• Natural News) The ability to spot tumors and metastases at an early stage would improve the survival chances of cancer patients. (naturalnews.com)
  • Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. (springer.com)
  • Lung metastases are cancerous tumors that start somewhere else in the body and spread to the lungs. (medlineplus.gov)
  • This runs counter to the prevailing assumption that metastasis occurs late in advanced primary tumors. (genomeweb.com)
  • To see if the two genes also contributed to metastases in humans, the scientists analyzed 10,000 samples of tumors collected from humans with 33 different types of cancer. (news-medical.net)
  • Interestingly, Chang said, his laboratory also discovered that although androgen deprivation therapy shrinks tumors, it also might inadvertently promote cell metastasis due to altered cell signaling in the region of the tumor. (rochester.edu)
  • Metabolic profiling of human prostate tumors identified a massive increase in the SRC-2-driven metabolic signature in metastatic tumors compared with that seen in localized tumors, further implicating SRC-2 as a prominent metabolic coordinator of cancer metastasis. (jci.org)
  • The tumor initially spreads via a hematogenous route to the pulmonary arterioles and capillaries with retrograde spread from hilar nodal metastases or upper abdominal tumors, but subsequently extends through the vascular walls, invades the low resistant peribronchovascular lymphatics, and spreads along the lymphatics. (medscape.com)
  • The aim of this analysis was to assess the efficacy of stereotactic body radiotherapy (SBRT) in terms of local control (LC) and progression-free survival (PFS) in patients with lymph node metastases (NMs) from solid tumors . (bvsalud.org)
  • Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma. (lu.se)
  • Knockout of Keap1 on the KP background (KPK mice) resulted in more thoracic and lymph node metastases relative to KP mice. (nature.com)
  • They found that supplementing the diet of lung tumour-bearing mice with either a pharmacological or dietary antioxidant, N -acetylcysteine (NAC) and vitamin E respectively, was sufficient to increase the amount of lymph node metastases relative to untreated control mice. (nature.com)
  • The NSUN3 levels were also predictive of disease stage and the presence of lymph node metastasis at the time of diagnosis, the team found. (fiercebiotech.com)
  • In mice, treatment with the two antibiotics decreased the number of lymph node metastases from 80% to 20%, the team reported. (fiercebiotech.com)
  • In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
  • Presence or absence of lymph node metastases is the most accurate prognostic indicator in breast cancer. (nih.gov)
  • She and her colleagues analyzed exome sequencing data from 23 patients with colorectal cancer who had distant metastases to the liver, a common metastatic site, or the brain, a less common, but often fatal metastatic site. (genomeweb.com)
  • For all but one of the cases analyzed, they found the distant metastases corresponded to a monophyletic clade. (genomeweb.com)
  • Breast cancer patients often face the additional risk of distant metastases, and the best way to find the presence of those abnormalities in the liver and bone is with PET/MRI, according to a study published in the October issue of Radiology . (auntminnie.com)
  • PET/CT scans were scheduled for various reasons, including evaluation after chemotherapy, monitoring distant metastases, and initial staging ( Radiology , October 2016, Vol. 281:1, pp. 193-202). (auntminnie.com)
  • In detecting distant metastases in the liver, PET/MRI had greater sensitivity than PET/CT. (auntminnie.com)
  • We compared the power of gene expression measurements with that of conventional prognostic markers, i.e., clinical, histo- pathological, and cell biological parameters, for predicting distant metastases in breast cancer patients using both established prognostic indices (e.g., the Nottingham Prognostic Index (NPI)) and novel combinations of conventional markers. (lu.se)
  • Furthermore, the scientists also found that the number of freely circulating tumor cells exhibiting this special polarity correlates with the risk of developing metastasis, both in human tumor cell lines and in mice. (dkfz.de)
  • When cancer cells spread from one area of the body to your bones, it is called bone metastasis (or bone mets). (oncolink.org)
  • What are the types of bone metastasis? (oncolink.org)
  • Fractures from bone metastases are called "pathologic" fractures. (oncolink.org)
  • High calcium levels: Some bone metastases can cause calcium to leak from the bones into the bloodstream. (oncolink.org)
  • You should tell your provider if you start to have any symptoms of bone metastases. (oncolink.org)
  • How are bone metastases diagnosed? (oncolink.org)
