AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
MetabolomeMetabolomicsGas Chromatography-Mass SpectrometryMass SpectrometryMetabolismPrincipal Component AnalysisChromatography, LiquidAdrenogenital SyndromeMetabolic Networks and PathwaysSteroid Metabolism, Inborn ErrorsSecondary MetabolismVolatile Organic CompoundsElectrophoresis, CapillaryProteomeMagnetic Resonance SpectroscopySystems BiologyCarbonEricaceaeModels, BiologicalTranscriptomeGene Expression ProfilingGlycolysisGene Expression Regulation, PlantMetagenomeSpectrometry, Mass, Electrospray IonizationArabidopsisBiosynthetic PathwaysPentose Phosphate PathwaySolid Phase MicroextractionTandem Mass SpectrometryDatabases, FactualAmino AcidsPlant LeavesLeast-Squares AnalysisEncyclopedias as TopicPolypharmacologyBiotransformationInformation Storage and RetrievalExhibits as TopicPersonsStevens-Johnson SyndromeNew YorkStreptomycesGenome-Wide Association StudyGenomeStreptomyces griseusMolecular Sequence DataElectronics, MedicalAmino Acids, Branched-ChainInsulin ResistanceInsulinBacteroidesGastrointestinal Tract
MetabolitesMicrobiome and metabolomeMetabolomicsMass spectrometryPursuing metabolome analysisSerumMetaboliteSecondary MetabolomeUrineCoverage of the metabolomeDiversity of the metabolomeAlterations in the metabolomeMetabolismMetabolicMicrobiota and metabolomeTranscriptome and MetabolomeMicrobialCerebrospinal fluidQuantitative metabolomeMiceArabidopsisEscherichiaCapillary ElectrophoresisMechanisticChromatographyMitochondrialEndogenousColorectal cancerTumorHMDBDatabaseVariationProfilingGenomeColiAnalysesBioinformaticsPhysicochemicalCardiacGeneticMetabolomicHuman
Metabolites18
  • The Escherichia coli metabolome has been characterised using the two-dimensional structures of 745 metabolites, obtained from the EcoCyc and KEGG databases. (nih.gov)
  • A library of fragments commonly found among these molecules has been employed to reveal the main constituents of metabolites, and to assist a broad classification of the metabolome into biochemically relevant classes. (nih.gov)
  • The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body. (hmdb.ca)
  • However, low-temperature-induced expression of CBF1, CBF2, CBF3 , and CBF-targeted genes was much lower in Cvi-1 than in Ws-2 plants, and the low-temperature metabolome of Cvi-1 plants was depleted in metabolites affected by CBF3 overexpression. (pnas.org)
  • Prior to the analysis, we prepared an E. coli metabolome list of 727 metabolites reported in the literature. (rsc.org)
  • Together, all the metabolites within a system are known as the metabolome, and the study of all the metabolites in a sample (such as a cell, tissue or organism) is called metabolomics. (separationsnow.com)
  • In 2007, the Human Metabolome Database was released - an open access database containing detailed information on over 40,000 metabolites found in the body, and there are equivalent databases for yeast, E. coli , and Arabidopsis plants. (separationsnow.com)
  • Goals: i) Investigate how the pregnant woman's diet and microbial metabolites are reflected in her metabolome and that of the newborn child ii) Explore associations between maternal diet, newborn metabolome, immune parameters and allergy development. (chalmers.se)
  • Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. (medsci.org)
  • Launched in January 2005, The Human Metabolome Project (HMP) was a multi-university, multi-investigator project led by Dr David Wishart of the University of Alberta which catalogued all of the known metabolites in human tissues and biofluids. (technologynetworks.com)
  • The HMP produced the first draft of the human metabolome in January 2007, that consisted of a database of approximately 2,500 metabolites, 1,200 drugs and 3,500 food components 13 . (technologynetworks.com)
  • Specifically, experimental problems arise from the technical difficulty of sampling rapidly enough to avoid artifacts for metabolites with fast turnover rate, and from the heterogeneous nature of the species that compose the metabolome, which calls for complex and thus error prone sample preparation procedures and diversified analytical platforms. (biomedcentral.com)
  • b) to establish a comprehensive set of chemical standards for soybean metabolites moving toward construction of a metabolome map with a focus on seed and drought effects on seed development and, c) to compile a database linking proteomic and metabolite information and associate this information to value-added soybean traits and markers for assisted breeding. (umsystem.edu)
  • The genetic influence over stochastic variation within the metabolome was highly metabolite specific, with neighboring metabolites in the same metabolic pathway frequently showing different levels of noise. (escholarship.org)
  • The CSF Metabolome database is a freely available electronic database containing detailed information about 468 small molecule metabolites found in human CSF along with 1650 concentration values . (csfmetabolome.ca)
  • The CSF Metabolome database is integrated into the Human Metabolome Database (HMDB) , allowing users to browse the data in different views, Metabolites, Concentrations and Diseases. (csfmetabolome.ca)
  • The Livestock Metabolome Database (LMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in different livestock species. (lmdb.ca)
  • The metabolome analysis of blood and several organs indicated complete deficiency of a naturally occurring potent antioxidant ergothioneine in octn1 -/- mice among 112 metabolites examined. (elsevier.com)
Microbiome and metabolome8
Metabolomics14
Mass spectrometry9
Pursuing metabolome analysis1
  • The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems. (ebooks.com)
Serum5
Metabolite6
Secondary Metabolome4
Urine2
Coverage of the metabolome2
Diversity of the metabolome1
Alterations in the metabolome2
  • Conclusions IBS symptoms are linked to FODMAP content and associated with alterations in the metabolome. (bmj.com)
