Metabolism protein isoforms. Medical search. Frequent questions

Glucose transport can be activated in skeletal muscle in response to insulin via activation of phosphoinositide (PI) 3-kinase and in response to contractions or hypoxia, presumably via activation of 5′ AMP-activated protein kinase (AMPK). (diabetesjournals.org)
This most likely occurs from defects in postreceptor insulin signal transduction at the level of insulin receptor substrate-1 and phosphoinositide (PI) 3-kinase ( 6 - 9 ) as well as defects in trafficking and/or function of GLUT4 ( 10 , 11 ), the major insulin-regulated GLUT isoform expressed in skeletal muscle ( 12 ). (diabetesjournals.org)
5' adenosine monophosphate-activated protein kinase, metabolism and exercise. (unicamp.br)
In yeast, a key regulator of PM homeostasis is target of rapamycin (TOR) complex 2 (TORC2), a multiprotein complex containing the evolutionarily conserved TOR protein kinase isoform Tor2 . (yeastgenome.org)
The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)
The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)
Here, we report that drug-targeted inhibition or silencing of Unc51-like kinase 1 (ULK1) results in repression of type I IFN-induced expression of the dACE2 isoform. (bvsalud.org)
Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
Here we report a new level of regulation wherein LCFA-CoA esters per se allosterically activate AMP-activated protein kinase (AMPK) β1-containing isoforms to increase fatty acid oxidation through phosphorylation of acetyl-CoA carboxylase. (mcmaster.ca)

In breast cancer, LACTB has a tumor suppressor function by modulating lipid metabolism. (wikipedia.org)
2017. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. (wikipedia.org)
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Eukaryotic cell survival requires maintenance of plasma membrane (PM) homeostasis in response to environmental insults and changes in lipid metabolism. (yeastgenome.org)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. (nature.com)
Fatty acid binding proteins are small cytoplasmic lipid binding proteins that are expressed in a tissue specific manner. (rndsystems.com)
Some FABP polymorphisms have been associated with disorders of lipid metabolism and the development of atherosclerosis. (rndsystems.com)
A mutation in the lipid-binding pocket of Ypt35p that reduces lipid binding markedly does not affect these PX domain protein interactions, arguing that lipid binding uses a different interaction surface than protein binding. (embl.de)
The activity of purified FAM92A1-NT* was verified bynegative stain EM.IIFourth, we were interested in the regulation of the lipid metabolism. (kth.se)
In recent research, new functions for the SREBP family have offered insight on the effect of lipid metabolism on various pathophysiological diseases (cancers, steatosis and immunity, PMID: 22154484). (novusbio.com)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)

Insulin produces the dephosphorylation of only a small subset of proteins at discrete locations, whereas PP1 is ubiquitously expressed and is found in virtually all cellular compartments, suggesting that mechanisms exist for the targeted regulation of PP1 in insulin-responsive cells that selectively permit activation of the enzyme only at these sites. (jci.org)
PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. (antikoerper-online.de)
Transcriptomic analysis of ZAP-isoform-specific knockout cells revealed uncharacterized host mRNAs targeted by ZAPL/S with broad cellular functions such as unfolded protein response (UPR), epithelial-mesenchymal transition (EMT), and innate immunity. (bvsalud.org)
Overall, this study demonstrates that the competition between splicing and IPA is a potential target for the modulation of the ZAPL/S balance, and reports new cellular transcripts and processes regulated by the ZAP isoforms. (bvsalud.org)
The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
Subcellular localization analysis indicated that p35 (p35f and p35iso) expression leads to the formation of stress granules, cellular structures that package mRNA and RNA-binding proteins during cell stress. (elsevierpure.com)
Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)
Her contributions place as a key molecular hub, that regulates key signaling pathways to coordinate cell metabolism and cellular function and overall promote anabolism in the context of cycling cells and in differentiated tissues (6-8) . (unil.ch)
It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
Furthermore, translational downregulation decreased cellular abundance of these proteins. (bvsalud.org)
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. (mcmaster.ca)
Cell membranes need to change their shapes during many cellular processeslike protein trafficking, cytokinesis and membrane homeostasis. (kth.se)
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. (bvsalud.org)
The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). (bvsalud.org)

