Metastasis lymphangiogenesis lymphatic metastasis. Medical search. Frequent questions

Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development). (wikipedia.org)
Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)
Lymphatic vasculature forms a network of vessels that drain interstitial fluid from tissues and return this fluid to the blood. (nii.ac.jp)
Lymphangiogesis, the formation of lymphatic vessels from preexisting lymphatic vessels, plays an important role in homeostasis of interstitial fluids and immunity. (nii.ac.jp)
Our appreciation for the varied functions of lymphatic vessels has evolved from different scientific disciplines. (jci.org)
Traditionally, microcirculatory physiologists studied the essential transport functions of lymphatic vessels in removing fluid, molecules, and cells after leaking from blood vessels in the periphery and before returning them to the blood circulation. (jci.org)
Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
These new ideas, in turn, reveal a paradigm whereby the transport and immune functions of lymphatic vessels, which were previously considered separately, are in fact intimately coupled. (jci.org)
While we particularly focus on LEC interactions with DCs and T cells, we also highlight features that support immune regulation, including the structure and function of lymphatic vessels and the compartmentalization of the LN stroma, which help control the manner in which LECs can interface with immune cells. (jci.org)
The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
Absence of Lymphangiogenesis and Intratumoural Lymph Vessels in Human Metastatic Breast Cancer," The Journal of Pathology, Vol. 200, 2003, pp. 195-206. (scirp.org)
While lymphatic vessels provide an important route for disseminating tumor cells, they are also a crucial interface between a developing malignancy and the host immune response. (aacrjournals.org)
Rather than acting as passive conduits, lymphatic vessels directly regulate their transport function and facilitate leukocyte trafficking for efficient induction of adaptive immunity in downstream draining lymph nodes. (aacrjournals.org)
We recently published that in the absence of dermal lymphatic vessels, the tumor microenvironment of murine melanoma remains completely uninflamed and fails to induce a robust T-cell response (1). (aacrjournals.org)
We therefore hypothesize that lymphatic vessels are (A) required for induction of adaptive immunity but (B) acquire immunosuppressive activity as a function of the accumulation of local cytotoxic immunity. (aacrjournals.org)
There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
Therapies targeted against lymphangiogenesis, the growth of new lymphatic vessels, are beginning to be explored. (harvard.edu)
Members of the vascular endothelial growth factor (VEGF) family, including VEGF-A and VEGF-C, stimulate the growth of blood vessels and lymphatic vessels. (harvard.edu)
A common receptor expressed on both adult blood vessels and lymphatic vessels is neuropilin 2 (NRP2). (harvard.edu)
In vivo, mock-transfected tumors are circumscribed with many large, open-lumened lymphatic vessels and contain intratumoral lymphatic vessels as well, while tumors overexpressing SEMA3F do not contain lymphatic vessels or have dilated surrounding lymphatics. (harvard.edu)
The angiopoietins are also involved in lymphangiogenesis, the formation of new lymphatic vessels, which plays a key role in tumor metastasis. (amgen.com)
Its primary activity is to inhibit lymphangiogenesis, the formation of new lymphatic vessels around a growing tumour. (checkorphan.org)
LYVE1 is mainly found in the endothelial cells that line lymphatic vessels. (prospecbio.com)
When acting as a transporter for HA, LYVE1 can take on various roles, including moderating the uptake for catabolism within the lymphatic endothelial cells or delivering HA into the lumen of lymphatic vessels for reuptake in the lymph nodes. (prospecbio.com)
Although it is clear that dissemination via the blood system involves hemangiogenesis, it is uncertain whether tumors also induce lymphangiogenesis or simply invade existing peritumoral vessels. (ox.ac.uk)
To address the issue we quantitated tumor lymph vessels in archival specimens of head and neck cancer by immunostaining for the recently described lymphatic endothelial marker LYVE-1, the vascular endothelial marker CD34, and the pKi67 proliferation marker, correlating lymph vessel density and proliferation index with clinical and pathological variables. (ox.ac.uk)
We also found that NO mediates lymph-angiogenesis and metastasis as well as function of lymphatic vessels. (harvard.edu)
We recently uncovered that restoration of perivascular NO gradients improves structure and function of both blood and lymphatic vessels, and response to radiation. (harvard.edu)
Our study elucidates cyclin dependent kinase 5 (Cdk5) as an essential player in the development of lymphatic vessels. (oncotarget.com)
