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  • mGlu2
  • Other mGlu subtypes, in particular mGlu2, mGlu8, and possibly mGlu4, are also localized presynaptically, but at perisynaptic sites outside the active zone of neurotransmitter release. (aspetjournals.org)
  • Group I mGlu receptors include mGlu1 and mGlu5, which when expressed are coupled via Gq to phospholipase C. Group II (mGlu2 and mGlu3) and group III (mGlu4,6,7,8) receptors are coupled to Gi and inhibit stimulated cAMP formation when expressed in cell lines. (aspetjournals.org)
  • novel
  • Cocaine-induced dysregulation of the glutamate system, and its consequent impact on plasticity and synaptic remodeling, will likely be an important consideration in the development of novel pharmacotherapies for cocaine addiction. (pubmedcentralcanada.ca)
  • Recent progress on the molecular and pharmacological aspects of these presynaptic mGlu receptors is unveiling their functions and the therapeutic directions of agents designed for these novel glutamate receptor targets. (aspetjournals.org)
  • For the most part, the cloning and identification of a novel heterogeneous family of mGlu receptors has driven this progress. (aspetjournals.org)
  • In conclusion, this thesis presents novel non-linear mixed effects models estimating the relationship between drug exposure and receptor occupancy, providing useful translational information, allowing for a better informed drug-development. (diva-portal.org)
  • endogenous
  • Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. (ku.dk)
  • GRM1
  • Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. (thefullwiki.org)
  • taste receptors
  • According to the scientists from the University of Liverpool (UK) and the Kyushu University (Japan), the effect is mediated by interactions with the gastrointestinal bitter taste receptors. (blogspot.com)
  • phospholipase
  • Publications] Yamashita, S.: 'The Ga protein GL2a improves the ability to detect the subthreshold expressions of receptors linked to phospholipase C in Xenopus oocytes. (nii.ac.jp)
  • Gene
  • Metabotropic glutamate receptor 3 is a protein that in humans is encoded by the GRM3 gene . (thefullwiki.org)
  • Remarkably, a functional SNP, rs945032, located in the promoter region of the bradykinin receptor B2 gene (BDKRB2) was associated to three disorders (panic disorder, substance abuse, and bipolar disorder), and two additional BDKRB2 SNPs to obsessive-compulsive disorder and major depression, providing evidence for common variants of susceptibility to several related psychiatric disorders. (genes2cognition.org)
  • functional
  • Unexpectedly, however, heterologous expression of GABA B(1) receptor protein has not made possible the measurement of robust functional responses. (aspetjournals.org)
  • Neuroscience
  • Examples of applications of PET imaging in neuroscience include studies of neuroreceptor/neurotransmitter levels in neuropsychiatric diseases (e.g., measuring receptor expression in schizophrenia) and of misfolded protein levels in neurodegenerative diseases (e.g., beta amyloid and tau deposits in Alzheimer's disease). (springer.com)
  • These receptors each have unique but overlapping distributions in the central nervous system, and the functions of each subtype within these groups have recently been an active area of neuroscience research. (aspetjournals.org)
  • mutations
  • The disruption of NMDA receptor targeting or signaling, as a result of the loss of SAP102, may lead to altered synaptic plasticity and may explain the intellectual impairment observed in individuals with DLG3 mutations. (genes2cognition.org)
  • hippocampal
  • Publications] Ito, I: 'Distribution and development of NMDA receptor activities at hippocampal synapses examined using mice lacking the e 1 subunt gene'Neurosci. (nii.ac.jp)
  • assay
  • Similar effects of CGP7930 are seen in a GTPγ[ 35 S] binding assay using a native GABA B receptor preparation (rat brain membranes). (aspetjournals.org)
  • Although these phenomena have been previously reported, they remain poorly understood, emphasizing the GloSensor assay as an important tool with which to study group II and group III mGlu receptors. (aspetjournals.org)
  • ligands
  • Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. (ku.dk)
  • forms of synaptic plasticity
  • NMDA receptors have been implicated in the induction of certain forms of synaptic plasticity, such as long-term potentiation and long-term depression, and these changes in synaptic efficacy have been proposed as neural mechanisms underlying memory and learning. (genes2cognition.org)
  • activates
  • Comments: Glutamate released by photoreceptor cells in the dark stimulates mGlu 6 on bipolar cell dendrites, which activates G o , and results in the closure of non-specific, and unidentified, cation channels. (guidetopharmacology.org)