Isoform-specific AMPK activity was measured in skeletal muscle in response to insulin, contraction, or hypoxia. (diabetesjournals.org)
GIBALA, M. J. Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time trial performance. (unicamp.br)
2016). MCT1 and MCT4 are MCT isoforms expressed in skeletal muscle (Bonen, 2001). (elsevierpure.com)
Halestrap, 2012), is the predominant isoform in oxidative skeletal muscle fibers and considered responsible for lactate uptake (Mccullagh et al. (elsevierpure.com)
Halestrap, 2012), is the isoform predominantly expressed in glycolytic skeletal muscle fibers and considered responsible for lactate release (Dimmer et al. (elsevierpure.com)
Isoforms that lack the n-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. (lu.se)

These genes increase oxygen availability by inducing erythropoiesis and angiogenesis, and also reduce its demand via regulation of energy metabolism by reducing oxidative phosphorylation and inducing non-oxygen-demanding glycolysis [ 5 , 6 , 7 ]. (springer.com)
Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
Comparative analysis within each field revealed a total of 32 differentially expressed proteins between GM and non-GM samples, and their molecular functions were mainly assigned to carbohydrate and energy metabolism, genetic information processing and stress response. (biosafety-info.net)

CYP3A4 is the major isoform responsible for fipronil oxidation in humans while CYP2C19 is considerably less active. (cdc.gov)
Fipronil metabolism was activated by testosterone in HLM but not in CYP3A4 Supersomes(R). Testosterone 6beta-hydroxylation in HLM was inhibited by fipronil. (cdc.gov)
Gefitinib metabolism: mainly by the cytochrome P450 drug metabolizing system utilizing principally CYP3A4 enzyme isoform. (pharmacology2000.com)
amobarbital will decrease the level or effect of vonoprazan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
efavirenz will decrease the level or effect of vonoprazan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
Furthermore, atazanavir and ritonavir are themselves substrates for CYP3A4 isoform of cytochrome P450. (who.int)

The protein phosphorylation-driven conformational change of p47(phox) enables its PX domain to bind to phosphoinositides, the interaction of which plays a crucial role in recruitment of p47(phox) from the cytoplasm to membranes and subsequent activation of the phagocyte oxidase. (embl.de)
Neurons from patients with fAD and patients with sAD showed increased phosphorylation of TAU protein at all investigated phosphorylation sites. (biomedcentral.com)
Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. (molvis.org)

Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
During her PhD, Isabel studied the regulation of the alternative splicing of the Fibronectin (FN1) and Lamin A/C ( LMNA ) genes, and their role in host cell invasion (1) , aging (2) and metabolism (3,4) . (unil.ch)
Sterol regulatory element-binding proteins (SREBPs) compose a family of transcriptional factors that regulate the expression of various genes required for the synthesis of phospholipids, fatty acids, and cholesterol. (novusbio.com)
Six common polymorphisms in vitamin D metabolism genes were genotyped. (medscape.com)

Alternative splicing results in multiple transcript variants encoding different protein isoforms. (wikipedia.org)
At least two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Two alternatively spliced transcript variants encoding distinct isoforms have been observed. (antikoerper-online.de)
Alternate transcription promoters generate two transcript variants, encoding a 128 aa and a 177 aa residue protein. (rndsystems.com)

Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)

Cell Metabolism, 29, 202-210. (lu.se)

Decreased expression of frataxin protein is responsible for the devastating rare genetic disease of Friedreich's ataxia. (nih.gov)
To the best of our knowledge this study represents the first evidence of protein identities with differentially expressed isoforms in Brazilian MON810 genetic background hybrid grown under field conditions. (biosafety-info.net)
The projects feature state-of-the-art methods for the investigation of cell biology, such as flow cytometry and confocal microscopy, protein interaction analyses using the proximity-ligation assay and Biacore, and genetic manipulation employing the Cas9/CRISPR system. (lu.se)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

Whether the differential expression of actin isoforms in human diseases is functionally relevant is not yet fully established, although studies on human actin mutations, actin null mice, and the N-terminal end of alpha-smooth muscle actin support this possibility. (unige.ch)
Importantly, the alternative splicing of the LMNA gene was highly sensitive to the levels of specific Serine-Arginine rich (SR) proteins (5) , and produced several splicing isoforms that affect adipose tissue metabolism and aging in opposite manners, with Lamin A and Progerin promoting energy expenditure and aging, while Lamin C favors slower metabolism and moderately slows the aging process in mice (4) . (unil.ch)
The level of UCP1, the key thermogenic protein in BAT, was progressively reduced in PV / and PV / mutant mice. (deiodinase.org)

