Metabolites include 1. Medical search. Frequent questions

An analytical method has been developed to determine MDMA enantiomers and those from its major metabolites, 3,4-methylenedioxyamphetamine (MDA), 3,4-dihydroxymeth-amphetamine (HHMA), and 4-hydroxy-3-methoxymethamphet-amine (HMMA). (erowid.org)
With increasing cannabis use, the potential for cannabis or one or more of its physically active constituents (cannabinoids) and their major metabolites interacting with other therapeutic agents also increases. (aspetjournals.org)

Many studies have analyzed nicotine metabolites in blood and urine to determine the toxicity caused by smoking, and assess exposure to cigarettes. (mdpi.com)
Methods were located for the analysis of propylene glycol dinitrate or its metabolites in expired air, blood, urine, and hand swabs. (cdc.gov)
Methods exist for detecting propylene glycol dinitrate and its metabolites in blood and urine. (cdc.gov)
The primary method of analysis for propylene glycol dinitrate and its metabolites in blood and urine is gas chromatography with electron capture detection (Litchfield 1968). (cdc.gov)
In general, THC metabolites are detectable in urine for approximately 3 to 15 days after use. (healthline.com)
Urine sample preparation for the analysis of hydroxyl-PAHs metabolites included enzymatic digestion, solid phase extraction, and isotope dilution GC/MS and microflow LC-Q-TOF MS detections. (cdc.gov)
There is limited analytical capability to detect selected brevitoxins or their metabolites in urine by immunoassay. (cdc.gov)
Determination of DDT and Metabolites, including DDA, in Human Urine by Gas Chromatography. (epa.gov)

They are foliar applied compounds that control many fungal diseases including early and late blights, leaf spots, rust mildew and scabs in various field crops such as fruits, nuts, cucurbits, vegetables, grapes, and ornamentals. (cdc.gov)
Like full-spectrum CBD products, broad-spectrum CBD products contain additional compounds found in the plant, including terpenes and other cannabinoids. (healthline.com)
A total of 92 neutral compounds including triterpenoids, polyprenols, and dolichols were identified using GC-MS and HPLC methods. (researchgate.net)
Examples are quantification of administered compounds in plasma of test animals, or biokinetic (ADME) studies of agrochemicals in plants - including sample generation in our greenhouse where needed. (basf.com)
All 27 compounds, including the two natural products 1 and 5a, were subsequently assayed in vitro for antiparasitic activity against Trypanozoma cruzi, Leishmania brasiliensis and Leishmania amazoniensis. (lu.se)
The compounds with the highest potencies as well as SI-values are esters of 1 with various carboxylic acids. (lu.se)
Algal biomass is a promising feedstock for sustainable production of a range of value-added compounds and products including food , feed, fuel. (bvsalud.org)

1-26, 2022 Mar 02. (bvsalud.org)

Preliminary results indicated that urinary PAH metabolite could be a sensitive biomarker following asphalt fume exposure. (cdc.gov)
Urinary excretion products included parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. (drugs.com)

In this study, we investigated the in vitro inhibitory effects of the individual major cannabinoids and metabolites ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), 11-nor-THC-carboxylic acid, and 11-hydroxy-THC on CES1 activity. (aspetjournals.org)
In other words, full-spectrum products include CBD alongside terpenes, flavonoids, and other cannabinoids such as THC. (healthline.com)

Each MetaboCard entry contains 130 data fields with 2/3 of the information being devoted to chemical/clinical data and the other 1/3 devoted to enzymatic or biochemical data. (hmdb.ca)

As 1,3-Butylene diacetate is highly water-soluble, the substance will readily dissolve into GI fluids. (europa.eu)
The database contains 220,945 metabolite entries including both water-soluble and lipid soluble metabolites. (hmdb.ca)

We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. (nih.gov)

