Metal cations divalent. Medical search. Frequent questions

In common with all members of the enolase superfamily, the carboxylic acid of the substrate is co-ordinated by the metal ions, and a proton adjacent to a carboxylic acid group of the substrate is abstracted by a base. (rcsb.org)
The fluoride ion interacts weakly with common metals in plumbing materials and the American Water Works Association Research Foundation has reported that fluoride ions contribute to corrosion to the same extent as at the same concentration chloride and sulfate ions. (cdc.gov)
Previously, ribozyme activity was observed in the absence of divalent metal ions and the presence of high concentrations of monovalent metal ions, although the activity was less than that observed in the presence of divalent metal ions. (nih.gov)
Hydrazones have been studied by liquid-liquid extraction towards the s-metal ions (Li + , Na + , and K + ) and d-metal ions (Cu 2+ and Cr 3+ ) from aqueous phase to organic phase. (hindawi.com)
DCT1 resides on the apical membrane of enterocytes and mediates the uptake of many metal ions, particularly ferrous iron, into these cells (Tandy et al. (reactome.org)
All the modified oxirane resins tested were found to be Ag+-selective in the presence of a range Of divalent (heavy) transition-metal ions. (strath.ac.uk)
In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. (embl.de)
however, the protein can transport some other metal ions as well. (medlineplus.gov)
Trivalent Al3+ or Fe3+ ions had much stronger effects than divalent Ca2+, Mg2+, or Mn2+. (ncsu.edu)
The relationship between the first coordination sphere and the electrochemical properties of the metal ions in organic media will be ultimately established. (eos-ecobat.eu)

The resulting cDNA was found to be a general divalent cation transporter or DCT1. (mayo.edu)
Functionally, DCT1 is an electrogenic, divalent transition-metal / H+ cotransporter. (mayo.edu)
The human gene SLC11A2 encodes the divalent cation transporter DCT1 (NRAMP2, Natural resistance-associated macrophage protein 2). (reactome.org)

Prion proteins may function as a metal binding protein because divalent cations such as copper, zinc and manganese can bind to octapeptide repeat sequences in the N-terminus of PrP(c). (nih.gov)

also known as NRAMP2 or DMT1) is considered to be a major cellular uptake mechanism for Fe(2+) and other essential divalent metals, but this protein also mediates uptake of Cd(2+), Pb(2+), and possibly of other toxic divalent metals. (nih.gov)

The SLC11A2 gene provides instructions for making a protein called divalent metal transporter 1 (DMT1). (medlineplus.gov)

In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. (embl.de)
Edetate disodium likewise forms chelates with other polyvalent metals and produces increases in urinary excretion of magnesium, zinc and other trace elements. (nih.gov)
This is typically performed through the heat digestion of RNA with a divalent metal cation (magnesium or zinc). (stw-news.org)

Strontium bis(2-ethylhexanoate) is the strontium salt of 2-ethylhexanoic acid, which readily dissociates to the corresponding divalent strontium cation and 2-ethylhexanoic acid anions. (europa.eu)
The relative standard deviations were smaller than 5.8%.The presence of high concentrations of mono and divalent anions such as chloride and sulfate has no significant influence on the determination of the perfluorinated alkyl substances (PFAS). (metrohm.com)
As for anions and cations, the only anion of significant levels detected in Brunei Rivers is chloride whereas only monovalent cation detected in significant levels, is sodium. (brunel.ac.uk)
There are ionic bonds in between cations and anions. (pediaa.com)
Polyfunctional sensors capable of independent detection of two or more kinds of "guests" from a multiple mixture of cations, anions, or molecules due to specific spectral responses via the same or different channels constitute a rapidly developing area of chemosensory science. (intechopen.com)

Edetate Disodium Injection, USP forms chelates with the cations of calcium and many divalent and trivalent metals. (nih.gov)
We demonstrate that the protein has low cation specificity and contains multiple binding sites able to chelate divalent and trivalent metals with low affinity. (cnr.it)

This gene encodes a member of the ZIP family of metal ion transporters. (nih.gov)

