Tumor suppressor proteinRBL1InhibitoryOncogenicLipidRegulatoryComplexesGenesTranscription factorsEncodePhosphorylationRegulateHumansCellularPromoting factorsMembersCellNoteFamilyFormCancerAdditionSporadic retinoblastomaP130Tumor suppressor1998Histone deacetylaseRepress transcriptionGenomeInteractsReplicationUnilateralTranscription FactorMediatorGeneBindsRolesChromatinActivatesStructuralBoundOccursPocketMotifUltimatelyComplexDomainHighlyHumanExpression
Tumor suppressor protein1
- gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. (wikipedia.org)
RBL11
- Pro-proliferative focus on genes cyclinD1 (CCND1) and E2F1 aswell as anti-proliferative goals CDKN1A (p21) PTEN RB1 RBL1 (p107) RBL2 (p130) had been proven as common goals for miR-17 -20 and -106b. (techblessing.com)
Inhibitory1
- The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
Oncogenic1
- Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. (wikipedia.org)
Lipid1
- On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
Regulatory5
- A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
- We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
- Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)
- A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
- It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (nih.gov)
Complexes2
- After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)
- Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
Genes3
- Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
- Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
- Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
Transcription factors1
- pRb binds and inhibits E2 promoter-binding-protein-dimerization partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. (wikipedia.org)
Encode1
- Many strikingly miR-17 -20 and -106b had been found to market cell proliferation by raising the intracellular activity of E2F transcription elements even though miR-17 -20 and -106b straight focus on the transcripts that encode because of this proteins family members. (techblessing.com)
Phosphorylation3
- pRb is a multifunctional protein with many binding and phosphorylation sites. (wikipedia.org)
- Within each domain, there are a variety of protein binding sites, as well as a total of 15 possible phosphorylation sites. (wikipedia.org)
- Generally, phosphorylation causes interdomain locking, which changes pRb's conformation and prevents binding to target proteins. (wikipedia.org)
Regulate1
- The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Humans1
- In humans, the protein is encoded by the RB1 gene located on chromosome 13-more specifically, 13q14.1-q14.2. (wikipedia.org)
Cellular1
- The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
Promoting factors1
- The pRb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis. (wikipedia.org)
Members1
- pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. (wikipedia.org)
Cell1
- They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
Note1
- Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
Family1
- RB/E2F-family proteins repress transcription. (wikipedia.org)
Form1
- Two forms of retinoblastoma were noticed: a bilateral, familial form and a unilateral, sporadic form. (wikipedia.org)
Cancer1
- Sufferers of the former were over six times more likely to develop other types of cancer later in life, compared to individuals with sporadic retinoblastoma. (wikipedia.org)
Addition1
- In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
Sporadic retinoblastoma3
- Sufferers of the former were over six times more likely to develop other types of cancer later in life, compared to individuals with sporadic retinoblastoma. (wikipedia.org)
- This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (wikipedia.org)
- 29. Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach. (nih.gov)
P1305
- El factor E2F4 recluta indirectamente factores de remodelación de la cromatina para actuar en REGIONES PROMOTORAS de genes, merced a la PROTEÍNA P130 SIMILAR A LA DEL RETINOBLASTOMA y la PROTEÍNA P107 SIMILAR A LA DEL RETINOBLASTOMA. (bvsalud.org)
- E2F4 recruits chromatin remodeling factors indirectly to target gene PROMOTER REGIONS through RETINOBLASTOMA LIKE PROTEIN P130 and RETINOBLASTOMA LIKE PROTEIN P107. (bvsalud.org)
- RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. (nih.gov)
- 30. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (nih.gov)
- 38. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. (nih.gov)
Tumor suppressor4
- gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. (wikipedia.org)
- 32. Control of glutamine metabolism by the tumor suppressor Rb. (nih.gov)
- A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. (bvsalud.org)
- It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. (bvsalud.org)
19981
Histone deacetylase2
- The pRb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis. (wikipedia.org)
- Retinoblastoma protein recruits histone deacetylase to repress transcription. (nih.gov)
Repress transcription1
- RB/E2F-family proteins repress transcription. (wikipedia.org)
Genome1
- 28. Variability in retinoblastoma genome stability is driven by age and not heritability. (nih.gov)
Interacts2
- Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. (embl-heidelberg.de)
- It interacts directly with FANCG PROTEIN and helps stabilize a complex with FANCA PROTEIN and FANCC PROTEIN . (nih.gov)
Replication5
- Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. (nih.gov)
- Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. (nih.gov)
- Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. (nih.gov)
- Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. (nih.gov)
- key target for these transcription factors is cdc18 gene, which encodes protein required for initiation of DNA replication (see text). (comprehensivephysiology.com)
Unilateral2
- Two forms of retinoblastoma were noticed: a bilateral, familial form and a unilateral, sporadic form. (wikipedia.org)
- 31. Unilateral retinoblastoma in an eye with Peters anomaly. (nih.gov)
Transcription Factor1
- Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity. (embl-heidelberg.de)
Mediator1
- In the SASP of cells that became senescent following several in vitro chemical and physical stress, we identified the IGFBP-4 protein that can be considered a general stress mediator. (elifesciences.org)
Gene3
- 24. Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis. (nih.gov)
- These results provide the first in vivo evidence supporting essential regulatory roles for KLFs in fat metabolism in C. elegans and shed light on the human counterpart in disease-gene association. (ijbs.com)
- We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
Binds4
- Although its common function is seen as binding and repressing E2F targets, pRb is likely a multifunctional protein as it binds to at least 100 other proteins. (wikipedia.org)
- pRb binds and inhibits E2 promoter-binding-protein-dimerization partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. (wikipedia.org)
- Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
- HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Roles2
- 25. From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway. (nih.gov)
- They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (childrensmercy.org)
Chromatin1
Activates2
Structural1
- Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. (embl-heidelberg.de)
Bound1
- Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. (embl-heidelberg.de)
Occurs1
- Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control. (embl-heidelberg.de)
Pocket3
- pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. (wikipedia.org)
- The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. (embl-heidelberg.de)
- The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. (embl-heidelberg.de)
Motif1
- Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)
Ultimately2
- The clinical signs of mice were significantly ameliorated, especially the cecum injury, while the secretion of pro-inflammatory associated cytokines such as IL-1α, IL-6, IL-17A and TNF-α was reduced, the expression of TLR4 was inhibited, which alleviated the inflammatory response, and the expression of the tight junction protein Claudin-1 was increased, ultimately promoting the recovery of host health. (bvsalud.org)
- Ultimately, when is a protein degraded? (biomedcentral.com)
Complex1
- HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
Domain5
- Taxonomic distribution of proteins containing CYCLIN domain. (embl-heidelberg.de)
- The complete taxonomic breakdown of all proteins with CYCLIN domain is also avaliable . (embl-heidelberg.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing CYCLIN domain in the selected taxonomic class. (embl-heidelberg.de)
- Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (embl-heidelberg.de)
- It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Highly1
- Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. (embl-heidelberg.de)
Human3
- Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. (wikipedia.org)
- 23. Rb suppresses human cone-precursor-derived retinoblastoma tumours. (nih.gov)
- The human rad51 protein: Polarity of strand transfer and stimulation by hRPA. (nih.gov)