• Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)
  • Treatment with the combination of rivoceranib and camrelizumab led to a statistically significant and clinically meaningful benefit in progression-free survival and overall survival compared with sorafenib in previously untreated patients with unresectable hepatocellular carcinoma. (onclive.com)
  • Treatment with the combination of rivoceranib and camrelizumab led to a statistically significant and clinically meaningful benefit in progression-free survival (PFS) and overall survival (OS) compared with sorafenib (Nexavar) in previously untreated patients with unresectable hepatocellular carcinoma (HCC), according to data from the phase 3 CARES 310 trial (NCT03764293) published in The Lancet . (onclive.com)
  • Traditionally, bile duct tumors located within the liver had been classified with hepatocellular carcinoma as primary liver tumors. (tri-kobe.org)
  • Chemoembolization was first used in hepatocellular carcinoma (HCC), one of the primary cancers of the liver, has been highly successful and has entered the classical treatment guidelines years ago. (interventionaloncology.center)
  • It is usually used in the description of desmoplastic small round cell tumors. (wikipedia.org)
  • In tumors, cancer cells secrete matrix degrading enzymes, such as matrix metalloproteinases (MMPs) that, once cleaved and activated, degrade the matrix, thereby releasing growth factors that signal for the growth of cancer cells. (wikipedia.org)
  • Primary breast cancer tumors may be removed or irradiated relatively simply, but distant metastases are difficult to treat. (spandidos-publications.com)
  • Accordingly, NSPs described herein are useful for delivering toxic agents to tumors with reduced risk to healthy cells. (justia.com)
  • KLT can directly inhibit and kill cells of various tumors, control lesions, and prevent metastasis. (kanglaite.com)
  • A: "Double-phase" refers to direct killing of tumor cells while improving body immune function and "broad spectrum" means that different kinds of tumors are quickly responded to KLT treatment with satisfactory therapeutic effect. (kanglaite.com)
  • Case demonstration A 63-year-old Caucasian female was referred to our unit with a history of rapidly increasing multiple metastases (duodenal, gastric and colon tumors, peritoneal and retroperitoneal carcinomatosis, many lung, bone and gallbladder metastases, mesenteric lymphadenopathies and 1 mind tumor) (Fig.?1). (uawildlifeschool.org)
  • Three patients experienced two histologic changes, which the changed tumors returned to its original subtype or changed to a combined tumor after treatments. (e-crt.org)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (tri-kobe.org)
  • Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)
  • Other described primary peritoneal cancers and tumors include malignant mesothelioma, benign papillary mesothelioma, desmoplastic small round cell tumors, peritoneal angiosarcoma, leiomyomatosis peritonealis disseminata (LPD), and peritoneal hemangiomatosis. (medscape.com)
  • While he admits these are not evidence-based decisions but rather judgment calls, Dr. Spencer also says that he considers radiation therapy with particularly dangerous tumors, such as Merkel cell carcinoma. (dermatologytimes.com)
  • Radiation therapy, surgery, chemotherapy, therapy with EGFR antibodies, immune checkpoint inhibitors or combined treatments are used for primary tumors and recurrent or metastatic disease. (biomedcentral.com)
  • MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
  • For example, it has been successfully utilized in the liver metastases of neuroendocrine tumors (NET) from the gastrointestinal tract and is now included in all treatment guidelines. (interventionaloncology.center)
  • In addition, chemoembolization has an important role in the rare vessel-rich tumors of the liver (hemangioperisitoma, hemangioblastoma, etc.) and other liver metastases (breast, kidney cancer, etc. (interventionaloncology.center)
  • Since the mixture is largely retained by tumor cells, it kills tumors and causes less damage to normal liver tissue. (interventionaloncology.center)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
  • Small cell lung cancer (SCLC) accounts for approximately 13-15% of all cases of lung cancer. (medscape.com)
  • Contrast-enhanced MRI of the brain in a patient with known small-cell lung cancer (SCLC). (medscape.com)
  • In 1998, the International Association for the Study of Lung Cancer (IASLC) classified SCLC into 3 general histologic subtypes: small, mixed, and combined. (medscape.com)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • Small cell lung cancer (SCLC) is characterized by poor prognosis and challenging diagnosis. (frontiersin.org)
