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  • Schizophrenia
  • Metabotropic glutamate receptor 5 neuroimaging in schizophrenia. (uzh.ch)
  • Examples of applications of PET imaging in neuroscience include studies of neuroreceptor/neurotransmitter levels in neuropsychiatric diseases (e.g., measuring receptor expression in schizophrenia) and of misfolded protein levels in neurodegenerative diseases (e.g., beta amyloid and tau deposits in Alzheimer's disease). (springer.com)
  • quisqualate
  • Alanine substitutions of four residues, Thr(188), Asp(208), Tyr(236), and Asp(318), which interact with the alpha-amino group of glutamate in the crystal, abolished their responses both to glutamate and quisqualate. (sigmaaldrich.com)
  • The mutations of the Tyr(74), Arg(78), and Gly(293) residues, which interact with the gamma-carboxyl group of glutamate, lost their responsiveness to glutamate but not to quisqualate. (sigmaaldrich.com)
  • phospholipase
  • Publications] Yamashita, S.: 'The Ga protein GL2a improves the ability to detect the subthreshold expressions of receptors linked to phospholipase C in Xenopus oocytes. (nii.ac.jp)
  • Previous studies show that the PDZ domain containing protein INAD, which functions in Drosophila vision, coordinates a signaling complex by binding directly to the light-sensitive ion channel, TRP, and to phospholipase C (PLC). (rupress.org)
  • membrane
  • In cultured hippocampal neurons, nonpalmitoylated ABP-L localizes with internal GluR2 pools expressed from a Sindbis virus vector, whereas pABP-L is membrane targeted and associates with surface-localized GluR2 receptors at the plasma membrane in spines. (jneurosci.org)
  • genes
  • Chromosomal localization of human glutamate receptor genes. (wikipedia.org)
  • Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: evaluation of the novel radiotracer [ 11 c]rs-016 targeting CB2 in atherosclerosis. (uzh.ch)
  • HOMER1
  • G) may create a new binding site of transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT) and could enhance HOMER1 intronic promoter activity. (springer.com)
  • expression
  • On the other hand, the C-terminal portion of Cupidin bound to Cdc42, a member of Rho family small GTPases, in a GTP-dependent manner in vitro , and Cupidin functionally interacted with activated-Cdc42 in a heterologous expression system. (jneurosci.org)
  • Rhynchophylline Downregulates Phosphorylated cAMP Response Element Binding Protein, Nuclear Receptor-related-1, and Brain-derived Neurotrophic Factor Expression in the Hippocampus of Ketamine-induced Conditioned Place Preference Rats. (nih.gov)
  • calmodulin
  • Hydrogen peroxide reduces calmodulin binding to RYR2 in rat cardiomyocytes. (nih.gov)
  • Title: Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. (nih.gov)
  • Disruption of calmodulin binding to KCNQ2 also impairs enrichment of heteromeric KCNQ2/KCNQ3 channels at the axonal surface by blocking their trafficking from the endoplasmic reticulum to the axon. (nih.gov)
  • In the current work, we show that rhodopsin, calmodulin, and PKC associate with the signaling complex by direct binding to INAD. (rupress.org)
  • interactions
  • Both homomeric and target binding occurred simultaneously through the same PDZ domains indicating that the two interactions were mediated by distinct regions. (rupress.org)
  • metabolic
  • Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. (springer.com)