On July 13, 2017, the House Appropriations Subcommittee released a proposal with $2.5 billion for NIA, which includes an additional $400 million above the FY 2017 funding level for Alzheimer's research. (nih.gov)
On September 6, 2017, the Senate Appropriations Subcommittee also released a proposal including additional funds for NIH. (nih.gov)
They proposed an additional $486.7 million above the FY 2017 funding level for NIA including, $414 million targeted for Alzheimer's research. (nih.gov)
The bill contains funding for NIH in the amount of $36.1 billion, a $2 billion increase over FY 2017, including $1.8 billion for Alzheimer's disease research, a $414 million increase over FY 2017 funding levels. (nih.gov)
On September 1, 2017, the U.S. Food and Drug Administration approved gemtuzumab ozogamicin (Mylotarg, Pfizer Inc.) for the treatment of newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adults and for treatment of relapsed or refractory CD33-positive AML in adults and in pediatric patients 2 years and older. (fda.gov)

A reliable method for metabolite extraction is central to mass spectrometry-based metabolomics. (frontiersin.org)
Here, we present a simplified metabolite extraction (SiMeEx) method, to efficiently and quickly extract metabolites from adherent mammalian cells. (frontiersin.org)
Our method excludes the cell scraping step and therefore allows for a more efficient extraction of polar metabolites in less than 30 min per 12-well plate. (frontiersin.org)
In this current study, we present a new and shorter method, termed as simplified metabolite extraction (SiMeEx), to extract metabolites from adherent mammalian cells. (frontiersin.org)
Their subsequent data analysis requires sophisticated data preprocessing steps, including the extraction of NMR features corresponding to specific metabolites. (nih.gov)
BF consistently improved metabolite signal extraction, as demonstrated by our correlation analyses with absolutely quantified metabolites. (nih.gov)
A new method of the determination polycyclic aromatic hydrocarbons (PAHs) in water samples was developed by continuous-flow microextraction (CFME) coupled with gas chromatography-mass spectrometry (GC-MS). In this experiment, 15 mL sample solution with no salt-added was flowed at the rate of 1.0 mL min(-1) through 3 microL benzene as extraction solvent. (who.int)
Under the optimal extraction conditions, the developed method was found to yield a linear calibration curve in the concentration range from 0.05 to 15 ng mL(-1). (who.int)

Although there have been a significant number of in vitro and in vivo assessments of the effects of cannabis on cytochrome P450 and UDP-glucuronosyltransferase enzyme systems, there is limited information regarding the effects of cannabis on the major hepatic esterase, carboxylesterase 1 (CES1). (aspetjournals.org)
Human bone marrow CD34(+) hematopoietic progenitor cells (HPC) were exposed in vitro to 1,4-BQ to assess cytotoxicity, genotoxicity, and DNA damage responses and the molecular mechanisms associated with these events. (rti.org)
It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. (researchgate.net)

1) Tolerances are established for residues of the insecticide tolfenpyrad, including its metabolites and degradates, in or on the commodities in the table below. (cornell.edu)

Additionally, analytical methods may be included that refine previously used methods to obtain lower detection limits, and/or to improve accuracy and precision. (cdc.gov)
To identify the plethora of different metabolites, specific analytical tools are required. (frontiersin.org)
The substance 1,3-Butylene diacetate is a diester of 1,3-Butylene glycol and Acetic acid and meets the definition of a mono-constituent substance based on the analytical characterization. (europa.eu)

Less than 1% of radiolabeled material in plasma comprises unconjugated raloxifene. (wikipedia.org)
Plasma metabolites may help to predict neurological outcomes in neonatal brain injury and enhance current clinical predictors. (nature.com)
Our study presents novel associations of plasma metabolites from the first 24 h of life and 2-year neurodevelopmental outcomes for infants with NE. (nature.com)
18 ] analysed the metabolome in cord blood plasma from 26 cases and 26 controls differing in their postnatal weight trajectories using targeted mass spectrometry (MS) analysis of 415 metabolites, nested in an American cohort. (nature.com)
Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. (springer.com)
Tandem mass spectrometry analysis of plasma from obese mice under CR showed no difference in Cur metabolite levels between groups supplemented with Cur alone or combined with Pip. (springer.com)
However, plasma IL-1β levels were inversely correlated with curcumin glucuronide. (springer.com)
In plasma, about 50%-80% of the salicylic acid and its metabolites are loosely bound to plasma proteins. (drugs.com)
This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. (biomedcentral.com)
In a case-control study nested in the Northern Sweden Health and Disease Study, pre-diagnostic concentrations of 148 plasma metabolites were determined using targeted mass spectrometry- and nuclear magnetic resonance-based metabolomics in 777 prostate cancer cases (follow-up ≥ 5 years) and 777 matched controls. (biomedcentral.com)