[ 39 ] This property is important because it allows association of divalent cations such as calcium and magnesium, which have been shown to cross-link with the polymer strands and provide greater binding force in a developed biofilm. (medscape.com)
In contrast, the presence of divalent cations, such as calcium and magnesium, which are normally present in water matrices, impairs PFOS recovery. (metrohm.com)
Magnesium is an alkaline earth metal that is in the group 2 of the periodic table of elements. (pediaa.com)
Magnesium often forms ionic compounds by forming the magnesium divalent cation. (pediaa.com)
Magnesium and other elements in the same group are considered as alkaline earth metals. (pediaa.com)
Magnesium has wide applications as a metal, especially in aircraft designing, and automotive designing. (pediaa.com)

Among these, the need for reliable electrochemical test protocols, mass transport limitations and high desolvation energies (due to strong cation-solvent and cation-anion interactions) are implied. (edu.hk)
The divalent metal ion Ca2+is of low toxicity so that the hazard profile is determined by the organic anion. (europa.eu)
Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the metal cation and the organic acid anion. (europa.eu)
This way forward is acceptable, since metal carboxylates are shown to dissociate to the organic anion and the metal cation upon dissolution in aqueous media. (europa.eu)
Once the individual transformation products of the metal carboxylate become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the "overall" toxicity of the dissociated metal carboxylate can be described by a combination of the toxicity of these transformation products, i.e. the metal cation and carboxylate anion according to an additivity approach. (europa.eu)
The strontium cation and the 2-ethylhexanoic acid anion are considered to represent the overall toxicity of strontium bis(2-ethylhexaate) in a manner proportionate to the free acid and the metal (represented by one of its readily soluble salts). (europa.eu)
This webinar will demonstrate how source-term reduction can be achieved using macroporous cation and anion resins and explain how these resins are becoming the industry standard at many utilities worldwide. (purolite.com)
More specifically, ECOBAT aims to understand the effect of the solvent and salt anion on reversible metal deposition and metal-ion intercalation in MABs using a single type of cathode materials. (eos-ecobat.eu)

in the early 1990's showed a surface-film controlled electrochemical behavior of Ca metal anodes in electrolytes with conventional organic solvents. (edu.hk)
e.g. stomach) into the cation (calcium) and the organic compound. (europa.eu)
The effect of chloroform and dichloromethane as organic solvents over the metal chlorides extraction was investigated at 25 ± 0.1°C by using flame atomic absorption. (hindawi.com)
No indications of complexation or masking of the metal ion through the organic acid were apparent during the water solubility and dissociation tests (please refer to the water solubility and dissociation in sections 4.8 and 4.21 of IUCLID). (europa.eu)
ECOBAT unites 5 experts in the domain of high-performance organic cathodes, efficient metal anode utilization, advanced electrolytes, combining both experimental and computational theoretical chemistry approaches. (eos-ecobat.eu)

A two-step divalent metal ion dependent folding pathway was observed for the ribozyme-substrate complex with a weak first transition observed at 0.25 mM Mg2+ and a strong second transition observed around 10 mM Mg2+, in agreement with studies using other biophysical and biochemical techniques. (nih.gov)

The product of this gene transports divalent metals and is involved in iron absorption. (nih.gov)
The presence of specific HMR clusters, associated with transposase genes, suggests that the selection pressure of the New Caledonian ultramafic soils has driven the specific adaptation of STM 6070 to heavy-metal-rich soils via horizontal gene transfer. (researchsquare.com)
DtxR, metallo-regulator was first isolated from Corynebacterium diphtheriae , where it influences the synthesis of diptheriae toxin gene, tox , in the presence of iron metal. (thepharmajournal.com)

Intracellular concentrations of essential metals are normally maintained within a narrow range, whereas the nonessential metals generally lack homeostatic controls. (nih.gov)

Toxicity of heavy metals in the environment. (cdc.gov)

abstract = "Divalent metal cations are essential to the structure and function of the ribosome. (psu.edu)

Transcriptional regulators from DtxR family are strictly iron metal dependant, though in-vitro, these metallo-regulators are known to bind to other divalent cations too. (thepharmajournal.com)
We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function. (cnr.it)

