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PurinesPyrimidinesPyrimidine NucleotidesPurine NucleotidesPyrimidine DimersPyrimidine NucleosidesPurine NucleosidesPurine-Nucleoside PhosphorylaseEnergy MetabolismLipid MetabolismPentosyltransferasesDeoxyribonuclease (Pyrimidine Dimer)Pyrimidine PhosphorylasesOrotic AcidUracilHypoxanthineHypoxanthinesUltraviolet RaysInosineNucleosidesOrotate PhosphoribosyltransferaseUridineAdeninePurine-Pyrimidine Metabolism, Inborn ErrorsDihydroorotaseKineticsPhosphoribosyl PyrophosphateDeoxyribodipyrimidine Photo-LyaseMetabolismUridine PhosphorylaseCytidineAspartate CarbamoyltransferaseMolecular Sequence DataBase SequenceDNAOrotidine-5'-Phosphate DecarboxylaseGuanosineDeoxyribonucleosidesCarbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)NucleotidesRibonucleosidesGlucoseLiverUracil NucleotidesDihydroorotate OxidaseUridine TriphosphateThymineUridine KinaseGuanineMutationEscherichia coliDNA RepairRibonucleotidesInosine MonophosphateUridine MonophosphateSubstrate SpecificityAdenosineRibosemonophosphatesDeoxyuridineChromatography, High Pressure LiquidNucleic Acid ConformationAdenosine Triphosphate5'-NucleotidaseNucleotidasesThiamineOxidation-ReductionMagnetic Resonance SpectroscopyMolecular StructureBiotransformationCarbon IsotopesHypoxanthine PhosphoribosyltransferaseAdenine PhosphoribosyltransferaseN-Glycosyl HydrolasesDeoxyadenosinesAmidophosphoribosyltransferaseCarbon RadioisotopesPentosephosphatesPhosphoribosylglycinamide FormyltransferaseMetabolic Networks and PathwaysNucleoside Transport ProteinsStructure-Activity RelationshipXanthineAdenosine DeaminaseFormycinsCytosinePhosphotransferasesThymidineAmino Acid SequenceDNA DamagePhosphoribosylaminoimidazolecarboxamide FormyltransferaseMetabolism, Inborn ErrorsHydroxymethyl and Formyl TransferasesNucleobase Transport ProteinsMethylthioinosineCell LineGlycolysisCarbamyl PhosphateAdenine NucleotidesCells, CulturedMicrosomes, Liver
NucleotideSynthesisUric acidNucleotidesInborn errorsCatabolism of purinesOxidative phosphorylationPathwayGoutCitric acidEnergy metabolismBiosynthesis and catabolismCytosineNovoMetabolic pathwaysProteinsEnzymesIntermediaryAtomsCarbohydrateThymineCellularUrinePyridineNucleosidesHeterocyclicBiochemistryNucleic acidsBasesGuanineFolicProteinDeficiencyAbsorptionOrganisms2020Host metabolismTherapeuticHemeCarbonBreakdownSelectiveLipidsChapterPentoseCarbohydratesQuizOccurs
Nucleotide12
  • Textbook of Biochemistry: With Clinical Correlations 7th, Purine and Pyrimidine Nucleotide Metabolism. (euroasfalti.net)
  • ATP.E. Disorders of Purine and Pyrimidine Metabolism Rebecca S. Wappner PURINE AND PYRIMIDINE METABOLISM Purine and pyrimidine nucleotides are important constituents of RNA, DNA, nucleotide sugars, and other high-energy compounds and of cofactors such as adenosine triphosphate and nicotinamide-adenine dinucleotide. (euroasfalti.net)
  • Therapeutic agents directed against nucleotide metabolism. (up.ac.za)
  • These vitamins are structurally diverse (derivatives of sugar, pyridine, purines, pyrimidine, organic acid complexes and nucleotide complex) and act as coenzymes, as oxidation-reduction agents, possibly as mitochondrial agents. (nih.gov)
  • Biological networks were built with the other survival genes using a protein-protein interaction network, which identified clusters of cellular processes, including protein ubiquitination, purine and pyrimidine metabolism, nucleotide excision repair, and NF-κB signaling. (aspetjournals.org)
  • It is due to excess degradation of purine nucleotide into uric acid mainly in diseases like cancer, trauma, psoriasis etc. decrease in uric acid elimination is due to reduced glomerular filtration rate. (gpatindia.com)
  • Defective nucleotide metabolism, excess uric acid in blood, obesity, over consumption of sea food, certain diseases like heart diseases. (gpatindia.com)
  • It is a pyrimidine nucleotide disorder. (gpatindia.com)
  • So the deficiency of UMP and other pyrimidine nucleotide result in the inhibition of DNA and RNA which further leads to megaloblastic anemia and growth retardation. (gpatindia.com)
  • Nucleotide Metabolism is an important issue in medical studies and therefore you can learn in this biochemistry article everything about purine & pyrimidines. (tuiasi.ro)
  • Purines and pyrimidines make up the two gatherings of nitrogenous bases, including the two gatherings of nucleotide bases. (tuiasi.ro)
  • Chemotherapy is the main option to control these pathogenic organisms and nucleotide metabolism is considered a promising area for the provision of antimicrobial therapeutic targets. (eurekaselect.com)