TonB, partner protein of FhuA, is one of three proteins from the energy-transducing complex TonB-ExbB-ExbD that is embedded in the cytoplasmic membrane. (mcgill.ca)
Fatty acid binding protein-6 (FABP6), also known as ileal bile acid binding protein (I-BABP) and gastrotropin, is a 15 kDa cytoplasmic protein that belongs to the FABP family. (rndsystems.com)
To investigate the biochemical characteristics of TDP-43, we examined truncation, isoforms, and cytoplasmic inclusion (foci) formation using TDP-43-expressing cells. (elsevierpure.com)
The shortest forms, lacking the hydrophobic stretch, may be soluble cytoplasmic proteins. (lu.se)

abstract = "TAR DNA-binding protein-43 (TDP-43) has been recently identified as a major component of the ubiquitinated inclusions found in frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis, diseases that are collectively termed TDP-43 proteinopathies. (elsevierpure.com)

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam. (cdc.gov)
Fipronil was incubated with human liver microsomes (HLM) and several recombinant cytochrome P450 (CYP) isoforms obtained from BD Biosciences. (cdc.gov)

To gain insight into the function of MMADHC, recombinant isoforms were purified and low-resolution structural features were determined. (mcgill.ca)
Panning combinatorial phage libraries against recombinant MMADHC allowed mapping of putative sites of interaction on each protein. (mcgill.ca)
In addition, you will have the opportunity to learn microbiologic and immunologic techniques and to express and purify recombinant proteins. (lu.se)

The orexin receptors (orexin 1R and orexin 2R) belong to the Family of G-protein coupled receptors. (researchgate.net)
of G-protein coupled receptors. (researchgate.net)

Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene. (wikipedia.org)

Two major alternatively spliced ZAP isoforms, the constitutively expressed ZAPL and the infection-inducible ZAPS, play overlapping yet different antiviral and other roles that need further characterization. (bvsalud.org)
Alternatively, spliced mRNAs typically encode distinct proteins or harbor modified cis-regulatory elements, thereby altering the level of protein expression. (unil.ch)

While the molecular nature of intracellular cobalamin metabolism in mammals remains poorly understood, the proteins MMACHC, MMADHC, LMBD1 and ABCD4 are implicated in its early uptake and processing. (mcgill.ca)
Two well-defined pathological hallmarks of AD have been described: the formation of extracellular amyloid plaques and the development of intracellular neurofibrillary tangles (NFTs) formed by aggregated hyperphosphorylated TAU protein [ 4 ]. (biomedcentral.com)
Cytoskeletal proteins appear to be involved in the control of intracellular signaling. (jneurosci.org)

Modulation of actin isoform expression is a well-established feature of developmental phenomena. (unige.ch)
Bin/Amphiphysin/Rvs (BAR) proteins are peripheralmembrane proteins (PMP) and play an important role in sculpturingmembranes and in the regulation of actin dynamics. (kth.se)
CryoEM reveals that themuscular BIN1 isoform does not bind to single actin filaments, althoughBIN1 can be co-sedimented with actin after polymerization of actin. (kth.se)
Thisimplies that BIN1 rather bundles actin than decorates single filaments.Third, we explored a strategy to purify an aggregation prone BAR protein.Aggregation is a property common in Peripheral Membrane Proteins. (kth.se)

This gene encodes a 54 kDa protein sharing significant sequence similarity to serine proteases of the penicillin binding protein and beta-lactamase superfamily occurring in bacteria. (wikipedia.org)
LACTB shares sequence similarity to the beta-lactamase/penicillin-binding protein family of serine proteases that are involved in bacterial cell wall metabolism. (wikipedia.org)

Recently, one important pathway for ROS regulation has been discovered, mediated by the signaling protein p66Shc. (nature.com)

Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF1 induced signaling. (thermofisher.com)

LACTB has also been identified to be a tumor suppressor through its effect on mitochondrial phospholipid metabolism and modulation of cell differentiation state. (wikipedia.org)
Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. (nih.gov)
Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)

Vitamin B12, or cobalamin, is a water-soluble vitamin required as cofactor for two mammalian enzymatic processes: methionine regeneration in the cytoplasm by methionine synthase (MS), and fatty acid/amino acid metabolism in mitochondria by methylmalonyl-CoA mutase (MCM). (mcgill.ca)
Glucose is fundamental to the metabolism of mammalian cells. (thermofisher.com)

Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. (nih.gov)
2002. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. . (oregonstate.edu)

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). (antikoerper-online.de)
Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. (nih.gov)
p66Shc is encoded by the ShcA gene locus that is expressed as three isoforms of about 46, 52, and 66 kDa in mammals. (nature.com)
Vitamin D-binding protein (VDBP), encoded by the GC gene, binds to 85% to 90% circulating 25(OH)D and thereby regulates the vitamin D bioavailability. (medscape.com)

Pancreatic ß-cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. (bvsalud.org)
Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. (bvsalud.org)
Prior to induction of ER stress or suppression of global translation, sustained high glucose suppressed glucose-stimulated insulin secretion and downregulated translation of not only insulin, but also of mRNAs related to insulin secretory granule formation, exocytosis, and metabolism-coupled insulin secretion. (bvsalud.org)
Our findings uncover a translational regulatory circuit during ß-cell glucose toxicity that impairs expression of proteins with critical roles in ß-cell function. (bvsalud.org)

Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Human SREBP2 protein (amino acids 48-403). (novusbio.com)

Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca2+-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of Aspergillus fumigatus. (uc.edu)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

It binds both fatty acids and bile acids and has roles in fatty acid transport and metabolism. (rndsystems.com)
Our research focuses on the roles of two particular RNA binding proteins of the SR protein family, SRSF1 and SRSF2, in metabolism and adipose tissue biology. (unil.ch)
Unlocking the Mysteries of the Immune System: new Roles of complement proteins in Diabetes and Cancer. (lu.se)

We found upregulation of the key fructose transporter and metabolizing enzyme mRNAs, Slc2a2 , Khka , and Khkc , and higher ketohexokinase activity in the Hif-p4h-2 gt/gt small intestine relative to the WT, suggesting enhanced metabolism of fructose in the former. (springer.com)

One clue to this dilemma has emerged from the identification of "targeting" subunits that allow for the compartmentalized activation of the phosphatase, resulting in the specific dephosphorylation of discrete pools of proteins within the cell. (jci.org)
Even when all three PH-containing proteins were absent, the remaining TORC2 subunits were PM-bound. (yeastgenome.org)
The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
a The transcript levels (FPKM) are average values and summed for subunits of a protein and for multiple isoforms. (biomedcentral.com)

Constitutive, but not inducible, isoforms of cyclo-oxygenase and nitric oxide synthase play an important role in abnormal microvessel responses to carbon dioxide and hydrogen ions in hyperoxia-injured lungs. (ersjournals.com)
However, these previous studies did not determine the relative contributions of COX (COX‐1 and COX‐2) and nitric oxide synthase (NOS) isoforms (endothelial constitutive (ecNOS) and inducible NOS (iNOS)) to the abnormal acinar microvessel response to HA 4 , 7 . (ersjournals.com)

Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1α (PP1α) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation. (jci.org)
Out of the three isoforms present (SREBP-1a, SREBP-1c and SREBP-2), SREBP-2 has been implicated more directly in the synthesis of cholesterol during metabolism. (novusbio.com)

The pharmaceutical literature consists of numerous examples of 2-D QSARs, 3-D QSARs and expert systems for modelling the individual components or phases of drug disposition and pharmacokinetics (i.e. absorption, distribution, metabolism and *Corresponding author. (cdc.gov)

In conclusion, obesity-related insulin resistance is associated with an isoform-specific impairment in AMPKα1 in response to contraction. (diabetesjournals.org)

SREBP-2 is expressed in both the cytoplasm and nucleus on a subcellular level, depending on the state of the protein. (novusbio.com)

Here we show for the first time by genome-wide two-hybrid screens and in vitro binding assays that the PX domain is a bona fide protein interaction domain. (embl.de)
Interactions of Grd19p, Vam7p, Vps5p, Vps17p, and Ypt35p with members of the Yip1p family of proteins were detected consistently and were verified by in vitro binding assays. (embl.de)
With a deletion mutant series, the critical domains for generating both isoforms were determined and applied to in vitro transcription/translation, revealing alternate in-frame translation start sites downstream of the natural initiation codon. (elsevierpure.com)
This study was designed to investigate the in vitro human metabolism of fipronil and to examine possible metabolic interactions that fipronil may have with other substrates. (cdc.gov)

In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)