  • If you have signs of bone metastasis, tests can be done to find the cause. (oncolink.org)
  • In some cases, bone metastasis may be found before the symptoms start. (oncolink.org)
  • Bone metastases often do not show up on plain x-rays until they are quite advanced. (oncolink.org)
  • A bone scan can find very early bone metastases. (oncolink.org)
  • Bone metastasis occurs when cancer cells spread from their original site to a bone. (mayoclinic.org)
  • Bone metastasis can occur in any bone but more commonly occurs in the spine, pelvis and thigh. (mayoclinic.org)
  • Bone metastasis may be the first sign that you have cancer, or bone metastasis may occur years after cancer treatment. (mayoclinic.org)
  • Bone metastasis can cause pain and broken bones. (mayoclinic.org)
  • Treatments can help reduce pain and other symptoms of bone metastases. (mayoclinic.org)
  • Sometimes, bone metastasis causes no signs and symptoms. (mayoclinic.org)
  • Bone metastasis occurs when cancer cells break away from the original tumor and spread to the bones, where they begin to multiply. (mayoclinic.org)
  • Bone metastases in patients with systemic cancer frequently manifest in the spine. (zeiss.com)
  • The median overall survival of patients with bone metastases is only 7-9 months 1 while some of these patients (with primary entities responsive to systemic treatment) can survive more than a decade. (zeiss.com)
  • Princeton cancer researchers Yibin Kang (left) and Mark Esposito, seen here in April 2019, discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation - when liquid blobs of living materials merge into each other. (princeton.edu)
  • This 3D image of human breast cancer bone metastases shows the formation of the newly described organelle (magenta) in cancer cells (cyan). (princeton.edu)
  • Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
  • We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
  • Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
  • Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
  • Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
  • Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)
  • Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
  • This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
  • We believe that these molecular targets could guide in determining timing of therapeutic interventions that offer the best opportunity to prevent and/or halt extent of bone metastases. (hindawi.com)
  • Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
  • ASTRO states that external beam radiation therapy (EBRT) continues to be the mainstay of treatment for bone metastases, however, the widespread variation in practice patterns has created a need for formal treatment guidelines. (cancernetwork.com)
  • Breast cancer patients with only or predominantly bone metastases have a median survival of 2.3 years following diagnosis, while metastatic prostate cancer patients have a median survival time of 11.3 months. (novapublishers.com)
  • Published by the International Journal of Oncology , Chang's laboratory found that bone marrow derived stem cells, which are recruited to the site of a growing tumor, are able to convert nearby normal fibroblast cells into cancer cells, resulting in tumor metastasis. (rochester.edu)
  • In turn, she plans to expand these experiments to look at other major sites for breast cancer metastasis, including the liver, bone, and brain. (manchester.ac.uk)
  • Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. (degruyter.com)
  • Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
  • A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
  • DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
  • In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
  • Metastasis to bone typically results in a poor prognosis, reducing life expectancy to 2-3 years post-diagnosis. (degruyter.com)
  • Bone cancer metastases usually occur in the axial skeleton, in areas with active hematopoiesis and high red marrow content. (degruyter.com)
  • In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
  • The antiretroviral drug maraviroc, a CCR5 receptor antagonist used in the treatment of HIV, may also be able to block bone metastases in prostate cancer patients, a new study shows. (pharmacytimes.com)
  • A recent study analyzed concurrent immunotherapy and stereotactic radiotherapy in melanoma patients with brain metastases. (medpagetoday.com)
  • We hope our technique, which is a novel AI-based predictive method of detecting radiotherapy failure in brain metastasis, will be able to help oncologists and patients make better informed decisions and adjust treatment in a situation where time is of the essence. (yorku.ca)
  • Systematic review of stereotactic body radiotherapy for nodal metastases. (bvsalud.org)
  • We believe this is the first time that phase separation has been implicated in cancer metastasis," said Kang. (princeton.edu)