Primary lymphatic vessels remodel into blind ending lymphatic capillaries that take up interstitial fluid and collecting lymphatic vessels that contain valves, are covered by smooth muscle cells and drain the lymph into the venous system [ 2 ]. (oncotarget.com)
However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive. (nih.gov)
Lymphatic vessels perform critical roles in organ functions, yet their roles in health and disease are poorly understood and understudied. (nih.gov)
In the digestive system, lymphatic vessel function is interwoven with organ function, both anatomically and physiologically and these vessels lie at the nexus of critical hormonal, digestive and immune functions. (nih.gov)
Lymphatic vessels within different organs and in different physiological and pathological processes show a remarkable plasticity and heterogeneity, reflecting their functional specialization. (nih.gov)
Many of these functions include key roles of lymphatic vessels, yet the roles of lymphatics, the character of the vessels in the intestinal environment and key regulators of lymphatic function in intestinal health and disease remain understudied. (nih.gov)
Nrp2 is a promising target for inhibition because it is highly expressed in lymphatic vessels. (elsevierpure.com)
Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. (ox.ac.uk)
Angiogenesis (the formation of new blood vessels) and lymphangiogenesis (formation of new lymphatic vessels), i.e., neovasculogenesis, are key determinants for the survival, proliferation, and metastasis of cancer cells. (toppersonalhealth.com)
Increased formation of new blood and lymphatic vessels in the liver. (toppersonalhealth.com)
The main interests of the Dr. Alitalo's group is to understand the mechanisms of development of blood vessels from preexisting ones in a process called angiogenesis and to learn analogous mechanisms of lymphangiogenesis. (euroacadti.eu)
They currently study angiogenesis and lymphatic vessels particularly in malignant tumors, focusing on the growth factor-receptor signaling and growth factor-mediated endothelial cell reprogramming. (euroacadti.eu)
MTC metastasizes through blood or lymphatic vessels. (fapesp.br)
Spread can occur by local invasion into the surrounding tissue, by systemic metastasis via tumor-associated blood vessels to distant organs, or by lymphatic metastasis via tumor-associated lymphatic vessels to draining sentinel lymph nodes, then to distal lymph nodes and from there to distant organs. (dermatologytimes.com)
Dr. Detmar notes, 'It is tempting to speculate that the lymphangiogenic factors, in addition to increasing the mass of tumor-associated lymphatic vessels, might activate the lymphatic endothelium to express increased amounts of chemokines or adhesion molecules and receptors, which are involved in tumor cell-LEC interactions, thereby actively contributing to cancer dissemination. (dermatologytimes.com)
In the cardiovascular system, the heart pumps new blood vessels and of lymphatic vessels from preexisting the blood through arteries into smaller arterioles and into ones, are involved in a number of physiological and patho- capillary beds. (sagepub.com)
e lymphatic network is composed of blind- in�ammation, increased blood �ow as a conse�uence of beginning thin-walled capillaries without pericyte coverage vesseldilationandedemaformationduetoincreasedperme- and with incomplete basal lamina as well as of collecting ability of the blood vessels. (sagepub.com)
However, this therapeutic regimen for ischemic limb using ADRCs did not affect remote melanoma growth nor the density of its feeder artery, angiogenesis and lymphatic vessels compared to the PBS group. (nagoya-u.ac.jp)
E.g. in lymphedema patients suffer from swollen limbs because lymphatic vessels are absent or not functioning properly. (jeltsch.org)
And the spread of cancer ("metastasis") seems to be intimately related to the lymphatic system as the cancer cells use the lymphatic vessels as pathways to travel within the body. (jeltsch.org)
It is obvious that many diseases could be treated if we would be able to influence the growth of both blood and lymphatic vessels. (jeltsch.org)
Our laboratory works on growth factors, that regulate the development and function of blood vessels and lymphatic vessels. (jeltsch.org)
All lymphatic vessels arise by angiogenesis. (jeltsch.org)
The first lymphatic vessels sprout from the venous compartment of the circulatory system. (jeltsch.org)
The only known growth factor, that stimulates the growth of lymphatic vessels was cloned in our laboratory: VEGF-C. VEGF-C binds to VEGF receptor-2 and VEGF receptor-3 (VEGFR-3). (jeltsch.org)
Administration of VEGF Trap, a receptor-based fusion protein that binds and neutralizes VEGF-A but not VEGF-C or -D, completely inhibited both hemangiogenesis and the outgrowth of LYVE-1(+) lymphatic vessels following injury. (ox.ac.uk)
Lymphatic vessels form from pre-existing vessels via lymphangiogenesis in both development and in pathological settings. (edu.au)
A potential diagnostic pitfall is the presence of vascular metastasis in the intracapsular lymphatic vessels of the node, which mimics capsular nevi. (medscape.com)