  • Screening in high-risk smokers results in a reduction in lung cancer mortality, however, screening efforts are primarily focused on non-small cell lung cancer (NSCLC). (frontiersin.org)
  • Lung cancers are histologically classified as Small Cell Lung Cancer (SCLC) or Non-Small Cell Lung Cancer (NSCLC). (frontiersin.org)
  • Although SCLC constitutes the minority of lung cancer cases, it represents an aggressive form of cancer characterized by a high growth fraction, early development of metastases, and extremely poor prognosis, with less than 7% 5-year survival rate ( 2 ). (frontiersin.org)
  • Non-Small Cell Lung Cancer" Encyclopedia , https://encyclopedia.pub/entry/3438 (accessed December 11, 2023). (encyclopedia.pub)
  • Lung cancer is divided to Non-Small Cell Lung Cancer (NSCLC) comprising about 85% of lung cancer cases, and small cell lung cancer (15% of lung cancer cases). (encyclopedia.pub)
  • Non-small cell lung cancer (NSCLC) has several subtypes: a. (encyclopedia.pub)
  • Lung cancer is the leading cancer killer in both men and women in the Unites States, with over 135,000 deaths expected during 2020 [ 1 ] Small cell lung cancer accounts for 15%, and non-small cell lung cancer (NSCLC) for 85% of lung cancer cases [ 2 ] . (encyclopedia.pub)
  • Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. (hindawi.com)
  • It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
  • Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
  • We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
  • Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
  • There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
  • In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
  • Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
  • Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
  • Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
  • This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
  • Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
  • We investigated the expression of receptor tyrosine kinase-like orphan receptor (ROR) 2 and Wnt5a and their prognostic significance in non-small cell lung cancer (NSCLC). (oncotarget.com)
  • 80% of lung cancer patients have non-small cell lung cancer (NSCLC) [ 1 - 3 ]. (oncotarget.com)
  • It is difficult to determine the lymph node metastasis of patients with clinically negative lymph nodes (cN0) non-small cell lung cancer (NSCLC) before surgery. (biomedcentral.com)
  • Lung cancer has become the most common malignant tumor in China with the highest morbidity and mortality, of which non-small cell lung cancer (NSCLC) accounts for 80% [ 1 , 2 ]. (biomedcentral.com)
  • Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). (bmj.com)
  • When lung cancer is combined with tuberculosis at the same time, it is easy to be misdiagnosed and missed. (researchsquare.com)
  • Human epidermal growth factor receptor 2 (HER2), a promising therapeutic target, can be mutated, amplified, or overexpressed in different malignancies, including non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancer cases [ 2 ]. (biomedcentral.com)
  • The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • Liquid Biopsy from research to clinical practice: focus on Non-Small Cell Lung Cancer. (cdc.gov)
  • Utility of comprehensive genomic profiling in directing treatment and improving patient outcomes in advanced non-small cell lung cancer. (cdc.gov)
  • Patients with NSCLC are usually evaluated for possible surgical excision, and their disease is staged by using the common tumor, nodes, and metastases (TNM) staging system. (medscape.com)
  • We determined that miR-375-3p can discriminate between SCLC and NSCLC patients, and between SCLC and Squamous Cell Carcinoma patients. (frontiersin.org)
  • There are three main subtypes of NSCLC which are adenocarcinoma (~40% of cases), squamous cell carcinoma (~25-30% of cases), and large-cell carcinoma (~10-15% of cases). (hindawi.com)
  • Our clinical findings suggest that high ROR2 or Wnt5a expression is associated with poor prognosis in NSCLC, and combined detection of ROR2 and Wnt5a is helpful in predicting the prognosis of NSCLC. (oncotarget.com)
  • The purpose of this study is to investigate risk factors of lymph node metastasis in cN0 NSCLC, thereby to identify the surgical indications for lymph node dissection in cN0 NSCLC. (biomedcentral.com)
  • Overall, 44 patients (6.8%) with cN0 NSCLC had lymph node metastasis. (biomedcentral.com)
  • 0.001) and preoperative serum carcinoembryonic antigen (CEA) level (p = 0.017) are independent risk factors lymph node metastasis in cN0 NSCLC. (biomedcentral.com)
  • The current standard method for early NSCLC surgery is lobectomy combined with complete lymph node dissection or sampling [ 6 ]. (biomedcentral.com)
  • Most early-stage NSCLC has no suspicious lymph node metastases and is identified as clinically negative lymph nodes (cN0) NSCLC. (biomedcentral.com)
