Metalloproteinases and tissue inhibitors of metalloproteinases. Medical search. Frequent questions

Remodeling of atrial extracellular matrix (ECM) in atrial fibrillation (AF) involves changes in the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). (unboundmedicine.com)
Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. (nih.gov)
The expression and regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in neuroectodermal precursor cells is undocumented. (uea.ac.uk)
Matrix metalloproteinases ( MMPs ) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy. (bvsalud.org)
By breaking down extracellular matrix (ECM) components and releasing the proteins composing the ECM and growth factors , as well as their receptors, MMPs affect tissue integrity and promote cancer cell invasion and metastasis . (bvsalud.org)
Matrix metalloproteinases (MMPs) are a large family of mostly secreted, extracellularly acting proteolytic enzymes. (nature.com)
Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. (nature.com)
However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. (indexindex.com)
The balance of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is crucial for the manifestation and progression of periodontal diseases and is one of the promising areas of scientific research in terms of developing methods for selective inhibition of MMPs. (spr-journal.ru)
The precursor of matrix metalloproteinase 9 (pro-MMP-9) forms a complex with the tissue inhibitor of metalloproteinases (TIMP)-1 through the C-terminal domain of each molecule, and the N-terminal domain of TIMP-1 in the complex interacts and inhibits active MMPs. (ox.ac.uk)
Matrix metalloproteinases (MMPs) are a family of endopeptidases playing a key role in tissue remodelling in both physiological and pathological conditions. (nih.gov)
Matrix metalloproteinases (MMPs) and their specific inhibitors, the tissue inhibitors of metalloproteinases (TIMPs) play an important role in inducing and preventing the degradation of the ECM, respectively [ 9 ]. (biomedcentral.com)
Among them, TIMP-1 is a widely expressed, and secreted protein that plays a critical role in tissue remodeling via inhibiting members of a large family of MMPs [ 13 ]. (biomedcentral.com)
The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
Covers methods for detecting or predicting diastolic heart failure by profiling matrix metalloproteinases and tissue inhibitors of MMPs. (genomeweb.com)
Excessive proteolytic activity, which relates to an imbalance of the elastase/alpha1-antitrypsin system or metalloprotease (MMPs) and their inhibitors (tissue inhibitors of metalloproteases [TIMPs]), may be important in lung destruction and formation of cysts. (medscape.com)
Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)

Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrix metalloproteinases. (wikipedia.org)
When cells were treated with physiological concentrations of progesterone, the production of two TIMPs increased, and essentially all TIMP-2 was found to be complexed with promatrix metalloproteinase 2 (proMMP-2)/progelatinase A. Progesterone did not modulate the production of proMMP-2 and resulted in the increased total amount of proMMP-2-TIMP-2 complex. (ox.ac.uk)

TY - JOUR T1 - Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation. (unboundmedicine.com)
pCellular activation of latent matrix metalloproteinase-2 (proMMP-2) requires formation of a cell membrane-associated activation complex that involves specific binding between the hemopexin domain of proMMP-2 (PEX) and the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (C-TIMP-2). (amrita.edu)
To investigate matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expressions in the cultured rat mesangial cells (MsC) transfected with Smad 7 vector and to elucidate the mechanism of Smad 7 in blocking tissue fibrosis. (eurekamag.com)
Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase. (ox.ac.uk)
The processing mechanism and gelatinolytic activity of the membrane-type matrix metalloproteinase 1 (MT-MMP-1) were examined by expressing in COS-1 cells a deletion mutant of MT-MMP-1 lacking the transmembrane domain (ΔMT1) and its site-directed mutant with a furin-resistant sequence in the propeptide domain (mutant ΔMT1). (elsevierpure.com)
INTRODUCTION: This study was designed to investigate the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their respective tissue inhibitors, tissue matrix metalloproteinase inhibitor-1 (TIMP-1) and tissue matrix metalloproteinase inhibitor-2 (TIMP-2), in eclamptic and preeclamptic pregnant women. (eastjmed.org)