  • Natural News) In this study, a team of researchers from Nanjing University of Chinese Medicine in China studied the effects of a modified decoction of si jun zi on the metastasis of colorectal cancer cells. (naturalnews.com)
  • NEW YORK (GenomeWeb) - Many colorectal cancer metastases may have arisen and spread even before the primary tumor was large enough to be detected, according to a new study. (genomeweb.com)
  • At the same time, the researchers found in a separate cohort of 2,751 patients with colorectal cancer, including 938 patients with metastatic cancer, that most metastases harbored a set of core colorectal cancer driver genes, but also an additional candidate metastasis driver gene. (genomeweb.com)
  • In this module, an overview of the most important aspects of successful management of patients with liver metastases from colorectal cancer are presented to the interventioinal radiologist. (cirse.org)
  • The main goal of our research is to understand how cancer-causing genes enable metastasis and use that information to identify targeted therapies that may prevent it. (news-medical.net)
  • Dhanasekaran and her colleagues genetically engineered mice to express both MYC and TWIST1 and found that these two major cancer-promoting genes led to metastases. (news-medical.net)
  • An analysis of The Cancer Genome Atlas also showed that in patients with head and neck cancer, higher levels of NSUN3 were correlated with genes that encode regulators of metastasis and response to low oxygen levels. (fiercebiotech.com)
  • They uncovered genes that either contributed to or suppressed the cells' metastatic ability, as well as physical metastasis "hubs" they believe could be targeted with new cancer therapies. (fiercebiotech.com)
  • Individuals with a first-time prostate cancer diagnosis and those who have undergone previous treatment for this form of cancer need to receive tests to determine their risk of metastasis. (medicalnewstoday.com)
  • 5. Radionuclides are most appropriate for patients who have several sites of painful osteoblastic metastases (like those that are commonly associated with prostate cancer) that cannot be safely treated with EBRT. (cancernetwork.com)
  • A recent study by cancer researcher Chawnshang Chang, Ph.D. , provides additional proof of a concept he's been investigating for years: that the environment surrounding a prostate tumor plays a major role in metastasis, and new treatments should be designed to target that environment as well as the tumor itself. (rochester.edu)
  • The latest paper suggests the microenvironment-the neighborhood of cells surrounding the tumor-is where stem cells can be recruited through altered cytokine-AR signals to boost prostate cancer metastasis. (rochester.edu)
  • Moreover, SRC-2 inhibition in murine models severely attenuated the survival, growth, and metastasis of prostate cancer. (jci.org)
  • According to a new study, a CCR5-blocking drug used to treat HIV may also be able to slow prostate cancer metastasis. (pharmacytimes.com)
  • Because this work shows we can dramatically reduce metastasis in pre-clinical models, and because the drug is already FDA approved for HIV treatment, we may be able to test soon whether this drug can block metastasis in patients with prostate cancer,' said senior author Richard Pestell, MD, PhD, MBA, director of the Sidney Kimmel Cancer Center at Thomas Jefferson University, in a press release. (pharmacytimes.com)
  • Building on this work, Dr. Pestell's team evaluated whether CCR5 was also involved in prostate cancer metastasis. (pharmacytimes.com)
  • Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment. (nih.gov)
  • Secondary tumours from metastasis in places such as the lungs, liver, brain, and bones also cause symptoms that can significantly affect people's daily lives. (manchester.ac.uk)
  • Cellular microenvironment and metastases. (medlineplus.gov)
  • Immunology, tumour microenvironment & metastasis - is a technical and knowledge-based forum for cancer researchers at Lund University with specific interest in immunology, tumour microenvironment & metastasis. (lu.se)
  • C ) H&E-stained sections of mouse lungs from experimental lung metastasis assay. (jci.org)
  • Lung metastasis disappeared but recurred 14 months later in conjunction with left breast metastasis which was resected. (karger.com)
  • Both studies then confirmed that BACH1 stabilization could drive metastasis by showing that subcutaneous implantation of Bach1 -depleted KP or KPK cells decreased lung metastases and that intravenous injection of Bach1 -deficient NAC-K cells inhibited metastasis to the lung. (nature.com)
  • 2020) MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity. (news-medical.net)
  • A liver metastasis may be present when the original (primary) cancer is diagnosed or it may occur months or years after the primary tumor is removed. (medlineplus.gov)