  • However, whether these inflammatory laboratory parameters have a predictive effect on the metastasis of NSCLC lymph nodes has been rarely reported. (biomedcentral.com)
  • This study aims to investigate the factors that can predict cN0 NSCLC lymph node metastasis, including basic characteristics of patients, imaging characteristics and preoperative examination of some hematological indicators. (biomedcentral.com)
  • We selected cN0 NSCLC patients with tumor diameter ≤ 30 mm and without imaging metastatic lymph nodes before surgery to study the incidence and risk factors for lymph node metastasis, thereby to provide the surgical indications for lymph node dissection in cN0 NSCLC. (biomedcentral.com)
  • The concentration of survivin in diseased tissue and miR-29a and IGRAs in serum in 25 patients with non-small-cell lung carcinoma (NSCLC) complicated by active pulmonary tuberculosis (APT) and 32 patients with NSCLC and 30 patients with APT were measured. (researchsquare.com)
  • prognosis differs JAM3 between the two histological subtypes ESqCC and esophageal adenocarcinoma [28 29 30 It is well known that SmCEC is similar RG2833 to small cell lung malignancy [31] and different from ESqCC and esophageal adenocarcinoma in tumor histology. (healthandwellnesssource.org)
  • The combined variety includes a significant proportion of squamous cell or adenocarcinoma cell cancers in addition to small cell cancers (1-3% of cases of SCLC). (medscape.com)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • Less common tumours of the appendix include signet-ring cell adenocarcinoma and paraganglioma . (cancerindex.org)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • Overall survival was statistically superior for cisplatin/pemetrexed versus cisplatin/gemcitabine in patients with adenocarcinoma and large-cell carcinoma histology, while patients with squamous cell histology had a significant improvement in survival with cisplatin/gemcitabine versus cisplatin/pemetrexed [ 81 ] . (encyclopedia.pub)
  • The most common histological change is the switch from adenocarcinoma (AdenoCa) to small cell carcinoma (SCC) against to tyrosine kinase inhibitors (TKI). (e-crt.org)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • EGFR a transmembrane tyrosine kinase offers been shown to be upregulated in a variety of squamous cell carcinomas and its downstream antiapoptotic signaling cascade has been well analyzed [4]. (ap26113.com)
  • The mix of cetuximab and radiotherapy (CRT) in addition has been tested in a number of various other EGFR-expressing squamous cell carcinomas including lung anal esophageal and uterine cervix squamous cell carcinoma [15-18]. (ap26113.com)
  • Tumor recurrence and metastasis towards the adjacent organs (often to the liver organ) were seen in nine sufferers. (healthandwellnesssource.org)
  • Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Electro-coagulation for the treatment of liver metastases. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
  • SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
  • The biliary system consists of a network of ducts that carry bile from the liver to the small bowel and is classified by its anatomic location (Figure 1 ). (tri-kobe.org)
  • Colloid scintigraphy (liver‐spleen scans) allows visualization of the liver parenchyma through accumulation of colloid‐based radiotracers in reticuloendothelial cells and was widely used in the past to detect focal liver lesions [2] . (radiologykey.com)
  • Analysis of TCGA pan-cancer data revealed significant overexpression of CASC9 across different other entities including bladder, liver, lung and stomach cancers and especially in squamous cell carcinoma (SCC) of the lung. (biomedcentral.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Following the good results obtained in the treatment of HCC, chemoembolization was also tried in liver metastases of different origin. (interventionaloncology.center)
  • Another common area of chemoembolization is liver metastases of the large intestine. (interventionaloncology.center)
  • In this method, chemotherapeutic drugs are mixed with lipiodol, a special oily contrast material that is attracted by tumor cells in the liver, and then injected into the tumor arteries. (interventionaloncology.center)
  • Invasive ductal carcinomas of the breast often have a stellate appearance caused by desmoplastic formations. (wikipedia.org)
  • We sought to compare the baseline demographics, standard pathologic factors and long - term clinical outcomes between ILC and infiltrating ductal carcinoma (IDC) using a large database. (biomedcentral.com)
  • An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