Chronic human exposure to benzene has been linked to several hematopoietic disorders, including leukemia and lymphomas. (rti.org)
Certain benzene metabolites, including benzoquinone (BQ), are genotoxic and mutagenic. (rti.org)
Other information on identity and properties Physical state: White crystalline solid (pure) Amber waxy solid (technical) Melting point: 40 C (pure) Solubility: Water - about 4 g/ml Benzene, toluene, methyl ethyl ketone, ethyl acetate, acetonitrile, methylene chloride, anisole, cyclohexanone, chloroform - 1 g/ml [xylene - 0.125 g/ml petroleum ether, cyclohexane - insoluble Volatility: Very low. (inchem.org)

Caffeine (1,3,7-trimethylxanthine) is a central nervous system stimulant. (drugs.com)
dapsone and a caffeine metabolite [ 1 ]. (who.int)

Method The sex-stratified association of 791 metabolites detected by liquid chromatography-mass spectrometry (LC-MS) and 91 lipoprotein particles measured by nuclear magnetic spectroscopy (NMR) with WHRadjfatmass and fat mass were assessed using three population-based cohorts: EpiHealth (n = 2350) as discovery cohort, with PIVUS (n = 603) and POEM (n = 502) as replication cohorts. (lu.se)

Significant (after false discovery rate correction) KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways included aminoacyl-tRNA biosynthesis, arginine biosynthesis, and metabolism of multiple amino acids. (nature.com)
Where the target area of metabolism is known more specifically, we offer targeted analytics of high sensitivity to quantify individual or groups of metabolites even more efficiently. (basf.com)

This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. (researchgate.net)
Given the tremendous promise of regenerative medicine to enhance human health and treat disease, Congress included a provision in the 21st Century Cures Act to support a Regenerative Medicine Innovation Project ($30 million distributed over FY17 through FY20) for the funding of clinical research to further the field of regenerative medicine (RM) using adult stem cells, including autologous, non-autologous use as well as eligible induced pluripotent stem cells (iPSC). (nih.gov)
This year, NIH and FDA issued RFA/RFPs for competitive revisions to utilize those funds to support ongoing clinical research studies in RM across several ICs including NIA. (nih.gov)
The detection of brevitoxins or their metabolites in clinical specimens. (cdc.gov)
The database is designed to contain or link three kinds of data: 1) chemical data, 2) clinical data, and 3) molecular biology/biochemistry data. (hmdb.ca)
C. Special clinical procedures and tests A specially trained health technician carried out the following on examined persons in the designated age ranges: 1. (cdc.gov)

Associations between prostate cancer risk and metabolite concentrations were investigated using conditional logistic regression conditioned on matching factors (body mass index, age and sample storage time). (biomedcentral.com)

1-propylene glycol mononitrate and 2-propylene glycol mononitrate. (cdc.gov)
The lower detection limit of the MS method was less than 1 mg/m3 propylene glycol dinitrate in air, but no information on accuracy and precision was reported. (cdc.gov)
Impriting ink composed of n-butyl alcohol, pharmaceutical glaze modified in SD-45, propylene glycol, SDA-3A alcohol, titanium dioxide, D&C Yellow No. 10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake. (rxlist.com)

Additionally, it inhibits the physiological traits of the S. aureus biofilm, including hydrophobicity, motility, eDNA, and PIA associated to the biofilm. (frontiersin.org)
Additionally, 8,610 protein sequences (enzymes and transporters) are linked to these metabolite entries. (hmdb.ca)
EB126/10 Add.1 contains the draft resolution initially considered by the Board and additionally reflects comments and proposals thereon made by members of the Board. (who.int)

The microbial community is also a natural source of metabolites and has the potential to be used to create antimicrobial and anti-biofilm agents. (frontiersin.org)
Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC). (stanford.edu)
The next section, Microbial Spoilage control in agriculture and food systems, including and Public Health Concerns, details microorganisms wastewater systems, is warranted. (cdc.gov)
For this update, data on 462 gut microbial metabolites were manually collected from 160 peer-reviewed primary publications. (who.int)
First, these data include experimental evidence on their microbial origin. (who.int)