The purpose of this study was to evaluate the solubility and absorption potential of 2 model metal allergens, cobalt, and beryllium , in the lung, gastrointestinal, and skin compartments. (cdc.gov)
Methods: Solubility of cobalt and beryllium metal particles was evaluated using 1 or more biologically relevant artificial solvents: lung airway lining fluid, lung alveolar macrophage phagolysosomal fluid, gastrointestinal fluid, and skin sweat. (cdc.gov)
Results: Dissolution rates for cobalt metal particles, in units of g/(cm2 × day), were fastest in gastrointestinal fluid (3.7 +/- 1.6 × 10 - 4) and slower in skin sweat (4.4 +/- 0.4 × 10 - 5), lung alveolar macrophage phagolysosomal fluid (2.8 +/- 0.8 × 10 - 5), and airway lining fluid (1.0 +/- 0.3 × 10 - 5). (cdc.gov)
beryllium , levels were assumed to be similar to divalent cations such as cobalt. (cdc.gov)
Conclusion: Cobalt and beryllium metal particles are soluble in biological fluids and may be absorbed via multiple exposure pathways. (cdc.gov)

MAL requires monovalent and divalent cation cofactors for full catalytic activity. (rcsb.org)
Here, we observed similar dynamics for U7 in the presence of 4 M Na+ or Li+, which were distinctively different than that observed in the presence of 10 mM Mg2+, indicating that U7 of the catalytic core forms a different microenvironment under monovalent versus divalent metal ion conditions. (nih.gov)
1. Cu(II) and Mn(II) Anchored on Functionalized Mesoporous Silica with Schiff Bases: Effects of Supports and Metal-Ligand Interactions on Catalytic Activity. (nih.gov)

Physiological role of iron metal is well documented as it is essential as a co-factor for the enzymes involved in the basic bio-chemical and metabolic reactions necessary for the microorganism like cellular respiration, as a part of the components of electron transport chain and for the enzymes involved in DNA replication. (thepharmajournal.com)

For beryllium metal particles, dissolution rates were fastest in gastrointestinal fluid (4.1 +/- 0.2 × 10 - 7) and slower in phagolysosomal fluid (1.1 +/- 1.4 × 10 - 7), skin sweat (1.7 +/- 0.6 × 10 - 8), and airway lining fluid (1.5 +/- 0.8 × 10 - 9). (cdc.gov)

RGD fits into a deep groove between the two subunits with the Arg residue contacting the α subunit and the Asp residue coordinating a divalent cation embedded in the β subunit, held in place by the Metal-Ion-Dependent Adhesion Site (MIDAS) ( Xiong,2002 ), while the flanking residues modify specificity and affinity. (eu.org)

20. Polyvinylpyrrolidone-Aminopropyl-SBA-15 schiff Base hybrid for efficient removal of divalent heavy metal cations from wastewater. (nih.gov)
In the context of the above applications, we have reported here the synthesis and characterization of novel macrocyclic hydrazone Schiff bases and their extraction study of some transition metal cations. (hindawi.com)

While the interfering divalent cations are exchanged for non-interfering sodium cations, PFOA and PFOS are directly transferred to the sample loop. (metrohm.com)

A component analysis showed that a mill deposit sample was a mixture of wood resin, fiber, metal cations, and other inorganics. (ncsu.edu)

They shed light on the physical interactions between a protein tyrosine kinase and a divalent metal activator. (uri.edu)
Lin X, Ayrapetov M, and Sun G. Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator. (uri.edu)
Based on the differential scanning calorimeter (DSC) method, some critical parameters, including pH, metal cations, and their interactions, on the thermal stability of pitch-related deposits were studied. (ncsu.edu)

Finally, the ability of divalent metal cations to activate Csk correlates to a combination of ionic radius and the coordination number. (uri.edu)

Since the binding of these metals to the octapeptide has been proposed to influence both structural and functional properties of prion proteins, alterations in transition metal levels can alter the course of the disease. (nih.gov)
Some of the factors that contribute to metal homeostasis have recently been identified at the molecular level and include proteins that mediate import of essential metals from the extracellular environment, those that regulate delivery to specific intracellular proteins or compartments, and those that mediate metal export from the cell. (nih.gov)