How tumors access and spread via the lymphatics is not understood. (ox.ac.uk)
Moreover, the lymphatic system contributes to tumor cell metastasis - tumors induce lymphangiogenesis to allow the dissemination of tumor cells [ 3 ]. (oncotarget.com)
kidney, angiogenesis (CD31-positive cells), lymphangiogenesis (LYVE-1-positive cells), and TAM (F4/80-positive cell) numbers in the tumors of LM8-bearing mice. (complementaryoncology.com)
criteria are the absence of extrahepatic metastasis and vascular invasion identifiable with preoperative images, a solitary tumor of 5 cm or less, or if there are multiple tumors, three or fewer tumors measuring 3 cm or less in diameter at a maximum (Milan criteria) (LF005401 level 2a). (hormonessignaling.com)
Using experiments involving transgenic mice, they have successfully shown that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis, leading to the promotion of hepatic tumors. (toppersonalhealth.com)
Dr. Detmar and his team of researchers conducted a study consisting of 45 patients with primary cutaneous melanoma, where the extent of tumor lymphangiogenesis in the excised primary tumors and the presence of metastases in the sentinel lymph node biopsy samples were examined. (dermatologytimes.com)
Results showed that prominent 'hot spots' of increased lymphatic vessel density were seen in the primary melanomas of patients whose tumors had metastasized to the sentinel lymph nodes, as compared to nonmetastatic tumors. (dermatologytimes.com)
Dr. Detmar postulates that metastatic melanomas can therefore be characterized by increased lymphangiogenesis, as compared to non-metastatic tumors, and that the degree of tumor lymphangiogenesis can serve as a novel predictor of lymph node metastasis and overall patient survival, independent of tumor thickness. (dermatologytimes.com)
In 1995, we demonstrated the prognostic importance of lymphatic invasion in rectal cancer and advocated the subdivision of stage III (Dukes' C) tumors according to lymphatic invasion ( 12 ). (iiarjournals.org)
2005). Lymphangiogenesis is also important for tumors expansion, especially the for lymph node metastasis (Kadowaki et al . (vin.com)

Lymphatic vasculature development" (PDF). (wikipedia.org)
This unequivocal requirement for a functional lymphatic vasculature in the priming of cutaneous immunity further supports the prediction that LVD may be a novel biomarker of immune reactivity within tumor parenchyma. (aacrjournals.org)
Dysfunction of the lymphatic vasculature results in lymphedema formation and compromises immune function. (oncotarget.com)
Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. (ox.ac.uk)

