• Primary cutaneous adenoid cystic carcinoma is a cutaneous condition characterized by a tumor that usually presents on the chest, scalp, or vulva of middle- to older-aged persons. (wikipedia.org)
  • In this report, we present a case of small bowel metastatic tumor from uterus presenting with profound anemia and impending obstruction. (karger.com)
  • Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. (nih.gov)
  • ASC is a rare tumor among esophageal carcinomas with a greater burden of metastatic disease than AC or SCC and worse OS than AC. (nih.gov)
  • revealed for the first time carcinoma ex microcystic adenoma in which the tumor, without metastases, showed inherent malignant changes [ 7 ]. (hindawi.com)
  • Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. (novusbio.com)
  • In the metastatic pancreatic cancer patient who had previously achieved a confirmed partial response, tumor reduction of both target lesions continued. (tmcnet.com)
  • To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. (hindawi.com)
  • Randomization was stratified by tumor histology (squamous cell carcinoma vs. adenocarcinoma), geographic region (Asia vs. ex-Asia), and Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0 vs. 1). (merck.com)
  • As they reported in Cell on Thursday, the researchers analyzed targeted panel sequence data for 15,632 primary and 10,143 metastatic tumors from a total of 25,755 metastatic cancer patients in the MSK-MET cohort, including patients who had matched primary and metastatic tumor samples sequenced. (genomeweb.com)
  • With insights from more than 99,400 metastatic events identified in 21,546 metastatic cancer patients, they flagged genomic patterns corresponding to metastases from dozens of cancer types that affected 21 different organs, along with suspicious primary tumor changes in individuals with metastatic disease. (genomeweb.com)
  • Even though most cancer deaths are due to metastatic disease, predicting whether or not an early-stage tumor will metastasize - as well as what organs will be eventually affected by metastases - remains a formidable challenge," Schultz explained. (genomeweb.com)
  • MSK investigators are now gearing up to do related research focused on treatments that target metastatic tumor drivers through the newly-funded Marie- Jos é e and Henry R. Kravis Cancer Ecosystems Project. (genomeweb.com)
  • Our cases comprised 1 patient with metastatic lung adenocarcinoma involving the brain (case 1), 1 patient with meningioma (case 2), and 1 patient with a metastatic perivascular epithelial cell tumor involving the liver ( Table ). (cdc.gov)
  • Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies. (cdc.gov)
  • Surgical treatment may be considered for cases with even rapid-growing tumors such as gastric carcinoma with no evidence of multi-organ dissemination, especially when presenting with progressive neurological deterioration. (unboundmedicine.com)
  • These types of tumors are termed metastatic (or secondary) cancers. (embracepetinsurance.com)
  • Primary liver tumors (those that originate in the liver) are most typically bile duct adenocarcinomas, but plenty of tumors (from the GI system and spleen, for example) like to metastasize here, setting up secondary residence. (embracepetinsurance.com)
  • A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
  • NEW YORK - By profiling genomic and clinical features in tumors from tens of thousands of cancer patients, a team led by investigators at Memorial Sloan Kettering Cancer Center has uncovered features that may help predict a tumor's metastatic potential and organ sites it may affect. (genomeweb.com)
  • In contrast to prior studies that centered on either primary or metastatic tumors as a group, the team set out to characterize integrated genomic and clinical features of metastatic disease in the context of cancer type and anatomic site of metastasis. (genomeweb.com)
  • Together with molecular data across 341 to 468 cancer genes profiled with the MSK-IMPACT clinical sequencing assay , these insights made it possible to compare molecular features found in tumors from primary or metastatic sites in individuals with or without metastases. (genomeweb.com)
  • The team's results revealed alterations that were relatively common in certain cancer types or in metastatic tumors springing up at specific target sites. (genomeweb.com)
  • Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
  • Investigators suggest basing personalized therapeutic choices for urothelial cancers on global assessments, rather than focusing on primary tumors, because of the high degree of genomic variability and discordance in metastatic disease. (medpagetoday.com)
  • A 42-year-old male presented with a rare intramedullary spinal cord metastasis from gastric carcinoma manifesting as rapidly worsening motor and sphincter disturbances. (unboundmedicine.com)
  • Typical sites of metastasis of endometrial carcinoma are pelvic and para-aortic lymph nodes, vagina, peritoneum, and lungs [ 2 ]. (karger.com)
  • In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
  • The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age. (jpalliativecare.com)
  • Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
  • Postoperative pathology indicated infiltrating adenocarcinoma (right upper lobe mass) with poor differentiation and lymph node metastasis. (spandidos-publications.com)
  • We describe the case of 61 year-old patient with primary adenocarcinoma of the lung , presenting with melaena as the first manifestation of small bowel metastasis. (ispub.com)
  • Using electronic health record data, the researchers searched for patients with metastatic disease and information about the timing of metastasis. (genomeweb.com)
  • Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. (cdc.gov)
  • 11. Largely varying patterns and trends of primary cancer-directed resection for gastric carcinoma with synchronous distant metastasis in Europe and the US: a population-based study calling for further standardization of care. (cancercentrum.se)
  • 670 Primary cutaneous adenoid cystic carcinomas have been misinterpreted as metastatic lesions. (wikipedia.org)
  • ients with recurrent unresectable or metastatic cervix carcinoma with squamous cell, adenocarcinoma or adenosquamous histology immediately after at the very least on prior platinum-based chemotherapy for metastatic/recurrent illness.Coquan et al. (trpv1inhibitor.com)
  • BMC Cancer(2021) 21:Page 5 ofTable 1 Study eligibility criteriaInclusion criteria - Female 18 years of age or older, with histologically confirmed recurrent unresectable or metastatic cervix carcinoma with squamous cell, adenocarcinoma or adenosquamous histology. (trpv1inhibitor.com)
  • It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma. (globaldata.com)
  • Black people are more likely to be diagnosed with squamous cell carcinoma. (cancer.net)
  • On the other hand, in the 171 primary lung cancer cases the squamous cell cancer was the predominant type followed by equal proportions of adenocarcinomas and small cell carcinomas. (cdc.gov)
  • Evaluate the association between baseline and change during treatment of skeletal muscle index (SMI) and intermuscular adipose tissue (IMAT) and overall survival among older patients with metastatic pancreatic cancer. (iu.edu)
  • Evaluation of the correlation between baseline levels of biomarkers of aging (CRP and IL-6) and overall survival among older patients with metastatic pancreatic cancer. (iu.edu)
  • Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies. (cdc.gov)
  • The researchers also found associations between primary cancer subtypes and the body sites that were later impacted by metastatic disease, including an overrepresentation in liver metastases among patients with metastatic forms of lung neuroendocrine cancer and an uptick in ovarian or peritoneum metastases in individuals with advanced lobular breast cancer. (genomeweb.com)
  • A new study compared survival outcomes among patients with metastatic bladder urothelial carcinoma across racial/ethnic groups with predicted life expectancy, as derived from Social Security Administration life tables. (medpagetoday.com)
  • Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. (ispub.com)
  • Metastases affecting the small bowel and originating from carcinoma of the lung are a rare occurrence, but recent reports suggest that they may be more frequent than previously thought as they rarely produce symptoms. (ispub.com)
  • We present a case of a 61 year old patient with upper gastrointestinal bleeding due to duodenal metastases from a primary adenocarcinoma of the lung with secondary deposits in the abdominal lymph nodes. (ispub.com)
  • Patient may possibly have received at least 1 prior chemotherapy regimen of platinum-based chemotherapy for recurrence or metastatic disease. (trpv1inhibitor.com)
  • Prior remedy for advanced/metastatic disease with bevacizumab and/or immune checkpoint inhibitors are permitted. (trpv1inhibitor.com)
  • This is a Phase II, open-label, multi-center study to determine the efficacy and safety of MEDI4736 evaluated as single agent or in combination with tremelimumab in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) whose disease has progressed on fluoropyrimidine containing or gemcitabine-containing first-line chemotherapy.This study will consist of Part A, lead-in, as well as a possible expansion Part B. (astrazenecaclinicaltrials.com)
  • pain over bony structures indicates metastatic disease. (medscape.com)
  • Background - Cancer of unknown primary origin (CUP) is defined by the presence of pathologically identified metastatic disease without clinical or radiological evidence of a primary tumour. (ices.on.ca)
  • By publicly releasing clinical and genomic data from more than 25,000 patients," he added, "we hope that this will become a valuable resource for the community that will empower researchers and facilitate the study of metastatic disease. (genomeweb.com)
  • Mortality is attributable largely to metastatic disease and a dearth of effective therapeutic interventions. (biologists.com)
  • In the United States, the disease is most common in White people, who are more likely to be diagnosed with adenocarcinoma. (cancer.net)
  • These investigators analyzed clinicopathological and outcomes data to better categorize the effects of 9 different types of variant histologies on disease-specific survival in patients with urothelial carcinoma of the bladder. (medpagetoday.com)
  • Patients with MTAP-deletion had a shorter time to progression to metastatic disease and inferior response to chemotherapy. (medpagetoday.com)
  • The prognostic significance of chronic kidney disease (CKD) in the management of upper tract urothelial carcinoma following radical nephroureterectomy remains unknown. (medpagetoday.com)
  • however, many patients present with metastatic disease with or without any clinical symptoms. (msdmanuals.com)
  • No evidence of metastatic disease M0. (who.int)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
  • Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
  • Weight loss - This is the second most common symptom, occurring in more than 50% of people with esophageal carcinoma. (medscape.com)
  • The most common metastatic sites were in the respiratory or digestive systems (n = 1,603), and the most common histology was adenocarcinoma (n = 939). (ices.on.ca)