A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus Aspergillus fumigatus and Suggests Noncanonical Functions within the Pathway. (uc.edu)
Human FABP6 isoform 2 contains 128 amino acid residues and is believed to be acetylated on Ala2. (rndsystems.com)
This is the first study showing that human UGT1A isoforms interact with other isoforms to change the enzymatic characteristics. (aspetjournals.org)
Other human CYP isoforms have minimal or no activity toward fipronil. (cdc.gov)
We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)

This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

Unlike crystals that are grown for soluble proteins (usually to 100 µm in size), the MP crystals of the ExbB-ExbD complex that we reproducibly grow in lipidic cubic phase are "showers", only 5 to 10 µm in all dimensions. (mcgill.ca)

HIF-P4H-2 inhibition enhances intestinal fructose metabolism protecting the liver. (springer.com)
Observations were made with and without inhibition of constitutive (endothelial constitutive NOS (ecNOS) and COX‐1) and inducible isoforms (iNOS and COX‐2) of NOS and COX. (ersjournals.com)

This resembles the β-amyloid precursor protein (APP) in Alzheimer disease (AD), which can be physiologically processed by α-, β-, and γ-secretases. (mdpi.com)
It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. (curehunter.com)

The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

Collectively, this study demonstrates that the 35-kDa isoforms of TDP-43 assemble in stress granules, suggesting that TDP-43 plays an important role in translation, stability, and metabolism of mRNA. (elsevierpure.com)

isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. (nih.gov)
Mature frataxin (81-210) is a critically important protein because it facilitates the assembly of mitochondrial iron-sulfur cluster protein complexes such as aconitase, lipoate synthase, and succinate dehydrogenases. (nih.gov)
There is three times as much isoform E in erythrocytes (20.9 ± 6.4 ng/mL) from the whole blood of healthy volunteers (n = 10) when compared with the mature mitochondrial frataxin present in other blood cells (7.1 ± 1.0 ng/mL). (nih.gov)
Isoform E lacks a mitochondrial targeting sequence and so is distributed to both cytosol and the nucleus when expressed in cultured cells. (nih.gov)

11. Amsel, A. & Roussel, J. Motivational properties of ences in post-transcriptional processes spark interest in the development of frustration: I. Effect on a running response of the (protein redistribution, degradation), pharmacotherapies that selectively reg- addition of frustration to the motivational com- plex. (lu.se)

2019) Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. (lu.se)

In contrast to ACE2, the short dACE2 isoform lacks the ability to bind the spike protein of SARS-CoV-2. (bvsalud.org)

Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)

The accompanying video shows a scale model for interaction of known proteins of E. coli that participate in transport of iron-siderophores across the cell envelope. (mcgill.ca)
The phox homology (PX) domain protein interaction network in yeast. (embl.de)
To analyze the protein-protein interaction between the UGT1As, we investigated the thermal stability and resistance to detergent. (aspetjournals.org)
The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
It has been known to interact and form a complex with the SCAP protein at the ER, in turn inhibiting interaction between SCAP and SEC24B. (novusbio.com)

Thank you for sharing this Drug Metabolism & Disposition article. (aspetjournals.org)
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We particularly focus on how these proteins participate in the onset and development of diet-induced obesity and insulin resistance. (unil.ch)

Anatomy33

Organisms17

Diseases4

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes83

Disciplines and Occupations3

Information Science5

Kinase10

Lipid13

Cellular14

Skeletal6

Energy metabolism3

CYP3A47

Phosphorylation3

Genes4

Transcript variants4

Transcription Factors1

Cell metabolism1

Genetic4

Mice3

Cytoplasmic4

Abstract1

Cytochrome2

Recombinant3

Receptors2

Humans1

Alternatively spliced2

Intracellular3

Actin4

Serine2

Regulation1

GLUT1

Phospholipid3

Mammalian2

Characterization2

Gene4

Glucose4

Membrane associated proteins1

Amino acids1

Endoplasmic Reticulum2

Roles3

Enzyme1

Subunits4

Abnormal2

Synthesis2

Pharmacokinetics1

AMPK1

Subcellular1

Vitro4

Cholesterol metabolism1

Human5

Transmembrane1

Soluble1

Inhibition2

Amyloid precurs2

Encodes2

MRNA1

Mitochondrial4

Transcriptional1

Cartilage Oligome1

Lacks1

Regulate1

Interaction5

Disposition2

Insulin resistance1