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)
Our recent study elucidates the serine-threonine kinase cyclin dependent kinase 5 (Cdk5) as the missing link in the regulation of Foxc2 in the lymphatic endothelium [ 12 ]. (oncotarget.com)

Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing. (wikipedia.org)
We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
VEGF-C functions in both physiological and pathological lymphangiogenesis, particularly in tumor metastasis, making it an attractive therapeutic target. (elsevierpure.com)
Both the ligand and receptor are usually co-expressed at sites of lymphatic vessel sprouting, in the embryo, and in various pathological conditions. (bio-techne.com)
We conclude that VEGF-A recruitment of monocytes/macrophages plays a crucial role in inducing inflammatory neovascularization by supplying/amplifying signals essential for pathological hemangiogenesis and lymphangiogenesis. (ox.ac.uk)

The role of the lymphatic system in these diseases has received renewed interest largely due to the discovery of lymphatic endothelial cell (LEC)-specific markers such as podoplanin, LYVE-1, PROX1, desmoplakin and VEGF-C receptor VEGFR-3. (wikipedia.org)
There are several known pro-lymphangiogenesis inducers such as VEGF-C, hyaluronic acid and ephrin-B2. (wikipedia.org)
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
VEGF messenger RNA (mRNA) is widely overexpressed in tissues and is associated with metastasis, recurrence, and prognosis [ 2 ]. (hindawi.com)
Tumour growth and metastasis are associated with angiogenesis and lymphangiogenesis through the production of vascular endothelial growth factor (VEGF) or VEGF-C in tumours, and the phosphorylation of VEGF receptor (VEGFR)-2 or VEGFR-3 in vascular endothelial cells or lymphatic endothelial cells (LECs). (complementaryoncology.com)
Wogonin had no effect on VEGF-C production in LM8 cells, or VEGFR-3 expression in human lymphatic endothelial cells (HLECs), however, it inhibited VEGF-C-induced VEGFR-3 phosphorylation in HLECs. (complementaryoncology.com)
The anti-tumour and anti-metastatic actions of wogonin may be associated with the inhibition of VEGF-C-induced lymphangiogenesis through a reduction in VEGF-C-induced VEGFR-3 phosphorylation by the inhibition of COX-2 expression and IL-1? (complementaryoncology.com)
Vascular endothelial growth factor-C (VEGF-C) is a secreted growth factor essential for lymphangiogenesis. (elsevierpure.com)
Our previous studies show that activation of the VEGF-C/VEGFR-3 axis promotes cancer metastasis and is associated with clinical progression in patients with lung cancer, indicating that VEGFR-3 is a potential target for cancer therapy. (oncotarget.com)
VEGF-C interactions with VEGF R3 are critical for lymphangiogenesis. (bio-techne.com)
Over-expression of VEGF-C in tumor cells induces tumoral lymphatic hyperplasia, neoangiogenesis, and vessel sprouting, resulting in enhanced lymph flow and metastasis to regional lymph nodes. (bio-techne.com)
According to Prof. Tanaka , "We demonstrated for the first time that hepatic angiogenesis and lymphangiogenesis were enhanced by saturated-fat- or trans-fat-rich diets, but not cholesterol-rich diets, mainly through the JNK-HIF1α-VEGF-C axis. (toppersonalhealth.com)
Most significantly, they have found that VEGF-C over-expression leads to lymphangiogenesis, intralymphatic tumor growth and lymph node metastasis in several tumor models. (euroacadti.eu)
Despite the fact that it is well-known that Vascular Endothelial Growth Factor (VEGF) binds to its receptor VEGFR and initiates endothelial cell proliferation, almost nothing is known about their involvement and mechanisms in the process of MTC metastasis.Interestingly, RET (RET/PTC) gene rearrangement, present in papillary thyroid carciomas, modulates the expression of many genes that could be involved on tumor growth and angiogenesis, such as CXCL12 and CXCR4. (fapesp.br)
It is also known that Tumor-Associated Macrophages (TAM) are attracted by CXCL12 and VEGF, and can promote angiogenesis and tumor metastasis. (fapesp.br)
Therefore, we propose to investigate p.G533C mutation on gene RET associated to inherited MTC genesis modulating different VEGF isoforms, VEGFR, and other mediators involved on the process of angiogenesis and lymphangiogenesis on tumor progression. (fapesp.br)
The elevated expression of several angiogenic factors, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF) and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. (dermatologytimes.com)
e lymphatic blood vascular endothelial cells are activated by several in�ammatory mediators (e.g., vascular endothelial growth capillariestakeupthisprotein-rich�uid,therebymaintaining factor- (VEGF-)A, tumor necrosis factor (TNF-) , inter- not only tissue �uid homeostasis but also exerting immune leukin (IL)-6, and IL-1), leading to the typical signs of surveillance. (sagepub.com)
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. (ox.ac.uk)
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. (ox.ac.uk)
We re-evaluated the potential role of VEGF-A in lymphangiogenesis using a novel model in which both lymphangiogenesis and hemangiogenesis are induced in the normally avascular cornea. (ox.ac.uk)
Furthermore, both lymphangiogenesis and hemangiogenesis were significantly reduced in mice transgenic for VEGF-A(164/164) or VEGF-A(188/188) (each of which expresses only one of the three principle VEGF-A isoforms). (ox.ac.uk)
Because VEGF-A is chemotactic for macrophages and we demonstrate here that macrophages in inflamed corneas release lymphangiogenic VEGF-C/VEGF-D, we evaluated the possibility that macrophage recruitment plays a role in VEGF-A-mediated lymphangiogenesis. (ox.ac.uk)
VEGF is one of most important mediators of neoplastic angiogenesis and lymphangiogenesis (Hirakawa et al . (vin.com)
It should be noted that studies of lymphatic vessel growth utilizing protein reagents or transgenic technology alone, in a tissue/cell culture environment, during tumor metastasis, in a lymphatic disease paradigm, or during tissue repair, have shown that various growth factors, such as platelet-derived growth factor BB (1), hepatocyte growth factor (2), fibroblast growth factor (3), and VEGF-A (4) appear to play a role. (arizona.edu)

Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
Tumour-associated macrophages (TAMs) play an important role in tumour lymphangiogenesis, and consequently stimulate metastasis through the lymphatic system to lymph nodes. (complementaryoncology.com)

We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
ICAM-)1, vascular cell adhesion molecule- (VCAM-)1, elargestcollectinglymphaticvessel,thethoracicduct,con- and E-selectin on activated blood vascular endothelial cells, nects the lymphatic system with the cardiovascular system. (sagepub.com)

A study in which the investigators injected PC3M-LN4 prostate cancer cells that are known to be rich in pericellular HA in mice, found that when Stabilin-2 was blocked with a blocking antibody prior to tumor injection, the number of lymph node metastases was dramatically reduced [ 7 ] . (encyclopedia.pub)
A follow-up human patient study in the evaluation of tongue cancer supports this finding in which the potential of solid tumor lymph node metastases is positively correlated with Stabilin-2 expression in lymph node [ 8 ] . (encyclopedia.pub)

Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both. (ox.ac.uk)

Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
In summary, our study elucidates the Cdk5-Foxc2 interaction as a critical regulator of lymphatic vessel development. (oncotarget.com)

Age and sex of patients, site, gross type, size (maximum tumor diameter), preoperative serum level of carcinoembryonic antigen (CEA), depth of wall invasion, status of lymph node metastasis, histopathological differentiation, degree of lymphatic and venous invasion, and presence or absence of postoperative adjuvant chemotherapy were extracted from operation records and pathology reports. (iiarjournals.org)