Here, a systematic investigation of the electrolyte formulation impact on the cation solvation structure and transport is presented. (edu.hk)
Characterization of the passivation layer formed onto the Ca metal anode in various electrolyte formulations using complementary techniques will be presented allowing for the identification of the most suitable passivation layer components in terms of divalent cation mobility. (edu.hk)

The galvanic interaction of different metals has a significant role in pipe corrosion, because many commercial metals are alloys of various metals. (cdc.gov)
Alexandre Ponrouch received his Ph.D. in 2010 from the Institut National de la Recherche Scientifique (INRS-EMT, Québec, Canada) working on electrodeposition of metals, alloys, and oxides nanotubes and nanowires for application in fuel cells and supercapacitors. (edu.hk)

16. A generalized method toward high dispersion of transition metals in large pore mesoporous metal oxide/silica hybrids. (nih.gov)
This versatility has made hydrazones good polydentate chelating agents that can form a variety of complexes with various transition and inner transition metals and have attracted the attention of many researchers [ 1 ]. (hindawi.com)

Micro-organisms have in place eloquent methods for iron metal uptake. (thepharmajournal.com)

His research is mainly focused on fundamental electrochemistry applied to the development of new electrolytes, interfaces, and interphases for post Li batteries, including Na-ion, Ca, Mg and multi cations-based batteries. (edu.hk)

STM 6070 is a heavy metal-tolerant strain that is highly effective at fixing nitrogen with M. pudica. (researchsquare.com)
Here we have provided an updated taxonomy for STM 6070 and described salient features of the annotated genome, focusing on heavy metal resistance (HMR) loci and heavy metal efflux (HME) systems. (researchsquare.com)
Although widely used industrially, these materials are costly to produce and often contain lead and other toxic heavy metals. (acs.org)
For heavy metals, only iron is detected in Brunei Rivers. (brunel.ac.uk)
1998. Accumulation of several heavy metals and lanthanides in mushrooms ( Agaricales ) from the Chicago region. (cdc.gov)
Over the past decades, the growing industrialization caused continuously increased release of heavy metal into environment. (ac.ir)
Through the food chain, heavy metals can be enriched in the body, causing serious harm. (ac.ir)
The removal and recycling of heavy metals are of great significance to environment protection, health concern as well as resource reuse. (ac.ir)
Pectic materials are available from a variety of natural sources and can be used as versatile adsorbents for heavy metal. (ac.ir)
It is known that birds are a sensitive indicator of the influence of environmentally unfavorable factors on the body of living objects, which can be indicated by the content of heavy metals in their body. (ac.ir)
For comparison, the content of heavy metals in feathers and internal organs of birds living in the city of Almaty (Kazakhstan) was determined. (ac.ir)
With increasing environmental pollution and the accumulation of heavy metals in the body, there was a tendency to a decrease in total protein and the most pronounced hypoproteinomy in the range of 35-39 g/l was observed in pigeons captured from the Almaty-1 railway station [13,21]. (ac.ir)

This drawback was overcome by applying Metrohm`s Inline Cation Removal. (metrohm.com)
After inline cation removal, PFAS recovery in water samples containing 350 mg/mL of Ca 2+ and Mg 2+ improved from 90…115% to 93…107%.While PFAS determination of low salt-containing water samples is best performed by straightforward direct-injection IC, water rich in alkaline-earth metals are best analyzed using Metrohm`s Inline Cation Removal. (metrohm.com)

A metal-free triiodide perovskite with a diazabicyclo group and a related bromide compound (top and bottom respectively) resemble barium titanate (middle) in terms of structure and ferroelectric properties. (acs.org)

Another major mechanism by which metals traverse cell membranes and produce cell injury is by forming complexes whose overall structures mimic those of endogenous molecules. (nih.gov)
Because other toxic metals also form complexes with endogenous molecules, comparable mechanisms may be involved in their membrane transport and disposition. (nih.gov)