  • nine had been treated with medical procedures accompanied by postoperative chemotherapy and three sufferers had been treated with medical procedures followed by a combined mix of postoperative radio-chemotherapy. (healthandwellnesssource.org)
  • The treatment is usually chemotherapy combined with radiation therapy. (encyclopedia.pub)
  • KLT can be used alone or combined with chemotherapy or radiation therapy or applied peri-operationally. (kanglaite.com)
  • Primary peritoneal carcinoma is treated with tumor debulking followed by chemotherapy with 5-fluorouracil, doxorubicin, or cisplatin. (medscape.com)
  • While surgical and medical oncologists do not think twice about combining treatments such as surgery, chemotherapy and radiation therapy, in the treatment of cancer patients, dermatologists rarely use adjuvant therapies once they have excised skin cancers, according to one dermatologist. (dermatologytimes.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
  • Many research studies, encompassing cell culture tests in the laboratory and also animal and some human studies, are coming to a conclusion often very different from the conventional perspective that chemotherapy and antioxidants should never be combined. (pinestreetfoundation.org)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • Chemoembolization or TACE (transarterial chemoembolization) is a treatment modality that combines intraarterial chemotherapy with embolization and is now widely used in some types of cancer. (interventionaloncology.center)
  • The most important advantage of lipiodol-TACE is that the lipiodol substance is retained much more in the tumor cells and the mixture can be used with any chemotherapy drug. (interventionaloncology.center)
  • In DEB-TACE, chemotherapy drugs are loaded into particles prepared from special substances with diameters smaller than 1 mm. (interventionaloncology.center)
  • In the reactive stroma hypothesis, tumor cells cause the proliferation of fibroblasts and subsequent secretion of collagen. (wikipedia.org)
  • Our results revealed that proinflammatory cytokines, including TNFα, contribute to NRP2 upregulation and SARS-CoV-2 proliferation in host human cells. (bvsalud.org)
  • SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
  • Accordingly, there is an unmet need for targeting of solid tumor cells for the treatment of malignant diseases that will show an affinity for cancer cells, deliver therapeutic payloads that inhibit proliferation and/or destroy cancerous tumor cells without inhibiting and/or destroying normal cells. (justia.com)
  • The proliferation of tumor cells is characterized by inflammation of tumor sites, the ability of tumor cells to evolve HSPG (heparan sulphate proteoglycans) in a similar manner to basal membrane Keratinocytes, and the presence of various growth factor receptors known to congregate at the surface of tumor cells. (justia.com)
  • The Wnt family encodes a large group of signaling molecules that are involved in cell proliferation, differentiation, migration and apoptosis [ 13 , 14 ]. (oncotarget.com)
  • Effects of lncRNA overexpression or downregulation on cell proliferation, clonogenicity, migration and chemosensitivity were studied in HNSCC cell lines. (biomedcentral.com)
  • Angiogenesis is the formation of new blood vessels from the existing vasculature, and it is significantly increased during tumor development with the aim to supply nutrients and oxygen that support the high rate proliferation of tumor cells. (researchsquare.com)
  • Studies have found that miRNA can affect a variety of biological effects, such as DNA damage repair, cell cycle arrest, cell hypoxia, proliferation and apoptosis, etc. (researchsquare.com)
  • FAs are structures composed of clustered transmembrane proteins called integrins that bind to the extracellular matrix and link to the actin cytoskeleton and control cell migration, proliferation, survival and differentiation (Gardel et al. (bio2009.org)
  • 27 lymph nodes with metastasis, and 20 extranodal tis- nasopharyngeal aspirates and blood samples, including in- sue samples. (cdc.gov)
  • In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)
  • Thus our aim in this study was to investigate the prognostic influence and relationship between tumor infiltrating inflammatory cells and various clinico-pathological characteristics of SmCEC patients with a slightly large sample size from two high incidence areas in China. (healthandwellnesssource.org)
  • We profiled deregulated circulating cell-free miRNAs in the plasma of SCLC patients. (frontiersin.org)
  • Some of the patients can be treated with ablative doses of radiation if the tumor is less than 5 cm and without lymph node metastasis. (encyclopedia.pub)
  • Phenotypic change into small cell carcinoma (SCC) is a resistance mechanism in NSCC treated with TKI, and small cell transformation occurs 3% to 14% of patients with EGFR mutations [ 3 , 4 ]. (e-crt.org)