EVT801 is a pre-clinical-stage, orally available, small molecule inhibitor of the lymphatic growth factor receptor VEGFR3, originally developed within Evotec's partnership with Sanofi. (checkorphan.org)
LYVE1, also known as lymphatic vessel endothelial receptor 1 or lymphatic vessel endothelial hyaluronic acid receptor 1, is a member of the link protein family, which has the capability to bind with hyaluronic acid. (prospecbio.com)
Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head and neck and colorectal carcinomas, and uncover a dramatic correlation between ESAM expression and nodal metastasis that identifies this marker as a possible prognostic indicator. (ox.ac.uk)
Vascular endothelial growth factor receptor 3 (VEGFR-3) supports tumor lymphangiogenesis. (oncotarget.com)
Says Prof. Tanaka, "Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators like CD31 and TEK receptor tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1. (toppersonalhealth.com)

Melanoma is the most lethal skin cancer with most deaths occurring from distant metastases. (harvard.edu)
In addition, no distant metastases were detected in any of the mice regardless the group. (nagoya-u.ac.jp)

Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis. (ox.ac.uk)
Aim: To determine correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarify the prognostic impact of lymphatic invasion. (iiarjournals.org)
Lymphatic invasion was calculated as an average and the degree was also determined (Ly0-3). (iiarjournals.org)
Clinicopathological factors including lymphatic invasion were assessed by uni- and multivariate analyses to determine factors affecting survival. (iiarjournals.org)
Survival was compared between different degrees of lymphatic invasion and lymph node metastasis. (iiarjournals.org)
Conclusion: Lymphatic invasion in colorectal cancer correlates well with the status of lymph node metastasis and disease stage, representing an independent prognostic factor after curative resection. (iiarjournals.org)
Lymphatic invasion can be used for evaluating tumor aggressiveness and estimating patient survival, irrespective of the actual number of positive lymph nodes found. (iiarjournals.org)
It is well-known that not only the presence or absence of lymph node metastasis, but also the degree of presence, is an important prognostic factor, along with depth of tumor invasion, and is useful in determining the adjuvant chemotherapy and surveillance program ( 3 , 4 ). (iiarjournals.org)
The present study examined correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarified the prognostic impact of lymphatic invasion, based on a large series and long-term follow-up of patients with colorectal cancer curatively treated. (iiarjournals.org)

Ongoing research in this area is essential to understanding how inflammatory lymphangiogenesis affects both cancer progression as well as chronic inflammation that leads to autoimmunity. (jci.org)
I continue to work on a variety of infectious diseases and immune disorders (e.g., inflammatory bowel disease, AIDS, Kaposi sarcoma, tuberculosis, filariasis, congenital/hereditary lymphatic system syndromes, opportunistic infections/neoplasms) and direct an internationally recognized Lymphedema-Angiodysplasia clinic. (arizona.edu)
The lymphatic system plays an important role in uptake of dietary fat and clearance of cholesterol from peripheral tissues and has been implicated in several disease states such as obesity, metabolic syndrome and inflammatory bowel disease (IBD). (nih.gov)

Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). (jci.org)
Lymphatic endothelial cells (LECs) themselves have been shown to play active roles in controlling their transport functions and in directly communicating with immune cells to modulate their immediate and downstream functions. (jci.org)

M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)
He explains that the extent of tumor lymphangiogenesis is a highly sensitive (83 percent) and specific (89 percent) prognostic marker of lymph node metastasis. (dermatologytimes.com)

Lymphatic vessel remodeling and lymphangiogenesis is correlated with melanoma progression and lymph node metastasis. (aacrjournals.org)

Yoshiyuki Kimura & Maho Sumiyoshi examined the effects of wogonin isolated from Scutellaria baicalensis roots on tumour growth and metastasis using a highly metastatic model in osteosarcoma LM8-bearing mice. (complementaryoncology.com)
We characterise molecular mechanisms that control lymphangiogenesis using model organisms (zebrafish and mice). (edu.au)

Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. (wikipedia.org)
Consistently, TCGA analysis of human cutaneous metastatic melanoma identified positive correlations between LEC gene expression and immune genes, including a T cell-inflamed signature, indicating a relationship between lymphatic vessel remodeling and local immunity. (aacrjournals.org)
To test the first part of this hypothesis (A), we have continued our published work and used a cutaneous model of viral infection to demonstrate the requirement for lymphatic vessel drainage in cutaneous immunity. (aacrjournals.org)
The lymphatic system is a crucial component of nutrient and hormone absorption, fluid homeostasis and immunity. (nih.gov)

My translational interests and contributions have spanned blood/lymphatic vascular endothelial cell biology and pathobiology in vitro and in vivo, hepatosplanchnic lymphatic/microcirculatory physiology, small animal models, in vivo lymphatic imaging, thoracic duct lymph drainage, lymphogenous cancer spread, and genomics/proteomics of lymphedema-angiodysplasia syndromes in man and experimental models, including defects, deficiency, and overexpression of human and murine lymphangio- gene-sis genes and their syndromic/phenotypic manifestations. (arizona.edu)
A sentinel lymph node (SLN) is the first lymph node or group of nodes to receive lymphatic drainage from a tumor at a particular anatomic area. (medscape.com)

In contrast, lymphatic vasculogenesis starts after the establishment of the blood circulatory system. (nature.com)
Lymphatic vessel formation starts after the circulatory system has been established by specification of lymphatic endothelial cells from preexisting embryonic veins. (oncotarget.com)
The lymphatic system or "second circulatory system" is a common transportation highway for metastases and tumor lymphangiogenesis and is common among the various types of cancer. (encyclopedia.pub)

The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. (nii.ac.jp)
Lymphatic vessel dysfunction is associated with various pathologic conditions, including immunologic disorders, lymphedema, as well as tumor dissemination. (oncotarget.com)

The lymphatic system is essential for the maintenance of tissue fluid homeostasis, enables the uptake of dietary lipids and regulates the immune response by serving as a trafficking route for immune cells [ 1 ]. (oncotarget.com)
Malfunctioning of the lymphatic system is associated with various pathologic conditions. (oncotarget.com)
The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. (nih.gov)
Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. (nih.gov)
esides the increased in�amma- tory cell in�ltration into the in�amed tissue, it has become In vertebrates, there are two vascular systems: the cardio- clearintherecentyearsthatacuteandchronicin�ammatory vascular and the lymphatic system. (sagepub.com)
Apart from the cardiovascular system there is another vascular system: the lymphatic system. (jeltsch.org)
Similar to the cardiovascular function, the lymphatic system plays an important role in several diseases. (jeltsch.org)
The lymphatic system develops later than the cardiovascular system. (jeltsch.org)
Since its first sequential visualization in 1902 by Florence Sabin, the development and maintenance of the lymphatic system has intrigued scientists and clinicians worldwide. (arizona.edu)
This article is a commentary on the usefulness of specific genetic engineering tools in understanding the development of the lymphatic system-with a focus on the questions that have been addressed using these tools, the extent to which the questions have actually been answered, and the questions that have subsequently been raised. (arizona.edu)

We found that lymphangiogenesis in chronic inflammation and secondary lymphedema was regulated by COX-2. (nii.ac.jp)

These biological phenomena occur by angiogenesis and lymphangiogenesis, respectively. (fapesp.br)
It is not meant to be a discussion of protein reagents or of specific biological situations that exhibit lymphangiogenesis (see reviews 5-7). (arizona.edu)