  • The prognosis is dependent on the stage of the disease and extent of metastases. (hindawi.com)
  • Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. (lu.se)
  • According to a recent study by Shanker and colleagues published in the Journal of Medical Imaging and Radiation Oncology, in patients with melanoma brain metastases (melanoma BM), concurrent treatment with immunotherapy and stereotactic radiosurgery is associated with improved clinical and radiological outcomes. (medpagetoday.com)
  • Although prior studies have suggested improved survival when stereotactic radiosurgery (SRS) and immunotherapy (IT) are concurrently combined to treat melanoma with brain metastasis, few studies have assessed local control and additional related clinicopathologic responses. (medpagetoday.com)
  • For patients with more than a single brain metastasis, radiation therapy, including stereotactic radiosurgery and whole-brain radiation therapy, has been the mainstay of treatment. (medscape.com)
  • Axial CT scan in a 58-year-old man with malignant melanoma shows multiple round nodules and masses of varying sizes in both lungs, consistent with metastases. (medscape.com)
  • Melanoma is the third most common systemic cancer that leads to brain metastases. (medscape.com)
  • The annual incidence of melanoma has increased over time, with brain metastases developing in 40% to 50% of patients with advanced melanoma. (medscape.com)
  • Traditional management of melanoma-related brain metastases has focused on symptom control as a result of the significant neurologic morbidity associated with the disease. (medscape.com)
  • Brain metastases, as in other systemic cancers, such as lung or breast, remain a significant complication of melanoma. (medscape.com)
  • Recent data have shown an incidence of brain metastases in ≤ 50% of patients with metastatic melanoma. (medscape.com)
  • [ 1 ] Because this is typically a late complication of systemic disease, melanoma-related brain metastases have been associated with significant neurologic morbidity and a poor median overall survival, with treatment, of approximately 9 months. (medscape.com)
  • [ 2 ] Factors that predict survival include age, performance status, and the number of brain metastases, which are summarized as the melanoma-specific graded prognostic assessment. (medscape.com)
  • [ 5 ] In this review, we discuss advances in the management approach to brain metastases in patients with melanoma and we highlight the current and potential therapeutic options for the management of this devastating disease. (medscape.com)
  • In mice bearing head and neck cancer, NSUN3-deficient cancer cells showed decreased metastases into both the lymph nodes and the lungs. (fiercebiotech.com)
  • Brain metastases are a type of cancerous tumour that develops when primary cancers in the lungs, breasts, colon or other parts of the body are spread to the brain via the bloodstream or lymphatic system. (yorku.ca)
  • [ 1 ] Lungs are the second most frequent site of metastases from extrathoracic malignancies. (medscape.com)
  • Natural News) In this study, researchers from Zhejiang Chinese Medical University investigated the effects of safflower yellow (SY), the active component of the herbaceous plant Carthamus tinctorius, on the pulmonary metastasis of breast cancer and its mechanism of action. (naturalnews.com)
  • But the latter modality retained its proficiency in detecting pulmonary metastases. (auntminnie.com)
  • Pulmonary metastasis is seen in 20-54% of extrathoracic malignancies. (medscape.com)
  • [ 1 ] The development of pulmonary metastases in patients with known malignancies indicates disseminated disease and places the patient in stage IV in TNM (tumor, node metastasis) staging systems. (medscape.com)
  • Imaging plays an important role in the screening and detection of pulmonary metastases. (medscape.com)
  • Chest radiography (CXR) is the initial imaging modality used in the detection of suspected pulmonary metastasis in patients with known malignancies. (medscape.com)
  • Several thermal ablation options are available for treatment of pulmonary metastases, which is performed under CT guidance. (medscape.com)
  • The microscopic spread of metastasis through lymphatics and perilymphatic connective tissue is seen histopathologically in 56% of patients with pulmonary metastasis. (medscape.com)
  • Cellular plasticity-including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis-is also covered. (cshlpress.com)
  • Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. (jci.org)
  • Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ) have now reported. (dkfz.de)
  • Generally, metastases have been thought to arise as a subset of cancer cells accumulates additional genomic alterations that enable them to spread. (genomeweb.com)
  • Metastasis is the movement or spreading of cancer cells from one organ or tissue to another. (medlineplus.gov)
