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  • tumor metastasis
  • Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. (redorbit.com)
  • They found that treatment with tumor exosomes increased the number of myeloid-derived suppressor cells, which inhibited immune activation and accelerated tumor metastasis in the lung. (redorbit.com)
  • In this study, Liu et al "identified the role of tumor exosomes in the enhancement of tumor metastasis through the expansion of myeloid-derived suppressor cells. (redorbit.com)
  • For example, recent studies have identified common markers on circulating tumor cells, which may allow for their characterization and provide further insights in tumor metastasis. (qiagen.com)
  • QIAGEN provides a broad range of assay technologies for tumor metastasis research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • The Human Tumor Metastasis RT² Profiler PCR Array is designed to represent 84 genes known to be involved in metastasis. (qiagen.com)
  • One of the most significant features of this work is that it highlights the way that tumors can have long-range effects on other parts of the body, which can then impact tumor metastasis or growth," said Varner. (medindia.net)
  • The researchers noted in their studies that it is possible to suppress tumor metastasis by reducing growth factor levels or by blocking activation of the α4β1 receptor. (medindia.net)
  • tissues
  • The location of the metastases is not always random, with different types of cancer tending to spread to particular organs and tissues at a rate that is higher than expected by statistical chance alone. (wikipedia.org)
  • In a paper published in the March 15, 2011 issue of Cancer Cell, UCSD scientists led by Jing Yang, PhD, assistant professor of pharmacology and pediatrics, identify a unique function of Twist1 in later life: it promotes the formation of invadopodia in tumor cells, a vital step in the spread of such cells (metastasis) to surrounding tissues and other parts of the body. (redorbit.com)
  • Roughly 90 percent of all cancer deaths are due to metastasis - the disease spreading from the original tumor site to multiple, distant tissues and finally overwhelming the patient's body. (medindia.net)
  • liver
  • The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. (springer.com)
  • Liver metastases addresses the contemporary multidisciplinary management of liver metastases. (springer.com)
  • Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. (springer.com)
  • researchers
  • The researchers report that mutations in mitochondrial DNA can spur metastasis and that it can be reversed with drugs, at least in mice. (freerepublic.com)
  • Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases. (worldcat.org)
  • Researchers report that cancers physically alter cells in the lymphatic system - a network of vessels that transports and stores immune cells throughout the body - to promote the spread of disease, a process called metastasis. (medindia.net)
  • proteins
  • LIMD2 had earlier been identified as a biomarker for papillary thyroid cancer metastasis and, as a member of the a family of proteins known to be active in both the cell's nucleus and cytoplasm, piqued the interest of the Rauscher laboratory. (redorbit.com)
  • theory
  • This "seed and soil" theory was challenged by James Ewing in 1928 who suggested that metastasis occurs purely by anatomic and mechanical routes. (news-medical.net)