Furthermore, our previous work demonstrated that vascular endothelial growth factor C (VEGFC)-driven lymphangiogenesis in the context of murine melanoma drove increased leukocyte infiltration but associated with poor CD8+ T cell priming in draining lymph nodes (4). (aacrjournals.org)
Recently we have demonstrated that one member of the class 3 semaphorins, Semaphorin 3F (SEMA3F), can inhibit human melanoma metastasis. (harvard.edu)
Melanoma researchers have therefore been concentrating their efforts on learning more about angiogenesis, lymphangiogenesis and the nature of metastasis in order to better understand which types of melanomas have a tendency to metastasize. (dermatologytimes.com)
Dr. Detmar set out to investigate whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes. (dermatologytimes.com)

Furthermore, others have recently demonstrated that lymphatic vessel density (LVD) in combination with intratumoral T cell function stratified best overall survival in nonmetastatic and metastatic colorectal cancer (2). (aacrjournals.org)
Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. (ox.ac.uk)
P = 0.017), but no obvious correlation with intratumoral lymphatics. (ox.ac.uk)

A number of studies have also flagged LYVE1 as a marker for lymphoid tissue and lymphangiogenesis. (prospecbio.com)

Yet, the knowledge about the regulation of lymphatic vessel development is still limited. (oncotarget.com)
The forkhead transcription factor Foxc2 plays a central role in lymphatic vessel development and lymphatic valve formation [ 4 - 6 ]. (oncotarget.com)

LYVE1 has also been found to play a role in HA localisation to the surface of the endothelial cells that line the lymphatic tissue. (prospecbio.com)
In conclusion, local implantation of ADRCs promotes angiogenesis in response to tissue ischemia in the hind limb without promoting remote tumor growth and related angio/lymphangiogenesis. (nagoya-u.ac.jp)
Lymphatics function to drain tissue fluid and traffic immune cells, but are also utilised by tumours to metastasise to lymph nodes and secondary sites in cancer. (edu.au)

Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)

Following cutaneous vaccinia infection we demonstrate that in the absence of lymphatic vessel transport, both cellular and humoral adaptive immune responses fail to initiate, leading to enhanced cutaneous immunopathology and persistent viral load. (aacrjournals.org)
As well as being involved in HA degradation and transportation, studies indicate that HA localisation towards lymphatic surfaces, which is linked to LYVE1, can affect the body's immune responses and tumour metastases. (prospecbio.com)

Lymphangiogenesis in Cancer Metastasis. (wikipedia.org)
High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation," Cancer Research, Vol. 60, No. 16, 2000, pp. 4324-4327. (scirp.org)
Metastasis is the most common cause of death in cancer patients. (harvard.edu)
Deciphering the mechanisms underlying increased risk of brain metastases in young women with triple negative breast cancer. (cuanschutz.edu)
Moreover, Foxc2 has been associated with cancer cell metastasis and epithelial-mesenchymal transition [ 9 , 10 ]. (oncotarget.com)
This is especially relevant for the liver sinusoids and lymph nodes which express high levels of Stabilin-2 and also are sites of metastases for a number of cancer types. (encyclopedia.pub)
Background: The degree of lymph node metastasis represents an important prognostic factor for cancer. (iiarjournals.org)
Although the prognostic import of lymph node metastasis is widely accepted in colorectal cancer, 12 nodes or more must be examined to adequately assess the degree of lymph node metastasis ( 5 , 6 ). (iiarjournals.org)

Anatomy19

Organisms8

Diseases50

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes13

Disciplines and Occupations1

Information Science2

Health Care9

Geographicals1

Vessels57

Tumors10

Vasculature4

Endothelium2

Pathological5

VEGF25

Tumour Lymphangiogenesis2

Blood vascular endothelial cells2

Lymph node metastases2

Altered lymphatic vessel1

Regulator of lymphatic2

Differentiation1

Receptor5

Distant metastases2

Invasion10

Inflammatory3

LECs2

Prognostic Marker2

Progression1

Mice2

Immunity4

Drainage2

Circulatory system3

Dissemination2

System10

Lymphedema1

Biological2

Melanoma4

Intratumoral3

Marker1

Vessel development2

Tissue3

Density1

Immune2

Cancer9