Synthesis9
  • In addition, increases in GPX, SOD3, G6PD, HK, and PFK at proteomic and transcriptomic levels suggested elevation of glycolysis and pentose phosphate pathway, synthesis of glutathione and nucleotides, and antioxidative pathway activity, whereas oxidative phosphorylation, TCA and mitochondrial energy metabolism were reduced. (frontiersin.org)
  • Causes of megaloblastic anemia include vitamin B 12 or folate deficiency (as a result of decreased intake, decreased absorption, or increased demand), specific drugs, inborn errors of metabolism, myelodysplastic syndromes , and problems with DNA synthesis (eg, from chemotherapy). (arupconsult.com)
  • Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. (frontiersin.org)
  • Virus infection may reprogram host metabolism for viral genome and protein synthesis, as well as lipid envelope generation for virion production. (frontiersin.org)
  • MZB has a very specific mechanism of action on the lymphocytes that inhibits their proliferation without interfering with purine synthesis in other cell types. (hindawi.com)
  • Hitchings, who would later become a member of the National Academy of Sciences, "talked about purines and pyrimidines, which I must confess I'd never even heard of up to that point, and it was really to attack a whole variety of diseases by interfering with DNA synthesis. (cuny.edu)
  • De-novo synthesis of Pyrimidines (Uracil, Thymine & Cytosine) Biosynthesis of pyrimidines is simple than that of purines. (tuiasi.ro)
  • Purines are derived either from dietary ingestion of purine-containing compounds or by de novo synthesis. (tuiasi.ro)
  • Unlike purine synthesis, pyrimidines are synthesized as bases and latter it is added to ribose sugar, i.e., the ring is completed before being it is linked to ribose-5-phosphate. (tuiasi.ro)
Uric acid10
Nucleotides7
Inborn errors4
  • Inborn errors of purine-pyrimidine metabolism are a class of inborn error of metabolism disorders specifically affecting purine metabolism and pyrimidine metabolism. (wikipedia.org)
  • Approach to the Patient With a Suspected Inherited Disorder of Metabolism Most inherited disorders of metabolism (inborn errors of metabolism) are rare, and therefore their diagnosis requires a high index of suspicion. (msdmanuals.com)
  • Examples of inborn errors of metabolism of nitrogen containing compounds. (up.ac.za)
  • Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. (cdc.gov)
Catabolism of purines2
Oxidative phosphorylation1
  • Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
Pathway3
  • Purines and pyrimidines may be synthesized de novo or recycled by a salvage pathway from normal catabolism. (msdmanuals.com)
  • Pyrimidine Metabolism Disorders Pyrimidines may be synthesized de novo or recycled by a salvage pathway from normal catabolism. (msdmanuals.com)
  • The result showed that the purine metabolism pathway is the most venerable target of BPA, which can be a potential endogenous biomarker for its exposure. (ntu.edu.sg)
Gout6
  • there is an increased excretion of xanthine and hypoxanthine in non-Lesch-Nyhan gout.D. what are the pyrimidines. (euroasfalti.net)
  • AMP, GMP, and IMP shift PRPP amido transferase from a small form to a large form.B. Human diseases that involve abnormalities in purine metabolism include gout, Lesch-Nyhan syndrome, adenosine deaminase deficiency, and purine nucleoside phosphorylase deficiency. (euroasfalti.net)
  • Though this statistical review adds nothing to our knowledge of how different purines affect gout in different ways, it certainly changed the way gout experts view diet. (goutpal.com)
  • Moderate intake of purine-rich vegetables or protein is not associated with an increased risk of gout. (goutpal.com)
  • There is no correlation between gout pain and purines. (goutpal.com)
  • Research published by Joosten in 2010 has led to suggestions that free fatty acids might be more important than purines in gout diet management [1] . (goutpal.com)
Citric acid2
Energy metabolism2
Biosynthesis and catabolism1
Cytosine5
Novo1
  • MZB inhibits the de novo purine biosynthesis of purines, but unlike azathioprine (AZT), it is not incorporated into nucleic acids in the cell. (hindawi.com)
Metabolic pathways4
  • Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. (euroasfalti.net)
  • The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into another chemical, each step being facilitated by a specific enzyme. (wikipedia.org)
  • A striking feature of metabolism is the similarity of the basic metabolic pathways among vastly different species. (wikipedia.org)