  • These findings, published today in eLife , may help clinicians to identify cancer patients at risk of metastasis, a process where cancer cells spread to other parts of the body. (news-medical.net)
  • But recently it has been suggested that EMT might also play a role in cancer metastasis, allowing cancer cells to escape from tumor masses and colonize distant organs. (genengnews.com)
  • Scientists attempting to understand metastasis have learnt that these secondary sites are not passive in this process but, in fact, sometimes help metastatic breast cancer cells to survive and multiply. (manchester.ac.uk)
  • Metastasis of cancer cells involves a process called epithelial-mesenchymal transition (EMT), wherein epithelial cells undergo phenotypic changes to resemble mesenchymal cells -- stem cells capable of turning into different types of adult cells. (naturalnews.com)
  • Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)
  • A brief overview about long-term outcomes of spinal metastases patients treated with Kypho-IORT created by Frederic Bludau, MD, on behalf of ZEISS, January 2021. (zeiss.com)
  • In a 2021 Science study, scientists from the Massachusetts Institute of Technology, the University of California, Berkeley and the University of California, San Francisco used the CRISPR gene editing tool to map out the development route of tumor metastasis. (fiercebiotech.com)
  • Clin Exp Metastasis;38(1): 11-29, 2021 02. (bvsalud.org)
  • We know from other studies that treating those metastases early will improve outcomes for the patients. (auntminnie.com)
  • A recent study by York University researchers suggests an innovative artificial intelligence (AI) technique they developed is considerably more effective than the human eye when it comes to predicting therapy outcomes in patients with brain metastases. (yorku.ca)
  • Interestingly, while KLF6-SV1 overexpression increased metastasis, it did not affect localized tumor growth. (jci.org)
  • And it's not clear why some cancers travel to the bones rather than to other common sites for metastasis, such as the liver. (mayoclinic.org)
  • Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. (google.co.uk)
  • This discovery might in future help to better predict individual risk for metastasis and find appropriate therapies that can reduce it. (dkfz.de)
  • With these advances, early trials have demonstrated improved overall survival in patients with brain metastases who receive these therapies either as single agents or as part of multimodality treatment regimens. (medscape.com)
  • Further, they noted most of these metastases actually diverged early in the emergence of the primary tumor. (genomeweb.com)
  • The cells that formed the metastasis were more closely related to the ancestors of the primary tumor than its present-day relatives," Curtis said. (genomeweb.com)
  • Previous studies have shown that using standard practices, such as MRI imaging - assessing the size, location - and number of brain metastases - well as the primary cancer type and condition of the patient, oncologists are able to predict treatment failure (defined as continued growth of the tumour) about 65 per cent of the time. (yorku.ca)
  • Due to the diagnostic challenge of determining the primary site for the metastases, immunohistochemistry is essential. (scielo.org.za)
  • We present the first report of a FIGO stage IV primary vaginal leiomyosarcoma with metastases to the lung and left breast. (karger.com)
  • Primary vaginal sarcoma with lung and breast metastases is very rare in female genital malignancies. (karger.com)
  • Renal metastases are usually discovered during evaluation of the primary tumor or incidentally during abdominal imaging. (msdmanuals.com)
  • Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. (lu.se)
  • The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS. (lu.se)
  • The occurrence of leptomeningeal metastases (LM) is a rare complication of cancer in which the disease spreads to the membranes (meninges) surrounding the brain and/or spinal cord. (medscape.com)
  • The symptoms caused by a brain metastasis depend on the tumor's location. (mdanderson.org)
  • For instance, a metastasis in a section of the brain that manages visual processing may cause vision problems. (mdanderson.org)
  • These are often the first symptoms of a brain metastasis. (mdanderson.org)
  • A headache caused by brain metastases usually becomes progressively worse as time passes. (mdanderson.org)
  • Brain metastases can impact your ability to hear, smell or see. (mdanderson.org)
  • 2,3 "To date, very few studies have used [Response Assessment in Neuro-Oncology] RANO-[brain metastases] BM criteria," the study authors noted in their paper. (medpagetoday.com)
  • Most of the liver and all of the brain metastases harbored many private clonal somatic SNVs, but no subclonal ones. (genomeweb.com)