  • Advanced age and immune system dysfunction are risk points for cutaneous squamous cell carcinoma (cSCC) and frequently provide patients with locally-advanced disease medically inoperable or surgically unresectable but potentially curable with radiotherapy. (ap26113.com)
  • For patients with tumor parenchyma ≤ 16.5 mm, the probability of lymph node metastasis is lower and lymph node sampling is feasible. (biomedcentral.com)
  • Clinicopathologic features, overall survival (OS), and recurrence/metastasis-free survival (RFS) were compared between 2,202 patients with IDC and 215 patients with ILC. (biomedcentral.com)
  • The frequencies of recurrence/metastasis ( P = 0.980) and death ( P = 0.064) were similar among patients with IDC and patients with ILC after adjustment for tumor size and nodal status. (biomedcentral.com)
  • ILC was not further subtyped in these databases, and patients with mixed ILC and IDC were excluded. (biomedcentral.com)
  • One-third of patients showed mixed response, among whom 88.2% (15/17) presented with LM increasing, but PL decreasing, while the others had the opposite pattern (p=0.002). (bmj.com)
  • This report shows the characterization of the humoral response elicited after vaccination with 400 µg of antigen combined with 200 µg of VSSP in cancer patients representative of the Cuban real clinical practice setting. (researchsquare.com)
  • A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
  • Also, the sympathectomy provided by an epidural anesthetic may provide moderation of hypertension if the tumor did manifest properties of a pheochromacytoma intraoperatively, although this has mixed results in patients treated with alpha blockers for known pheochromocytoma. (ispub.com)
  • In the present study, Snail and RhoA were observed to be overexpressed in breast cancer tissues compared with normal breast tissues and the expression of Snail and RhoA was associated with the differentiation grade and lymph node metastasis of breast cancer, respectively. (spandidos-publications.com)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
  • By RT-qPCR analysis we furthermore detected stronger CASC9 overexpression in pure SCC of the urinary bladder and mixed urothelial carcinoma with squamous differentiation than in pure urothelial carcinomas. (biomedcentral.com)
  • But occasionally cells are challenging or missing to acquire because of the metastases area, needing an invasive and harmful procedure potentially. (uawildlifeschool.org)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • SCLC, previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non-small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics. (medscape.com)
  • The mixed variety encompasses mixed cell and large cell cancers. (medscape.com)
  • 1 Intro Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the United States with an increasing incidence over the past few decades. (ap26113.com)
  • Primary peritoneal cancers, some of which have been implicated in many cases of carcinomas of unknown primary origin, include ovarian cancer arising in women several years after bilateral oophorectomy. (medscape.com)
  • The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
  • Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • An enlarged ovary with a papillary serous carcinoma on the surface. (medscape.com)
  • Symptoms and signs may result from the location of the primary local invasion or compression of adjacent thoracic structures, distant metastases, or paraneoplastic phenomena. (cancer.gov)
  • Tumor cell motility is the hallmark of invasion and an essential step in metastasis. (spandidos-publications.com)
  • Although a direct link between Snail expression and tumor metastasis has not yet been reported, a number of studies have shown that the overexpression of Snail is correlated with tumor invasion ( 7 ). (spandidos-publications.com)
  • Moreover some individuals present with SB590885 considerable local invasion or metastasis rendering the cSCC surgically unresectable. (ap26113.com)
  • Squamous cell carcinoma with perineural invasion has an ominous side, according to Dr. Spencer. (dermatologytimes.com)
  • The other case is the situation of either poorly differentiated squamous cell carcinoma or squamous cell carcinoma with perineural invasion. (dermatologytimes.com)
  • Symptoms from distant metastases may also be present and include neurological defect or personality change from brain metastases or pain from bone metastases. (cancer.gov)
  • 8. Subjects are allowed to receive palliative radiation therapy (including brain radiotherapy for symptomatic brain metastases and radiotherapy for bone metastases), but the radiotherapy must be completed at least 1 week before enrollment, and the toxicity related to radiotherapy should be restored to less than or equal to 1 degree (CTCAE 5.0, excluding hair loss). (who.int)
  • Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)
  • We believe that these molecular targets could guide in determining timing of therapeutic interventions that offer the best opportunity to prevent and/or halt extent of bone metastases. (hindawi.com)
  • Large cell carcinoma, or d. mixed histology. (encyclopedia.pub)
  • Four cases showed combined histology in the first or second change. (e-crt.org)
  • The histology of NSCC can be changed to a single pattern or combined subtypes after various treatment modalities, and the phenotypic changes seem not fixed. (e-crt.org)
  • Torres A et al reported in December 2004 in Dermatologic Surgery that use of 5 percent imiquimod cream prior to Mohs surgery resulted in a smaller defect than with excision only of basal cell carcinoma. (dermatologytimes.com)
  • In a more recent study by Butler DF, Parekh PK and Lenis A, in the January 2009 issue of Dermatologic Surgery , researchers found no statistically significant benefit in using imiquimod 5 percent cream as an adjunctive treatment of nodular, nasal basal cell carcinomas before Mohs surgery. (dermatologytimes.com)
  • Each patient was free of distant metastasis at the time of the first diagnosis, and exhibited infiltrative carcinoma. (biomedcentral.com)
  • After treatment with TKI and immunotherapy, an EGFR (epidermal growth factor receptor)-mutant AdenoCa changed to squamous cell carcinoma (SqCa). (e-crt.org)
  • Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
  • One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
  • SCLC is an aggressive form of primary pulmonary neuroendocrine tumor with short doubling time and a tendency for early metastasis. (medscape.com)
  • Mixed adenoneuroendocrine carcinoma (MANEC) is a rare subtype of neuroendocrine neoplasm consisting of both adenocarcinomatous and neuroendocrine cells. (biomedcentral.com)
  • They can arise everywhere, since neuroendocrine cells are virtually distributed in each organ. (springeropen.com)
  • Cancer begins as cells that grow uncontrollably, usually as a result of an internal change or oncogenic mutations within the cell. (wikipedia.org)
  • The interaction between cancer cells and surrounding tumor stroma is thus bidirectional, and the mutual cellular support allows for the progression of the malignancy. (wikipedia.org)
  • Furthermore, the cancer cells secrete matrix degrading enzymes to destroy normal tissue ECM thereby promoting growth and invasiveness of the tumor. (wikipedia.org)
  • Historically, the histologic identification of small cell cancer dates back to the 1920s, when the small cell/oat cell tumor was shown to be a carcinoma of the lung and not an oat cell sarcoma of the mediastinum, as thought earlier. (medscape.com)
  • Cancer of the Appendix (also known as appendiceal cancer) occurs when cells in the appendix become abnormal and multiply without control. (cancerindex.org)
  • Overexpression of Snail has been associated with breast cancer metastasis, although the specific role of Snail in the process remains unclear. (spandidos-publications.com)
  • One important insight came from the discovery that the increased motility and invasiveness of cancer cells is reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development ( 2 ). (spandidos-publications.com)
  • A number of reports have shown that RhoA expression is upregulated in a group of malignancies ( 13 ) and that the activity of RhoA is correlated with lymph node metastasis in colorectal cancer ( 14 ). (spandidos-publications.com)
  • We hypothesized that Snail, as a transcription factor, may promote breast cancer metastasis through the regulation of RhoA expression and activity. (spandidos-publications.com)
  • In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks. (wikipedia.org)
  • These vesicles are constitutively secreted by all cell types and EVs released from cancer cells can functionally alter recipient cells by reprogramming them to become active contributors to tumor growth, metastasis, and immunosuppression ( 10 ). (frontiersin.org)
  • The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects. (justia.com)
  • For example, those agents that target actively dividing cells are not able to discriminate between actively dividing cancer cells and actively dividing healthy cells. (justia.com)
  • Thus, in the process of destroying or inhibiting the rapidly dividing cancer cells, many of the healthy cells are also damaged. (justia.com)
  • High and specific binding of 68 Ga-BMS-986192 to human PD-L1-expressing cancer cells was confirmed, which closely correlates with the respective PD-L1 expression level determined by flow cytometry and immunohistochemistry staining. (snmjournals.org)
  • In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