The metabolites of raloxifene include several glucuronides. (wikipedia.org)

The applicant commits to submit an updated ERA that includes the ongoing and agreed studies, namely: the log Kow determination and if required a bioconcentration test (OECD 305), the repetition of the activated sludge respiration inhibition test (OECD 209) and the consequent revision of the PEC/PNEC ratio, and the sediment organism toxicity test. (janusinfo.se)

Metabolites, on the other hand, are chemicals that participate in life processes later and can more directly reflect dynamic changes in the body ( 18 ). (frontiersin.org)
We quantify the chemical residue or metabolites of chemicals in any biological matrix according to OECD / SANCO standards - where required under GLP compliance. (basf.com)
We also offer to identify typical phase 1 and phase 2 metabolites of chemicals in biological systems. (basf.com)
Maternal illnesses like diabetes mellitus, conditions such as iodine and folic acid deficiency, and exposure to medicinal and recreational drugs including alcohol and tobacco, certain environmental chemicals, and high doses of radiation are other factors that cause birth defects. (who.int)
Most birth defects of environmental origin can be prevented by public health approaches, including prevention of sexually-transmitted diseases, legislation controlling sound management of toxic chemicals (e.g. certain agricultural chemicals), vaccination against rubella, and fortification of basic foods with micronutrients (iodine and folic acid). (who.int)

3-Bromopropionic acid is a human metabolite of 1-bromopropane and a proposed biomarker of exposure. (cdc.gov)
As metabolome data scientists with expertise in biochemistry, systems biology, and biomarker identification, we have a strong track record in extracting and interpreting the most relevant findings from multidimensional metabolite profiling and other "omics" data. (basf.com)

However, no methods of detecting the chemical or its metabolites in tissues were found. (cdc.gov)
During the absorption process and after absorption, aspirin is mainly hydrolyzed to salicylic acid and distributed to all body tissues and fluids, including fetal tissues, breast milk, and the central nervous system (CNS). (drugs.com)

DrugBank contains equivalent information on ~2832 drugs and 800 drug metabolites, T3DB contains information on ~3670 common toxins and environmental pollutants, SMPDB contains pathway diagrams for ~132,335 human metabolic, drug and disease pathways as well as ~60,628 pathways for other organisms, while FooDB contains equivalent information on ~70,000 food components and food additives. (hmdb.ca)
The submitted environmental risk assessment (ERA) includes a phase II tier A analysis. (janusinfo.se)

We deliver mass spectrometry (MS)-based metabolite and protein analytics, data interpretation as well as plant testing capabilities under GLP and GLP-like quality standards to BASF operating divisions, corporate research projects and external customers. (basf.com)

Potential sources for human exposure include foods grown in treated soil or contaminated water. (cdc.gov)
This method assesses human exposure to select pesticide metabolites of non-persistent pesticides. (cdc.gov)
Apoptosis and cytotoxicity were dose-dependent, with exposure to 10 microM 1,4-BQ resulting in approximately 60% cytotoxicity relative to untreated controls. (rti.org)
Inhalational exposure may cause respiratory symptoms such as cough, dyspnea and bronchospasm (1-4). (cdc.gov)

The metabolites of S. aureus biofilm treated with LAB-CFS were greater in the LAB-bf-CFS than they were in the LAB-pk-CFS, according to metabolomics studies. (frontiersin.org)

As it is not understood which molecular features of 1 are important for the antiparasitic activity, several analogues were synthesized and assayed. (lu.se)
In this study, we have synthesized 25 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen analogues of 1 and its co-metabolite pulchral (5a), by semi-synthetic procedures starting from the natural product pulchrol (1) itself. (lu.se)

95%), including to both albumin and α1 acid glycoprotein, but not to sex hormone-binding globulin. (wikipedia.org)
A significant part of the breast microbiota includes lactic acid bacteria, whose cell-free supernatant (LAB-CFS) may prevent bacteria from secreting virulence factors and lessen their pathogenicity ( 12 , 13 ). (frontiersin.org)
The respective molecular weights of 1,3-Butylene glycol (90.12 g/mol) and Acetic acid (60.05 g/mol) do favour absorption, as well. (europa.eu)

