat breast cancer cell line. (wikipedia.org)
  • We focus on a class of genes known as metastasis suppressor genes and, in particular, breast cancer metastasis suppressor I (BRMS1). (mskcc.org)
  • Determine the maximum tolerated dose of vinorelbine and celecoxib in women with relapsed or metastatic breast cancer. (knowcancer.com)
  • This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • Johnsson A, Kiani NA, Gernaat SAM, Wilking U, Shabo I, Hedayati E. Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study. (cancercentrum.se)
  • Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)
  • In patients with primary renal or testicular cancer, chest CT scanning should be performed based on the presence of metastatic disease elsewhere. (medscape.com)
  • The presence of metastatic disease is associated with a very poor prognosis, with reported survival times in the range of 1 month. (vin.com)
  • Metastasis from endometrial cancer to small bowel is very rare [ 3 ]. (karger.com)
  • A majority of cancer-related deaths are attributed to metastasis rather than to localized primary tumor progression. (medscape.com)
  • Now, two studies provide complementary evidence demonstrating that both endogenous and exogenous antioxidants can induce stabilization of BACH1 to promote lung cancer metastasis. (nature.com)
  • To examine how exogenous antioxidants might influence lung cancer metastasis, Wiel et al. (nature.com)
  • 69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC. (hindawi.com)
  • Distant metastasis is the main cause of the treatment failure of the patients with colorectal cancer. (hindawi.com)
  • RYBREVANT is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test [see Dosage and Administration (2.1) ] , whose disease has progressed on or after platinum-based chemotherapy. (drugs.com)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • Bone metastases, or bone mets, occur when cancer cells from a primary tumor spread to the bone. (massgeneral.org)
  • Metastases after age 30 are usually adenocarcinoma (a type of cancer that involves the cells lining the walls of different organs in the body). (massgeneral.org)
  • Metastatic disease is very serious, but advances in cancer care mean that many patients still have significant amounts of quality time for themselves and their families. (massgeneral.org)
  • Gastric adenocarcinoma is one of the common causes of cancer death in the world. (lww.com)
  • This case is reported due to the rarity of cutaneous metastasis at multiple sites from a highly aggressive adenocarcinoma in a young patient, to emphasize the importance of cutaneous metastasis as a poor prognostic sign in patients with a history of cancer. (lww.com)
  • On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA inhibitor for imaging and therapy (PSMA I&T) for 68 Ga-based PET and 177 Lu-based endoradiotherapeutic treatment in patients with metastatic and castration-resistant disease. (snmjournals.org)
  • As a consequence, PSMA has attracted attention as a target for molecular imaging and for targeted radioligand therapy, especially in metastatic castrate-resistant prostate cancer (mCRPC). (snmjournals.org)
  • There was no evidence of metastatic spread, and so my T4N0M0 designation equated it to a stage 2b small intestine cancer. (cancer.org)
  • Brain metastases from gastric cancer are rare and are diagnosed in less than 1% of patients with gastric cancer. (scielo.org.pe)
  • Gastric cancer is the most chemosensitive adenocarcinoma among digestive neoplasms. (cancernetwork.com)
  • Forty-six patients with locally advanced or metastatic gastric cancer received a median of 3 courses each. (cancernetwork.com)
  • Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities - a retrospective multicentre study. (vin.com)
  • Cancer metastasis is the leading cause of death in cancer patients. (frontiersin.org)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Cancer metastasis is a complicated process, which is one of the main causes of the recurrence and death of cancer patients. (frontiersin.org)
  • During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
  • Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
  • The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
  • patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • The primary reason people die from cancer is the development of metastatic disease. (mskcc.org)
  • As a surgeon-scientist who cares for patients with earlier stage lung and esophageal cancer, my laboratory studies why patients with completely resected cancer still develop metastases and die. (mskcc.org)
  • The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • Starting with a luciferase assay, insights gleaned from the Cancer Genome Atlas transcriptome sequencing efforts, and a rapid amplification of cDNA ends experiment, the researchers found a LINC00673 isoform that appeared to influence WNT/beta-catenin signaling in lung adenocarcinoma cells. (genomeweb.com)