The data presented will demonstrate the superiority of macroporous cations used to remove divalent metals such as Co-58/60. (purolite.com)
They also demonstrate critical differences in the metal activator coordination sphere in protein tyrosine kinase Csk and a protein Ser/Thr kinase, the cAMP-dependent protein kinase. (uri.edu)

Within Cupriavidus , several species seem particularly adapted to metal-rich environments [21, 22]. (researchsquare.com)
Having completed my PhD in 1995 entitled The influence of monovalent and divalent metal cations on growth and morphology in Candida species at The University of Dundee I joined SCRI in 1998 and was involved in the assessment of field trials for the Integrated Control of Raspberry Root Rot ( P. fragariae var rubi ) project. (hutton.ac.uk)

An active mutant of Asn319 is generated, and this mutation does not alter the metal binding characteristics. (uri.edu)
The present study was designed to amplify, express, purify the DtxR protein and study it's binding characteristics with various divalent cations through bio-physical technique. (thepharmajournal.com)

Transport of toxic metals by molecular mimicry. (nih.gov)
however, others are less specific and interact with multiple metals, including toxic metals. (nih.gov)

Demineralization involves incubating bone that has been pulverized into a powder in a chelating agent in order to sequester the divalent metal cations that comprise the mineral matrix of bone tissue. (uncg.edu)

When metal pipe corrosion occurs, it is a result of the electrochemical electron exchange resulting from the differential galvanic properties between metals, the ionic influences of solutions, aquatic buffering, or the solution pH. (cdc.gov)
Electron paramagnetic resonance (EPR) spectroscopy was used to examine changes in internal structure and dynamics of the hammerhead ribozyme upon metal ion induced folding, changes in pH, and the presence and absence of ribozyme inhibitors. (nih.gov)

Protein tyrosine kinase Csk requires two Mg 2+ cations for activity: one (M1) binds to ATP, and the other (M2) acts as an essential activator. (uri.edu)
Schmelcher M, Waldherr F, Loessner MJ: Listeria bacteriophage peptidoglycan hydrolases feature high thermoresistance and reveal increased activity after divalent metal cation substitution. (her2signaling.com)

Microorganisms employs a battery of iron, Fe 2+ , sensing genes, which are essential for quenching, acquiring and assimilating iron metal from the micro-organisms milieu and thus, important for surviving successfully inside the host. (thepharmajournal.com)

At the level recommended by the U.S. Public Health Service for fluoridation of public water supplies (0.7 mg/L, or parts per million), the fluoride ion has little influence on either corrosion or on the amounts of corroded metals released into the water. (cdc.gov)

This illustrates the capability of pendent hydroxy groups to seriously reduce the stability of complexes of small cations compared to those of large cations. (strath.ac.uk)

The content of these metals in food, drinking water, and atmospheric air should be strictly controlled [5-8]. (ac.ir)

Instead, Ca are currently being considered as safer metal anode alternative. (edu.hk)
These limitations fuel the development of future battery types, including Metal-Anode Batteries (MABs) based on monovalent or divalent, earth-abundant cations. (eos-ecobat.eu)

May also transport other divalent cations. (nih.gov)

For corrosion of metal water pipes to occur, an electrochemical cell must be present. (cdc.gov)
Various metals have been used as battery anodes in electrochemical cells ever since the birth of the batteries with Volta's pile and in the first commercialized primary (Zn/MnO2, Leclanché 1866) and secondary (Pb/acid, Planté 1859) batteries. (edu.hk)

The ability of nonessential metals to interact with binding sites for essential metals is critical for their ability to gain access to specific cellular compartments and for their ability to disrupt normal biochemical or physiological functions. (nih.gov)
The valency of metal cations determined the ability of capturing pitch the formation of deposits. (ncsu.edu)

The metal ion site is located in a large cleft between the domains. (rcsb.org)
Conventional perovskites consist of large and small metal cations, represented by A and B, respectively, in the general chemical formula. (acs.org)

Anatomy6

Organisms3

Chemicals and Drugs104

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DCT13

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NRAMP21

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