  • The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • There are only a few studies looking at outcomes of skin cancer surgery with and without prior treatment with imiquimod, and results are mixed. (dermatologytimes.com)
  • When cancer spreads from its original place to another part of the body, the new tumor has the same kind of abnormal cells and the same name as the primary tumor. (healthyprostateclub.com)
  • For example, if prostate cancer spreads to bones, the cancer cells in the bones are actually prostate cancer cells. (healthyprostateclub.com)
  • Taking a deeper look into the research literature yields many examples where oxidative stress on cancer cells has been shown to be counterproductive. (pinestreetfoundation.org)
  • When oxidative stress levels are reduced in cancer cells, their growth is more easily controlled through a process called apoptosis. (pinestreetfoundation.org)
  • However, when oxidative stress levels go up, cancer cell death happens through a slower, messier, and less effective pathway called pyknosis or necrosis. (pinestreetfoundation.org)
  • Additionally, the ability of the body to "clean up" the resulting cellular debris from cancer cell death is also inhibited by oxidative stress. (pinestreetfoundation.org)
  • Long non-coding RNAs (lncRNAs) have moved into the focus of cancer research as good candidates for tumor biomarkers and as regulators of various neoplastic cell properties. (biomedcentral.com)
  • Metastasis is the main cause of cancer-related deaths worldwide, and therefore we have studied experimental and spontaneous mouse models of melanoma and breast cancer metastasis to demonstrate the efficacy and mechanism of a combination of A 2A Ri in combination with anti-PD-1 monoclonal antibody (mAb). (aacrjournals.org)
  • CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterial-derived adjuvant VSSP. (researchsquare.com)
  • Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)
  • RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
  • In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
  • RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
  • Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
  • In both cases, the resulting binary effect is lethal to cancer cells. (interventionaloncology.center)
  • These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)
  • A Five-Gene Expression Signature Predicts Ovarian Cancer Metastasis. (cdc.gov)
  • Acinar cell carcinoma is a rare cause of pancreatic cancer. (msdmanuals.com)
  • As a result of the tumor's continued enlargement, significant vascularity, and possible metastases, feasible excision during the cesarean was impossible and, therefore, a vaginal delivery was decided upon. (ispub.com)
  • There is inadequate information to document the effectiveness of PEI as an alternative to surgical resection for the treatment of hepatic metastases. (aetna.com)
  • Radiolabeled 99m Tc‐red blood cell imaging is used for confirmation of hepatic hemangiomas when US, CT, or MRI are equivocal or there is a contraindication to intravenous contrast. (radiologykey.com)
  • Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
  • Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
  • The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. (biomedcentral.com)
  • Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
  • The cell surface molecules EpCAM, PVR and CD73 are overexpressed on CAISMOV24 cells compared to the primary malignant cells. (biomedcentral.com)
  • Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
  • Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)
  • However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
  • Ideally, the more a cell line resembles the primary malignant cells, the more useful it will be for scientific research. (biomedcentral.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • The brain is one of the predominant sites for SCLC metastasis. (medscape.com)
  • SCLC accounts for approximately 15% of bronchogenic carcinomas. (cancer.gov)
  • Our results corroborate with the idea that genomic alterations, depicted by CNVs, can be used for subtyping epithelial ovarian carcinomas. (biomedcentral.com)
  • To identify the expression patterns of NRP under inflamed and noninflamed conditions, next-generation sequencing (RNA-seq), immunohistochemistry, quantitative real-time PCR, and Western blotting were performed using primary cultured fibroblast-like synoviocytes, MH7A (immortalized cell line of human rheumatoid fibroblast-like synoviocytes), immortalized MRC5 (human embryonic lung fibroblast), and synovial tissues. (bvsalud.org)
  • Multiplex immunohistochemistry detected significantly lower fractions of CD8 + cells (p=0.036) and CD56 dim+ cells (p=0.016) in LM compared with PL. Single-cell RNA sequencing also characterized lower effector CD8 + T cells activation and NK cells cytotoxicity in LM. (bmj.com)