The inhibitory activities of glycosylated TIMP-1 and TIMP-3, but not TIMP-2, in AF tissues were markedly elevated and also localized in the atrial interstitium. (unboundmedicine.com)
TIMP-1 was found to be mostly colocalized with gelatinase activity over the AF tissues, implying the coexistence of gelatinase activity and TIMP-1, but TIMP-3 appeared only partially colocalized and discontinued the gelatinase activity surrounding the cardiomyocytes. (unboundmedicine.com)
In this study, we tested the feasibility of inhibiting activation of proMMP-2 by exogenous inhibitors, which block the binding between PEX and TIMP-2. (amrita.edu)
The recombinant C-TIMP-2 and synthetic peptides from C-TIMP-2 were used as inhibitors for proMMP-2 activation. (amrita.edu)
It is possible that Smad 7 can alleviate the development of tissue fibrosis by upregulating the expression of MMP-2 and downregulating the expression of TIMP-2 in mesangial cells. (eurekamag.com)
Rabbit uterine cervical fibroblasts in culture produces tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2. (ox.ac.uk)
These observations provide the first evidence that progesterone participates in maintaining the homeostasis of connective tissue matrix in uterine cervix by augmenting both TIMP-1 and TIMP-2 production along with the known suppressive effects on the proMMP-1 and proMMP-3 production. (ox.ac.uk)
These results suggest that neutrophil elastase may participate in the connective tissue destruction at the inflammatory sites not only by its direct action on matrix macromolecules but also by rendering pro-MMP-9 in the pro-MMP-9.TIMP-1 complex activable by MMP-3 as well as activating pro-MMP-3. (ox.ac.uk)
ΔMT1 isolated in a complex form with tissue inhibitor of metalloproteinases 2 (TIMP-2) from the stable transfectants demonstrated the NH 2 -terminal sequence of Ala 113 -Ile-Gln-Gly-Leu, indicating cleavage at one amino acid down-stream from the furin recognition sequence. (elsevierpure.com)
ΔMT1 isolated in a complex form with tissue inhibitor of metalloproteinases 2 (TIMP-2) from the stable transfectants demonstrated the NH2-terminal sequence of Ala113-Ile-Gln-Gly-Leu, indicating cleavage at one amino acid down-stream from the furin recognition sequence. (elsevierpure.com)
Duodenal biopsies from untreated, treated celiac patients and controls were used to quantify the expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12, MMP-14, their inhibitor TIMP-1, IFN-gamma and TNF-alpha by using real-time reverse transcription-polymerase chain reaction and the gelatin/casein/elastin activities by gel zymography, and to isolate lamina propria mononuclear cells (LPMCs). (nih.gov)
Our laboratory identified altered levels of tissue inhibitor of metalloproteinase (TIMP)-1 in brain lysates from human immunodeficiency virus (HIV)-1 infected patients, compared to age-matched controls, and interleukin (IL)-1β as a key regulator of astrocyte TIMP-1. (utmb.edu)
TIMP-1 promoter-driven luciferase plasmids were used to evaluate TIMP-1 promoter activity in inhibitor-treated astrocytes. (utmb.edu)
These data show that extracellular regulated kinase (ERK) 1/2-selective inhibitors block IL-1β-induced astrocyte TIMP-1 expression, but did not decrease C/EBPβ expression in parallel. (utmb.edu)
The p38 kinase (p38K) inhibitors partially blocked both IL-1β-induced astrocyte TIMP-1 expression and C/EBPβ expression. (utmb.edu)
The ERK1/2-selective inhibitor abrogated IL-1β-mediated increases in TIMP-1 promoter activity. (utmb.edu)
It belongs to the family of TIMP genes and is known to inhibit the activity of matrix metalloproteinases. (thermofisher.com)
It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. (peprotech.com)
Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/Î²-catenin signaling. (peprotech.com)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)

Expression of metalloproteinases and their tissue inhibitors in the detrusor muscle. (usp.br)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) in serum, plasma, tissue homogenates and other biological fluids. (pharmas-eu.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (pharmas-eu.org)
Description: Quantitative sandwich ELISA for measuring Human Tissue inhibitors of metalloproteinase 3 (TIMP3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (pharmas-eu.org)

Description: A sandwich ELISA kit for detection of Tissue Inhibitors Of Metalloproteinase 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (pharmas-eu.org)

LTP-associated MMP proteolysis is probably then terminated by an increase in the activity of endogenous inhibitors called tissue inhibitors of metalloproteinases. (nature.com)

