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  • agnogenic myeloid me
  • The splenomegaly associated with myelofibrosis and agnogenic myeloid metaplasia should not be considered a manifestation of the fundamental proliferative process, nor should it be considered as necessarily compensatory for reduced marrow haematopoiesis. (bmj.com)
  • Consideration of two cases studied by the authors indicates that marked clinical improvement may be associated with splenectomy in selected cases of agnogenic myeloid metaplasia. (bmj.com)
  • This includes patients with agnogenic myeloid metaplasia (also known as idiopathic myelofibrosis) and patients with a preceding history of polycythemia vera or essential thrombocytemia (also known as post-polycytemic myelofibrosis). (clinicaltrials.gov)
  • focal
  • Focal apocrine metaplasia is frequently seen within intraductal papillomas but is almost always absent in intraductal papillary carcinomas, making it a useful adjunct in the differential diagnosis along with other features (Figure 3, A and B). (thefreedictionary.com)
  • tissues
  • If the stimulus causing metaplasia is removed or ceases, tissues return to their normal pattern of differentiation. (wikipedia.org)
  • The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the change: Epigenetics Induced stem cells List of biological development disorders Reprogramming Transdifferentiation The AMA Home Medical Encyclopedia, Random House, p. 683 Robbins and Cotran - Pathologic Basis of Disease, 7th Edition, Saunders, p. 10 Prof. Dr. Clark S., Australian Cancer institute, premalignant conditions. (wikipedia.org)
  • metaplastic
  • Whenever present, squamous metaplasia should be diagnosed and graded based on the number and size of metaplastic areas. (nih.gov)
  • Metaplastic change is often viewed as a premalignant condition that requires immediate intervention, either surgical or medical, because metaplasia is associated with cancer. (wikipedia.org)
  • incidental
  • While it may be an incidental finding in rats, hepatocyte metaplasia can be induced by peroxisome proliferators, by methyl-deficient diets, and experimentally by copper administration/withdrawal. (nih.gov)
  • change
  • Metaplasia is a change in which one terminally differentiated cell type is replaced by another cell type of the same germ line. (nih.gov)
  • cell
  • A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. (hindawi.com)
  • However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. (hindawi.com)
  • On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the "Ets" transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma. (hindawi.com)
  • Atoh1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered "intractable" in the clinical settings. (hindawi.com)
  • The cell of origin for many types of metaplasias are controversial or unknown. (wikipedia.org)
  • Anyway, the phenomenon of smooth muscle cell metaplasia occurring in association with endometriosis (endomyometriosis), as well as of smooth muscle differentiation at endometrio-myometrial junction independently from actually engendering uterus-like configurations in several locations of the pelvis, have been pointed out by several authors. (wikipedia.org)
  • present
  • We present results of 2 similarly designed but separate phase 2 studies involving single-agent lenalidomide (CC-5013, Revlimid) in a total of 68 patients with symptomatic myelofibrosis with myeloid metaplasia (MMM). (nih.gov)