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KidneyRegenerationUreterExtremitiesAmbystoma mexicanumMesodermSalamandridaeCell DifferentiationNotophthalmus viridescensTurbellariaAmbystomaAnimal FinsNephronsPlanariansGene Expression Regulation, DevelopmentalMorphogenesisIn Situ HybridizationTriturusPAX2 Transcription FactorTailWnt4 ProteinWilms TumorWolffian DuctsOrganogenesisOrgan Culture TechniquesHomeodomain ProteinsMesonephrosAmputationForelimbGlial Cell Line-Derived Neurotrophic FactorUrodelaPleurodelesNerve TissueStem CellsZebrafishSignal TransductionNotophthalmusImmunohistochemistryTranscription FactorsWnt ProteinsEmbryonic and Fetal DevelopmentEmbryonic InductionDolichosEpitheliumMolecular Sequence DataUrogenital SystemLimb BudsTretinoinMSX1 Transcription FactorBone Morphogenetic ProteinsCell ProliferationFibroblast Growth FactorsEmbryo, MammalianRNA, MessengerCartilageKidney NeoplasmsKidney TubulesGene ExpressionBone Morphogenetic Protein 4Cells, CulturedBone Morphogenetic Protein 7Base SequenceBody PatterningAnaplasiaEpidermisGenes, HomeoboxCell DedifferentiationReverse Transcriptase Polymerase Chain ReactionWound HealingAmputation StumpsAmino Acid SequenceZebrafish ProteinsHedgehog ProteinsMice, TransgenicAnimal StructuresPentosan Sulfuric PolyesterTrans-ActivatorsDNA, ComplementaryCell LineageEmbryo, NonmammalianModels, BiologicalTime FactorsGene Expression ProfilingAnimals, Genetically ModifiedCell DivisionEpithelial CellsMice, KnockoutDNA PrimersProto-Oncogene Proteins c-retFlank PainDermisGene Expression RegulationT-Box Domain ProteinsPhenotypeChick EmbryoUrogenital AbnormalitiesEmbryonic DevelopmentTenascinWT1 ProteinsCell Line
Ureteric budGDNFMesodermInteractionsKidneyFormsEarlyGrowth
Ureteric bud5
  • Despite its transiency, the mesonephros is crucial for the development of structures such as the Wolffian duct (or mesonephric duct), which in turn gives rise to the ureteric bud of the metanephric kidney. (wikipedia.org)
  • The permanent kidney of amniotes, the metanephros, develops during the 10th week in human embryos and is formed by the reciprocal interactions of the metanephrogenic blastema (or metaneophrogenic mesenchyme) and the ureteric bud. (wikipedia.org)
  • Gonadal derived neurotrophic factor (GDNF) secreted by the metanephrogenic blastema activates the receptor tyrosine kinase RET, via the co-receptor GFRα1 and triggers outgrowth of Ret positive cells from the nephric duct towards the GDNF signal, promoting ureteric bud outgrowth and invasion. (wikipedia.org)
  • The posterior location of the ureteric bud results from a combination of repression of GDNF expression in the more anterior regions by the actions of Slit-2/Robo-2 in the mesenchyme and Sprouty , which reduces the sensitivity of the anterior mesonephric duct to the action of GDNF. (clinicalgate.com)
  • Bone morphogenetic protein ( BMP ) signaling in the surrounding mesoderm is also inhibitory to outgrowth of the ureteric bud, but within the metanephrogenic blastema its action is counteracted by the BMP-inhibitory actions of gremlin , which is produced within the blastema itself. (clinicalgate.com)
GDNF1
  • The formation of GDNF in the metanephric mesenchyme is regulated by WT-1 . (clinicalgate.com)
Mesoderm4
  • Intermediate mesoderm or intermediate mesenchyme is a narrow section of the mesoderm (one of the three primary germ layers) located between the paraxial mesoderm and the lateral plate of the developing embryo. (wikipedia.org)
  • This can be seen in early stages of intermediate mesoderm differentiation where higher levels of BMP stimulate growth of lateral plate tissue, whilst lower concentrations lead to paraxial mesoderm and somite formation. (wikipedia.org)
  • The adult kidney, also referred to as the metanephric kidney, forms at the posterior end of the intermediate mesoderm after the degeneration of previous, less complex kidney structures. (wikipedia.org)
  • Multiphasic determination and differentiation of mouse metanephric mesoderm in vitro. (clinicalgate.com)
Interactions1
  • A third theme comprises the dependence of differentiation and the maintenance of many structures in the urogenital system on epithelial-mesenchymal interactions. (clinicalgate.com)
Kidney2
  • The cells of the pronephric duct migrate caudally whilst inducing adjacent mesenchyme to form the tubules of the initial kidney-like structure called the pronephros. (wikipedia.org)
  • These early forms of the kidney are later supplanted by the definitive metanephric kidneys, but as they regress, certain components are retained to be reused by other components of the urogenital system. (clinicalgate.com)
Forms1
  • Within the comma, a group of cells farthest from the end of the metanephric duct becomes polarized and forms a central lumen and a basal lamina on the outer surface. (clinicalgate.com)
Early1
  • During the early phases of migration of the metanephric kidneys, the mesonephric kidneys regress. (clinicalgate.com)
Growth1
  • After a growth phase, mitotic activity within the rounded blastemal mesenchyme decreases, and the primordium of the tubule assumes a comma shape. (clinicalgate.com)