  • The histological diagnosis was gastric adenocarcinoma. (unboundmedicine.com)
  • Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma. (ispub.com)
  • Distribution of lung cancers by histological cell type in 306 cases showed no major differences in 3 major cell types of squamous, small cell, and adenocarcinomas. (cdc.gov)
  • Accurately diagnosing and staging patients with upper tract urothelial carcinoma (UTUC) has proven challenging for clinicians. (medpagetoday.com)
  • Dr. Li discusses how liquid biopsies are being assessed as surrogates for biopsies in urothelial carcinoma. (medpagetoday.com)
  • In Urothelial Carcinoma, How Do Variant Histologies Impact Survival? (medpagetoday.com)
  • A new retrospective analysis suggests that urothelial carcinoma with glandular differentiation (UC-GD) is similar to urothelial carcinoma not otherwise specified (UC-NOS), while primary bladder and urachal adenocarcinomas are similar to colorectal adenocarcinomas. (medpagetoday.com)
  • Pure small cell carcinoma of the prostate (SCPCa) is a very rare condition usually with poor survival after diagnosis. (karger.com)
  • 2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
  • 7. Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates. (cancercentrum.se)
  • Metastatic Adenocarcinoma of Prostate in a 28-Year-Old Male: The outcome is poor in young patients? (jpalliativecare.com)
  • Most of the published data has reported poor outcome in younger patients with metastatic prostate cancer. (jpalliativecare.com)
  • OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. (knowcancer.com)
  • Ferguson MK, Durkin A. Long-term survival after esophagectomy for Barrett's adenocarcinoma in endoscopically surveyed and nonsurveyed patients. (medscape.com)
  • The approval was based on data from KEYNOTE-590 ( NCT03189719 ), a multicenter, randomized, double-blind placebo-controlled trial that enrolled 749 patients with locally advanced unresectable or metastatic esophageal or GEJ carcinoma (Siewert Type I) who were not candidates for surgical resection or definitive chemoradiation. (merck.com)
  • The most frequent cancerous lesion was the scamous cell carcinoma (9 patients). (bvsalud.org)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
  • For negative in situ hybridization controls, we used tissue specimens from patients with Merkel cell polyomavirus-positive Merkel cell carcinoma and BK polyomavirus nephropathy and a T-cell lymphoma tissue microarray that included 1 case of Merkel cell polyomavirus-positive T-cell lymphoma. (cdc.gov)
  • The results of cytological examination of bronchial excretions however, proved positive for non-small cell carcinoma of the lung. (ispub.com)
  • and a 3L non-clear cell renal cell carcinoma patient with SD. (tmcnet.com)
  • The incidence of renal cell carcinoma (RCC) is high, and its outcomes remain poor. (biologists.com)
  • The patient had a past surgical history of a total abdominal hysterectomy for endometrial carcinoma, which was performed 5 months prior to presentation. (karger.com)
  • In Barrett's metaplastic tissue and carcinoma, however, stronger bands at 108 kDa and 45 kDa were also present, suggesting either decreased glycosylation or a truncated protein in the metaplastic and neoplastic tissue, respectively. (nih.gov)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • Primary mucinous adenocarcinoma is an extremely rare type of bladder cancer, with aggressive behavior and poor response to chemotherapy and radiotherapy. (bvsalud.org)
  • In addition in squamous carcinoma and adenocarcinoma E-cad was characteristically expressed in the cytoplasm and this was associated with poor morphological differentiation. (nih.gov)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
  • It seems to show different clinical features compared to other prostate cancer subtypes, specifically adenocarcinoma. (karger.com)
  • Trial Description: This trial is testing whether molecularly targeted oral medications called talazoparib and tazemetostat can be safely combined for the treatment of prostate cancer , and whether the combination is effective in shrinking or preventing the growth of metastatic prostate cancer . (dana-farber.org)
  • Colon adenocarcinoma (COAD) is the most common type of colorectal cancer ( 1 ). (frontiersin.org)
  • Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression," the authors wrote. (genomeweb.com)
  • They also pointed to ties between enhanced chromosomal instability and metastatic burden, particularly in certain cancer types. (genomeweb.com)
  • Conversely adenocarcinoma was the most frequent cancer (84%) in the cases excluded as probably metastatic cancers. (cdc.gov)
  • Distribution of lung cancer by site of origin and cell type showed that the majority of the squamous cancers originated in the main stem bronchus whereas adenocarcinomas tended to originate predominantly in the peripheral lung. (cdc.gov)
  • Lung carcinoma is the leading cause of cancer-related death in men and women worldwide. (msdmanuals.com)
  • Adenocarcinoma: This malignancy can arise from any of the tissues of the GI system, but the stomach and intestines are predisposed. (embracepetinsurance.com)
  • However, uterine serous carcinoma has a higher tendency for lymphovascular invasion in addition to intraperitoneal and extra-abdominal spread. (karger.com)
  • This report documents the case of a 57‑year‑old male patient initially diagnosed with non‑metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. (spandidos-publications.com)
  • Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumour involving the duodenum and the proximal jejunum. (ispub.com)