  • Coronal positron emission tomogram shows abnormal areas of increased metabolic activity in the left hilar and left adrenal regions consistent with a hilar tumor with left adrenal metastasis. (medscape.com)
  • In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. (absoluteastronomy.com)
  • At 34 weeks the tumor was noted to have significant enlargement (14.1x23.2x26 cm), increased vascularity concerning for adrenal cortical carcinoma. (ispub.com)
  • This is especially true for carcinoids, even because there is a small core of well differentiated NENs with a relatively high proliferative index showing the ability to metastasize as poorly differentiated forms [ 5 ]. (springeropen.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • however, advanced tumor stages and positive lymph node metastasis were significantly associated with poor overall survival. (biomedcentral.com)
  • PD-L1 binding assays were performed using the transduced PD-L1-expressing lymphoma cell line U-698-M and wild-type U-698-M cells as a negative control. (snmjournals.org)
  • BK virus, simian munohistochemical testing showed that 1 T-cell lymphoma virus 40, and JC virus DNA sequences have been detected expressed MCPyV T-antigen. (cdc.gov)
  • The NHL samples were classifi ed as B- as previously described ( 20 ), omitting the deparaffi niza- cell lymphoma (n = 133), NK/T-cell lymphoma (n = 18), or tion step. (cdc.gov)
  • According to this classification, the small-cell subtype includes the previous World Health Organization (WHO) variety of oat cell and intermediate types. (medscape.com)
  • In this process, epithelial cells acquire fibroblast-like properties such as the functional loss of E-cadherin. (spandidos-publications.com)
  • Genital warts, which are a form of benign tumor of epithelial cells, are also caused by various strains of HPV. (wikipedia.org)
  • A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
  • Primary peritoneal carcinoma usually manifests with abdominal distention and diffuse nonspecific abdominal pain secondary to ascites. (medscape.com)
  • Blocking the interaction of the immune checkpoint molecule programmed cell death protein-1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for immune oncology. (snmjournals.org)
  • Simultaneously it is able to protect normal cells and improve immune function. (kanglaite.com)
  • Cysts are encircled by various kinds of immune system cells, including M2-like macrophages and cytotoxic T (Compact disc8+) and helper T (Compact disc4+) cells, aswell as cells of non-immune origin, such as for example interstitial/stromal cells (4). (baxkyardgardener.com)
  • During apoptosis, cells are removed by the immune system before they lose their cell wall, thus avoiding an inflammatory response to the dying cells. (pinestreetfoundation.org)
  • However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
  • Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
  • In Cox regression analysis, age at diagnosis, tumor grade and stage, lymph node metastasis, surgery, and tumor size were independently associated with mortality. (biomedcentral.com)
  • To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP‑2, were reduced in the breast tumor cell lines MDA‑MB‑231 and MDA‑MB‑435S, and their biological responses were studied in vitro and in vivo. (spandidos-publications.com)
  • The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. (spandidos-publications.com)
  • [ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)
  • Although a report has shown that RhoB, a small GTPase involved in cytoskeletal actin rearrangement, lies downstream of Slug ( 11 ), another member of the Snail super-family, there is no evidence to support a link between Snail and Rho GTPases. (spandidos-publications.com)
  • The fallopian tubes are small ducts that connect the ovaries to the uterus. (cancer.net)
  • The frontal section shows the fallopian tubes, 2 small ducts that link the 2 ovaries (1 on each side) to the hollow, pear-shaped uterus. (cancer.net)
  • Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
  • The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. (biomedcentral.com)
  • This would also explain the high incidence of meningiomas around the sagittal sinus, which has a high concentration of meningothelial cells. (medscape.com)
  • Studies have shown a correlation between Snail expression and the degree of infiltration in breast carcinomas ( 8 ). (spandidos-publications.com)
  • This was observed in desmoplastic melanoma, in which the tumor cells are phenotypically fibroblastic and positively express genes associated with ECM production. (wikipedia.org)
  • Biopsies of the colon and belly concluded the living of melanoma metastases. (uawildlifeschool.org)