Please contact us with your task for metabolite profiling in any biological system. (basf.com)

This method allowed for the precise quantification of targeted metabolite biomarkers using an OC blood cohort comprising control samples (n = 464), benign samples (n = 3), and OC samples (n = 13).Eleven functional modules were identified as significant differentiators (false discovery rate, FDR (stanford.edu)
We included 983 participants in our case-cohort study. (nih.gov)

These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. (rti.org)
1960). TOXICOLOGICAL STUDIES Special studies on the metabolites A summary of the results of acute toxicity studies on vamidothion sulfoxide is shown in Table 1. (inchem.org)

In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. (rti.org)
Critical know-how and utmost focus to operational quality are essential to successfully utilize Metabolite Profiling. (basf.com)

It also yielded a higher proportion of statistically significant metabolite features in our differential metabolite analyses. (nih.gov)

As the molecular weight of 1,3-Butylene diacetate is 174.20 g/mol, absorption of the intact molecule in the gastrointestinal (GI) tract can be anticipated. (europa.eu)
The molecular weight of the parent substance 1,3-Butylene diacetate (174.2 g/mol) does suggest absorption as described above. (europa.eu)

Pizarro N, Farre M, Pujadas M, Peiro AM, Roset PN, Joglar J, de la Torre R. "Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine)" Drug Metab Dispos . (erowid.org)
Drug tests screen for THC or one of its main metabolites, THC-COOH. (healthline.com)

In the Metabolome-Wide Association Study analysis, we identified three and eight metabolites associated with rapid growth and overweight, respectively, after FDR correction. (nature.com)

The structures of these metabolites were determined by chemical and spectral methods including 1H-13C 2-D shift correlation. (eurekamag.com)

Severe side effects may include blood clots and stroke. (wikipedia.org)
Metabolites help enhance the absorption of vitamin c by your white blood cells and we use a unique, chemical-free manufacturing process that neutralizes ph which makes it non-acidic. (ralphs.com)

The structures of the mesial temporal lobe include the hippocampus, amygdala, and parahippocampal gyrus. (medscape.com)

Although interindividual variations were evident in the cellular response to 1,4-BQ, there was no gender difference in the response overall. (rti.org)

Nine metabolites, including ceramides, sphingomyelins or glycerophosphatidylcholines, were inversely associated with WHRadjfatmass in both sexes. (lu.se)

Out of 193 metabolites, 57 met the pre-defined quality control criteria for analysis. (nature.com)
In addition, we performed a look-up analysis of 43 pre-annotated metabolites, previously associated with birthweight or rapid growth. (nature.com)
Results Of the 193 LC-MS-metabolites being associated with WHRadjfatmass in EpiHealth (false discovery rate (FDR) <5%), 52 were replicated in a meta-analysis of PIVUS and POEM. (lu.se)

VAMIDOTHION JMPR 1973 IDENTITY Chemical name O,O-dimethyl S-[2-(1-methylcarboylethylthio)ethyl] phosphorothioate. (inchem.org)
In accordance with Annex VIII, Column 1, Item 8.8.1, of Regulation (EC) No 1907/2006 and with Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (ECHA, 2008), assessment of the toxicokinetic behaviour of the substance 1,3-Butylene diacetate was conducted to the extent that can be derived from the relevant available information. (europa.eu)

Most notably our Metabolite Profiling data added to more than 1.000 rat studies constitute the MetaMap ® Tox database, the world's largest consistent repository of Metabolite Profiling data to refine and reduce animal testing. (basf.com)
There are no studies available in which the toxicokinetic behaviour of 1,3-Butylene diacetate has been investigated. (europa.eu)
The results of these studies differ somewhat as regards metabolites associated with disease risk. (biomedcentral.com)
These new data will help in the selection of metabolites to be measured in studies on the role of the microbiota in human health, and will facilitate the interpretation of findings on their associations with disease outcomes. (who.int)

Absorption after oral administration is also expected when the "Lipinski Rule of Five" ((Lipinski, 2001), refined by Ghose (1999)) is applied to the substance 1,3-Butylene diacetate. (europa.eu)