  • With a series of follow-up experiments, together with data from the Atlas of Noncoding RNAs in Cancer, they found that LINC00673-v4 was not only found at higher-than-usual levels in lung adenocarcinoma cells, but also appeared to influence the invasiveness of lung cancer cell lines as well as the progression and metastatic potential of lung cancers in a mouse model. (genomeweb.com)
  • Tissue microarrays from 629 resected primary lung cancers and 422 resected pulmonary epithelial metastases from various sites (whereof 275 colorectal cancer) were investigated for the immunohistochemical expression of CDH17, GPA33, MUC2, MUC6, SATB2, and SMAD4, for comparison with CDX2, CK20, CK7, and TTF-1. (lu.se)
  • However, no single or combination of markers can categorically distinguish primary lung cancers from metastatic GI tract cancer. (lu.se)
  • Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
  • Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • The occurrence of small intestinal metastases from primary lung cancer is rare. (spandidos-publications.com)
  • Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. (spandidos-publications.com)
  • Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
  • Furthermore, the gastrointestinal (GI) tract is not a common site of primary lung cancer metastasis ( 4 ). (spandidos-publications.com)
  • This suggests that the process of GI metastasis of lung cancer is subtle and lacks specific clinical symptoms. (spandidos-publications.com)
  • The present report describes an uncommon case of small intestinal metastasis from lung cancer. (spandidos-publications.com)
  • Differences between the features of primary cancer and matched metastatic cancer have recently drawn attention in research. (jnccn.org)
  • This study investigated the concordance in microsatellite instability (MSI) and mismatch repair (MMR) status between primary and corresponding metastatic colorectal cancer (CRC). (jnccn.org)
  • Along with the change of MSI-high in primary cancer to MSS in metastatic cancer, lymphocyte infiltration decreased significantly ( P =.008). (jnccn.org)
  • The histologic subtype, metastasis site, and certain patient characteristics can offer clues to the cancer primary. (medscape.com)
  • Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)
  • Cost-Minimization Analysis of Pembrolizumab Monotherapy Versus Nivolumab in Combination with Ipilimumab as First-Line Treatment for Metastatic PD-L1-Positive Non-small Cell Lung Cancer: A US Payer Perspective. (cdc.gov)
  • CT guidance is often required for obtaining samples from a suspected metastatic disease. (medscape.com)
  • Pineal metastases are usually asymptomatic unless a certain volume is reached, then causing a local mass effect that may manifest as a Parinaud syndrome or increased intracranial pressure symptoms related to obstructive hydrocephalus 1,3 . (radiopaedia.org)
  • These metastases are usually asymptomatic but may present as perforation, obstruction, malabsorption, or haemorrhage. (ispub.com)
  • Bone-targeting properties of (223)Ra could also potentially be used for treating skeletal metastasis from other primary cancers. (researchgate.net)
  • MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)
  • Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. (lu.se)
  • 165 U/L were 3.29 times more likely to have lymph node involvement than patients with ALP levels 165 U/L. There was no statistically significant correlation between ALP level and sex, age, tumour histological type, site and size of tumour, depth of penetration, distant metastasis, degree of differentiation, presence of lymphatic invasion and presence of simultaneous multiple cancers. (who.int)
  • [ 2 ] The development of pulmonary metastases in patients with known malignancies indicates disseminated disease and places the patient in stage IV in TNM (tumor, node, metastasis) staging systems. (medscape.com)
  • Imaging plays an important role in the screening and detection of pulmonary metastases. (medscape.com)
  • Several thermal ablation options are available for treatment of pulmonary metastases, which is performed under CT guidance. (medscape.com)
  • The most sensitive markers for GI origin were GPA33 (positive in 98%, 60%, and 100% of pulmonary metastases from. (lu.se)
  • ASC is a rare tumor among esophageal carcinomas with a greater burden of metastatic disease than AC or SCC and worse OS than AC. (nih.gov)
  • Biopsy revealed metastatic ACC, and all the nodules were enucleated. (hindawi.com)
  • Biopsy was performed and revealed metastatic ACC. (hindawi.com)
  • Metastasis was confirmed to be adenocarcinoma by FNA or Biopsy when feasible, though several pulmonary masses were diagnosed based on radiography alone. (vin.com)
  • FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. (uc.edu)
  • Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. (uc.edu)
  • First-in-human 68 Ga-PSMA I&T PET imaging allowed high-contrast detection of bone lesions, lymph node, and liver metastases. (snmjournals.org)
  • 2.5 X the upper limit of normal in the absence of liver metastases. (who.int)