Description: A sandwich quantitative ELISA assay kit for detection of Rat Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (orbitalbiosciences.com)

TIMP4 is highly expressed in adipose tissue, its levels are further elevated following high-fat diet, but its role in obesity is unknown. (nih.gov)
Adipose tissue of Timp4 -/- -HFD mice showed reduced hypertrophy and fibrosis compared to WT-HFD mice. (nih.gov)
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. (thermofisher.com)

Primary human astrocytes were cultured and treated with mitogen activated protein kinase-selective small molecule inhibitors, and IL-1β. (utmb.edu)
Unnatural amino acids capable of covalently modifying protein phosphatases and their use as general and specific inhibitors and probes. (genomeweb.com)

Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)

To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
Matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 in cerium oxide induced pulmonary fibrosis. (cdc.gov)

Progesterone increases the production of tissue inhibitor of metalloproteinases-2 in rabbit uterine cervical fibroblasts. (ox.ac.uk)

Tissues and Cells. (lu.se)

The key consequences of such tissue destruction are morbidity and mortality in TB patients. (ersjournals.com)
Alpha-1 Antitrypsin Deficiency Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)

Such inflammatory tissue damage is responsible for morbidity and mortality in patients. (ersjournals.com)

Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)

To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. (cdc.gov)

Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them. (nih.gov)

Description: serum, plasma, tissue homogenates or other biological fluids. (pharmas-eu.org)

These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)

Tissue inhibitor of metalloproteinase family. (nih.gov)

Cite this: Tissue Inhibitor of Matrix Metalloproteinase-2 in Nasopharyngeal Carcinoma - Medscape - Jul 03, 2007. (medscape.com)
Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and extracellular matrix mRNA following exposure to mineral fibers and cigarette smoke in vivo. (nih.gov)
To determine the effect of mineral fibers and cigarette smoke on remodeling of lung tissues, we examined matrix metalloproteinase-1 (MMP-1), MMP-2, tissue inhibitors of metalloproteinase-1 (TIMP-1), TIMP-2, and types I and IV collagen mRNA levels from rat lungs exposed to mineral fibers and/or cigarette smoke in vivo. (nih.gov)
To investigate the optimal dosage of pirfenidone for the treatment of pulmonary fibrosis induced by bleomycin in Wistar rats, and the alteration of expressions of transforming growth factor beta-1 (TGF-beta 1), tissue inhibitor of metalloproteinase-1 (TIMP-1), and matrix metalloproteinase-13 (MMP-13) in lung tissue. (nih.gov)
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. (nih.gov)
Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged febrile seizures. (nih.gov)
Serum levels of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in subacute sclerosing panencephalitis. (nih.gov)
TIMP-3 (tissue inhibitor of metalloproteinases-3) is 1 of 4 members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases. (nih.gov)
Lindsey, ML & Zamilpa, R 2012, ' Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction ', Cardiovascular Therapeutics , vol. 30, no. 1, pp. 31-41. (nebraska.edu)
OBJECTIVE--To investigate the production of the matrix metalloproteinase (MMP), collagenase (MMP-1), and its natural inhibitor, the tissue inhibitor of metalloproteinases (TIMP) by diseased human tendon samples in organ culture. (academicoo.com)
2. A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease. (nih.gov)
3. Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. (nih.gov)
11. Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers. (nih.gov)
Protein malnutrition (PM) can lead changes in extracellular matrix (ECM) from several organs and tissues, including hematopoietic, with functional impairments. (usp.br)
However, at the higher doses, both particles induced a dose-related inflammation, cytotoxicity, inflammatory cytokines, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP at 1day post-exposure. (nih.gov)
The current pathogenetic theories for the development of COPD include an imbalance between the protease and antiprotease system, dysregulation of oxidant-antioxidant activity and chronic airway inflammation, processes that lead to the progressive destruction and abnormal repair of the lung connective tissue matrix. (bmj.com)
The effect of siPEG10 was suppressed by inhibitors of matrix metalloproteinase (MMP). (cancerindex.org)
To investigate possible genetic associations of matrix metalloproteinase-1 ( MMP1 ) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. (molvis.org)
Matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 in cerium oxide induced pulmonary fibrosis. (cdc.gov)
Collagen, the most abundant structural protein in the body, has become the most widely used matrix for tissue engineering. (bl.uk)
The collagen is broken down by tissue/cell derived collagenases, which are members of the matrix metalloproteinase (MMP) family of enzymes. (bl.uk)
It seems likely that the retention of matrix stiffness is attributable to a reduction in the rate of substrate degradation by collagenolytic enzymes, which in turn can be attributed to their inhibition by the ACE inhibitors, though the mechanism of inhibition is still not fully understood. (bl.uk)
3. Visse R, Nagase H. Matrix metalloprooteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. (bvsalud.org)
Cholesterol can accumulate in the tendon non-collagenous matrix which may affect both global and local tissue mechanics. (bvsalud.org)