When bacteria digest or ferment prebiotics, beneficial metabolites known as short-chain fatty acids are produced. (naturesway.com)

To identify polyphenols capable of inhibiting the formation of oligomers, polyphenols were added in 10-fold excess to monomeric Aβ 1-42 prior to induction of oligomerization. (confex.com)

Metabolite levels were compared to 2-year neurodevelopmental outcomes measured by the Bayley Scales of Infant and Toddler Development III (Bayley-III). (nature.com)
However, there were no significant changes in mRNA levels of the DNA repair genes ku80, rad51, xpa, xpc, and ape1 as well as p53 following treatment with 1,4-BQ. (rti.org)
There was a trend for lower levels of tryptophan metabolites in children that followed a rapid growth to obesity at 7 years trajectory. (nature.com)
Compliance with the tolerance levels specified below is to be determined by measuring only tolfenpyrad (4-chloro-3-ethyl-1-methyl- N -[[4-(4-methylphenoxy)phenyl]methyl]-1 H - pyrazole -5-carboxamide) in or on the commodity. (cornell.edu)

Is our breakthrough patented vitamin c formula supported with naturally occurring metabolites. (ralphs.com)

Polyphenols investigated include quercetin (QUE) and some of its most common metabolites, rhamnetin (RHA), isorhamnetin (IRHA), and tamarixetin (TAM). (confex.com)

The area under the receiver operator curve for multivariate prediction models including these metabolites and traditional risk factors was 0.77 for rapid growth and 0.82 for overweight, compared with 0.69 and 0.69, respectively, for models using traditional risk factors alone. (nature.com)
The metabolites identified here may assist in the identification of children at risk of developing obesity and improve understanding of mechanisms involved in postnatal growth. (nature.com)

On the basis of these findings, a diagnosis of sequestrated Hansen type 1 disk extrusion without extradural hemorrhage was made. (avma.org)

Birth defects can be defined as structural or functional abnormalities, including metabolic disorders, which are present from birth. (who.int)

We demonstrate that SiMeEx achieves the same metabolite recovery as using a standard method containing a scraping step, in various immortalized and primary cells. (frontiersin.org)

Here, we searched for metabolites and lipoprotein particles associated with fat distribution, measured as waist/hip ratio adjusted for fat mass (WHRadjfatmass), and general adiposity measured as percentage fat mass. (lu.se)

We describe the design of a new algorithm and software system capable of handling these high volumes of data, while including quality control methods for maintaining data quality. (mdpi.com)
Areas of focus may include improved tools, methods, standards, or applied science that support a better understanding and improved evaluation of product manufacturing, quality, safety, or effectiveness. (nih.gov)
To further augment the commercial value of algal metabolites, efficient valorization methods and biorefining channels are essential. (bvsalud.org)

1 in 700 live births in the USA and 11.2 in 10,000 live births in Europe. (bvsalud.org)

Elimination of butalbital is primarily via the kidney (59%-88% of the dose) as unchanged drug or metabolites. (drugs.com)
This approval includes a lower recommended dose and schedule of gemtuzumab ozogamicin than what FDA approved previously in 2000, as well as a different patient population. (fda.gov)

Anatomy12

Organisms14

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes40

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care7

Major metabolites2

Urine8

Compounds7

20221

Urinary2

Cannabinoids2

Enzymatic1

Water-soluble2

Lipid1

20175

Extraction8

Vitro3

Insecticide1

Analytical3

Plasma10

Benzene3

Caffeine2

Chromatography1

Metabolism2

Clinical6

Concentrations1

Propylene3

Additionally3

Microbial5

Glucuronides1

Inhibition1

Chemicals5

Biomarker2

Tissues2

Environmental2

Protein1

Exposure4

Metabolomics1

Analogues2

Acid3

Biological1

Cohort2

Toxicity2

Utilize2

Analyses1

Molecular weight2

Main2

Correction1

Correlation1

Blood2

Structures1

Cellular1

Inversely1

Analysis3

Chemical2

Studies4

Absorption1

Beneficial1

Formation1

Levels4

Naturally1

Common1

Growth2

Findings1

Metabolic disorders1

Method1

Mass1

Methods3

Live births1

Dose2