  • Imaging guidance is also used in histologic confirmation of metastatic disease. (medscape.com)
  • Patients with MTAP-deletion had a shorter time to progression to metastatic disease and inferior response to chemotherapy. (medpagetoday.com)
  • This lung adenocarcinoma may be a useful experimental model for studying tumor progression, paraneoplastic syndromes and immunology in carcinogenic studies. (oldcitypublishing.com)
  • Twenty percent of metastatic disease is isolated to the lungs. (medscape.com)
  • Chest radiograph of a 58-year-old man with malignant melanoma (note surgical clips in right lower neck) shows multiple pulmonary nodules of varying sizes consistent with metastatic disease. (medscape.com)
  • Mice with early morbidity resulting in euthanasia had the highest rate of metastatic disease. (cdc.gov)
  • Pineal gland metastasis is a rare site of metastatic disease. (radiopaedia.org)
  • The bone is a common site for metastatic disease. (massgeneral.org)
  • Staging studies are usually done to determine the extent of the metastatic disease and plan the most appropriate treatment. (massgeneral.org)
  • Chemotherapy, use of hormones and palliative radiation therapy, that is radiation to treat the symptoms not cure, are other options used to care for patients with metastatic disease. (massgeneral.org)
  • These patients living with metastatic disease have a phenomenal amount of inner strength and hope. (massgeneral.org)
  • Cutaneous metastasis may be the first presentation of internal malignancies even with a short history of disease in young patients. (lww.com)
  • PSMA expression correlates with the malignancy of the disease, being further increased in metastatic and hormone-refractory patients ( 4 ). (snmjournals.org)
  • The physical examination was nonfocal for a source of metastatic disease. (aafp.org)
  • Additionally, the CT scan revealed two hypodense areas in the liver and a 15-mm nodule in the lower lobe of the right lung, suspicious for metastatic disease. (aafp.org)
  • Mortality is attributable largely to metastatic disease and a dearth of effective therapeutic interventions. (biologists.com)
  • CT and PET/CT are useful in evaluating lymph node metastases and distant metastatic disease. (bvsalud.org)
  • Metastatic disease to the colon is a very rare entity with only 5 cases described in english literature. (bvsalud.org)
  • The staging CT-scan showed a mass in the tail of the pancreas involving the spleen and left kidney, thickening of the sigmoid colon, multiple mesenteric masses and trabecular changes in the ischium, suggesting metastatic disease. (bvsalud.org)
  • 6. Metastatic unresectable form of the disease that has not previously received any systemic therapy for the metastatic process (previous neo-/adjuvant therapy completed at least 6 months before the detection of metastases is allowed). (who.int)
  • 1. Previous systemic therapy for metastatic disease. (who.int)
  • Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma. (cdc.gov)
  • Sister Joseph's nodule is a lymphatic metastasis to the umbilical region. (aafp.org)
  • Lymphatic spread occurs either in an antegrade fashion by lymphatic invasion through the diaphragm and/or pleural surfaces or retrograde lymphatic spread from hilar lymph nodal metastasis. (medscape.com)
  • To identify the population of patients with high risk of distant metastasis and the poor prognosis before treatment, so as to provide early intervention and better treatment decision. (hindawi.com)
  • Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
  • Once distant metastasis occurs, there is almost no opportunity for surgery and the prognosis is poor. (spandidos-publications.com)
  • We present a case of a 61 year old patient with upper gastrointestinal bleeding due to duodenal metastases from a primary adenocarcinoma of the lung with secondary deposits in the abdominal lymph nodes. (ispub.com)
  • RNA sequencing of cell lines generated from KP and KPK lung tumours revealed upregulation of metastatic genes in Keap1 mutant cells. (nature.com)
  • Chest radiography (CXR) is the initial imaging modality used in the detection of suspected pulmonary metastasis in patients with known malignancies. (medscape.com)
  • Most patients with bony metastases present with pain in the area of the lesion with decreased mobility and motion. (massgeneral.org)
  • The majority of patients with metastases of the small bowel referred to in the literature, present with bowel perforation. (ispub.com)
  • Initial human PET imaging studies using 68 Ga-PSMA I&T, as well as endoradiotherapeutic treatment of 2 patients with metastatic PC using 177 Lu-PSMA I&T, were performed. (snmjournals.org)
  • In Peru and in the world, standard recommendations on how to treat these patients have not yet been established, although it is known that surgical resection of brain metastases can significantly decrease morbidity and prolong survival compared to non-surgical approaches. (scielo.org.pe)
