• Image-guided percutaneous radiofrequency ablation and cryoablation techniques have been studied in clinical trials and are considered effective options in pain palliation of patients with bone metastatic disease. (clinicaltrials.gov)
  • miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with risk of distal metastasis. (nih.gov)
  • miR-335 suppresses metastasis and migration through targeting of the progenitor cell transcription factor SOX4 and extracellular matrix component tenascin C. Expression of miR-126 and miR-335 is lost in the majority of primary breast tumours from patients who relapse, and the loss of expression of either microRNA is associated with poor distal metastasis-free survival. (nih.gov)
  • The identified subset of metastasis relevant genes in osteoblastic OS overlapped only minimally with differentially expressed genes in the other four preosteoblast or nonosteoblastic cell line systems. (hindawi.com)
  • The results imply an OS phenotype specific expression pattern of metastasis regulating proteins and form a basis for further investigation of gene expression profiles in patients' samples combined with survival analysis with the aim to optimize treatment strategies to develop new drugs and to consequently improve the survival of patients with the most common form of osteoblastic OS. (hindawi.com)
  • Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid. (wikipedia.org)
  • Osteosarcomas tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (the RB gene and p53 gene are commonly involved). (wikipedia.org)
  • 68Ga-DOTA-TATE PET/CT plays an important role in neuroendocrine neoplasm(NEN)diagnosis and biological charecteristcs evaluation.Skeleton is the second common metastatic organ in NEN after liver and it affects the quality of patient's life. (enets.org)
  • this text defines a fracture as a break in the continuity of the bone (and the anatomical location of the fracture). (spotidoc.com)
  • Sometimes a sudden fracture is the first symptom, because affected bone is not as strong as normal bone and may fracture abnormally with minor trauma. (wikipedia.org)
  • To date, the functional importance of ALDH enzymes in prostate carcinogenesis, progression and metastasis has remained elusive. (nih.gov)
  • Our findings show, for the first time, that the ALDH7A1 enzyme is functionally involved in the formation of bone metastases and that the effect appeared dependent on the microenvironment, i.e., bone versus prostate. (nih.gov)
  • Osteosarcoma (OS) is a rare bone neoplasm that affects mainly adolescents. (hindawi.com)
  • Osteosarcoma (OS) is a rare but highly malignant neoplasm of bone that affects mainly young patients during the second decade of their lives. (hindawi.com)
  • Not only fluoride concentration in bones, Fluoride exposures of osteosarcoma patients are also proven to be not significantly different from healthy people. (wikipedia.org)
  • You may need ongoing tests, bone scans, or treatment. (drugs.com)
  • 0. and orthopedic surgical treatment for skeletal metastasis [HR (95% CI) 1.710 (1.148-2.547), p = 0.were significant, independent, good prognostic factors. (biomedcentral.com)
  • The search for metastasis predicting markers is therefore imperative to optimize treatment strategies for patients at risk and important for the search of new drugs for the treatment of this devastating disease. (hindawi.com)
  • The identification of proteins that are involved in OS progression and metastasis is therefore of immediate importance to develop new and improved treatment strategies. (hindawi.com)
  • The plethora of ongoing clinical trials will hopefully translate into improved treatments options for patients suffering from bone metastatic cancers. (symptoma.com)
  • Bone cement may be used along with other treatments to strengthen the bone. (drugs.com)
  • The use of positron emission tomography (PET) in clinical oncology continues to increase and although there is now a large literature on the use of PET with various tracers in a wide variety of cancers, there has previously been relatively little use specifically in the evaluation of skeletal metastases. (icr.ac.uk)
  • Furthermore, a number of genes/factors involved in migration, invasion and metastasis were affected including transcription factors (snail, snail2, and twist) and osteopontin, an ECM molecule involved in metastasis. (nih.gov)
  • Your healthcare provider may recommend that you get more calcium and vitamin D. Calcium and vitamin D work together to build and protect bones. (drugs.com)
  • 0. and radiation therapy for skeletal metastasis [HR (95% CI) 1.791 (1.170-2.742), p = 0.were significant, independent, good prognostic factors. (biomedcentral.com)