13. A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease. (nih.gov)
20. [Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis]. (nih.gov)

6. The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression. (nih.gov)

Protease inhibitors (PIs) are important regulators of physiology and represent anti-parasitic druggable and vaccine targets. (biomedcentral.com)
Protease inhibitors are among some of the most attractive potential anti-tick vaccine antigens. (biomedcentral.com)
The balance between proteases and protease inhibitors is essential for the regulation of normal homeostasis across life: from microbes, to plants, to animals. (biomedcentral.com)
Thus, to avoid aberrant protease activity, protease inhibitors tightly and precisely control protease activity. (biomedcentral.com)

The purpose of this thesis was to investigate the potential of the ACE inhibitors captopril and enalapril to inhibit enzymatic collagen degradation, and ultimately slow down the rate at which collagen is degraded by cells of the body. (bl.uk)

CONCLUSIONS--Tendon tissue can actively secrete procollagenase, an enzyme that, once activated, is capable of remodelling collagen, the major connective tissue component of tendon. (academicoo.com)

4. Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. (nih.gov)
8. Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis. (nih.gov)

To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. (cdc.gov)

Recent clinical trials have targeted specific pathways implicated in the pathogenesis of IPF and these have included γ-interferon, endothelin receptor antagonists, antioxidants, etanercept, pirfenidone and tyrosine kinase inhibitors 1 - 6 . (ersjournals.com)

Individually, TGF-β1 and PEG10 siRNA increase AKT phosphorylation, whereas an AKT inhibitor, MK2206, mitigates the effect of PEG10 silencing on cell migration. (cancerindex.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. (nih.gov)

The mRNA expression of MMP-9,-11 and -14 was significantly upregulated in Stage IV compared to normal/benign ovarian tissues. (frontiersin.org)

7. Extracellular regulation of metalloproteinases. (nih.gov)
The proteins harboring the NTR domain fulfill diverse biological roles ranging from axon guidance, regulation of Wnt signalling, to the control of the activity of metalloproteinases. (embl.de)

Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
From the 19 best predictive clusters, 2-3 biomarkers were selected based on their pathophysiological profile (chemoattractants, inflammation, tissue destruction and repair) and the statistical significance of their relationship with clinically important end points was tested. (bmj.com)
Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)

Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
As re-emergent interest in regenerative medicine seeks to isolate molecular pathways controlling tissue regeneration in mammals, Acomys may prove useful in identifying mechanisms to promote regeneration in lieu of fibrosis and scarring. (nature.com)
The potential to manipulate the strength and stability of collagen implants by treating them with ACE inhibitors has major implications throughout the fields of tissue engineering, regenerative medicine and cosmetic surgery. (bl.uk)

Epithelial ovarian cancer development and progression is a multi-stage process that originates in the epithelial cells of the female reproductive tract and in the majority of cases follows a transcoelomic route involving mainly organs and tissues within the peritoneal cavity ( 1 , 2 ). (frontiersin.org)

The 'seeding' theory proposes that the formation of peritoneal dissemination is a multistep process, including detachment from the primary tumour, transmigration and attachment to the distant peritoneum, invasion into subperitoneal tissue and proliferation with blood vascular neogenesis. (spandidos-publications.com)
The 'seeding' theory demonstrates that several consecutive steps participate in the development of peritoneal dissemination, including detachment from the primary tumour, transmigration to the peritoneum, attachment to peritoneal mesothelial cells or lymphatic stomata, invasion through the basement membrane to subperitoneal tissue and proliferation with blood vascular neogenesis ( Fig. 1 ) ( 7 ). (spandidos-publications.com)