  • She elucidated some alterations in metabolic pathways that led to resistance to the purine antagonists. (cuny.edu)
Proteins1
Enzymes1
  • Enzymes are crucial to metabolism because they allow organisms to drive desirable reactions that require energy and will not occur by themselves, by coupling them to spontaneous reactions that release energy. (wikipedia.org)
Intermediary3
  • c) Regulators of intermediary metabolism d) All of the above 2. (euroasfalti.net)
  • The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. (wikipedia.org)
  • The intermediary metabolism of small molecules is the meat and potatoes of cell function. (cshlpress.com)
Atoms1
Carbohydrate1
Thymine1
  • Thymine (2, 4-dioxy-5-methyl pyrimidine): (C5H6O2N2), found in DNA molecules only, has MW=126.13 Daltons. (tuiasi.ro)
Cellular3
  • Cellular metabolism relies on just a few redox cofactors. (biorxiv.org)
  • Increasing evidence has shown that virus infection, similar to cancer development, depends on the reprogramming of cellular metabolism to produce biomass for viral replication and virion production. (frontiersin.org)
  • Purines and pyrimidines are essential building blocks of DNA, RNA, and compounds involved in cellular energy transfer and biosynthetic reactions (e.g., adenosine triphosphate, ATP). (tuiasi.ro)
Urine2
  • Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation. (uib.no)
  • Metabolism is rapid, and the excess is excreted in the urine. (nih.gov)
Pyridine1
Nucleosides1
Heterocyclic2
  • N ucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). (chemicalland21.com)
  • Pyrimidine is a heterocyclic aromatic organic compound that is composed of carbon and hydrogen. (tuiasi.ro)
Biochemistry1
  • The book develops these concepts into the more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including particular aspects of metabolism in some organs and tissues, and the biochemical bases of endocrinology, immunity, vitamins, hemostasis, and apoptosis. (stanford.edu)
Nucleic acids1
Bases4
Guanine1
  • Purine and pyrimidine disorders have a wide spectrum of signs and symptoms, including autism, kidney stones, susceptibility to … It comprises adenine and guanine as nucleobases. (tuiasi.ro)
Folic3
Protein1
  • Purine content of food must be related not only to weight but also to energy and to protein, particularly if new foodstuffs or a vegetarian diet are ingested. (goutpal.com)
Deficiency1
  • doi: 10.1080/15257770.2015.1125001 that involve abnormalities in purine nucleoside phosphorylase deficiency ):578-594. (euroasfalti.net)
Absorption2
  • purine sources differ in their absorption rates, a fact not taken into account in our food tables. (goutpal.com)
  • Drugs that induce megaloblastic anemia typically interfere with vitamin B 12 or folate absorption or metabolism. (arupconsult.com)
Organisms1
  • Metabolism (/məˈtæbəlɪzəm/, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. (wikipedia.org)
20201
Host metabolism1
  • Understanding the impact of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the host metabolism is still in its infancy but of great importance. (mdpi.com)
Therapeutic2
  • The metabolism of cancer cells is also different from the metabolism of normal cells, and these differences can be used to find targets for therapeutic intervention in cancer. (wikipedia.org)
  • In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers. (frontiersin.org)
Heme1
Carbon3
  • Purines have two carbon-nitrogen rings and pyrimidines have one carbon-hydrogen ring. (tuiasi.ro)
  • Purines and pyrimidines both are made up of the aromatic ring having carbon and nitrogen in it. (tuiasi.ro)
  • Regardless of the route of exposure, chloroform is excreted from the body primarily as expired carbon dioxide, although at higher concentrations, where metabolism is saturated, appreciable levels of parent compound may be exhaled as well (Brown et al. (cdc.gov)
Breakdown1
  • pyrimidine catabolism phosphate synthetase-II undergo breakdown such that useful parts can be triggered by administration of 5-fluorouracil to with! (euroasfalti.net)
Selective1
  • Since then, receptor subtypes for adenosine-selective (P1 receptors) and purine and pyrimidine selective (P2 receptors) have been cloned and characterized. (euroasfalti.net)
Lipids1
Chapter1
Pentose1
  • Purines and pyrimidines are an important ingredient of the DNA along with the phosphate and the pentose sugar. (tuiasi.ro)
Carbohydrates1
Quiz1
Occurs1
  • Metabolism of chloroform occurs primarily by cytochrome p-450-dependent pathways, with CYP2E1 (ethanol-inducible) being the primary isozyme responsible (Wang et al. (cdc.gov)