  • Longer survivorship also allows time for the development of brain metastases. (novapublishers.com)
  • Multidisciplinary clinics for brain metastases are again desirable with the joint input of the radiation oncologists and neurosurgeons. (novapublishers.com)
  • They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. (cshlpress.com)
  • The downside of PET/CT is its low sensitivity for brain and liver metastases and its emission of a relatively high radiation dose, which has potentially adverse effects for young breast cancer patients who face the prospect of multiple periodic scans. (auntminnie.com)
  • This delay is time patients with brain metastases cannot afford, as it is a particularly debilitating condition with most people succumbing to the disease between three months to five years after diagnosis. (yorku.ca)
  • As with other brain metastases, a multidisciplinary treatment approach that includes surgery and radiation therapy is typically used, with historically little role for systemic, cytotoxic therapy. (medscape.com)
  • Until recently, management of brain metastases has primarily focused on local, intracranial control of disease. (medscape.com)
  • in this series, patients with brain metastases received an increased dose of MTX to 1 g/m 2 IV infused over 24 hours, followed by folinic acid. (medscape.com)
  • Brain metastasis is a dreaded complication that significantly reduces the quality of life in breast cancer patients . (bvsalud.org)
  • The data of breast cancer patients with brain metastasis who were treated with WBRT using cobalt -60 equipment between 2005 and 2009 were retrospectively collected from the departmental medical record unit. (bvsalud.org)
  • The information extracted included biodata, presenting symptoms, imaging modality for confirmation of brain metastasis , treatment records , performance status pre-WBRT and 4 weeks post-WBRT, and other supportive treatments . (bvsalud.org)
  • Patients with more than three brain deposits accounted for 71.2% of all the brain metastases . (bvsalud.org)
  • WBRT is an effective treatment modality for patients with brain metastasis in our resource -poor environment . (bvsalud.org)
  • The impact of this information is two-fold: to assure aggressive therapy at the time of diagnosis for men with metastasis-prone disease and provide a rationale for active surveillance (and not overtreatment) for men with indolent disease [disease that progresses at a slow pace]. (medicalnewstoday.com)
  • So we wanted to see if full-body imaging at the time of diagnosis could detect more metastases," she added. (auntminnie.com)
  • Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. (springer.com)
  • The team next showed that exposing mice with liver cancer caused by MYC alone to Ccl2 and Il13 causes metastasis. (news-medical.net)
  • Treatment with the antibiotics reduced cancer metastases in mice, the team reported in a new study published in Nature. (fiercebiotech.com)
  • Lymphatic spread occurs either in an antegrade fashion by lymphatic invasion through the diaphragm and/or pleural surfaces or retrograde lymphatic spread from hilar lymph nodal metastasis. (medscape.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. (cshlpress.com)
  • Symptoms of LM may be seen concurrently with symptoms from other manifestations of cancer that has spread to the CNS, such as solid tissue metastases and epidural spinal cord compression. (medscape.com)
  • These very close relationships, among very diverse research areas, allow us to bring in technologies from many different angles, and allow breakthroughs to understanding the mechanisms of metabolism in cancer - its progression, metastasis and the immune response - and also come up with new ways to target it. (princeton.edu)
  • The new data point to possible hints as to how mitochondria might contribute to metastasis-namely, Welch and colleagues found immune, microbial, and metabolic, changes associated with mitochondrial background that they are now pursuing with follow up investigations. (the-scientist.com)
  • This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. (google.co.uk)
  • Consequently, the stage-dependent metabolic traits may provide therapeutic windows for preventing or reducing metastasis, and targeting the new metabolic traits arising in established metastases may allow their eradication. (nih.gov)
  • In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. (cshlpress.com)
  • Now, an international team of scientists led by the German Cancer Research Center (DKFZ) has fingered certain modifications in mitochondrial RNA as culprits behind cancer metastasis. (fiercebiotech.com)
  • Dr Harrison believes the Quasi-Vivo ® system will allow scientists to answer some of the burning questions about breast cancer metastasis in much more detail and on a much larger scale than other methods. (manchester.ac.uk)