5 Recent studies have suggested that increased apoptosis of the alveolar wall accounts in part for the loss of lung tissue that characterises emphysema. (bmj.com)

In parasites including ticks, protease inhibitor function is viewed from two perspectives: one being their significance in regulating the homeostasis of the tick itself, and the other being their significance in regulating the parasite-host interaction. (biomedcentral.com)

Western blotting and collagen fragment analysis confirmed that the collagenolytic activity detected was attributable to the metalloproteinase fibroblast collagenase (MMP-1). (academicoo.com)
To determine whether the ACE inhibitors were able to affect the mechanical properties of fibroblast-populated collagen lattices (FPCLs), a technique was developed for the characterisation of their time-dependent properties. (bl.uk)
other neoplastic disorders can cause local tissue infiltration without metastasis such as desmoid tumours which are mesenchymal tumours characterised histologically by fibroblast proliferation and marked production of collagen 13 . (ersjournals.com)

It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. (cancerindex.org)

9. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. (nih.gov)

Alpha-1 Antitrypsin Deficiency Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

17. Metalloproteinases and metalloproteinase inhibitors in age-related diseases. (nih.gov)

Temas para TCC Human shoulder tendon biopsy samples in organ culture produce procollagenase and tissue inhibitor of metalloproteinases. (academicoo.com)
Human prostate cancer cell lines PC-3 and DU-145 (ATCC) were grown in MEM media with 10% FBS and antibiotics in 24-well tissue culture plates. (drrathresearch.org)

We conducted bioinformatic analyses of genome and transcriptome data to determine the protease inhibitor (PI) repertoire in Amblyomma americanum and in 25 other ixodid tick species. (biomedcentral.com)

Gene polymorphism -418 G/C of tissue inhibitor of metalloproteinases 2 is associated with abdominal aortic aneurysm. (cdc.gov)

Being the most common and important models in trauma research, this review focuses on hemorrhagic shock, blunt chest trauma, bone fracture, skin and soft-tissue trauma, burns, traumatic brain injury and polytrauma. (biomedcentral.com)

Our hypothesis is based on the evidence that the fundamental hallmarks of cancer, such as genetic alterations, uncontrolled proliferation and tissue invasion are, in fact, the essence of the pathobiological characteristics and hallmark features of IPF. (ersjournals.com)

5. Metalloproteinases and their tissue inhibitors in Alzheimer's disease and other neurodegenerative disorders. (nih.gov)

These results indicate that tendon tissue cells are capable of producing a remodelling response, even in end stage tendon disease. (academicoo.com)

Stretching experiments performed in the presence of a specific inhibitor of extracellular signal-regulated kinase (ERK) showed a strong suppression of the stretch-induced increase in MMP-1 and -3. (eur.nl)

Salamanders capable of limb regeneration form a blastema (a mass of lineage-restricted progenitor cells 4 ) after limb loss, and our findings suggest that ear tissue regeneration in Acomys may proceed through the assembly of a similar structure. (nature.com)

Anatomy42

Organisms13

Diseases20

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes41

Disciplines and Occupations1

Information Science3

Health Care1

MMPs17

TIMPs2

Matrix Metalloproteinase6

TIMP20

Expression1

TIMP33

ELISA Kit1

Endogenous1

TIMP11

TIMP43

Protein2

Stem cells1

Fibrosis2

Increases1

Cells1

Destruction2

Inflammatory1

Levels1

Lung1

Form1

Serum1

Play1

Family1

Matrix24

Disintegrin And Metalloproteinase2

Endogenous inhibitors1

Protease inhibitors4

Degradation1

Connective1

Cartilage2

Proteomics1

Pirfenidone1

Phosphorylation2

Regulate1

MRNA1

Regulation2

Inflammation3

Regenerative medicine3

Organs1

Tumour2

Lung tissue1

Perspectives1

Collagen3

Apoptosis1

Procollagen1

Emphysema1

Vitro1

Diseases1

Human2

Genome1

Gene1

Soft tissue1

Proliferation1

Disorders1

Tendon1

Specific1

Structure1