  • Moreover, HO-1 expression correlated with reduced overall survival of patients with lung adenocarcinoma and glioblastoma. (jci.org)
  • A high concordance was found in patients with liver, lung, or distant lymph node metastases. (jnccn.org)
  • The microscopic spread of metastasis through lymphatics and perilymphatic connective tissue is seen histopathologically in 56% of patients with pulmonary metastasis. (medscape.com)
  • This report documents the case of a 57‑year‑old male patient initially diagnosed with non‑metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. (spandidos-publications.com)
  • They found that supplementing the diet of lung tumour-bearing mice with either a pharmacological or dietary antioxidant, N -acetylcysteine (NAC) and vitamin E respectively, was sufficient to increase the amount of lymph node metastases relative to untreated control mice. (nature.com)
  • Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumour involving the duodenum and the proximal jejunum. (ispub.com)
  • However, it is unclear whether lycopene can act as an adjuvant to increase the anti-metastatic activity of anticancer drugs. (frontiersin.org)
  • Although generally a poor prognostic sign, long-term survival may be possible if the nodule represents a solitary metastasis. (aafp.org)
  • Knockout of Keap1 on the KP background (KPK mice) resulted in more thoracic and lymph node metastases relative to KP mice. (nature.com)
  • Cell lines derived from tumours of control and NAC-treated K mice (con-K and NAC-K hereafter) were then used to gain a mechanistic understanding of the pro-metastatic antioxidant effects. (nature.com)
  • Results: Twenty-three percent of the filtered air controls, 26.5% of the MWCNT-exposed, and 51.9% of the MCA-exposed mice, had lung bronchiolo-alveolar adenomas and lung adenocarcinomas. (cdc.gov)
  • Indeed, 62% of the mice exposed to MCA followed by MWCNT had bronchiolo-alveolar adenocarcinomas compared to 13% of the mice that received filtered air, 22% of the MCA-exposed, or 14% of the MWCNT-exposed. (cdc.gov)
  • In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
  • Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)
  • Implant success in eight LAC1-bearing mice generations was 100%, with a fast evolution (58 survival days) and good metastatic capacity (41% of animals with metastases). (oldcitypublishing.com)
  • Axial CT scan in a 58-year-old man with malignant melanoma shows multiple round nodules and masses of varying sizes in both lungs, consistent with metastases. (medscape.com)
  • The lungs are the most common metastatic site. (biologists.com)
  • [ 1 ] Lungs are the second most frequent site of metastases from extrathoracic malignancies. (medscape.com)
  • Haemorrhage as a first presentation of small bowel metastases is extremely rare and is related to very poor patient survival especially when these are located in the duodenum. (ispub.com)
  • In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
  • I'm 39 years old and was just diagnosed in August 2013 with adenocarcinoma of the small intestine (jejunum location). (cancer.org)
  • Brain metastases. (nature.com)
  • It was decided to perform a tumor excision by neurosurgery, whose pathological anatomy study revealed metastatic adenocarcinoma to the brain. (scielo.org.pe)
  • The most common pattern of pulmonary metastasis is the presence of multiple, well-defined nodules. (medscape.com)
  • We report the case of a 19-year young man with gastric adenocarcinoma who had multiple skin nodules over the trunk during presentation. (lww.com)
  • Recently, epithelial-mesenchymal transition (EMT) programs have become the focus of the mechanism of metastasis [ 1 , 17 - 20 ]. (intechopen.com)
  • A 75-year-old man with a three-year history of metastatic lung adenocarcinoma was diagnosed with cutaneous lymphangitic carcinomatosa of unique morphology. (cdlib.org)
  • [ 2 ] with the ungs being the second most frequent site of metastases from extrathoracic malignancies. (medscape.com)
  • The most common primary site of colorectal metastasis is the breast, followed by the lung and malignant melanoma [ 1 ]. (hindawi.com)
  • Our recent focus is LUAD organotropism, or the preferential metastasis to specific organ sites, and we have identified specific mutations that drive site-specific metastasis of LUAD. (mskcc.org)
  • We investigate BRMS1-mediated suppression of metastases in p53mut lung adenocarcinoma (LUAD), as well as the identification of a novel germline point mutation of BRMS1 variant 2, a pro-metastatic variant. (mskcc.org)
  • Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
  • Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
  • In this study, we collected single-cell sequencing datasets of LUAD and applied an integrated bioinformatic method to depict the transcriptome characteristic of LUAD in normal, tumoral, and metastasis condition. (aging-us.com)
  • Development of cutaneous metastasis during presentation is even rarer in any age group. (lww.com)
  • Cutaneous metastases are rare and generally seen in advanced stage. (lww.com)