  • Mutations in ocd1 caused dramatic alterations in the metabolome in the endosperm. (plantcell.org)
Metabolism5
  • The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. (wikipedia.org)
  • The past decade of research in cancer metabolism reveals the untapped value of exploring human metabolome for the discovery of novel therapeutic and diagnostic biomarkers for human cancers and other diseases. (aacrjournals.org)
  • To test if multi-cellular organisms also display natural genetic variation in the stochastic link between genotype and phenotype, we measured the metabolome, growth and defense metabolism within an Arabidopsis RIL population and mapped quantitative trait loci. (prolekare.cz)
  • Pathway analysis of the transcriptome and metabolome revealed specific genotypic responses with respect to primary sugar accumulation, citric acid metabolism, and raffinose family oligosaccharide biosynthesis. (biomedcentral.com)
  • In this study we report the changes observed in the primary metabolism of E. grandis bark during two contrasting seasons in Brazil, summer (wet) and winter (dry), through the combination of transcripts (RT-qPCR), proteome (2-DE gels) and metabolome (GC-MS) analysis, in an integrated manner. (biomedcentral.com)
Metabolic2
  • The findings persisted after adjustment for body mass index.CONCLUSIONS: The numerous differences found between persistently physically active and inactive individuals in the circulating metabolome together indicate better metabolic health in the physically active than in inactive individuals. (environment-health.ac.uk)
  • The urinary adrenal steroid metabolome provides a tool for metabolic risk stratification and may identify those patients who can benefit from definitive treatment of cortisol excess, e.g. tumour removal in patients with MACE. (endocrine-abstracts.org)
Microbiota and metabolome3
Transcriptome and Metabolome1
Microbial1
Cerebrospinal fluid1
Quantitative metabolome3
Mice2
  • Conclusion This is the first description of the VOC metabolome of C57 BL/6 mice. (bmj.com)
  • Afmid mice did not present statistically significant differences in their volatile faecal metabolome when compared to their respective WT littermates. (open.ac.uk)
Arabidopsis4
  • Here we examined the changes that occur in the Arabidopsis metabolome in response to low temperature and assessed the role of the CBF cold response pathway in bringing about these modifications. (pnas.org)
  • Extensive cold-induced changes also occurred in the metabolome of Arabidopsis Cape Verde Islands-1 (Cvi-1) plants, which were found to be less freezing tolerant than Ws-2 plants. (pnas.org)
  • Taken together, the results indicate that the metabolome of Arabidopsis is extensively reconfigured in response to low temperature, and that the CBF cold response pathway has a prominent role in this process. (pnas.org)
  • Using an Arabidopsis reciprocal RIL population, we showed that there is significant genetic diversity influencing stochastic variation in the plant metabolome, defense chemistry, and growth. (escholarship.org)
Escherichia1
Capillary Electrophoresis1
Mechanistic1
  • Objective To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS. (medworm.com)
Chromatography1
Mitochondrial1
  • We investigated metabolomes of 25 mitochondrial myopathy or ataxias patients, 16 unaffected carriers, six IBM and 15 non‐mitochondrial neuromuscular disease ( NMD ) patients and 30 matched controls. (embopress.org)
Endogenous2
Colorectal cancer1
Tumor1
HMDB1
Database7
  • By coupling to ChemSpider, a major chemical database, we have identified structures for much of the reported metabolome and, where structure identification fails, been able to suggest extensions to ChemSpider. (springer.com)
  • Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)
  • The Human Metabolome Database also supports extensive text, sequence , chemical structure and relational query searches. (csfmetabolome.ca)
  • The CSF Metabolome database is supported by David Wishart, Departments of Computing Science & Biological Sciences, University of Alberta. (csfmetabolome.ca)
  • The CSF Metabolome Database is offered to the public as a freely available resource. (csfmetabolome.ca)
  • Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (CSF Metabolome Database) and the original publication (see below). (csfmetabolome.ca)
  • We ask that users who download significant portions of the database cite the CSF Metabolome Database paper in any resulting publications. (csfmetabolome.ca)
Variation1
Profiling4
Genome1
  • This is due to the fact that the metabolome does not have a direct link to the genome such as mRNA or proteins. (biomedcentral.com)
Coli1
Analyses1
  • However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. (springer.com)
Bioinformatics2
  • To encourage public awareness, discussion and collaboration at this important scientific frontier, this Frontiers Research Topic therefore aims to provide an encyclopedic reference to the current state of the art in metabolome-related bioinformatics. (frontiersin.org)
  • Contributions of any type in any area of metabolome-related bioinformatics are enthusiastically welcomed. (frontiersin.org)
Physicochemical1
  • Physicochemical properties of the metabolome have been calculated to provide an overview of this set of cognate ligands. (nih.gov)
Cardiac3
  • Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy. (ox.ac.uk)
  • We used the Mybpc3-targeted knock-in mouse model of HCM to investigate changes in the cardiac metabolome following perhexiline treatment. (ox.ac.uk)
  • The total cardiac purine metabolome includes all of the adenine and guanine nucleoside and nucleosides and related molecules involved throughout the intracellular and extracellular compartments and various cell types in the heart. (elsevier.com)
Genetic1
Metabolomic1
  • Central to the global flow of metabolomic information are public metabolome databases, many of which have emerged in recent years. (frontiersin.org)
Human1